Publications by authors named "Suqin Liu"

38 Publications

Copper (II) Ion-Modified Gold Nanoclusters as Peroxidase Mimetics for the Colorimetric Detection of Pyrophosphate.

Sensors (Basel) 2021 Aug 17;21(16). Epub 2021 Aug 17.

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai 201620, China.

Copper (II) ions have been shown to greatly improve the chemical stability and peroxidase-like activity of gold nanoclusters (AuNCs). Since the affinity between Cu and pyrophosphate (PPi) is higher than that between Cu and AuNCs, the catalytic activity of AuNCs-Cu decreases with the introduction of PPi. Based on this principle, a new colorimetric detection method of PPi with high sensitivity and selectivity was developed by using AuNCs-Cu as a probe. Under optimized conditions, the detection limit of PPi was 0.49 nM with a linear range of 0.51 to 30,000 nM. The sensitivity of the method was three orders of magnitude higher than that of a fluorescence method using AuNCs-Cu as the probe. Finally, the AuNCs-Cu system was successfully applied to directly determine the concentration of PPi in human urine samples.
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http://dx.doi.org/10.3390/s21165538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400922PMC
August 2021

FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis.

Metabolism 2021 Sep 29;122:154840. Epub 2021 Jul 29.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA. Electronic address:

Objective: Ferroptosis is indicated in cardiovascular diseases. Given the prominent role of mitophagy in the governance of ferroptosis and our recent finding for FUN14 domain containing 1 (FUNDC1) in obesity anomalies, this study evaluated the impact of FUNDC1 deficiency in high fat diet (HFD)-induced cardiac anomalies.

Methods And Materials: WT and FUNDC1 mice were fed HFD (45% calorie from fat) or low fat diet (LFD, 10% calorie from fat) for 10 weeks in the presence of the ferroptosis inhibitor liproxstatin-1 (LIP-1, 10 mg/kg, i.p.).

Results: RNAseq analysis for differentially expressed genes (DEGs) reported gene ontology term related to ferroptosis and mitophagy in obese rat hearts, which was validated in obese rodent and human hearts. Although 10-week HFD intake did not alter global metabolism, cardiac geometry and function, ablation of FUNDC1 unmasked metabolic derangement, pronounced cardiac remodeling, contractile, intracellular Ca and mitochondrial anomalies upon HFD challenge, the effects of which with exception of global metabolism were attenuated or mitigated by LIP-1. FUNDC1 ablation unmasked HFD-evoked rises in fatty acid synthase ACSL4, necroptosis, inflammation, ferroptosis, mitochondrial O production, and mitochondrial injury as well as dampened autophagy and DNA repair enzyme 8-oxoG DNA glycosylase 1 (OGG1) but not apoptosis, the effect of which except ACSL4 and its regulator SP1 was reversed by LIP-1. In vitro data noted that arachidonic acid, an ACSL4 substrate, provoked cytochrome C release, cardiomyocyte defect, and lipid peroxidation under FUNDC1 deficiency, the effects were interrupted by inhibitors of SP1, ACSL4 and ferroptosis.

Conclusions: These data suggest that FUNDC1 deficiency sensitized cardiac remodeling and dysfunction with short-term HFD exposure, likely through ACSL4-mediated regulation of ferroptosis.
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http://dx.doi.org/10.1016/j.metabol.2021.154840DOI Listing
September 2021

Fe induction strategy for hollow porous N-doped carbon with superior performance in oxygen reduction.

Chem Commun (Camb) 2021 Jul;57(58):7108-7111

College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, P. R. China.

An Fe induction strategy is introduced to achieve template-free synthesis of Co,Fe dual-metal N-codoped hollow porous carbon from zeolitic imidazole frameworks, which is beneficial for the exposure of highly dispersed metal (M)-Nx active sites and enhancement of mass transport, thereby exhibiting a superior electrocatalytic activity (E1/2, 0.86 VRHE).
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http://dx.doi.org/10.1039/d1cc02127cDOI Listing
July 2021

Dual Substitution Strategy in Co-Free Layered Cathode Materials for Superior Lithium Ion Batteries.

ACS Appl Mater Interfaces 2021 Apr 16;13(16):18733-18742. Epub 2021 Apr 16.

College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Chemical Power Sources, and Hunan Provincial Key Laboratory of Efficient and Clean Utilization of Manganese Resources, Central South University, Changsha, Hunan 410083, P. R. China.

A dual substitution strategy is introduced to Co-free layered material LiNiMnO by partially replacing Li and Ni with Na and Al, respectively, to achieve a superior cathode material for lithium ion batteries. Na ion functions as a "pillar" and a " cationic barrier" in the lithium layer while Al ion plays an auxiliary role in stabilizing structure and lattice oxygen to improve the electrochemical performance and safety. The stability of lattice oxygen comes from the binding energy between the Ni and O, which is larger due to higher valences of Ni ions, along with a stronger Al-O bond in the crystal structure and the "cationic barrier" effect of Na ion at the high-charge. The more stable lattice oxygen reduces the cation disorder in cycling, and Na in the Li layer squeezes the pathway of the transition metal from the LiM (M = metal) layer to the Li layer, stabilizing the layered crystal structure by inhibiting the electrochemical-driven cation disorder. Moreover, the cathode with Na-Al dual-substitution displays a smaller volume change, yielding a more stable structure. This study unravels the influence of Na-Al dual-substitution on the discharge capacity, midpoint potential, and cyclic stability of Co-free layered cathode materials, which is crucial for the development of lithium ion batteries.
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http://dx.doi.org/10.1021/acsami.1c01221DOI Listing
April 2021

Ultrasmall 2 D Co Zn (Benzimidazole) Metal-Organic Framework Nanosheets and their Derived Co [email protected],N-Codoped Graphene for Efficient Oxygen Reduction Reaction.

ChemSusChem 2020 Mar 5;13(6):1556-1567. Epub 2019 Dec 5.

College of Chemistry and Chemical Engineering and Hunan Provincial Key Laboratory of Chemical Power Sources, Central South University, Changsha, Hunan, 410083, P. R. China.

The development of nonprecious metal-nitrogen-carbon (M-N-C) materials with efficient metal utilization and abundant active sites for the oxygen reduction reaction (ORR) is of great significance for fuel cells and metal-air batteries. Ultrasmall 2 D Co Zn (benzimidazole) [Co Zn (bim) ] bimetallic metal-organic framework (MOF) nanosheets (≈2 nm thick) are synthesized by a novel bottom-up strategy and then thermally converted into a core-shell structure of sub-5 nm Co nanodots (NDs) wrapped with 2 to 5 layers of Co,N-codoped graphene ([email protected]). The size of the Co NDs in [email protected] could be precisely controlled by the Co/Zn ratio in the Co Zn (bim) nanosheet. As an ORR electrocatalyst, the optimized [email protected] exhibits an excellent half-wave potential of 0.841 V (vs. RHE), a high limiting current density of 6.42 mA cm , and great stability in alkaline electrolyte. [email protected] also has great ORR performance in neutral electrolyte, as well as in Mg-air batteries. The experimental studies and DFT calculations reveal that the high performance of [email protected] is mainly attributed to its great O absorptivity, which is endowed by the abundant Co-N and pyridinic-N in the FLG shell and the strong electron-donating ability from the Co ND core to the FLG shell. This elevates the e orbital energy of Co and lowers the activation energy for breaking the O=O/O-O bonds. This work sheds light on the design and fabrication of 2 D MOFs and MOF-derived M-N-C materials for energy storage and conversion applications.
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http://dx.doi.org/10.1002/cssc.201902776DOI Listing
March 2020

Sub-20 nm Carbon Nanoparticles with Expanded Interlayer Spacing for High-Performance Potassium Storage.

ACS Appl Mater Interfaces 2019 Jan 28;11(1):930-939. Epub 2018 Dec 28.

College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Chemical Power Sources , Central South University , Changsha , Hunan 410083 , P. R. China.

Carbon materials are most promising candidates for potassium-ion battery (PIB) anodes because of their high electrical conductivities, rational potassium storage capabilities, and low costs. However, the large volume change during the K-ion insertion/extraction and the sluggish kinetics of K-ion diffusion inhibit the development of carbon-based materials for PIBs. Here, under the guidance of density functional theory, N/P-codoped ultrafine (≤20 nm) carbon nanoparticles (NP-CNPs) with an expanded interlayer distance, improved electrical conductivity, shortened diffusion distance of K ions, and promoted adsorption capability toward K ions are synthesized through a facile solvent-free method as a high-performance anode material for PIBs. The NP-CNPs show a high capacity of 270 mA h g at 0.2 A g, a remarkable rate capability of 157 mA h g at an extremely high rate of 5.0 A g, and an ultralong cycle life with a high capacity of 190 mA h g and a retention of 86.4% at 1.0 A g after 4000 cycles. The potassium storage mechanism and low volume expansion for NP-CNPs are revealed through cyclic voltammetry, in situ Raman, and ex situ XRD. This work paves a new way to design and fabricate carbon-based nanostructures with high reversible capacity, great rate capability, and stable long-term performance.
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http://dx.doi.org/10.1021/acsami.8b18553DOI Listing
January 2019

Morphology-dependent electrochemical performance of Ni-1,3,5-benzenetricarboxylate metal-organic frameworks as an anode material for Li-ion batteries.

J Colloid Interface Sci 2018 Nov 22;530:127-136. Epub 2018 Jun 22.

College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China; Hunan Provincial Key Laboratory of Chemical Power Sources, Central South University, Changsha, Hunan 410083, PR China; Hunan Provincial Key Laboratory of Efficient and Clean Utilization of Manganese Resources, Central South University, Changsha, Hunan 410083, PR China. Electronic address:

The performance of energy storage materials is substantially dependent on their nanostructures. Herein, Ni-1,3,5-benzenetricarboxylate metal-organic frameworks (Ni-BTC MOFs) with different morphologies are controllably synthesized using a facile solvothermal method by simply adjusting the solvent and their electrochemical performance as an anode material for lithium-ion batteries is thoroughly investigated. Among the synthesized Ni-BTC MOFs with different morphologies, a hierarchical mesoporous flower-like Ni-BTC MOF (Ni-BTC) assembled from two-dimensional nanosheets shows the best electrochemical properties including a high capacity of 1085 mA h g at 100 mA g (358 mA h g at 5000 mA g), excellent cycling stability at 1000 mA g for 1000 cycles, and great rate performance, which is superior to most of the reported MOF-based anode materials for lithium-ion batteries. The outstanding electrochemical performance of Ni-BTC is originated from its unique and stable hierarchical mesoporous morphology with a high specific surface area and improved electrical/ionic conductivity. Moreover, our study demonstrates that the charge-discharge mechanism of the Ni-BTC electrode involves the insertion/extraction of Li ions to/from the organic moieties in Ni-BTC during the charge-discharge process without the direct engagement of Ni. This work highlights that the nanostructure design is an effective strategy to obtain promising energy storage materials.
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http://dx.doi.org/10.1016/j.jcis.2018.06.057DOI Listing
November 2018

Dual-target recognition sandwich assay based on core-shell magnetic mesoporous silica nanoparticles for sensitive detection of breast cancer cells.

Talanta 2018 May 3;182:306-313. Epub 2018 Feb 3.

School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address:

A novel dual-target recognition sandwich strategy for selective capture and detection of MCF-7 breast cancer cells based on core-shell magnetic mesoporous silica ([email protected]@[email protected]) nanoparticles was developed. [email protected]@[email protected] nanoparticles, which were prepared by a layer-by-layer method and were used for the first time to capture cancer cells, have large surface areas, particularly accessible mesochannels, and good biocompatibility, enabling aptamers to be compactly anchored onto the surface of the core-shell magnetic nanoparticles. A mucin 1 protein (MUC1)-targeted [email protected]@[email protected] nanoparticle was used as an affinity magnetic isolate material to capture target MCF-7 cells selectively and to reduce interference through affinity interaction between the anti-MUC1 aptamer and the MUC1 protein over-expressed on the surface of the MCF-7 cells. Meanwhile, a folate receptor (FR)-targeted affinity fluorescent probe (FA-BSA-FITC) was developed by coupling folic acid and FITC to the surface of BSA, enabling high sensitivity, selective fluorescent labeling of FR over-expressed MCF-7 cells. A dual-target recognition sandwich assay was developed based on the MUC1-targeted magnetic nanoparticles and the FR-targeted fluorescent probes. Under optimum conditions, a quantitative assay of MCF-7 cells was achieved with a dynamic range of 10-10 cells/mL (R = 0.9991). This assay showed high specificity and sensitivity to the target MCF-7 cells. Finally, the proposed strategy could be extended to detect MCF-7 cells in human plasma and whole blood with a recovery range of 86.1-104.0% and a RSD range of 1.2-8.4%, respectively. This indicates that the dual-target recognition method developed in this research exhibits good selectivity, anti-interference capability, and reliability even in plasma and whole blood samples and is more suitable for complex samples than previous targeted assays. Therefore, the approach proposed here may have great potential for early breast cancer diagnosis.
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http://dx.doi.org/10.1016/j.talanta.2018.01.067DOI Listing
May 2018

Rationally designed MoS/protonated g-CN nanosheet composites as photocatalysts with an excellent synergistic effect toward photocatalytic degradation of organic pollutants.

J Hazard Mater 2018 Apr 6;347:431-441. Epub 2018 Jan 6.

College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, P.R. China. Electronic address:

The positively charged ultrathin g-CN nanosheets are prepared by ultrasonic-assisted exfoliation of the protonated g-CN. Compared with the protonated g-CN and exfoliated g-CN, the positively charged ultrathin g-CN has abundant functional groups as well as desired dispersibility in deionized water, thus it could serve as a basic building block for designing related heterojunction composites. To take a full advantage of these features, the positively charged ultrathin g-CN/MoS composites are fabricated through a simple electrostatic adsorption and self-assembly process followed by a hydrothermal method. By loading an appropriate amount of MoS on the ultrathin g-CN nanosheets, the as-fabricated composites exhibit considerable improvement on the photocatalytic activities toward the degradation of typical organic pollutants (i.e., methyl orange and phenol) under visible light irradiation. The composite containing 2 wt% MoS shows the highest efficiency of about 96.5% for the methyl orange degradation, which is about 3.5 times and 8 times compared to those of the positively charged ultrathin g-CN and bulk g-CN, respectively. The superb photocatalytic performance benefits from the unique advantages, including richly available reaction sites, aligned energy levels between g-CN and the MoS, and efficient electron transfer. This work opens new possibilities for the rational design and construction of the g-CN based composites as highly efficient and stable visible-light driven photocatalysts for the degradation of organic pollutants.
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http://dx.doi.org/10.1016/j.jhazmat.2018.01.010DOI Listing
April 2018

Plasma-Induced Oxygen Vacancies in Urchin-Like Anatase Titania Coated by Carbon for Excellent Sodium-Ion Battery Anodes.

ACS Appl Mater Interfaces 2018 Feb 13;10(8):7031-7042. Epub 2018 Feb 13.

College of Chemistry and Chemical Engineering, ‡Innovation Base of Energy and Chemical Materials for Graduate Students Training, and §School of Mathematics and Statistics, Central South University , Changsha, Hunan 410083, P. R. China.

The incorporation of oxygen vacancies in anatase TiO has been studied as a promising way to accelerate the transport of electrons and Na ions, which is important for achieving excellent electrochemical properties for anatase TiO. However, wittingly introducing oxygen vacancies in anatase TiO for sodium-ion anodes by a facile and effective method is still a challenge. In this work, we report an innovative method to introduce oxygen vacancies into the urchin-like N-doped carbon coated anatase TiO (NC-DTO) by a facile plasma treatment. The superiorities of the oxygen vacancies combined with the conductive N-doped carbon coating enable the obtained NC-DTO of greatly improved sodium storage performance. When served as the anode for sodium-ion batteries, the NC-DTO electrode shows superior electrochemical performance (capacity: 272 mA h g at 0.25 C, capacity retention: 98.8% after 5000 cycles at 10 C, as well as ultrahigh capacity: 150 mA h g at 15 C). Density functional theory calculations combined with experimental results suggest that considerably improved sodium storage performance of NC-DTO is due to the enhanced electronic conductivity from the N-doped carbon layer as well as narrowed band gap and lowered sodiation energy barrier from the introduction of oxygen vacancies. This work highlights that introducing oxygen vacancies into TiO by plasma is a promising method to enhance the electrochemical property of TiO, which also can be applied to different metal oxides for energy storage devices.
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http://dx.doi.org/10.1021/acsami.7b13760DOI Listing
February 2018

The immune impact of mimic endoscopic retrograde appendicitis therapy and appendectomy on rabbits of acute appendicitis.

Oncotarget 2017 Sep 15;8(39):66528-66539. Epub 2017 Mar 15.

Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

This study was conducted to evaluate the immune impact of mimic endoscopic retrograde appendicitis therapy and appendectomy on rabbits of acute suppurative appendicitis and to determine whether TLR4/MYD88/NF-κB signaling pathway was activated in this process. 48 rabbits were assigned into 4 groups: group I, the mimic endoscopic retrograde appendicitis therapy group; group II, the appendectomy group; group III, the model group; and group IV, the blank group. White blood cells decreased, while levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, interleukin-4, and interleukin-10 increased on the 2 day in group I and II. IgA in feces decreased at 2 weeks, while fecal microbiota changed at 2 and 4 weeks after appendectomy. CD8 cells in appendix of group I increased within 8 weeks. Upregulated expression of TLR4, MYD88, and nuclear NF-κB were detected on the 2 day in group I and II. Mimic endoscopic retrograde appendicitis therapy and appendectomy are effective ways for acute suppurative appendicitis. Mimic endoscopic retrograde appendicitis therapy was more preferable due to its advantage in maintaining intestinal immune function. TLR4/MYD88/NF-κB signaling pathway was activated in acute phase of appendicitis.
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http://dx.doi.org/10.18632/oncotarget.16236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630433PMC
September 2017

A Low-Cost and High-Performance Sulfonated Polyimide Proton-Conductive Membrane for Vanadium Redox Flow/Static Batteries.

ACS Appl Mater Interfaces 2017 Sep 15;9(38):32643-32651. Epub 2017 Sep 15.

Wuhan NARI Limited Company of State Grid Electric Power Research Institute , Wuhan, Hubei 430074, P.R. China.

A novel side-chain-type fluorinated sulfonated polyimide (s-FSPI) membrane is synthesized for vanadium redox batteries (VRBs) by high-temperature polycondensation and grafting reactions. The s-FSPI membrane has a vanadium ion permeability that is over an order of magnitude lower and has a proton selectivity that is 6.8 times higher compared to those of the Nafion 115 membrane. The s-FSPI membrane possesses superior chemical stability compared to most of the linear sulfonated aromatic polymer membranes reported for VRBs. Also, the vanadium redox flow/static batteries (VRFB/VRSB) assembled with the s-FSPI membranes exhibit stable battery performance over 100- and 300-time charge-discharge cycling tests, respectively, with significantly higher battery efficiencies and lower self-discharge rates than those with the Nafion 115 membranes. The excellent physicochemical properties and VRB performance of the s-FSPI membrane could be attributed to the specifically designed molecular structure with the hydrophobic trifluoromethyl groups and flexible sulfoalkyl pendants being introduced on the main chains of the membrane. Moreover, the cost of the s-FSPI membrane is only one-fourth that of the commercial Nafion 115 membrane. This work opens up new possibilities for fabricating high-performance proton-conductive membranes at low costs for VRBs.
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http://dx.doi.org/10.1021/acsami.7b07437DOI Listing
September 2017

One-Step Electrodeposition of Nanocrystalline ZnCoO Films with High Activity and Stability for Electrocatalytic Oxygen Evolution.

ACS Appl Mater Interfaces 2017 May 9;9(20):17186-17194. Epub 2017 May 9.

College of Chemistry and Chemical Engineering and ‡Innovation Base of Energy and Chemical Materials for Graduate Students Training, Central South University , Changsha, Hunan 410083, P.R. China.

The development of highly active, environmentally friendly, and long-term stable oxygen evolving catalysts at low costs is critical for efficient and scalable H production from water splitting. Here, we report a new and facile one-step electrodeposition of nanocrystalline spinel-type ZnCoO films from an alkaline Zn-Co-tartrate solution. The electrodeposited ZnCoO electrode could be directly used as the anode for the water electrolysis without any post treatment. The ZnCoO film shows a low and stable overpotential of ∼0.33 V at 10 mA cm (and ∼0.35 V at 20 mA cm) for over 10 h and a Tafel slope of ∼39 mV dec toward the oxygen evolution reaction (OER) in 1 M NaOH, comparable to the best performance of the nonprecious OER catalysts reported for alkaline media. The enhanced OER activity of ZnCoO compared to CoO could be attributed to the surface structural modification and higher density of the accessible active Co sites induced by the incorporation of Zn. The electrodeposition method in this paper could also be used to synthesize other binary and ternary metal oxide based catalytic electrodes for reactions such as the OER and oxygen reduction reaction (ORR).
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http://dx.doi.org/10.1021/acsami.7b04841DOI Listing
May 2017

Cover features and new Associate Editors of the Journal of Environmental Sciences.

J Environ Sci (China) 2016 Oct 21;48:1-5. Epub 2016 Sep 21.

Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2G3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jes.2016.09.003DOI Listing
October 2016

[Onset time and efficacy of sublingual immunotherapy with Dermatophagoides farinae drops in children with allergic rhinitis].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2015 Aug;50(8):622-6

Department of Otorhinolaryngology, Hangzhou Traditional Chinese Medicine Hospital, Hangzhou 310007, China.

Objective: To investigate the onset time and efficacy of sublingual immunotherapy (SLIT) with Dermatophagoides farinae drops in children with house dust mites (HDM)-induced allergic rhinitis (AR).

Methods: One hundred and forty three children with perennial moderate to severe HDM-induced AR were treated by SLIT with standardized Dermatophagoides farinae extract. One hundred children who finally completed two years treatment were divided into two groups according to the age: younger children group (aged 4-8 years, n = 52) and older children group (aged 9-14 years, n = 48). Respectively, Each children was assessed before and after 1st, 2nd, 3rd, 6th, 12th, 24th months of the treatment. Total nasal symptom score (TNSS), total medication score (TMS) and visual analogue scale (VAS) were evaluated at each visit. All clinical data were analyzed retrospectively with the SPSS 19.0 software.

Results: TNSS, TMS and VAS of two groups decreased significantly after three months of the treatment compared with before (younger children group: Z value was -3.843, -3.534, -3.940, older children group: Z value was -3.938, -3.405, -3.953, all P < 0.05). TNSS and VAS of younger children group decreased significantly after two months of the treatment compared with before (6.4 ± 1.6, 5.3 ± 1.4 vs 8.6 ± 1.2, 7.9 ± 1.6, Z value was -3.843, -3.940, both P < 0.05). Five children (5%) experienced local adverse events and 2 children (2%) experienced mild systemic adverse events. No severe adverse events happened during the treatment.

Conclusions: SLIT with Dermatophagoides farinae drops is an efficient and safe treatment for children with HDM-induced AR. Its onset of action can be observed as early as 3 months after treatment.
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August 2015

Long-lived Aqueous Rechargeable Lithium Batteries Using Mesoporous LiTi2(PO4)[email protected] Anode.

Sci Rep 2015 Dec 9;5:17452. Epub 2015 Dec 9.

College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P.R. China.

The instability of anode materials during cycling has been greatly limiting the lifetime of aqueous rechargeable lithium batteries (ARLBs). Here, to tackle this issue, mesoporous LiTi2(PO4)[email protected] composites with a pore size of 4 nm and a large BET surface area of 165 m(2) g(-1) have been synthesized by a novel two-step approach. The ARLB with this type of LiTi2(PO4)[email protected] anode, commercial LiMn2O4 cathode and 2 M Li2(SO4) aqueous solution (oxygen was removed) exhibited superior cycling stability (a capacity retention of 88.9% after 1200 cycles at 150 mA g(-1) and 82.7% over 5500 cycles at 750 mA g(-1)) and excellent rate capability (discharge capacities of 121, 110, 90, and 80 mAh g(-1) based on the mass of LiTi2(PO4)3 at 30, 150, 1500, and 3000 mA g(-1), respectively). As verified, the mesoporous structure, large surface area and high-quality carbon coating layer of the LiTi2(PO4)[email protected] composite contribute to the breakthrough in achieving excellent electrochemical properties for ARLB.
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http://dx.doi.org/10.1038/srep17452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673533PMC
December 2015

Advanced aqueous rechargeable lithium battery using nanoparticulate LiTi2(PO4)3/C as a superior anode.

Sci Rep 2015 Jun 2;5:10733. Epub 2015 Jun 2.

College of Chemistry and Chemical Engineering, Hunan University of Arts and Science, Changde, 415000, P.R. China.

Poor cycling performance arising from the instability of anode is still a main challenge for aqueous rechargeable lithium batteries (ARLB). In the present work, a high performance LiTi2(PO4)3/C composite has been achieved by a novel and facile preparation method associated with an in-situ carbon coating approach. The LiTi2(PO4)3/C nanoparticles show high purity and the carbon layer is very uniform. When used as an anode material, the ARLB of LiTi2(PO4)3/C//LiMn2O4 delivered superior cycling stability with a capacity retention of 90% after 300 cycles at 30 mA g(-1) and 84% at 150 mA g(-1) over 1300 cycles. It also demonstrated excellent rate capability with reversible discharge capacities of 115 and 89 mAh g(-1) (based on the mass of anode) at 15 and 1500 mA g(-1), respectively. The superior electrochemical properties should be mainly ascribed to the high performance of LiTi2(PO4)3/C anode, benefiting from its nanostructure, high-quality carbon coating, appropriate crystal structure and excellent electrode surface stability as verified by Raman spectra, electrochemical impedance spectroscopy (EIS), X-ray diffraction (XRD) and scanning electron microscopy (SEM) measurements.
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http://dx.doi.org/10.1038/srep10733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451790PMC
June 2015

Rapid detection of genetic mutations in individual breast cancer patients by next-generation DNA sequencing.

Hum Genomics 2015 Feb 8;9. Epub 2015 Feb 8.

The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.

Breast cancer is the most common malignancy in women and the leading cause of cancer deaths in women worldwide. Breast cancers are heterogenous and exist in many different subtypes (luminal A, luminal B, triple negative, and human epidermal growth factor receptor 2 (HER2) overexpressing), and each subtype displays distinct characteristics, responses to treatment, and patient outcomes. In addition to varying immunohistochemical properties, each subtype contains a distinct gene mutation profile which has yet to be fully defined. Patient treatment is currently guided by hormone receptor status and HER2 expression, but accumulating evidence suggests that genetic mutations also influence drug responses and patient survival. Thus, identifying the unique gene mutation pattern in each breast cancer subtype will further improve personalized treatment and outcomes for breast cancer patients. In this study, we used the Ion Personal Genome Machine (PGM) and Ion Torrent AmpliSeq Cancer Panel to sequence 737 mutational hotspot regions from 45 cancer-related genes to identify genetic mutations in 80 breast cancer samples of various subtypes from Chinese patients. Analysis revealed frequent missense and combination mutations in PIK3CA and TP53, infrequent mutations in PTEN, and uncommon combination mutations in luminal-type cancers in other genes including BRAF, GNAS, IDH1, and KRAS. This study demonstrates the feasibility of using Ion Torrent sequencing technology to reliably detect gene mutations in a clinical setting in order to guide personalized drug treatments or combination therapies to ultimately target individual, breast cancer-specific mutations.
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http://dx.doi.org/10.1186/s40246-015-0024-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348109PMC
February 2015

[Clinical characteristics of benign paroxysmal positional vertigo secondary to sudden deafness].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2013 Jan;27(1):31-3

Department of Otorhinolaryngology, Hangzhou Traditional Chinese Medicine Hospital, Hangzhou 310007, China.

Objective: To retrospectively analyze the clinical characteristics of the benign paroxysmal positional vertigo (BPPV) secondary to the sudden deafness (SD) and to explore pathogenetic mechanism.

Method: One hundred and seventy-eight cases of the SD in our department were retrospectively analyzed. They were all treated under the guidance of clinical guidelines.

Result: (1) In all these patient's with SD, there were 31 cases with BPPV secondary to the SD. There were 26 cases of BPPV of posterior semicircular canal and 5 cases of BPPV of lateral BPPV semicircular canal. All patients with BPPV were diagnosed as the same ears as the SD, including 16 cases on left sides and 15 on right sides. (2) The interval between the onset of SD and BPPV was less than one week in 27 cases, between one week and one month in 3 cases, and between one and three months in 1 case. (3) All patients with BPPV secondary to the SD were cured with Epley maneuver or Barbecue roll maneuver.

Conclusion: The occurrence of BPPV may follow SD, and the major of BPPV secondary to the SD occurs in the posterior semicircular canal. The canalith repositioning is an effective therapy to the secondary BPPV.
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January 2013

Surface modification of coconut shell based activated carbon for the improvement of hydrophobic VOC removal.

J Hazard Mater 2011 Aug 27;192(2):683-90. Epub 2011 May 27.

Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China.

In this study, coconut shell based carbons were chemically treated by ammonia, sodium hydroxide, nitric acid, sulphuric acid, and phosphoric acid to determine suitable modification for improving adsorption ability of hydrophobic volatile organic compounds (VOCs) on granular activated carbons (GAC). The saturated adsorption capacities of o-xylene, a hydrophobic volatile organic compound, were measured and adsorption effects of the original and modified activated carbons were compared. Results showed that GAC modified by alkalis had better o-xylene adsorption capacity. Uptake amount was enhanced by 26.5% and reduced by 21.6% after modification by NH(3)H(2)O and H(2)SO(4), respectively. Compared with the original, GAC modified by acid had less adsorption capacity. Both SEM/EDAX and BET were used to identify the structural characteristics of the tested GAC, while IR spectroscopy and Boehm's titration were applied to analysis the surface functional groups. Relationships between physicochemical characteristics of GAC and their adsorption performances demonstrated that o-xylene adsorption capacity was related to surface area, pore volume, and functional groups of the GAC surface. Removing surface oxygen groups, which constitute the source of surface acidity, and reducing hydrophilic carbon surface favors adsorption capacity of hydrophobic VOCs on carbons. The performances of modified GACs were also investigated in the purification of gases containing complex components (o-xylene and steam) in the stream.
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http://dx.doi.org/10.1016/j.jhazmat.2011.05.069DOI Listing
August 2011

A rapid and universal bacteria-counting approach using CdSe/ZnS/SiO2 composite nanoparticles as fluorescence probe.

Anal Bioanal Chem 2010 Feb 17;396(4):1397-404. Epub 2009 Dec 17.

Department of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.

In this paper, a rapid, simple, and sensitive method was described for detection of the total bacterial count using SiO(2)-coated CdSe/ZnS quantum dots (QDs) as a fluorescence marker that covalently coupled with bacteria using glutaraldehyde as the crosslinker. Highly luminescent CdSe/ZnS were prepared by applying cadmium oxide and zinc stearate as precursors instead of pyrophoric organometallic precursors. A reverse-microemulsion technique was used to synthesize CdSe/ZnS/SiO(2) composite nanoparticles with a SiO(2) surface coating. Our results showed that CdSe/ZnS/SiO(2) composite nanoparticles prepared with this method possessed highly luminescent, biologically functional, and monodispersive characteristics, and could successfully be covalently conjugated with the bacteria. As a demonstration, it was found that the method had higher sensitivity and could count bacteria in 3 x 10(2) CFU/mL, lower than the conventional plate counting and organic dye-based method. A linear relationship of the fluorescence peak intensity (Y) and the total bacterial count (X) was established in the range of 3 x 10(2)-10(7) CFU/mL using the equation Y = 374.82X-938.27 (R = 0.99574). The results of the determination for the total count of bacteria in seven real samples were identical with the conventional plate count method, and the standard deviation was satisfactory.
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http://dx.doi.org/10.1007/s00216-009-3352-1DOI Listing
February 2010

A robust and fast bacteria counting method using CdSe/ZnS core/shell quantum dots as labels.

J Microbiol Methods 2009 Dec 30;79(3):367-70. Epub 2009 Sep 30.

Department of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.

A rapid, sensitive fluorescence measurement method for detecting the bacterial count using CdSe/ZnS as a fluorescence marker was described. High-quality CdSe/ZnS nanocrystals were synthesized and successfully conjugated with bacteria. The fluorescence intensity was proportional to bacterial count in the range of 10(2)-10(8)CFU/mL and the low detection limit was 10(2)CFU/mL.
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http://dx.doi.org/10.1016/j.mimet.2009.09.019DOI Listing
December 2009

[Chemical constituents from Neo-Taraxacum siphonathum].

Zhongguo Zhong Yao Za Zhi 2009 Apr;34(8):1002-4

School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.

Objective: To study the chemical constituents from the antioxidant fraction of Neo-Taraxacum siphonathum.

Method: Various chromatographic techniques were used to isolate and purify the constituents. The structures were elucidated on the basis of chemical evidence and spectral analysis.

Result: Ten compounds were isolated and identified from Neo-T. siphonathum, caffeic acid (1), chlorogenic acid (2), quercetin (3), luteolin (4), quercetin-3-O-beta-D-glucopyranoside (5), quercetin-3-O-alpha-D-arabinofuranoside (6), quercetin-3-O-alpha-D-arabinopyranoside (7), luteolin-7-O-beta-D-glucopyranoside (8), beta-sitosterol (9) and daucosterol (10).

Conclusion: Compounds 1-10 were isolated from this plant for the first time.
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April 2009

A high-speed counter-current chromatography- HPLC-DAD method for preparative isolation and purification of two polymethoxylated flavones from Taraxacum mongolicum.

J Chromatogr Sci 2009 May-Jun;47(5):349-53

School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.

After an initial clean-up step on silica gel, a preparative high-speed counter-current chromatography coupled with on-line high-performance liquid chromatography-diode array detection method (HSCCC-HPLC-DAD) was successfully developed for the isolation and determination two polymethoxylated flavones, 3',4',7-trimethoxyquercetin and artemetin, from the aerial part of Taraxacum mongolicum. The HSCCC separation was performed with a two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (6:5:6:5, v/v/v/v) at a flow rate of 1.5 mL/min and at 800 rpm. The on-line purity monitoring of a representative aliquot from each HSCCC fraction was operated automatically. Using this method, fractions with high purity were collected. The HSCCC purification step was done in 5 h, and afforded 84.2 mg of 3',4',7-trimethoxyquercetin and 52.3 mg of artemetin, with purity over 98% from 200 mg of the enriched extracts of T. mongolicum. The structures were identified by electorspray ionization mass spectrometry and 1H NMR experiments. To our best knowledge, 3',4',7-trimethoxyquercetin was obtained from the plant of genus Taraxacum for the first time by our group. This hyphenated method could be used for the preparation of bioactive compounds with higher purity from natural products.
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http://dx.doi.org/10.1093/chromsci/47.5.349DOI Listing
June 2009

Detection of P. aeruginosa using nano-structured electrode-separated piezoelectric DNA biosensor.

Talanta 2004 Feb;62(2):271-7

College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.

A DNA biosensor for detection of Pseudomonas aeruginosa was set up based on the modification of two membranes (nano-TiO(2) and nano-TiO(2)-polyethylene glycol hybrid membrane) to the ESPS surface. These two membrane materials were synthesized by sol-gel method. The detection was accomplished by modifying ss-DNA on the sensitive membrane and then hybridizing with their complementary strands from the P. aeruginosa in liquid phase. UV spectrum was used to identify the purity and concentration of extracted DNA; IR spectrum and SEM were used to characterize the properties of the membrane. The detection was highly improved by adoption of nanotechnology and hybrid membrane. Less than 3h was sufficient. The detection linear range was from 10(-1) to 10(-3)gl(-1) and the limit of detection was 10(-4)gl(-1).
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http://dx.doi.org/10.1016/j.talanta.2003.07.007DOI Listing
February 2004

Tertiary amino groups modified macroporous crosslinked poly(styrene-co-divinylbenzene) and its oxidized adsorbent: Synthesis, characterization, and adsorption behavior.

J Hazard Mater 2009 Mar 27;162(2-3):771-6. Epub 2008 May 27.

College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.

Macroporous crosslinked poly(p-vinylphenyltrimethylamine) (PVPTA) and its oxidized adsorbent (OPVPTA) were synthesized and their adsorption behaviors for phenol were comparatively studied in hexane as well as in aqueous solution. The results indicated that the adsorption was enhanced after PVPTA being oxidized, and the adsorption capacity of phenol onto OPVPTA was higher than that onto the commercial Amberlite XAD-4 resin in aqueous solution. The adsorption isotherms in hexane were fitted to Langmuir and Freundlich models, and it was found that the Freundlich model was suitable for characterizing the adsorption, whereas the correlation of the equilibrium adsorption in aqueous solution was linear. The adsorption was very sensitive to the solution pH and the optimum condition was at about the neutral solution. The adsorption thermodynamic parameters were calculated and it revealed that the adsorption was an exothermic, spontaneous, and more ordered process. Investigation of the adsorption mechanism suggested that hydrogen bonding was the primary driving force for the adsorption.
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http://dx.doi.org/10.1016/j.jhazmat.2008.05.100DOI Listing
March 2009

Arsenic re-mobilization in water treatment adsorbents under reducing conditions: Part II. XAS and modeling study.

Sci Total Environ 2008 Mar;392(1):137-44

Center for Environmental Systems, Stevens Institute of Technology, Hoboken, NJ 07030, USA.

The mechanism of arsenic re-mobilization in spent adsorbents under reducing conditions was studied using X-ray absorption spectroscopy and surface complexation model calculations. X-ray absorption near edge structure (XANES) spectroscopy demonstrated that As(V) was partially reduced to As(III) in spent granular ferric hydroxide (GFH), titanium dioxide (TiO2), activated alumina (AA) and modified activated alumina (MAA) adsorbents after 2 years of anaerobic incubation. As(V) was completely reduced to As(III) in spent granular ferric oxide (GFO) under 2-year incubation. The extended X-ray absorption fine structure (EXAFS) spectroscopy analysis showed that As(III) formed bidentate binuclear surface complexes on GFO as evidenced by an average As(III)-O bond distance of 1.78 A and As(III)-Fe distance of 3.34 A. The release of As from the spent GFO and TiO2 was simulated using the charge distribution multi-site complexation (CD-MUSIC) model. The observed redox ranges for As release and sulfate mobility were described by model calculations.
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http://dx.doi.org/10.1016/j.scitotenv.2007.10.033DOI Listing
March 2008

Synthesis, characterization, and adsorption behavior of aniline modified polystyrene resin for phenol in hexane and in aqueous solution.

J Colloid Interface Sci 2008 Jan 2;317(2):434-41. Epub 2007 Oct 2.

College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, People's Republic of China.

Macroporous crosslinked poly(p-vinylbenzylaniline) (PVBA) was synthesized and its adsorption isotherms for phenol in hexane and in aqueous solution were comparatively measured. It was shown that the adsorption isotherms in hexane were straight lines and passed through the origin, whereas those in aqueous solution could be simulated by Freundlich isotherms. Adsorption enthalpies of phenol onto PVBA were calculated, and the results indicated that the adsorption was an exothermic process. Comparison of the adsorption behaviors of PVBA, poly(p-vinylbenzylmethylamine) (PVBMA), and poly(p-vinylbenzyl-p-nitroaniline) (PVBNA) for phenol in hexane suggested that hydrogen bonding and pi-pi stacking were primarily responsible for the adsorption, the nitrogen atom and benzene ring of PVBA acted as hydrogen bonding acceptors and formed hydrogen bonding with the hydrogen atom of hydroxyl group of phenol. Investigation of the adsorption mechanism in aqueous solution revealed that hydrogen bonding and hydrophobic interaction were the main driving forces.
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http://dx.doi.org/10.1016/j.jcis.2007.09.077DOI Listing
January 2008

Arsenic remobilization in water treatment adsorbents under reducing conditions: Part I. Incubation study.

Sci Total Environ 2008 Jan 25;389(1):188-94. Epub 2007 Sep 25.

Center for Environmental Systems, Stevens Institute of Technology, Hoboken, NJ 07030, USA.

The redox transformation and mobility of arsenic in spent adsorbents under reducing conditions were studied using an incubation test with mixed reducing bacteria, high-performance liquid chromatography-atomic fluorescence spectrometry for speciation of soluble arsenic (As), and thermodynamic calculations. The spent adsorptive media, including granular ferric hydroxide, granular ferric oxide, titanium dioxide, activated alumina and modified activated alumina, were collected from pilot-scale filters that were tested for removal of arsenate [As(V)] from groundwater in New Jersey, USA. During 65 days of incubation of the spent adsorbents with nutrient media in closed containers, the electron activity, pe, was reduced from about 1.7 to -7. Meanwhile, reduction of Fe(III) to Fe(II), As(V) to arsenite [As(III)], and sulfate to sulfide occurred. Less than 4% total As was released from iron-based media in the pe range between -3 and -7 due to reduction of As(V) to As(III) and reductive dissolution of ferric (hydr)oxides. Up to 38% As was released from the TiO2 adsorbent, which occurred at extremely low redox potential (i.e., pe<-6). The findings of this study will improve our ability to predict arsenic mobility when As-containing spent media are disposed of in landfills and the environment.
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http://dx.doi.org/10.1016/j.scitotenv.2007.08.030DOI Listing
January 2008

Adsorption behavior, thermodynamics, and mechanism of phenol on polymeric adsorbents with amide group in cyclohexane.

J Colloid Interface Sci 2007 Dec 17;316(1):10-8. Epub 2007 Sep 17.

College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.

Macroporous cross-linked poly(N-methyl-N-p-vinylbenzylacetamide) (PMVBA), poly(N-methyl-N-p-vinylbenzylcaprolactam) (PMVBC), and poly(N-methyl-N-p-vinylbenzylurea) (PMVBU) were synthesized and their adsorption behavior for phenol in cyclohexane was investigated. The results indicated that the adsorption capacities of phenol on the three adsorbents followed the order PMVBU > PMVBA > PMVBC. Adsorption isotherms of phenol on the three polymeric adsorbents were measured and correlated to a Freundlich isotherm. Adsorption enthalpy, adsorption Gibbs free energy, and adsorption entropy were calculated using thermodynamic function relationships. It was found that the adsorption enthalpy of phenol on PMVBU was almost twice that on PMVBA and PMVBC. Analysis of the adsorption mechanism suggested that hydrogen bonding was the primary driving force for phenol adsorbed on the adsorbents in cyclohexane, and multiple hydrogen bonding was involved for PMVBU with phenol.
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http://dx.doi.org/10.1016/j.jcis.2007.07.080DOI Listing
December 2007
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