Sungyong You

Sungyong You

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Quantitative proteomic analysis of prostate tissue specimens identifies deregulated protein complexes in primary prostate cancer.

Clin Proteomics 2019 13;16:15. Epub 2019 Apr 13.

Division of Cancer Biology and Therapeutics, Departments of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Rm. 4009, Davis Research Bldg 8700 Beverly Blvd, Los Angeles, CA 90048 USA.

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http://dx.doi.org/10.1186/s12014-019-9236-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461817PMC
April 2019

Integrated proteomic and phosphoproteomic analyses of cisplatin-sensitive and resistant bladder cancer cells reveal CDK2 network as a key therapeutic target.

Cancer Lett 2018 11 24;437:1-12. Epub 2018 Aug 24.

Department of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA; University of California, Los Angeles, CA, USA; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183052
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http://dx.doi.org/10.1016/j.canlet.2018.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181132PMC
November 2018

Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential.

Cancer Res 2018 11 28;78(21):6086-6097. Epub 2018 Aug 28.

Division of Cancer Biology and Therapeutics, Department of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0608DOI Listing
November 2018

Quantitative Proteomic Analysis Reveals Caffeine-Perturbed Proteomic Profiles in Normal Bladder Epithelial Cells.

Proteomics 2018 10 11;18(20):e1800190. Epub 2018 Oct 11.

Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1002/pmic.201800190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493332PMC
October 2018

Circulating monocytes from prostate cancer patients promote invasion and motility of epithelial cells.

Cancer Med 2018 09 9;7(9):4639-4649. Epub 2018 Aug 9.

Urologic Oncology Program/Uro-Oncology Research Laboratories, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.

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http://dx.doi.org/10.1002/cam4.1695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143932PMC
September 2018

Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2.

J Immunol 2018 07 23;201(2):359-370. Epub 2018 May 23.

Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul 06591, Korea;

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http://dx.doi.org/10.4049/jimmunol.1701097DOI Listing
July 2018

Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis.

Sci Rep 2018 Jul 18;8(1):10859. Epub 2018 Jul 18.

Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41598-018-29085-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052149PMC
July 2018

The Tumor-Like Phenotype of Rheumatoid Synovium: Molecular Profiling and Prospects for Precision Medicine.

Arthritis Rheumatol 2018 05 31;70(5):637-652. Epub 2018 Mar 31.

Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/art.40406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920713PMC
May 2018

Transcriptome analysis of wild-type and afsS deletion mutant strains identifies synergistic transcriptional regulator of afsS for a high antibiotic-producing strain of Streptomyces coelicolor A3(2).

Appl Microbiol Biotechnol 2018 Apr 17;102(7):3243-3253. Epub 2018 Feb 17.

Interdisciplinary Program for Biochemical Engineering, Seoul National University, Seoul, South Korea.

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http://dx.doi.org/10.1007/s00253-018-8838-3DOI Listing
April 2018

A Systems Approach to Prostate Cancer Classification-Response.

Cancer Res 2017 12 6;77(24):7133-7135. Epub 2017 Dec 6.

Division of Cancer Biology and Therapeutics, Departments of Surgery & Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0239DOI Listing
December 2017

Identification of Caveolin-1 as an Invasion-Associated Gene in Liver Cancer Cells Using Dendron-Coated DNA Microarrays.

Appl Biochem Biotechnol 2017 Aug 12;182(4):1276-1289. Epub 2017 Jan 12.

Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, South Korea.

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http://dx.doi.org/10.1007/s12010-017-2398-3DOI Listing
August 2017

MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis.

Exp Mol Med 2017 08 4;49(8):e363. Epub 2017 Aug 4.

Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.1038/emm.2017.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579506PMC
August 2017

MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer.

Cancer Res 2017 05 15;77(9):2306-2317. Epub 2017 Feb 15.

Division of Cancer Biology and Therapeutics, Departments of Surgery, Biomedical Sciences and Pathology and Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2942DOI Listing
May 2017

Differential perturbation of the interstitial cystitis-associated genes of bladder and urethra in rat model.

Cell Cycle 2017 Apr 22;16(8):749-758. Epub 2017 Feb 22.

b Departments of Surgery and Biomedical Sciences , Cedars-Sinai Medical Center , Los Angeles , CA , USA.

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http://dx.doi.org/10.1080/15384101.2017.1295184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405721PMC
April 2017

Remote focusing multifocal plane microscopy for the imaging of 3D single molecule dynamics with cellular context.

Proc SPIE Int Soc Opt Eng 2017 Jan 17;10070. Epub 2017 Feb 17.

Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.

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http://dx.doi.org/10.1117/12.2251218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463995PMC
January 2017

Integrated Classification of Prostate Cancer Reveals a Novel Luminal Subtype with Poor Outcome.

Cancer Res 2016 09 14;76(17):4948-58. Epub 2016 Jun 14.

Division of Cancer Biology and Therapeutics, Departments of Surgery & Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047668PMC
http://dx.doi.org/10.1158/0008-5472.CAN-16-0902DOI Listing
September 2016

GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness.

J Rheumatol 2016 Mar 1;43(3):474-85. Epub 2016 Feb 1.

From the POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea, Seoul; Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Korea; Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.E.J. Han, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S.A. Yoo, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; G.M. Kim, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; D. Hwang, PhD, Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, DGIST; C.S. Cho, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S. You, PhD, Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center; W.U. Kim, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea.

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http://dx.doi.org/10.3899/jrheum.150523DOI Listing
March 2016

Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer.

Database (Oxford) 2015 29;2015. Epub 2015 Mar 29.

Medicinal Bioconvergence Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea, School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang 790-784, Republic of Korea, Department of New Biology and Center for Plant Aging Research, Institute for Basic Science, DGIST, Daegu 711-873, Republic of Korea and Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea Medicinal Bioconvergence Research Center and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea, School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang 790-784, Republic of Korea, Department of New Biology and Center for Plant Aging Research, Institute for Basic Science, DGIST, Daegu 711-873, Republic of Korea and Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea

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http://dx.doi.org/10.1093/database/bav022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377328PMC
September 2015

Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes.

Sci Rep 2015 Jul 16;5:12136. Epub 2015 Jul 16.

1] Division of Cancer Biology and Therapeutics, Departments of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048 [2] Urological Diseases Research Center, Boston Children's Hospital, Boston, MA 02115 [3] Department of Surgery, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1038/srep12136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503992PMC
July 2015

Phospholipids of tumor extracellular vesicles stratify gefitinib-resistant nonsmall cell lung cancer cells from gefitinib-sensitive cells.

Proteomics 2015 Feb 16;15(4):824-35. Epub 2015 Jan 16.

Department of Applied Chemistry, College of Applied Science, Kyung Hee University, Yongin, Republic of Korea.

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http://dx.doi.org/10.1002/pmic.201400243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305024PMC
February 2015

Engineering multivalent antibodies to target heregulin-induced HER3 signaling in breast cancer cells.

MAbs 2014 Mar-Apr;6(2):340-53. Epub 2013 Dec 26.

Department of Immunology; University of Texas Southwestern Medical Center; Dallas, TX USA.

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http://dx.doi.org/10.4161/mabs.27658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984324PMC
November 2014

Urinary proteome profile predictive of disease activity in rheumatoid arthritis.

J Proteome Res 2014 Nov 15;13(11):5206-17. Epub 2014 Sep 15.

Department of Molecular Medicine and Biopharmaceutical Sciences, School of Convergence Science and Technology and College of Medicine or College of Pharmacy, Seoul National University , Seoul 110-799, Korea.

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http://dx.doi.org/10.1021/pr500467dDOI Listing
November 2014

Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment.

Proteomics 2014 Aug 16;14(16):1845-56. Epub 2014 Jul 16.

Department of Applied Chemistry, College of Applied Science, Kyung Hee University, Yongin, Republic of Korea.

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http://dx.doi.org/10.1002/pmic.201400008DOI Listing
August 2014

RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization.

Endocr Relat Cancer 2014 Apr 4;21(2):311-26. Epub 2014 Mar 4.

Uro-Oncology Research, Department of Medicine, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, California 90048, USA Departments of Surgery Biomedical Sciences Biostatistics and Bioinformatics Center, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, California, USA Department of Pathology, School of Medicine, University of Alabama, Birmingham, Alabama, USA Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, USA.

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http://dx.doi.org/10.1530/ERC-13-0548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959765PMC
April 2014

β1-integrin-dependent migration of microglia in response to neuron-released α-synuclein.

Exp Mol Med 2014 Apr 18;46:e91. Epub 2014 Apr 18.

1] Department of Biomedical Science and Technology, Konkuk University, Seoul, Korea [2] IBST, Konkuk University, Seoul, Korea.

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http://www.nature.com/articles/emm20146
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http://dx.doi.org/10.1038/emm.2014.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972795PMC
April 2014

Identification of key regulators for the migration and invasion of rheumatoid synoviocytes through a systems approach.

Proc Natl Acad Sci U S A 2014 Jan 27;111(1):550-5. Epub 2013 Dec 27.

School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790-784, Korea.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1311239111
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http://dx.doi.org/10.1073/pnas.1311239111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890851PMC
January 2014

A synthetic form of frizzled 8-associated antiproliferative factor enhances p53 stability through USP2a and MDM2.

PLoS One 2012 6;7(12):e50392. Epub 2012 Dec 6.

Division of Cancer Biology and Therapeutics, Departments of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050392PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516501PMC
May 2013

A systems approach to rheumatoid arthritis.

PLoS One 2012 11;7(12):e51508. Epub 2012 Dec 11.

School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051508PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519858PMC
May 2013

'Omics' approaches to understanding interstitial cystitis/painful bladder syndrome/bladder pain syndrome.

Int Neurourol J 2012 Dec 31;16(4):159-68. Epub 2012 Dec 31.

Division of Cancer Biology and Therapeutics, Departments of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.5213/inj.2012.16.4.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547176PMC
December 2012

Urinary exosomes and proteomics.

Mass Spectrom Rev 2011 Nov-Dec;30(6):1185-202. Epub 2011 May 4.

Department of Molecular Medicine, Cell and Matrix Biology Research Institute, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea.

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http://dx.doi.org/10.1002/mas.20319DOI Listing
April 2012

A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis.

J Exp Med 2012 Apr 19;209(4):871-86. Epub 2012 Mar 19.

Research Institute of Immunobiology, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul 137-701, South Korea.

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http://dx.doi.org/10.1084/jem.20111783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328363PMC
April 2012

Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping.

Nat Rev Cancer 2011 Sep 23;11(10):708-18. Epub 2011 Sep 23.

Medicinal Bioconvergence Research Center, WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea.

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http://dx.doi.org/10.1038/nrc3124DOI Listing
September 2011

Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.

Proteomics 2011 Jun 18;11(12):2459-75. Epub 2011 May 18.

Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

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http://dx.doi.org/10.1002/pmic.201000443DOI Listing
June 2011

Principal network analysis: identification of subnetworks representing major dynamics using gene expression data.

Bioinformatics 2011 Feb 30;27(3):391-8. Epub 2010 Dec 30.

School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang, Republic of Korea.

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http://dx.doi.org/10.1093/bioinformatics/btq670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031040PMC
February 2011

From proteomics toward systems biology: integration of different types of proteomics data into network models.

BMB Rep 2008 Mar;41(3):184-93

School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Korea.

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http://dx.doi.org/10.5483/bmbrep.2008.41.3.184DOI Listing
March 2008