Suneel S Apte

Suneel S Apte

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ADAMTS Proteins: Concepts, Challenges, and Prospects.

Authors:
Suneel S Apte

Methods Mol Biol 2020 ;2043:1-12

Department of Biomedical Engineering-ND20, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.

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http://dx.doi.org/10.1007/978-1-4939-9698-8_1DOI Listing
January 2020

Expression Analysis by RNAscope™ In Situ Hybridization.

Methods Mol Biol 2020 ;2043:173-178

Department of Biomedical Engineering-ND20, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.

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http://dx.doi.org/10.1007/978-1-4939-9698-8_14DOI Listing
January 2020

Visualization and Quantification of Pericellular Matrix.

Methods Mol Biol 2020 ;2043:261-264

Department of Biomedical Engineering-ND20, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.

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http://dx.doi.org/10.1007/978-1-4939-9698-8_21DOI Listing
January 2020

Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.

Matrix Biol 2019 Sep 7;82:38-53. Epub 2019 Feb 7.

Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44120, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685762PMC
September 2019

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

Matrix Biol 2019 04 7;77:117-128. Epub 2018 Sep 7.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.09.004DOI Listing
April 2019

Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families.

Matrix Biol 2019 01 17;75-76:114-125. Epub 2018 May 17.

The Rappaport Faculty of Medicine and Research Institute, Technion - Israel Institute of Technology, Haifa 31096, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240406PMC
January 2019

ADAMTS proteins in human disorders.

Matrix Biol 2018 10 6;71-72:225-239. Epub 2018 Jun 6.

Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, United States. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146047PMC
October 2018

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

Authors:
Bram P Prins Timothy J Mead Jennifer A Brody Gardar Sveinbjornsson Ioanna Ntalla Nathan A Bihlmeyer Marten van den Berg Jette Bork-Jensen Stefania Cappellani Stefan Van Duijvenboden Nikolai T Klena George C Gabriel Xiaoqin Liu Cagri Gulec Niels Grarup Jeffrey Haessler Leanne M Hall Annamaria Iorio Aaron Isaacs Ruifang Li-Gao Honghuang Lin Ching-Ti Liu Leo-Pekka Lyytikäinen Jonathan Marten Hao Mei Martina Müller-Nurasyid Michele Orini Sandosh Padmanabhan Farid Radmanesh Julia Ramirez Antonietta Robino Molly Schwartz Jessica van Setten Albert V Smith Niek Verweij Helen R Warren Stefan Weiss Alvaro Alonso David O Arnar Michiel L Bots Rudolf A de Boer Anna F Dominiczak Mark Eijgelsheim Patrick T Ellinor Xiuqing Guo Stephan B Felix Tamara B Harris Caroline Hayward Susan R Heckbert Paul L Huang J W Jukema Mika Kähönen Jan A Kors Pier D Lambiase Lenore J Launer Man Li Allan Linneberg Christopher P Nelson Oluf Pedersen Marco Perez Annette Peters Ozren Polasek Bruce M Psaty Olli T Raitakari Kenneth M Rice Jerome I Rotter Moritz F Sinner Elsayed Z Soliman Tim D Spector Konstantin Strauch Unnur Thorsteinsdottir Andrew Tinker Stella Trompet André Uitterlinden Ilonca Vaartjes Peter van der Meer Uwe Völker Henry Völzke Melanie Waldenberger James G Wilson Zhijun Xie Folkert W Asselbergs Marcus Dörr Cornelia M van Duijn Paolo Gasparini Daniel F Gudbjartsson Vilmundur Gudnason Torben Hansen Stefan Kääb Jørgen K Kanters Charles Kooperberg Terho Lehtimäki Henry J Lin Steven A Lubitz Dennis O Mook-Kanamori Francesco J Conti Christopher H Newton-Cheh Jonathan Rosand Igor Rudan Nilesh J Samani Gianfranco Sinagra Blair H Smith Hilma Holm Bruno H Stricker Sheila Ulivi Nona Sotoodehnia Suneel S Apte Pim van der Harst Kari Stefansson Patricia B Munroe Dan E Arking Cecilia W Lo Yalda Jamshidi

Genome Biol 2018 07 17;19(1):87. Epub 2018 Jul 17.

Genetics Research Centre, Molecular and Clinical Sciences Institute, St George's University of London, London, SW17 0RE, UK.

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http://dx.doi.org/10.1186/s13059-018-1457-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048820PMC
July 2018

The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification.

JCI Insight 2018 Apr 5;3(7). Epub 2018 Apr 5.

Department of Biomedical Engineering and the Orthopaedic and Rheumatologic Institute, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1172/jci.insight.92941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928868PMC
April 2018

Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis.

Sci Rep 2017 12 8;7(1):17225. Epub 2017 Dec 8.

Department of Medical Technology, Graduate School of Health Sciences, Okayama University, 2-5-1, Shikata-cho, Okayama, Japan.

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http://dx.doi.org/10.1038/s41598-017-17613-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722896PMC
December 2017

Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma.

J Clin Endocrinol Metab 2017 05;102(5):1631-1641

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.

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http://dx.doi.org/10.1210/jc.2016-3527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443325PMC
May 2017

Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease.

Sci Rep 2017 02 8;7:41871. Epub 2017 Feb 8.

Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.

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http://www.nature.com/articles/srep41871
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http://dx.doi.org/10.1038/srep41871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296908PMC
February 2017

Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome.

Sci Rep 2016 Sep 30;6:33974. Epub 2016 Sep 30.

Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://www.nature.com/articles/srep33974
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043182PMC
http://dx.doi.org/10.1038/srep33974DOI Listing
September 2016

Immunoregulatory roles of versican proteolysis in the myeloma microenvironment.

Blood 2016 08 3;128(5):680-5. Epub 2016 Jun 3.

Division of Hematology/Oncology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI; University of Wisconsin Carbone Cancer Center, Madison, WI;

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http://dx.doi.org/10.1182/blood-2016-03-705780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974200PMC
August 2016

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.

Matrix Biol 2015 May-Jul;44-46:24-37. Epub 2015 Mar 11.

Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2015.03.001DOI Listing
March 2016

Metalloproteinases: A parade of functions in matrix biology and an outlook for the future.

Matrix Biol 2015 May-Jul;44-46:1-6. Epub 2015 Apr 23.

Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2015.04.005DOI Listing
March 2016

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.

Angiogenesis 2016 Jan 7;19(1):53-65. Epub 2015 Oct 7.

Laboratory of Connective Tissues Biology, Tour de Pathologie, GIGA-R, University of Liege, B23/3, 4000, Sart Tilman, Belgium.

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http://link.springer.com/10.1007/s10456-015-9488-z
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http://dx.doi.org/10.1007/s10456-015-9488-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700087PMC
January 2016

Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.

Authors:
Suneel S Apte

Biochem J 2016 Jan;473(1):e1-4

Department of Biomedical Engineering (ND20), Cleveland Clinic Lerner Research Institute and the Orthopaedic and Rheumatologic Research Center, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, U.S.A.

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http://dx.doi.org/10.1042/BJ20151072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525052PMC
January 2016

ADAMTS proteins as modulators of microfibril formation and function.

Matrix Biol 2015 Sep 7;47:34-43. Epub 2015 May 7.

Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731137PMC
September 2015

Isolation and purification of versican and analysis of versican proteolysis.

Methods Mol Biol 2015 ;1229:587-604

Department of Biomedical Engineering (ND20), Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

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http://dx.doi.org/10.1007/978-1-4939-1714-3_46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525050PMC
June 2015

ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.

Cell Rep 2015 Jun 28;11(10):1519-28. Epub 2015 May 28.

Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472575PMC
June 2015

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.

Dis Model Mech 2015 May 11;8(5):487-99. Epub 2015 Mar 11.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA

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http://dx.doi.org/10.1242/dmm.017046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415891PMC
May 2015

Human eye development is characterized by coordinated expression of fibrillin isoforms.

Invest Ophthalmol Vis Sci 2014 Nov 18;55(12):7934-44. Epub 2014 Nov 18.

Department of Biomedical Engineering, Cleveland Clinic, Lerner Research Institute, Cleveland, Ohio, United States.

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http://dx.doi.org/10.1167/iovs.14-15453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263138PMC
November 2014

Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5.

J Biol Chem 2014 Oct 13;289(40):27859-73. Epub 2014 Aug 13.

From the Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195,

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http://dx.doi.org/10.1074/jbc.M114.573287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183820PMC
October 2014

A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.

Genesis 2014 Jul 8;52(7):702-12. Epub 2014 May 8.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

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http://dx.doi.org/10.1002/dvg.22784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107014PMC
July 2014

Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.

Mol Cancer Ther 2014 May 14;13(5):1259-69. Epub 2014 Mar 14.

Authors' Affiliations: Infinity Pharmaceuticals, Inc., Cambridge, Massachusetts; Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio; Program in Developmental and Stem Cell Biology, Hospital for Sick Children; University Musculoskeletal Oncology Unit and Lunenfeld Research Institute, Mount Sinai Hospital; and Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0731DOI Listing
May 2014

The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis.

Matrix Biol 2014 Apr 18;35:34-41. Epub 2014 Jan 18.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0945053X140000
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http://dx.doi.org/10.1016/j.matbio.2014.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525047PMC
April 2014

Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome.

Mol Cell Proteomics 2014 Feb 26;13(2):580-93. Epub 2013 Nov 26.

ETH Zurich, Department of Biology, Institute of Molecular Health Sciences, Schafmattstr. 22, 8093 Zurich, Switzerland;

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http://dx.doi.org/10.1074/mcp.M113.035139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916655PMC
February 2014

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

Invest Ophthalmol Vis Sci 2013 Dec 23;54(13):8337-44. Epub 2013 Dec 23.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

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http://dx.doi.org/10.1167/iovs.13-13121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875392PMC
December 2013

Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix.

Glia 2013 Jun 28;61(6):972-84. Epub 2013 Mar 28.

Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1002/glia.22489DOI Listing
June 2013

The biology of the extracellular matrix: novel insights.

Curr Opin Rheumatol 2013 Jan;25(1):65-70

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1097/BOR.0b013e32835b137bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560377PMC
January 2013

Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines.

J Orthop Res 2012 Feb 28;30(2):226-33. Epub 2011 Jul 28.

Cleveland Clinic, Department of Biomedical Engineering, Cleveland, Ohio 44195, USA.

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http://doi.wiley.com/10.1002/jor.21508
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http://dx.doi.org/10.1002/jor.21508DOI Listing
February 2012

ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesis.

Invest Ophthalmol Vis Sci 2012 Jan 31;53(1):461-9. Epub 2012 Jan 31.

Departments of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1167/iovs.10-5955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292378PMC
January 2012

Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and function.

Cell Mol Life Sci 2011 Oct 20;68(19):3137-48. Epub 2011 Aug 20.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1007/s00018-011-0780-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729447PMC
October 2011

Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.

Dev Biol 2011 Sep 1;357(1):152-64. Epub 2011 Jul 1.

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, 29425, USA.

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http://dx.doi.org/10.1016/j.ydbio.2011.06.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435578PMC
September 2011

ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts.

J Biol Chem 2011 May 14;286(19):17156-67. Epub 2011 Mar 14.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1074/jbc.M111.231571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089559PMC
May 2011

Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation.

Development 2010 Dec 1;137(23):4029-38. Epub 2010 Nov 1.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA.

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http://dx.doi.org/10.1242/dev.050591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976286PMC
December 2010

Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies.

Matrix Biol 2010 May 22;29(4):304-16. Epub 2010 Jan 22.

Department of Regenerative Medicine and Cell Biology, 171 Ashley Avenue, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/j.matbio.2010.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862783PMC
May 2010

In situ hybridization for metalloproteinases and their inhibitors.

Methods Mol Biol 2010 ;622:195-209

Clinical Research Center, Oulu University Hospital, Oulu, Finland.

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http://dx.doi.org/10.1007/978-1-60327-299-5_11DOI Listing
April 2010

ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells.

Am J Pathol 2010 Mar 21;176(3):1494-504. Epub 2010 Jan 21.

Department of Biomedical Engineering (ND20), Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.2353/ajpath.2010.090655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832168PMC
March 2010

Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96.

J Biol Chem 2010 Jan 29;285(1):197-205. Epub 2009 Oct 29.

Department of Biochemistry, College of Science, Yonsei University, Seoul 120-749, Korea.

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http://dx.doi.org/10.1074/jbc.M109.039677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804166PMC
January 2010

A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms.

Authors:
Suneel S Apte

J Biol Chem 2009 Nov 4;284(46):31493-7. Epub 2009 Sep 4.

Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.R109.052340
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http://dx.doi.org/10.1074/jbc.R109.052340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797218PMC
November 2009

Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan.

J Biol Chem 2009 Oct 11;284(44):30004-15. Epub 2009 Aug 11.

Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1074/jbc.M109.038059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781554PMC
October 2009

Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues.

Gene Expr Patterns 2009 Jun 27;9(5):314-23. Epub 2009 Feb 27.

Department of Biomedical Engineering and Orthopaedic and Rheumatologic Institute, ND20-Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1016/j.gep.2009.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725439PMC
June 2009

Characterization of proADAMTS5 processing by proprotein convertases.

Int J Biochem Cell Biol 2009 May 1;41(5):1116-26. Epub 2008 Nov 1.

Department of Pharmacology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Que. J1H 5N4, Canada.

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http://dx.doi.org/10.1016/j.biocel.2008.10.008DOI Listing
May 2009

Functional analysis of an ADAMTS10 signal peptide mutation in Weill-Marchesani syndrome demonstrates a long-range effect on secretion of the full-length enzyme.

Hum Mutat 2008 Dec;29(12):1425-34

Department of Biomedical Engineering and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1002/humu.20797DOI Listing
December 2008

Characterization of a novel epigenetically-silenced, growth-suppressive gene, ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma.

Int J Cancer 2008 Jul;123(2):401-408

Department of Biology and Center for Cancer Research, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong (SAR), People's Republic of China.

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http://dx.doi.org/10.1002/ijc.23528DOI Listing
July 2008

Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques.

Circulation 2008 Feb 4;117(7):931-9. Epub 2008 Feb 4.

Donald W. Reynolds Cardiovascular Clinical Research Center and Fondation Leducq Transatlantic Network on Atherothrombosis, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.707448DOI Listing
February 2008

The secreted metalloprotease ADAMTS20 is required for melanoblast survival.

PLoS Genet 2008 Feb 29;4(2):e1000003. Epub 2008 Feb 29.

Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265537PMC
February 2008

ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely expressed during mouse embryogenesis and is regulated during skeletal myogenesis.

Matrix Biol 2007 Jul 30;26(6):431-41. Epub 2007 Mar 30.

Department of Biomedical Engineering and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1016/j.matbio.2007.03.003DOI Listing
July 2007

O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily.

J Biol Chem 2007 Jun 29;282(23):17024-31. Epub 2007 Mar 29.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M701065200
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http://dx.doi.org/10.1074/jbc.M701065200DOI Listing
June 2007

Regulation of ADAMTS9 secretion and enzymatic activity by its propeptide.

J Biol Chem 2007 Jun 2;282(22):16146-54. Epub 2007 Apr 2.

Department of Biomedical Engineering and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1074/jbc.M610161200DOI Listing
June 2007

Cell-surface processing of pro-ADAMTS9 by furin.

J Biol Chem 2006 May 14;281(18):12485-94. Epub 2006 Mar 14.

Department of Biomedical Engineering and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1074/jbc.M511083200DOI Listing
May 2006

Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis.

Development 2006 Apr;133(8):1587-96

Department of Biomedical Engineering and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.02308
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http://dx.doi.org/10.1242/dev.02308DOI Listing
April 2006

The characterisation of six ADAMTS proteases in the basal chordate Ciona intestinalis provides new insights into the vertebrate ADAMTS family.

Int J Biochem Cell Biol 2005 Sep;37(9):1838-45

Wellcome Trust Centre for Cell-Matrix Research, Michael Smith Building, Faculty of Life Sciences, University of Manchester, UK.

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http://dx.doi.org/10.1016/j.biocel.2005.03.009DOI Listing
September 2005

Adamts9 is widely expressed during mouse embryo development.

Gene Expr Patterns 2005 Jun 20;5(5):609-17. Epub 2005 Apr 20.

Department of Biomedical Engineering and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic Foundation (ND20), OH 44195, USA.

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http://dx.doi.org/10.1016/j.modgep.2005.03.004DOI Listing
June 2005

Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/ccl2 and interleukin-8/CXCL8 in endothelial cells during angiogenesis.

J Biol Chem 2005 Jan 29;280(2):1292-8. Epub 2004 Oct 29.

Departamento de Investigación Básica, Centro Nacional de Investigaciones Cardiovasculares, Ronda de Poniente, 5, 28760-Tres Cantos, Spain.

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http://dx.doi.org/10.1074/jbc.M408673200DOI Listing
January 2005

Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation.

J Biol Chem 2004 Dec 7;279(49):51208-17. Epub 2004 Sep 7.

Department of Biomedical Engineering and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1074/jbc.M409036200DOI Listing
December 2004

Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process.

Circ Res 2004 Nov 4;95(11):1082-90. Epub 2004 Nov 4.

Department of Veterinary Pathobiology, University of Missouri, 126A Connaway Hall, 1600 E Rollins Rd, Columbia, MO 65211, USA.

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http://dx.doi.org/10.1161/01.RES.0000150046.48115.80DOI Listing
November 2004

ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain.

J Biol Chem 2004 Aug 10;279(34):35159-75. Epub 2004 Jun 10.

Department of Biomedical Engineering, Lerner Research Institute, Orthopedic Research Center, Cleveland Clinic Foundation, Ohio 44195, USA.

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August 2004

A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family.

Authors:
Suneel S Apte

Int J Biochem Cell Biol 2004 Jun;36(6):981-5

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation (ND20), 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1016/j.biocel.2004.01.014DOI Listing
June 2004

ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases.

Matrix Biol 2003 Nov;22(6):501-10

Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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November 2003

A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation.

Development 2003 Oct;130(19):4665-72

Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02476, USA.

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http://dx.doi.org/10.1242/dev.00668DOI Listing
October 2003

Matrix metalloproteinases: old dogs with new tricks.

Genome Biol 2003 29;4(6):216. Epub 2003 May 29.

Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1186/gb-2003-4-6-216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC193609PMC
July 2003

Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.

J Biol Chem 2003 Mar 3;278(11):9503-13. Epub 2003 Jan 3.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1074/jbc.M211009200DOI Listing
March 2003

Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix.

J Biol Chem 2002 Apr 22;277(14):12182-9. Epub 2002 Jan 22.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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April 2002