Publications by authors named "Suna Onengut-Gumuscu"

61Publications

Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation.

Cancers (Basel) 2020 Jan 3;12(1). Epub 2020 Jan 3.

Department of Medicine and University of Virginia Cancer Center, Division of Hematology & Oncology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

View Article and Find Full Text PDF
January 2020

The active contribution of OPCs to neuroinflammation is mediated by LRP1.

Acta Neuropathol 2020 02 24;139(2):365-382. Epub 2019 Sep 24.

Department of Neuroscience, Center for Brain Immunology and Glia, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA.

View Article and Find Full Text PDF
February 2020

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.

J Am Soc Nephrol 2019 10 19;30(10):2000-2016. Epub 2019 Sep 19.

Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts;

View Article and Find Full Text PDF
October 2019

In situ 10-cell RNA sequencing in tissue and tumor biopsy samples.

Sci Rep 2019 03 20;9(1):4836. Epub 2019 Mar 20.

Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, USA.

View Article and Find Full Text PDF
March 2019

Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes?

J Clin Endocrinol Metab 2017 08;102(8):2873-2880

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Miami School of Medicine, Miami, Florida 33136.

View Article and Find Full Text PDF
August 2017

Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes.

Diabetes 2016 Mar 2;65(3):794-802. Epub 2015 Dec 2.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL Genetics Institute, University of Florida, Gainesville, FL

View Article and Find Full Text PDF
March 2016

Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains.

BMC Genet 2015 Nov 10;16:133. Epub 2015 Nov 10.

Department of Radiology & Medical Imaging, University of Virginia, Snyder Bldg Rm 266, 480 Ray C. Hunt Dr., P.O. Box 801339, Fontaine Research Park, Charlottesville, VA, 22908, USA.

View Article and Find Full Text PDF
November 2015

Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.

Nat Genet 2015 Aug 13;47(8):898-905. Epub 2015 Jul 13.

1] Department of Medicine, Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [3] Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA. [4] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [5] Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.

View Article and Find Full Text PDF
August 2015

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping.

PLoS Genet 2015 Jun 24;11(6):e1005272. Epub 2015 Jun 24.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

View Article and Find Full Text PDF
June 2015

HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study.

Am J Gastroenterol 2015 Jun 26;110(6):915-20. Epub 2015 May 26.

1] Pediatric Epidemiology Center, University of South Florida, Tampa, Florida, USA [2] Department of Clinical Sciences, Lund University, Malmo, Sweden.

View Article and Find Full Text PDF
June 2015

Cytomegalovirus infection enhances the immune response to influenza.

Sci Transl Med 2015 Apr;7(281):281ra43

Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA 94305, USA. Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA. The Howard Hughes Medical Institute.

View Article and Find Full Text PDF
April 2015

Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes.

Hum Mol Genet 2015 Mar 25;24(6):1774-90. Epub 2014 Nov 25.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK,

View Article and Find Full Text PDF
March 2015

A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations.

Genet Epidemiol 2014 Dec 4;38(8):661-70. Epub 2014 Nov 4.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.

View Article and Find Full Text PDF
December 2014

Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13.

Diabetes 2014 Dec 9;63(12):4360-8. Epub 2014 Jul 9.

Center for Public Health Genomics, UVA School of Medicine, University of Virginia, Charlottesville, VA Department of Public Health Sciences, UVA School of Medicine, University of Virginia, Charlottesville, VA

View Article and Find Full Text PDF
December 2014

A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples.

BMC Genomics 2014 Apr 11;15:274. Epub 2014 Apr 11.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, CB2 0XY, Cambridge, UK.

View Article and Find Full Text PDF
April 2014

Imputing amino acid polymorphisms in human leukocyte antigens.

PLoS One 2013 6;8(6):e64683. Epub 2013 Jun 6.

Harvard-MIT (Massachusetts Institute of Technology) Division of Health Sciences and Technology, Boston, Massachusetts, United States of America.

View Article and Find Full Text PDF
January 2014

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Nat Genet 2013 Jun 21;45(6):670-5. Epub 2013 Apr 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

View Article and Find Full Text PDF
June 2013

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.

PLoS Genet 2013 Apr 4;9(4):e1003444. Epub 2013 Apr 4.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

View Article and Find Full Text PDF
April 2013

Recent progress in the genetics of diabetes.

Horm Res 2009 Jan 21;71 Suppl 1:17-23. Epub 2009 Jan 21.

Department of Public Health Sciences and Medicine, Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.

View Article and Find Full Text PDF
January 2009

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes.

J Immunol 2007 Oct;179(7):4704-10

Translational Research Program, Benaroya Research Institute, Virginia Mason, Seattle, WA 98101, USA.

View Article and Find Full Text PDF
October 2007

A haplotype-based analysis of the PTPN22 locus in type 1 diabetes.

Diabetes 2006 Oct;55(10):2883-9

Molecular Genetics Program, Benaroya Research Institute, 1201 Ninth Ave., Seattle, WA 98101-2795, USA.

View Article and Find Full Text PDF
October 2006

Recent advances in the immunogenetics of human type 1 diabetes.

Curr Opin Immunol 2006 Oct 1;18(5):634-8. Epub 2006 Aug 1.

Program in Molecular Genetics, Benaroya Research Institute, Seattle, WA 98101-2795, USA.

View Article and Find Full Text PDF
October 2006

The genetics of type 1 diabetes: lessons learned and future challenges.

J Autoimmun 2005 2;25 Suppl:34-9. Epub 2005 Nov 2.

Molecular Genetics Program, Benaroya Research Institute, 1201 Ninth Avenue, Seattle, WA 98101-2795, USA.

View Article and Find Full Text PDF
June 2006

A functional variant of IRS1 is associated with type 1 diabetes in families from the US and UK.

Mol Genet Metab 2004 Apr;81(4):291-4

Molecular Genetics Program, Benaroya Research Institute, Seattle, WA 98101, USA.

View Article and Find Full Text PDF
April 2004

Mapping genes for autoimmunity in humans: type 1 diabetes as a model.

Immunol Rev 2002 Dec;190:182-94

Molecular Genetics Program, Virginia Mason Research Center, Seattle, WA 98101, USA.

View Article and Find Full Text PDF
December 2002