Publications by authors named "Sumiya Khan"

2 Publications

  • Page 1 of 1

Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial.

BMJ Open Gastroenterol 2017 20;4(1):e000164. Epub 2017 Sep 20.

School of Medicine, Yale University, New Haven, Connecticut, USA.

Background: Patients with irritable bowel syndrome (IBS) are often placed on diets guided by food intolerance assays, although these have not been validated. We assessed the effects of individualised diets in patients with IBS guided by a leucocyte activation test.

Methods: This is a parallel-group, double-blind, randomised controlled trial of 58 adults with IBS seen at an academic health centre in Northeast USA. Peripheral venous blood was analysed using a leucocyte activation test; individual foods were reported to produce positive or negative results. Participants were randomised to a 4-week diet with either individualised guidance to eliminate foods with positive assay results and allow foods with negative assay results (intervention), or with individualised guidance, matched in rigour and complexity, to eliminate foods with negative assay results and allow foods with positive assay results (comparison). The primary outcome was between-group differences in the IBS Global Improvement Scale (GIS). Secondary outcomes included reductions in IBS Symptom Severity Scale (SSS) scores and increases in IBS Adequate Relief (AR) and Quality of Life (QOL) scores. An aptamer-based proteomic analysis was conducted in strong responders.

Results: The intervention group had significantly greater increases in mean GIS score after 4 weeks (0.86 vs comparison; 95% CI 0.05 to 1.67; p=0.04) and 8 weeks (1.22 vs comparison; 95% CI 0.22 to 2.22; p=0.02). The intervention group also had significantly greater reductions in mean SSS score at 4 weeks (-61.78 vs comparison; 95% CI -4.43 to -119.14; p=0.04) and 8 weeks (-66.42 vs comparison; 95% CI -5.75 to -127.09; p=0.03). There were no significant differences between intervention and comparison groups in mean AR or QOL scores. A reduction in neutrophil elastase concentration was associated with reduced symptoms.

Conclusions: Elimination diets guided by leucocyte activation tests reduced symptoms. These findings could lead to insights into the pathophysiology of IBS.

Trial Registration Number: NCT02186743.
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http://dx.doi.org/10.1136/bmjgast-2017-000164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628288PMC
September 2017

Nutritional guidelines for school lunch programs: a survey of islamic schools and recommendations for creating a culture of healthful eating.

J IMA 2011 Jul;43(2):48-57

Chair-Elect, Muslims in Dietetics and Nutrition (MIDAN), Hamden, Connecticut;

Objective: To determine the status of lunch programs in Islamic schools in the United States and develop recommendations for improving them.

Study Design: The Islamic Medical Association of North America (IMANA) conducted a survey of lunch programs by mailing questionnaires to 100 Islamic schools in the United States. Muslims in Dietetics and Nutrition (MIDAN) developed lunch menus using American and ethnic foods conforming to nationally recommended guidelines.

Results: Forty-eight Islamic schools responded to the survey, revealing that 20 schools follow guidelines and only six have dietitians advising on menu planning. Based on this survey, IMANA, with the assistance of MIDAN, has developed a summary of guidelines that schools can follow. These guidelines include sample menus of American and ethnic foods, recommendations for creating a n environment for healthful eating, and sources for funding school lunch programs.

Conclusions: IMANA and MIDAN, recognizing the scientific significance and religious relevance of a nutritious diet, have developed these recommendations. This information is provided to aid Islamic schools in implementing guidelines for nutritionally balanced school lunch menus and in creating a culture that fosters a healthful lifestyle.
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http://dx.doi.org/10.5915/43-2-8279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516056PMC
July 2011
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