Publications by authors named "Sumeet A Khetarpal"

25Publications

Volanesorsen, Familial Chylomicronemia Syndrome, and Thrombocytopenia.

N Engl J Med 2019 12;381(26):2582-2584

Massachusetts General Hospital, Boston, MA

View Article and Find Full Text PDF
December 2019

Natural human genetic variation determines basal and inducible expression of , an obesity-associated gene.

Proc Natl Acad Sci U S A 2019 11 28;116(46):23232-23242. Epub 2019 Oct 28.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

View Article and Find Full Text PDF
November 2019

Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week.

J Am Coll Cardiol 2019 07;74(4):578-586

Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts. Electronic address:

View Article and Find Full Text PDF
July 2019

HDL Cholesterol Metabolism and the Risk of CHD: New Insights from Human Genetics.

Curr Cardiol Rep 2017 11 4;19(12):132. Epub 2017 Nov 4.

Perelman School of Medicine at the University of Pennsylvania, 11-162 TRC, 3400 Civic Center Blvd, Philadelphia, PA, 19104, USA.

View Article and Find Full Text PDF
November 2017

Deep Apolipoprotein Proteomics to Uncover Mechanisms of Coronary Disease Risk.

J Am Coll Cardiol 2017 02;69(7):801-804

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

View Article and Find Full Text PDF
February 2017

Targeting ApoC-III to Reduce Coronary Disease Risk.

Curr Atheroscler Rep 2016 09;18(9):54

Perelman School of Medicine, University of Pennsylvania, 11-125 SCTR, 3400 Civic Center Blvd, Philadelphia, PA, 19104, USA.

View Article and Find Full Text PDF
September 2016

Lnc-ing Common Polymorphisms to Statin Responsiveness at the MYLIP Locus.

Circ Cardiovasc Genet 2016 06;9(3):206-9

Departments of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

View Article and Find Full Text PDF
June 2016

Therapeutic Targets of Triglyceride Metabolism as Informed by Human Genetics.

Trends Mol Med 2016 Apr 14;22(4):328-340. Epub 2016 Mar 14.

Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104-5159, USA. Electronic address:

View Article and Find Full Text PDF
April 2016

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.

Proc Natl Acad Sci U S A 2015 Nov 9;112(47):14623-8. Epub 2015 Nov 9.

Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark;

View Article and Find Full Text PDF
November 2015

Relation of atherogenic lipoproteins with estimated glomerular filtration rate decline: a longitudinal study.

BMC Nephrol 2015 Aug 4;16:130. Epub 2015 Aug 4.

Section of Nephrology, Department of Medicine, Yale School of Medicine, Program of Applied Translational Research, Yale University, New Haven, USA.

View Article and Find Full Text PDF
August 2015

Plasma apolipoprotein C-III levels, triglycerides, and coronary artery calcification in type 2 diabetics.

Arterioscler Thromb Vasc Biol 2015 Aug 11;35(8):1880-8. Epub 2015 Jun 11.

From the Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (A.Q., S.A.K., D.J.R., M.P.R.); Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (A.V.K.); and Division of Cardiology, Department of Medicine, University of California at San Francisco (A.Q.).

View Article and Find Full Text PDF
August 2015

Triglyceride-rich lipoproteins and coronary artery disease risk: new insights from human genetics.

Arterioscler Thromb Vasc Biol 2015 Feb 8;35(2):e3-9. Epub 2015 Jan 8.

From the Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

View Article and Find Full Text PDF
February 2015

Bilateral earlobe creases and coronary artery disease.

Circulation 2014 Jul;130(1):92-3

From the Department of Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

View Article and Find Full Text PDF
July 2014

Genetics of lipid traits: Genome-wide approaches yield new biology and clues to causality in coronary artery disease.

Biochim Biophys Acta 2014 Oct 12;1842(10):2010-2020. Epub 2014 Jun 12.

Perelman School of Medicine, University of Pennsylvania, USA. Electronic address:

View Article and Find Full Text PDF
October 2014

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

Authors:
Gina M Peloso Paul L Auer Joshua C Bis Arend Voorman Alanna C Morrison Nathan O Stitziel Jennifer A Brody Sumeet A Khetarpal Jacy R Crosby Myriam Fornage Aaron Isaacs Johanna Jakobsdottir Mary F Feitosa Gail Davies Jennifer E Huffman Ani Manichaikul Brian Davis Kurt Lohman Aron Y Joon Albert V Smith Megan L Grove Paolo Zanoni Valeska Redon Serkalem Demissie Kim Lawson Ulrike Peters Christopher Carlson Rebecca D Jackson Kelli K Ryckman Rachel H Mackey Jennifer G Robinson David S Siscovick Pamela J Schreiner Josyf C Mychaleckyj James S Pankow Albert Hofman Andre G Uitterlinden Tamara B Harris Kent D Taylor Jeanette M Stafford Lindsay M Reynolds Riccardo E Marioni Abbas Dehghan Oscar H Franco Aniruddh P Patel Yingchang Lu George Hindy Omri Gottesman Erwin P Bottinger Olle Melander Marju Orho-Melander Ruth J F Loos Stefano Duga Piera Angelica Merlini Martin Farrall Anuj Goel Rosanna Asselta Domenico Girelli Nicola Martinelli Svati H Shah William E Kraus Mingyao Li Daniel J Rader Muredach P Reilly Ruth McPherson Hugh Watkins Diego Ardissino Qunyuan Zhang Judy Wang Michael Y Tsai Herman A Taylor Adolfo Correa Michael E Griswold Leslie A Lange John M Starr Igor Rudan Gudny Eiriksdottir Lenore J Launer Jose M Ordovas Daniel Levy Y-D Ida Chen Alexander P Reiner Caroline Hayward Ozren Polasek Ian J Deary Ingrid B Borecki Yongmei Liu Vilmundur Gudnason James G Wilson Cornelia M van Duijn Charles Kooperberg Stephen S Rich Bruce M Psaty Jerome I Rotter Christopher J O'Donnell Kenneth Rice Eric Boerwinkle Sekar Kathiresan L Adrienne Cupples

Am J Hum Genet 2014 Feb;94(2):223-32

Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA; National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, MA 01702, USA. Electronic address:

View Article and Find Full Text PDF
February 2014

The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.

PLoS One 2012 20;7(2):e31616. Epub 2012 Feb 20.

Division of Translational Medicine and Human Genetics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

View Article and Find Full Text PDF
June 2012

Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol.

PLoS Genet 2011 Dec 8;7(12):e1002393. Epub 2011 Dec 8.

Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism, and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

View Article and Find Full Text PDF
December 2011