Publications by authors named "Suman Panda"

10 Publications

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Frontiers in G-Quadruplex Therapeutics in Cancer: Selection of Small Molecules, Peptides and Aptamers.

Chem Biol Drug Des 2021 Jun 20. Epub 2021 Jun 20.

Department of Biophysics, Bose Institute, P-1/12 CIT Road, Scheme VIIM, Kankurgachi, Kolkata, 700054, India.

G-quadruplex, a unique secondary structure in nucleic acids found throughout human genome, elicited widespread interest in the field of therapeutic research. Being present in key regulatory regions of oncogenes, RNAs and telomere, G-quadruplex structure regulates transcription, translation, splicing etc. Changes in its structure and stability leads to differential expression of oncogenes causing cancer. Thus, targeting G-Quadruplex structures with small molecules/other biologics has shown elevated research interest. Covering previous reports, in this review we try to enlighten the facts on the structural diversity in G-quadruplex ligands aiming to provide newer insights to design first-in-class drugs for the next generation cancer treatment.
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http://dx.doi.org/10.1111/cbdd.13910DOI Listing
June 2021

Does Dental Fear in Children Predict Untreated Dental Caries? An Analytical Cross-Sectional Study.

Children (Basel) 2021 May 12;8(5). Epub 2021 May 12.

Division of Dental Public Health, Department of Preventive Dental Sciences, Jazan University, Jazan 45142, Saudi Arabia.

Despite free health care services in Saudi Arabia, the prevalence of caries in children is substantially greater in comparison to other high-income countries. Dental fear in children may be an important issue that needs attention. Therefore, the aim was to investigate the role of dental fear in predicting untreated dental caries in schoolchildren. This analytical cross-sectional study included children aged 8-10 years residing in Saudi Arabia. Dental status via oral examinations was surveyed with the WHO standardized chart and the Children Fear Survey Schedule-Dental Subscale was used to score dental fear. Descriptive, binary, and multivariable logistic regression analyses were performed to report the findings at 5% statistical significance. Overall, there were 798 schoolchildren with an average fear score of 36. Nearly 70.4% reported fear of someone examining their mouth. About 76.9% had at least one carious tooth in their oral cavity. Children with dental fear were 1.8 times (OR = 1.80; 95% CI = 1.26, 2.56) more likely to have at least one untreated carious tooth in their oral cavity than those who did not express fear during oral examinations and dental procedures. Thus, the current study concludes that fear of dentists and dental treatment procedures successfully predicts untreated carious teeth in schoolchildren.
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http://dx.doi.org/10.3390/children8050382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151813PMC
May 2021

Correlation of BODE index with quality of life in stable Chronic Obstructive Pulmonary Disease (COPD) patients - A prospective study.

J Family Med Prim Care 2020 Nov 30;9(11):5606-5613. Epub 2020 Nov 30.

Specialist, Department of Pulmonology, Tata Main Hospital, Tata Steel, Jamshedpur, Jharkhand, India.

Background And Aims: Chronic obstructive pulmonary disease (COPD) is characterized by slow progressive deterioration of respiratory function with systemic effects which have a great impact on health-related quality of life (HRQoL). The severity of airflow limitation in COPD, as reflected by forced expiratory volume in one second (FEV1) does not represent the systemic consequences of COPD. Hence, a multidimensional grading system, BODE index (Body mass index, Airflow obstruction, Dyspnea and Exercise capacity) that assessed both the pulmonary and systemic manifestations has recently been proposed to provide useful prognostic information and predict the outcome in COPD patients. The objective of this study was to evaluate the relationship between BODE index and health-related quality of life (HRQOL) in stable COPD patients and its usefulness in predicting the disease exacerbations.

Materials And Methods: Sixty stable COPD patients who presented in the out-patient departments of Medicine and Pulmonology were recruited over one year period. We evaluated them by body-mass index, forced expiratory volume in one second (FEV1), Modified Medical Research Council dyspnea scale and six minute walk test (6MWT). BODE index was calculated using these variables. Disease duration, number of exacerbations and hospitalization in the previous year were recorded. We also administered the St. George's Respiratory Questionnaire (SGRQ) to assess the health related quality of life (HRQoL) in these patients. BODE scores were categorized into four quartiles, quartile one to four with scores of 0-2, 3-4, 5-6 and 7-10, respectively.

Results: According to BODE score, (16) 26.7% of patients were BODE 1, (27) 45% BODE 2, (15) 25% BODE 3 and (2) 3.3% were BODE 4. Higher BODE quartiles were associated with higher total SGRQ scores and SGRQ subscale scores (symptom, activity and impact). Very strong correlations were found between BODE quartiles and total SGRQ scores ( < 0.01). Among the components of BODE index, the decrease in the FEV1 (%predicted) and 6MWD, and the increase of MMRC dyspnea grade were associated with worsening of health status (increase in total SGRQ and SGRQ subscales). BODE index also correlated with the acute exacerbations ( < 0.0012) during one year follow-up.

Conclusion: BODE index strongly correlated with the HRQoL and also reliably predicted acute exacerbations in stable COPD patients.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_735_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842444PMC
November 2020

Multi-organ dysfunction following honeybee bite-A rare entity.

J Family Med Prim Care 2020 Sep 30;9(9):5052-5054. Epub 2020 Sep 30.

M.D. Medicine, Consultant, Tata Main Hospital, Jamshedpur, Jharkhand, India.

Honeybee bites have been known to cause localized allergic reactions and anaphylaxis but systemic toxic reactions leading to multiorgan dysfunction is very rare. Serious complications like acute renal failure, acute myocardial infarction (Kounis syndrome) and even death have been reported as the complication of honeybee bite. Herein, we report a case of multiorgan dysfunction following honeybee bite, which was complicated with acute kidney injury, thrombocytopenia, bradycardia, keratitis, and deranged liver function along with localized allergic reaction and pain.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_629_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652159PMC
September 2020

Persistent cough: An unexpected diagnosis.

J Family Med Prim Care 2020 May 31;9(5):2548-2551. Epub 2020 May 31.

Department of Medicine, Tata Main Hospital, Jamshedpur, Jharkhand, India.

Esophageal cancer is the eighth most common cancer and the sixth most common cause of cancer death globally. Esophageal squamous cell carcinoma (ESCC) accounts for 70%-90% of esophageal cancers worldwide, 5% are adenocarcinoma, and 5% represent rare malignancies and metastases from other organs. We present a case where a 54-year-old lady, with multiple readmissions for persistent dry cough and respiratory symptoms, turns out to be an esophageal malignancy. CECT thorax revealed an enhancing wall thickening of the esophagus with paraoesophageal fat stranding, mediastinal lymphadenopathy, and subsegmental right lobe atelectasis, suggestive of a probable esophageal malignancy. An upper gastrointestinal endoscopy showed a circumferential esophageal growth which on biopsy and histopathological examination turned out to be a moderately differentiated squamous cell carcinoma of esophagus.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_41_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380793PMC
May 2020

Solute carrier proteins and c-Myc: a strong connection in cancer progression.

Drug Discov Today 2020 05 24;25(5):891-900. Epub 2020 Feb 24.

Department of Biophysics, Bose Institute, P-1/12 CIT Road, Scheme VIIM, Kankurgachi, Kolkata, 700054, India. Electronic address:

Solute carrier proteins (SLCs), the most understudied and second largest group of membrane proteins, maintain cellular metabolic homeostasis via the export and import of various solute, ions, metabolites, and even drugs. Given the importance of SLCs in maintaining normal cellular function, dysregulation of these proteins leads to the dramatic progression of cancers in neoplastic cells. The importance of these transporters as drug targets is gradually being realized by the scientific community. In this review, we describe the role of SLCs in hallmarks of cancer, focusing mainly on the connection between oncogenes (Myc) and SLCs in breast cancer. We also discussed the role of glucose and amino acid transporters in cancer cells and how they can be manipulated to develop anticancer therapies.
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http://dx.doi.org/10.1016/j.drudis.2020.02.007DOI Listing
May 2020

A clinical dilemma in an unconscious patient.

J Family Med Prim Care 2019 Oct 31;8(10):3428-3430. Epub 2019 Oct 31.

Department of Gen. Medicine, TMH, Jamshedpur, Jharkhand, India.

Snake bite is a major life-threatening emergency seen more commonly in rural tropical countries. In general, about 70% of the bites are nonpoisonous, 15% are dry bites, and only 15% cause envenomation. Venom is the saliva of snake ejected during biting, from the poison apparatus (the modified parotid glands). It can be neurotoxic, vasculotoxic, or myotoxic in its action. The polyvalent antisnake venom is effective against most common poisonous snakes. Prompt diagnosis and timely administration of the polyvalent antisnake venom can reduce mortality and morbidity to a great extent. We present a case which was brought to the emergency department of without any previous forthcoming history of snakebite, with symptom such as abdominal pain, chest pain, vomiting, and respiratory distress followed by loss of consciousness. The patient was timely resuscitated and with prompt use of polyvalent ASV and neostigmine the patient recovered without any neurological symptoms within a week.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_672_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857395PMC
October 2019

Multiple Bilateral Unerupted Supplemental Premolars: An Unusual Presentation in a Nonsyndromic Patient.

Int J Clin Pediatr Dent 2017 Apr-Jun;10(2):217-222. Epub 2017 Jun 1.

Assistant Professor, Department of Pedodontics, College of Dentistry, Jizan Kingdom of Saudi Arabia.

Supernumerary teeth are one of the routinely encountered developmental disturbances representing one or more extra teeth in the jaws. These may resemble the teeth of the group to which it belongs, i.e., molars, premolars, or incisors, or it may bear little or no resemblance. Based on the morphologic appearance, it is classified as supplemental teeth or rudimentary teeth. The supplemental teeth are those that resemble the teeth to which it is associated and rudimentary teeth are those that do not resemble the teeth. Supplemental teeth, most of the times, are associated with syndromes and they can also be present in the absence of systemic pathology. Literature reveals predilection of the presence of supplemental premolars of 2:1 in males. This is the case report of a 14-year-old male who presented with multiple unerupted bilateral supplemental premolars on both the arches.

How To Cite This Article: Satish V, Panda S, Maganur P, Ahmed A. Multiple Bilateral Unerupted Supplemental Premo-lars: An Unusual Presentation in a Nonsyndromic Patient. Int J Clin Pediatr Dent 2017;10(2):217-222.
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http://dx.doi.org/10.5005/jp-journals-10005-1439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571397PMC
June 2017

Cariogenic Potential of the commonly Prescribed Pediatric Liquid Medicaments in Kingdom of Saudi Arabia: An in vitro Study.

J Contemp Dent Pract 2017 Apr 1;18(4):307-311. Epub 2017 Apr 1.

Department of Preventive Dental Sciences, Division of Pedodontics, College of Dentistry, Jazan University, Jazan Kingdom of Saudi Arabia.

Aim: The aim of this study was to assess the cariogenic potential of the commonly prescribed pediatric liquid medicaments (PLMs) for dental disease in Jazan region, Kingdom of Saudi Arabia.

Materials And Methods: Seven most commonly prescribed PLMs were selected by prior questioning the pediatric dentists as well as general dentists in Jazan region. The endogenous pH and sucrose concentrations of the liquid medicaments were assessed. The endogenous pH was assessed by Hanna pH meter instrument. The sucrose concentration was assessed by anthrone reagent method.

Results: All the PLM were acidic. The pH of the PLM ranged from 4.22 to 6.10. All the PLM contained sucrose and its concentration ranged from 5.38 to 11.41 gm% in the samples.

Conclusion: In this study, all the PLM were acidic and contained sucrose. Hence, they have cariogenic potential.

Clinical Significance: Parents and dentists are unaware of the hidden sugars and cariogenicity of these medications. Strict oral hygiene instructions are mandatory for the children taking these medications. The use of PLM should also be minimized and parents should seek early dental treatment to restore child's oral health.
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http://dx.doi.org/10.5005/jp-journals-10024-2036DOI Listing
April 2017

Diagnosis and Management of a Patient with Congenitally Missing Maxillary First Permanent Molars: A Rare Case Report.

Case Rep Dent 2016 25;2016:5891705. Epub 2016 Jul 25.

College of Dentistry, Jazan University, P.O. Box 114, Gizan 45142, Saudi Arabia.

Congenitally missing teeth are the most commonly seen dental anomalies. Agenesis of the permanent first molar has the least frequency of all the tooth types, and it usually occurs in association with oligodontia or anodontia. Thus, agenesis of the bilateral maxillary first permanent molar is an extremely rare occurrence, and no such case has been reported in ethnic Saudi Arabian population. We hereby report a case of nonsyndromic bilateral congenitally missing maxillary first permanent molar in an eight-year-old Saudi female patient. Comprehensive oral rehabilitation was done for the patient. The implications of the tooth agenesis are also discussed. The prognosis of this case is presented.
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http://dx.doi.org/10.1155/2016/5891705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976171PMC
August 2016
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