Publications by authors named "Sulayman D Dib-Hajj"

99Publications

Sodium channel Nav1.6 in sensory neurons contributes to vincristine-induced allodynia.

Brain 2020 Aug;143(8):2421-2436

Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1093/brain/awaa208DOI Listing
August 2020

Pharmacological activity and NMR solution structure of the leech peptide HSTX-I.

Biochem Pharmacol 2020 Nov 7;181:114082. Epub 2020 Jun 7.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia; National Cancer Institute, National Institutes of Health, Frederick, MD 21702, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2020.114082DOI Listing
November 2020

Pharmacological characterization of a rat Nav1.7 loss-of-function model with insensitivity to pain.

Pain 2020 06;161(6):1350-1360

Department of Neurology, Yale University School of Medicine, New Haven, CT, United States.

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http://dx.doi.org/10.1097/j.pain.0000000000001807DOI Listing
June 2020

A Novel Gain-of-Function Nav1.9 Mutation in a Child With Episodic Pain.

Front Neurosci 2019 3;13:918. Epub 2019 Sep 3.

Department of Neurology, Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, United States.

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http://dx.doi.org/10.3389/fnins.2019.00918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733892PMC
September 2019

Na 1.6 regulates excitability of mechanosensitive sensory neurons.

J Physiol 2019 07 13;597(14):3751-3768. Epub 2019 May 13.

IMB Centre for Pain Research, Institute for Molecular Bioscience, 306 Carmody Rd (Building 80), University of Queensland, Brisbane, Queensland, 4072, Australia.

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http://dx.doi.org/10.1113/JP278148DOI Listing
July 2019

The Two Sides of Na1.7: Painful and Painless Channelopathies.

Neuron 2019 03;101(5):765-767

Department of Neurology, Yale University, New Haven, CT 06510, USA; Center for Neuroscience & Regeneration Research, Yale University, New Haven, CT 06510, USA; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT 06516, USA.

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http://dx.doi.org/10.1016/j.neuron.2019.02.016DOI Listing
March 2019

Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics.

Annu Rev Neurosci 2019 07 31;42:87-106. Epub 2019 Jan 31.

Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA; email:

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https://www.annualreviews.org/doi/10.1146/annurev-neuro-0709
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http://dx.doi.org/10.1146/annurev-neuro-070918-050144DOI Listing
July 2019

The Role of Voltage-Gated Sodium Channels in Pain Signaling.

Physiol Rev 2019 04;99(2):1079-1151

Nuffield Department of Clinical Neurosciences, University of Oxford , Oxford , United Kingdom ; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine , New Haven, Connecticut ; and Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut.

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http://dx.doi.org/10.1152/physrev.00052.2017DOI Listing
April 2019

Lacosamide in patients with Nav1.7 mutations-related small fibre neuropathy: a randomized controlled trial.

Brain 2019 02;142(2):263-275

Department of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The Netherlands.

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https://academic.oup.com/brain/article/142/2/263/5289372
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http://dx.doi.org/10.1093/brain/awy329DOI Listing
February 2019

Pediatric Erythromelalgia and SCN9A Mutations: Systematic Review and Single-Center Case Series.

J Pediatr 2019 03 9;206:217-224.e9. Epub 2018 Nov 9.

Clinical Neurosciences (Pediatric Pain Research Group), UCL GOS Institute of Child Health, London, UK; Department of Pediatric Anesthesia and Pain Medicine, Great Ormond Street Hospital NHS Foundation Trust, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183146
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http://dx.doi.org/10.1016/j.jpeds.2018.10.024DOI Listing
March 2019

Somatosensory Neurons Enter a State of Altered Excitability during Hibernation.

Curr Biol 2018 09 30;28(18):2998-3004.e3. Epub 2018 Aug 30.

Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA; Department of Neuroscience, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2018.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173314PMC
September 2018

The Novel Activity of Carbamazepine as an Activation Modulator Extends from Na1.7 Mutations to the Na1.8-S242T Mutant Channel from a Patient with Painful Diabetic Neuropathy.

Mol Pharmacol 2018 11 22;94(5):1256-1269. Epub 2018 Aug 22.

Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut (C.H., M.E., F.B.D.-H., L.M., S.G.W., S.D.D.-H.); Center for restoration of Nervous System Function, Veterans Affairs Medical Center, West Haven, Connecticut (C.H., M.E., F.B.D.-H., L.M., S.G.W., S.D.D.-H.); Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom (A.C.T., I.B., D.L.B.); Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa (A.C.T.); and Oxford Medical Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom (C.F.)

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http://dx.doi.org/10.1124/mol.118.113076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501587PMC
November 2018

Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits.

Mol Brain 2018 08 7;11(1):45. Epub 2018 Aug 7.

Department of Neurology, Yale University Schoolof Medicine, New Haven, CT, 06510, USA.

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http://dx.doi.org/10.1186/s13041-018-0388-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081954PMC
August 2018

Nonmuscle myosin II isoforms interact with sodium channel alpha subunits.

Mol Pain 2018 Jan-Dec;14:1744806918788638. Epub 2018 Jun 29.

1 Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1177/1744806918788638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052497PMC
December 2018

Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner.

Mol Pain 2018 Jan-Dec;14:1744806918782229. Epub 2018 May 23.

1 Discipline of Neuroscience and Department of Anatomy and Physiology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://journals.sagepub.com/doi/10.1177/1744806918782229
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http://dx.doi.org/10.1177/1744806918782229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024516PMC
October 2018

Conditional knockout of Na1.6 in adult mice ameliorates neuropathic pain.

Sci Rep 2018 03 1;8(1):3845. Epub 2018 Mar 1.

Department of Neurology, Yale University School of Medicine, New Haven, CT, 06510, USA.

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http://dx.doi.org/10.1038/s41598-018-22216-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832877PMC
March 2018

Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Na1.7 mutation that massively hyperpolarizes activation.

Sci Rep 2018 01 29;8(1):1811. Epub 2018 Jan 29.

Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA, 06510.

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http://dx.doi.org/10.1038/s41598-018-20221-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788866PMC
January 2018

Na1.7 as a Pharmacogenomic Target for Pain: Moving Toward Precision Medicine.

Trends Pharmacol Sci 2018 03 20;39(3):258-275. Epub 2018 Jan 20.

Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.11.010DOI Listing
March 2018

Brain activity associated with pain in inherited erythromelalgia: stimulus-free pain engages brain areas involved in valuation and learning.

Neurobiol Pain 2018 Jan-Jul;3:8-14. Epub 2018 Jan 31.

Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, United States.

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http://dx.doi.org/10.1016/j.ynpai.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505710PMC
January 2018

Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability.

J Clin Invest 2017 Jun 22;127(7):2805-2814. Epub 2017 May 22.

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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https://www.jci.org/articles/view/92373
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http://dx.doi.org/10.1172/JCI92373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490760PMC
June 2017

Sodium channels in pain disorders: pathophysiology and prospects for treatment.

Pain 2017 04;158 Suppl 1:S97-S107

aDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA bCenter for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA cRehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA dDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA eThe John B. Pierce Laboratory, New Haven, CT, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000000854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350027PMC
April 2017

A SCN10A SNP biases human pain sensitivity.

Mol Pain 2016 2;12. Epub 2016 Sep 2.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

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http://dx.doi.org/10.1177/1744806916666083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011395PMC
October 2017

Familial gain-of-function Na1.9 mutation in a painful channelopathy.

J Neurol Neurosurg Psychiatry 2017 03 8;88(3):233-240. Epub 2016 Aug 8.

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://jnnp.bmj.com/lookup/doi/10.1136/jnnp-2016-313804
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http://dx.doi.org/10.1136/jnnp-2016-313804DOI Listing
March 2017

Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli.

J Neurosci 2016 07;36(28):7511-22

Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, Rehabilitation Research Center, Veterans Administration Connecticut Healthcare System, West Haven, Connecticut 06516, and

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http://dx.doi.org/10.1523/JNEUROSCI.0462-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705539PMC
July 2016

iFGF14-Navs: A monogamous partnership?

Channels (Austin) 2016 11 28;10(6):435-6. Epub 2016 Jun 28.

a Center for Neuroscience & Regeneration Research, Yale Medical School and Veterans Affairs Hospital , West Haven , CT , USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034771PMC
http://dx.doi.org/10.1080/19336950.2016.1204829DOI Listing
November 2016

Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling.

JAMA Neurol 2016 Jun;73(6):659-67

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut4Neurorehabilitation Research Center, Department of Neurology, Veterans Affairs Medical Center, West Haven, Connecticut.

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http://dx.doi.org/10.1001/jamaneurol.2016.0389DOI Listing
June 2016

Inherited erythromelalgia due to mutations in SCN9A: natural history, clinical phenotype and somatosensory profile.

Brain 2016 Apr 26;139(Pt 4):1052-65. Epub 2016 Feb 26.

Centre for Neuroscience and Regeneration Research, Yale University Medical School, New Haven, CT 06510 And Neuroscience Research Centre (Bldg. 34), Veterans Affairs Connecticut Healthcare, West Haven, CT, 06516, USA.

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http://dx.doi.org/10.1093/brain/aww007DOI Listing
April 2016

Diversity of composition and function of sodium channels in peripheral sensory neurons.

Pain 2015 Dec;156(12):2406-7

aDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA. bCenter for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA. cRehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000000353DOI Listing
December 2015

NaV1.9: a sodium channel linked to human pain.

Nat Rev Neurosci 2015 Sep 5;16(9):511-9. Epub 2015 Aug 5.

Department of Neurology and the Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA; and the Rehabilitation Research Center at the Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA.

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http://dx.doi.org/10.1038/nrn3977DOI Listing
September 2015

Virus-Mediated Knockdown of Nav1.3 in Dorsal Root Ganglia of STZ-Induced Diabetic Rats Alleviates Tactile Allodynia.

Mol Med 2015 Jun 18;21:544-52. Epub 2015 Jun 18.

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, United States of America; and Center for Neuroscience and Regeneration Research, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, United States of America.

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http://www.molmed.org/content/pdfstore/15_063_Tan.pdf
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http://dx.doi.org/10.2119/molmed.2015.00063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607619PMC
June 2015

Preferential targeting of Nav1.6 voltage-gated Na+ Channels to the axon initial segment during development.

PLoS One 2015 15;10(4):e0124397. Epub 2015 Apr 15.

Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, United States of America; Molecular, Cellular and Integrative Neuroscience Program, Colorado State University, Fort Collins, Colorado, United States of America.

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https://pdfs.semanticscholar.org/0dd7/d5b5fdb92afe6167195650
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http://dx.plos.org/10.1371/journal.pone.0124397
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124397PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398423PMC
January 2016

Human Na(v)1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons.

J Neurophysiol 2015 May 18;113(9):3172-85. Epub 2015 Mar 18.

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut; and Center for Neuroscience and Regeneration Research, Veterans Affairs Medical Center, West Haven, Connecticut

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http://dx.doi.org/10.1152/jn.00113.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432682PMC
May 2015

Oral administration of PF-01247324, a subtype-selective Nav1.8 blocker, reverses cerebellar deficits in a mouse model of multiple sclerosis.

PLoS One 2015 6;10(3):e0119067. Epub 2015 Mar 6.

Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut, United States of America; Rehabilitation Research Center, Veterans' Affairs Connecticut Healthcare System, West Haven, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119067PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352054PMC
January 2016

Destruction of paranodal architecture in inflammatory neuropathy with anti-contactin-1 autoantibodies.

J Neurol Neurosurg Psychiatry 2015 Jul 18;86(7):720-8. Epub 2015 Feb 18.

Department of Neurology, University Hospital Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1136/jnnp-2014-309916DOI Listing
July 2015

Depolarized inactivation overcomes impaired activation to produce DRG neuron hyperexcitability in a Nav1.7 mutation in a patient with distal limb pain.

J Neurosci 2014 Sep;34(37):12328-40

Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut 06516,

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http://dx.doi.org/10.1523/JNEUROSCI.2773-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615500PMC
September 2014

Translational pain research: Lessons from genetics and genomics.

Sci Transl Med 2014 Aug;6(249):249sr4

Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA. Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA. Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA.

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http://dx.doi.org/10.1126/scitranslmed.3007017DOI Listing
August 2014

Neuropathic pain in two-generation twins carrying the sodium channel Nav1.7 functional variant R1150W.

Pain 2014 Oct 10;155(10):2199-203. Epub 2014 Aug 10.

Department of Neurology, University of Würzburg, Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pain.2014.08.003DOI Listing
October 2014

Human pain in a dish: Native DRG neurons and differentiated pluripotent stem cells.

Pain 2014 Sep 15;155(9):1681-2. Epub 2014 Jul 15.

Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Rehabilitation Research Center, Veterans Administration Connecticut Healthcare System, West Haven, CT 06516, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pain.2014.07.010DOI Listing
September 2014

A novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy.

Neurobiol Dis 2014 Sep 27;69:117-23. Epub 2014 May 27.

Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-5618, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124819PMC
September 2014

Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy.

Brain 2014 Jun 27;137(Pt 6):1627-42. Epub 2014 Apr 27.

1 Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, and Centre for Neuroscience and Regeneration Research, Veterans Affairs Medical Centre, West Haven, CT 06516, USA

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http://dx.doi.org/10.1093/brain/awu079DOI Listing
June 2014

Screening fluorescent voltage indicators with spontaneously spiking HEK cells.

PLoS One 2013 31;8(12):e85221. Epub 2013 Dec 31.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America ; Department of Physics, Harvard University, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085221PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877367PMC
September 2014

Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state.

J Neurosci 2013 Oct;33(42):16586-93

Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, and Arizona Research Laboratories Division of Biotechnology, University of Arizona, Tucson, Arizona 85721.

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http://dx.doi.org/10.1523/JNEUROSCI.2307-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618534PMC
October 2013

The G1662S NaV1.8 mutation in small fibre neuropathy: impaired inactivation underlying DRG neuron hyperexcitability.

J Neurol Neurosurg Psychiatry 2014 May 4;85(5):499-505. Epub 2013 Sep 4.

Department of Neurology, Yale University School of Medicine, , New Haven, Connecticut, USA.

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http://dx.doi.org/10.1136/jnnp-2013-306095DOI Listing
May 2014

Wound-healing growth factor, basic FGF, induces Erk1/2-dependent mechanical hyperalgesia.

Pain 2013 Oct 16;154(10):2216-26. Epub 2013 Jul 16.

Max Planck Institute for Molecular Genetics, Berlin, Germany; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/j.pain.2013.07.005DOI Listing
October 2013

Molecular architecture of a sodium channel S6 helix: radial tuning of the voltage-gated sodium channel 1.7 activation gate.

J Biol Chem 2013 May 27;288(19):13741-7. Epub 2013 Mar 27.

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1074/jbc.M113.462366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650411PMC
May 2013

A new Nav1.7 mutation in an erythromelalgia patient.

Biochem Biophys Res Commun 2013 Mar 30;432(1):99-104. Epub 2013 Jan 30.

Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1016/j.bbrc.2013.01.079DOI Listing
March 2013

The Na(V)1.7 sodium channel: from molecule to man.

Nat Rev Neurosci 2013 Jan 12;14(1):49-62. Epub 2012 Dec 12.

Department of Neurology, and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1038/nrn3404DOI Listing
January 2013

Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn.

Mol Pain 2012 Nov 7;8:82. Epub 2012 Nov 7.

Department of Neurology and Paralyzed Veterans of America Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1186/1744-8069-8-82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517774PMC
November 2012

Virus-mediated shRNA knockdown of Na(v)1.3 in rat dorsal root ganglion attenuates nerve injury-induced neuropathic pain.

Mol Ther 2013 Jan 21;21(1):49-56. Epub 2012 Aug 21.

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/mt.2012.169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538302PMC
January 2013

Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury.

J Neurosci 2012 Aug;32(32):10819-32

Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0304-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621015PMC
August 2012

Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system.

Pain 2012 Oct 15;153(10):2017-30. Epub 2012 Jun 15.

Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.pain.2012.04.022DOI Listing
October 2012

PKCε phosphorylation of the sodium channel NaV1.8 increases channel function and produces mechanical hyperalgesia in mice.

J Clin Invest 2012 Apr 19;122(4):1306-15. Epub 2012 Mar 19.

Ernest Gallo Clinic and Research Center, Department of Neurology, UCSF, Emeryville, California 94608, USA.

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http://dx.doi.org/10.1172/JCI61934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315445PMC
April 2012

Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia and acromesomelia in a kindred with a novel NaV1.7 mutation.

Brain 2012 Feb 26;135(Pt 2):345-58. Epub 2012 Jan 26.

Neuroscience and Regeneration Research Centre, VA Connecticut Healthcare System, 950 Campbell Avenue, Building 34, West Haven, CT 06516, USA.

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https://academic.oup.com/brain/article/135/2/345/264217
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http://dx.doi.org/10.1093/brain/awr349DOI Listing
February 2012

Deletion mutation of sodium channel Na(V)1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability.

Brain 2011 Jul;134(Pt 7):1972-86

Department of Neurology and Centre for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1093/brain/awr143DOI Listing
July 2011

Nav1.7 is the predominant sodium channel in rodent olfactory sensory neurons.

Mol Pain 2011 May 10;7:32. Epub 2011 May 10.

Department of Neurology, Yale University School of Medicine, New Haven, 06520, USA.

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http://dx.doi.org/10.1186/1744-8069-7-32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101130PMC
May 2011

Paroxysmal extreme pain disorder: a molecular lesion of peripheral neurons.

Nat Rev Neurol 2011 Jan 16;7(1):51-5. Epub 2010 Nov 16.

Yale University Neuroscience and Regeneration Research Center, VA Connecticut Healthcare System, 950 Campbell Avenue, Building 34, West Haven, CT 06516, USA.

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http://dx.doi.org/10.1038/nrneurol.2010.162DOI Listing
January 2011

Proteomics of voltage-gated ion channels.

Neurosci Lett 2010 Dec 16;486(2):51-2. Epub 2010 Sep 16.

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http://dx.doi.org/10.1016/j.neulet.2010.09.022DOI Listing
December 2010

Isoform-specific and pan-channel partners regulate trafficking and plasma membrane stability; and alter sodium channel gating properties.

Neurosci Lett 2010 Dec 17;486(2):84-91. Epub 2010 Sep 17.

Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, United States.

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http://dx.doi.org/10.1016/j.neulet.2010.08.077DOI Listing
December 2010

Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK.

J Biol Chem 2010 Aug 8;285(34):26149-61. Epub 2010 Jun 8.

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1074/jbc.M109.098681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924020PMC
August 2010

Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability.

Mol Pain 2010 Jun 8;6:35. Epub 2010 Jun 8.

Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898769PMC
June 2010

Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disorders.

Mol Pain 2010 Apr 29;6:24. Epub 2010 Apr 29.

Department of Neurology and Center for Neuroscience & Regeneration Research, Yale University School of Medicine, New Haven, CT, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876140PMC
April 2010

A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neurons.

Exp Neurol 2010 Aug 24;224(2):362-8. Epub 2010 Apr 24.

Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.

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August 2010

A new Nav1.7 sodium channel mutation I234T in a child with severe pain.

Eur J Pain 2010 Oct 10;14(9):944-50. Epub 2010 Apr 10.

Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://doi.wiley.com/10.1016/j.ejpain.2010.03.007
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October 2010