Publications by authors named "Sujatha Venkataraman"

57Publications

Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma.

Cell Rep 2020 04;31(1):107485

Morgan Adams Foundation Pediatric Brain Tumor Research Program, Aurora, CO, USA; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA; Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO, USA; Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.03.049DOI Listing
April 2020

Role of MYC-miR-29-B7-H3 in Medulloblastoma Growth and Angiogenesis.

J Clin Med 2019 Aug 2;8(8). Epub 2019 Aug 2.

Departments of Cancer Biology and Pharmacology, University of Illinois College of Medicine Peoria, Peoria, IL 61605, USA.

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https://www.mdpi.com/2077-0383/8/8/1158
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http://dx.doi.org/10.3390/jcm8081158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723910PMC
August 2019

Therapeutic targeting of immune checkpoints with small molecule inhibitors.

Am J Transl Res 2019 15;11(2):529-541. Epub 2019 Feb 15.

Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine Peoria, IL.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413273PMC
February 2019

Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor.

Oncotarget 2017 Nov 19;8(57):97290-97303. Epub 2017 Oct 19.

Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

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http://dx.doi.org/10.18632/oncotarget.21932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722562PMC
November 2017

Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma.

Oncol Rep 2018 Feb 29;39(2):455-464. Epub 2017 Nov 29.

Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.

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http://dx.doi.org/10.3892/or.2017.6122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783612PMC
February 2018

NF-κB upregulation through epigenetic silencing of LDOC1 drives tumor biology and specific immunophenotype in Group A ependymoma.

Neuro Oncol 2017 Oct;19(10):1350-1360

Department of Pediatrics, University of Colorado Denver, Aurora, Colorado; Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, Colorado; Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado; Department of Neurosurgery, University of Colorado Denver, Aurora, Colorado.

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http://dx.doi.org/10.1093/neuonc/nox061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596179PMC
October 2017

MPS1 kinase as a potential therapeutic target in medulloblastoma.

Oncol Rep 2016 Nov 12;36(5):2633-2640. Epub 2016 Sep 12.

Department of Pediatrics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055207PMC
http://dx.doi.org/10.3892/or.2016.5085DOI Listing
November 2016

Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in MYC-driven medulloblastoma.

Oncotarget 2016 Aug;7(33):53881-53894

Department of Pediatrics and Section of Pediatric Hematology/Oncology/BMT, Children's Hospital Colorado and University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States.

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http://dx.doi.org/10.18632/oncotarget.10692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288228PMC
August 2016

MnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene.

Free Radic Biol Med 2016 05 2;94:185-94. Epub 2016 Mar 2.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.02.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486868PMC
May 2016

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.

ACS Chem Biol 2016 Apr 8;11(4):921-30. Epub 2016 Jan 8.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus , 12850 East Montview Boulevard, V20-2102, Aurora, Colorado 80045, United States.

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http://dx.doi.org/10.1021/acschembio.5b00725DOI Listing
April 2016

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma.

Mol Cancer 2014 Mar 24;13:72. Epub 2014 Mar 24.

Department of Pediatrics and Section of Pediatric Hematology/Oncology/BMT, Children's Hospital Colorado and University of Colorado Denver, Anschutz Medical Campus, 12800 E 19th Ave, Mail Stop 8302, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1186/1476-4598-13-72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987923PMC
March 2014

Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells.

Neuro Oncol 2013 Feb 28;15(2):149-60. Epub 2012 Nov 28.

Department of Pediatrics and Section of Pediatric Hematology/Oncology/BMT, Children’s Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1093/neuonc/nos285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548579PMC
February 2013

Inhibition of cyclin-dependent kinase 6 suppresses cell proliferation and enhances radiation sensitivity in medulloblastoma cells.

J Neurooncol 2013 Jan 9;111(2):113-21. Epub 2012 Nov 9.

Department of Pediatrics, Children's Hospital Colorado and University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1007/s11060-012-1000-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681514PMC
January 2013

Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle.

Cancer Res 2012 Aug 18;72(15):3807-16. Epub 2012 Jun 18.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429130PMC
August 2012

Targeting the enhancer of zeste homologue 2 in medulloblastoma.

Int J Cancer 2012 Oct 30;131(8):1800-9. Epub 2012 Jul 30.

Department of Pediatrics, The Children's Hospital and University of Colorado, Anschutz Medical Campus, CO, USA.

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http://dx.doi.org/10.1002/ijc.27455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375399PMC
October 2012

Targeting Aurora Kinase A enhances radiation sensitivity of atypical teratoid rhabdoid tumor cells.

J Neurooncol 2012 May 15;107(3):517-26. Epub 2012 Jan 15.

Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1007/s11060-011-0795-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681522PMC
May 2012

The rate of oxygen utilization by cells.

Free Radic Biol Med 2011 Aug 27;51(3):700-12. Epub 2011 May 27.

Free Radical and Radiation Biology Program and ESR Facility, The University of Iowa, Iowa City, IA 52242–1181, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2011.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147247PMC
August 2011

UVA/B-induced formation of free radicals from decabromodiphenyl ether.

Environ Sci Technol 2009 Apr;43(7):2581-8

Department of Occupational and Environmental Health, Interdisciplinary Graduate Program in Human Toxicology, Free Radical and Radiation Biology Program, ESR Facility, and Hygienic Laboratory, The University of Iowa, Iowa City, Iowa 52242, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685467PMC
http://dx.doi.org/10.1021/es8022978DOI Listing
April 2009

Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells.

Free Radic Biol Med 2008 Oct 22;45(8):1094-102. Epub 2008 Jul 22.

Free Radical and Radiation Biology Program, B180 Medical Laboratories, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242-1181, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2008.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614346PMC
October 2008

Manganese superoxide dismutase modulates hypoxia-inducible factor-1 alpha induction via superoxide.

Cancer Res 2008 Apr;68(8):2781-8

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242-1181, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633869PMC
April 2008

Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth.

Aging Cell 2008 Jun 10;7(3):405-17. Epub 2008 Mar 10.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2008.00384.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538945PMC
June 2008

Superoxide signaling mediates N-acetyl-L-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutase.

Cancer Res 2007 Jul;67(13):6392-9

Department of Microbiology and Immunology, State University of New York at Buffalo School of Medicine, Buffalo, New York, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0225DOI Listing
July 2007

Glutathione peroxidase-1 inhibits UVA-induced AP-2alpha expression in human keratinocytes.

Biochem Biophys Res Commun 2006 Dec 7;351(4):1066-71. Epub 2006 Nov 7.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.10.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913288PMC
December 2006

Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells.

J Biol Chem 2006 Dec 13;281(49):37416-26. Epub 2006 Oct 13.

Department of Surgery and University of Iowa College of Medicine, Holden Comprehensive Cancer Center, and Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1074/jbc.M605063200DOI Listing
December 2006

Mn-superoxide dismutase overexpression enhances G2 accumulation and radioresistance in human oral squamous carcinoma cells.

Antioxid Redox Signal 2006 Jul-Aug;8(7-8):1273-81

Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, 52242, USA.

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http://dx.doi.org/10.1089/ars.2006.8.1273DOI Listing
October 2006

Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor.

Oncogene 2005 Dec;24(55):8154-66

Department of Radiation Oncology, Free Radical and Radiation Biology Program, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242-1181, USA.

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http://dx.doi.org/10.1038/sj.onc.1208986DOI Listing
December 2005

Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.

J Biol Chem 2005 Feb 23;280(6):4254-63. Epub 2004 Nov 23.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1074/jbc.M411662200DOI Listing
February 2005

Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells.

Oncogene 2005 Jan;24(1):77-89

Free Radical and Radiation Biology Program -- ESR Facility, University of Iowa, Iowa City, IA 52242-1101, USA.

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http://dx.doi.org/10.1038/sj.onc.1208145DOI Listing
January 2005

Overexpression of manganese superoxide dismutase promotes the survival of prostate cancer cells exposed to hyperthermia.

Free Radic Res 2004 Oct;38(10):1119-32

Department of Radiation Oncology, Free Radical and Radiation Biology Program, EMRB 68, The University of Iowa, Iowa City, IA 52242-1101, USA.

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http://dx.doi.org/10.1080/10715760400010470DOI Listing
October 2004

Detection of lipid radicals using EPR.

Antioxid Redox Signal 2004 Jun;6(3):631-8

Free Radical and Radiation Biology & ESR Facility, The University of Iowa, Iowa City, IA 52242-1101, USA.

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http://dx.doi.org/10.1089/152308604773934396DOI Listing
June 2004

Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.

Proc Natl Acad Sci U S A 2004 Apr 8;101(16):5898-903. Epub 2004 Apr 8.

Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0307718101
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http://dx.doi.org/10.1073/pnas.0307718101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395895PMC
April 2004

High levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophages.

Am J Respir Cell Mol Biol 2004 Jul 12;31(1):43-53. Epub 2004 Feb 12.

Department of Medicine, University of Iowa Roy J. and Lucille A Carver College of Medicine, Iowa City Veterans Administration medical Center, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1165/rcmb.2003-0377OCDOI Listing
July 2004

Electron paramagnetic resonance for quantitation of nitric oxide in aqueous solutions.

Methods Enzymol 2002 ;359:3-18

University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1016/s0076-6879(02)59167-9DOI Listing
January 2003

Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species.

J Biol Chem 2002 Jun 2;277(23):20919-26. Epub 2002 Apr 2.

Department of Exercise Science and Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1074/jbc.M109801200DOI Listing
June 2002