Suhasini Iyer

Suhasini Iyer

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Suhasini Iyer

Suhasini Iyer

Publications by authors named "Suhasini Iyer"

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24Publications

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Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development.

Biopharm Drug Dispos 2016 Mar 15;37(2):51-65. Epub 2015 May 15.

Genentech Research and Early Development, Genentech Inc., South San Francisco, CA, USA.

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http://dx.doi.org/10.1002/bdd.1952DOI Listing
March 2016

Challenges and advances in the assessment of the disposition of antibody-drug conjugates.

Biopharm Drug Dispos 2016 Mar 8;37(2):66-74. Epub 2015 Jun 8.

Department of Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech, Inc, South San Francisco, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032988PMC
http://dx.doi.org/10.1002/bdd.1957DOI Listing
March 2016

Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates.

Pharm Res 2015 Nov 2;32(11):3470-9. Epub 2014 Dec 2.

Department of Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech, Inc, 1 DNA Way (Mailstop 463A), South San Francisco, CA, 94080, USA.

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http://dx.doi.org/10.1007/s11095-014-1584-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596897PMC
November 2015

Modeling approach to investigate the effect of neonatal Fc receptor binding affinity and anti-therapeutic antibody on the pharmacokinetic of humanized monoclonal anti-tumor necrosis factor-α IgG antibody in cynomolgus monkey.

Eur J Pharm Sci 2014 Jan 31;51:51-8. Epub 2013 Aug 31.

Clinical Pharmacology and Therapeutic, Children Hospital of Philadelphia, PA, United States; School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2013.08.033DOI Listing
January 2014

Pharmacokinetics and pharmacodynamics of anti-BR3 monoclonal antibody in mice.

Pharm Res 2012 Nov 18;29(11):3180-7. Epub 2012 Jul 18.

Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, 431 Kapoor Hall, Buffalo, New York 14214, USA.

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http://dx.doi.org/10.1007/s11095-012-0813-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632054PMC
November 2012

Monoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development?

Expert Opin Drug Metab Toxicol 2012 Feb 17;8(2):141-60. Epub 2012 Jan 17.

Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech, Inc., 1 DNA Way, Mail Stop 463A, South San Francisco, California 94080, USA.

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http://www.tandfonline.com/doi/full/10.1517/17425255.2012.64
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http://dx.doi.org/10.1517/17425255.2012.643868DOI Listing
February 2012

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?

MAbs 2011 Jan-Feb;3(1):61-6. Epub 2011 Jan 1.

Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Inc., South San Francisco, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038012PMC
http://dx.doi.org/10.4161/mabs.3.1.13799DOI Listing
July 2011

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys.

Drug Metab Dispos 2010 Apr 13;38(4):600-5. Epub 2010 Jan 13.

Department of Pharmacokinetics and Pharmacodynamics Sciences, Genentech Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1124/dmd.109.031310DOI Listing
April 2010

Evidence for an asialoglycoprotein receptor on nonparenchymal cells for O-linked glycoproteins.

J Pharmacol Exp Ther 2008 Nov 26;327(2):308-15. Epub 2008 Aug 26.

Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech, Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1124/jpet.108.142232DOI Listing
November 2008

Topical application of a novel immunomodulatory peptide, RDP58, reduces skin inflammation in the phorbol ester-induced dermatitis model.

J Invest Dermatol 2005 Sep;125(3):473-81

Department Discovery Research, Sangstat Medical Corporation, Fremont, California 94080, USA.

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http://dx.doi.org/10.1111/j.0022-202X.2005.23831.xDOI Listing
September 2005

Attenuation of aortic graft arteriosclerosis by systemic administration of Allotrap peptide RDP58.

Transpl Int 2003 Dec 27;16(12):849-56. Epub 2003 Aug 27.

Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, E1540, Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, Pennsylvania, USA.

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http://dx.doi.org/10.1007/s00147-003-0617-zDOI Listing
December 2003

Rational design and development of RDP58.

Curr Pharm Des 2002 ;8(24):2217-29

Sangstat Medical Corporation, Fremont, CA 94555, USA.

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http://dx.doi.org/10.2174/1381612023393170DOI Listing
February 2003

Gene transfer of heme oxygenase-1 and carbon monoxide delivery inhibit chronic rejection.

Am J Transplant 2002 Aug;2(7):581-92

Institut National de la Santé Et de la Recherche Médicale U437, Institut de Transplantation et de Recherche en Transplantation and CHU de Nantes, France.

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August 2002

Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway.

Transplantation 2002 Jan;73(2):287-92

Division of Liver and Pancreas Transplantation, Dumot-UCLA Transplant Center, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1097/00007890-200201270-00023DOI Listing
January 2002