Publications by authors named "Sue Haupt"

52Publications

TP53 Status, Patient Sex, and the Immune Response as Determinants of Lung Cancer Patient Survival.

Cancers (Basel) 2020 Jun 11;12(6). Epub 2020 Jun 11.

Tumor Suppression Laboratory, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia.

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http://dx.doi.org/10.3390/cancers12061535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352604PMC
June 2020

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation.

Int J Mol Sci 2020 May 13;21(10). Epub 2020 May 13.

Tumour Suppression Laboratory, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia.

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http://dx.doi.org/10.3390/ijms21103452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278985PMC
May 2020

Corrigendum to 'The long and the short of it: the MDM4 tail so far'.

J Mol Cell Biol 2019 Dec;11(12):1104

Tumor Suppression Laboratory, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia.

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http://dx.doi.org/10.1093/jmcb/mjz109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934149PMC
December 2019

Cannibalism in Breast Cancer: The Dangers of Overeating.

Trends Cancer 2019 12 6;5(12):761-762. Epub 2019 Nov 6.

Tumor Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2019.10.008DOI Listing
December 2019

Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network.

Nat Commun 2019 11 26;10(1):5385. Epub 2019 Nov 26.

Tumor Suppression Laboratory, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria, 3000, Australia.

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http://dx.doi.org/10.1038/s41467-019-13266-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879765PMC
November 2019

E6AP Promotes a Metastatic Phenotype in Prostate Cancer.

iScience 2019 Dec 2;22:1-15. Epub 2019 Nov 2.

Tumour Suppression Laboratory, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia; Department of Pathology, Peter MacCallum Cancer Centre, Melbourne 3000, Australia; Department of Clinical Pathology, University of Melbourne, Parkville, VIC 3010, Australia; Department of Biochemistry and Molecular Biology, Monash University, Melbourne 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.10.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864340PMC
December 2019

Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma.

Cancer Lett 2019 Oct 20;461:21-30. Epub 2019 Jun 20.

Women's Cancer Research Center, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology; University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.canlet.2019.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682463PMC
October 2019

E6AP goes viral: the role of E6AP in viral- and non-viral-related cancers.

Carcinogenesis 2019 07;40(6):707-714

Tumour Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1093/carcin/bgz072DOI Listing
July 2019

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects.

Cell Rep 2019 04;27(2):442-454.e5

Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.048DOI Listing
April 2019

A quantitative model to predict pathogenicity of missense variants in the TP53 gene.

Hum Mutat 2019 06 18;40(6):788-800. Epub 2019 Mar 18.

Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/humu.23739DOI Listing
June 2019

The long and the short of it: the MDM4 tail so far.

J Mol Cell Biol 2019 03;11(3):231-244

Tumor Suppression Laboratory, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1093/jmcb/mjz007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478121PMC
March 2019

New insights on the regulation of locus expression.

Oncotarget 2017 Dec 1;8(63):106147-106148. Epub 2017 Nov 1.

Cristina Gamell: The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia; Tumor Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia.

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http://dx.doi.org/10.18632/oncotarget.22258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739710PMC
December 2017

P53 at the start of the 21st century: lessons from elephants.

F1000Res 2017 22;6:2041. Epub 2017 Nov 22.

Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.12688/f1000research.12682.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701437PMC
November 2017

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis.

Redox Biol 2018 04 1;14:100-115. Epub 2017 Sep 1.

Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Burwood, Victoria 3125, Australia; Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596264PMC
April 2018

The role of MDM2 and MDM4 in breast cancer development and prevention.

J Mol Cell Biol 2017 02;9(1):53-61

Tumour Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.

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http://dx.doi.org/10.1093/jmcb/mjx007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439375PMC
February 2017

The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.

Cancer Res 2016 07 26;76(14):4236-48. Epub 2016 May 26.

Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Australia. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1553DOI Listing
July 2016

Mutant p53 Drives Cancer by Subverting Multiple Tumor Suppression Pathways.

Front Oncol 2016 27;6:12. Epub 2016 Jan 27.

Tumour Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Department of Pathology, The University of Melbourne, Parkville, VIC, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.

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http://dx.doi.org/10.3389/fonc.2016.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728204PMC
February 2016

Clinical Overview of MDM2/X-Targeted Therapies.

Front Oncol 2016 27;6. Epub 2016 Jan 27.

The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW, Australia; Faculty of Medicine, St. Vincent's Clinical School, UNSW Australia, Sydney, NSW, Australia.

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http://dx.doi.org/10.3389/fonc.2016.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728205PMC
February 2016

Regulation of Mutant p53 Protein Expression.

Front Oncol 2015 17;5:284. Epub 2015 Dec 17.

Tumour Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology and Department of Pathology, The University of Melbourne, Parkville, VIC, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.

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http://dx.doi.org/10.3389/fonc.2015.00284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681805PMC
January 2016

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma.

Gut 2015 Oct 17;64(10):1506-16. Epub 2015 Jul 17.

Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia University of Melbourne Department of Surgery, St. Vincent's Hospital, Melbourne, Victoria, Australia.

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http://gut.bmj.com/content/64/10/1506.full.pdf
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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2015-309770
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http://dx.doi.org/10.1136/gutjnl-2015-309770DOI Listing
October 2015

p53 Calls upon CIA (Calcium Induced Apoptosis) to Counter Stress.

Front Oncol 2015 10;5:57. Epub 2015 Mar 10.

Tumour Suppression Laboratory, Peter MacCallum Cancer Centre , Melbourne, VIC , Australia ; Sir Peter MacCallum Department of Oncology, The University of Melbourne , Parkville, VIC , Australia ; Department of Pathology, The University of Melbourne , Parkville, VIC , Australia ; Department of Biochemistry and Molecular Biology, Monash University , Melbourne, VIC , Australia.

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http://dx.doi.org/10.3389/fonc.2015.00057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354267PMC
March 2015

Role of p53 in the progression of gastric cancer.

Oncotarget 2014 Dec;5(23):12016-26

Cancer Genetics and Genomics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia. Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia. Department of Gastroenterology, Royal Melbourne Hospital, Parkville, VIC, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322971PMC
http://dx.doi.org/10.18632/oncotarget.2434DOI Listing
December 2014

The p53-Mdm2 loop: a critical juncture of stress response.

Subcell Biochem 2014 ;85:161-86

Lautenberg Center, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://link.springer.com/10.1007/978-94-017-9211-0_9
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http://dx.doi.org/10.1007/978-94-017-9211-0_9DOI Listing
December 2014

PML tumour suppression and beyond: therapeutic implications.

FEBS Lett 2014 Aug 15;588(16):2653-62. Epub 2014 Feb 15.

Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, East Melbourne 3002, Victoria, Australia; Sir Peter MacCallum Department of Oncology, the University of Melbourne, Parkville 3010, Victoria, Australia.

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http://dx.doi.org/10.1016/j.febslet.2014.02.007DOI Listing
August 2014

New Strategies to Direct Therapeutic Targeting of PML to Treat Cancers.

Front Oncol 2013 17;3:124. Epub 2013 May 17.

Tumour Suppression Laboratory, Peter MacCallum Cancer Centre East Melbourne, VIC, Australia ; Sir Peter MacCallum Department of Oncology, The University of Melbourne Parkville, VIC, Australia.

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http://dx.doi.org/10.3389/fonc.2013.00124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656422PMC
June 2013

c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity.

Biochemistry 2013 May 26;52(18):3119-29. Epub 2013 Apr 26.

Research Division, The Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne 3002, Victoria, Australia.

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http://dx.doi.org/10.1021/bi301710cDOI Listing
May 2013

Restoring PML tumor suppression to combat cancer.

Cell Cycle 2012 Oct 14;11(20):3705-6. Epub 2012 Sep 14.

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http://dx.doi.org/10.4161/cc.22043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495802PMC
October 2012

MDM4 is a key therapeutic target in cutaneous melanoma.

Nat Med 2012 Aug 22;18(8):1239-47. Epub 2012 Jul 22.

Center for the Biology of Disease, Laboratory for Molecular Cancer Biology, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium; Center for Human Genetics, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/nm.2863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744207PMC
August 2012

Mutant p53 subverts PLK2 function in a novel, reinforced loop of corruption.

Cell Cycle 2012 Jan 15;11(2):217-8. Epub 2012 Jan 15.

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http://dx.doi.org/10.4161/cc.11.2.18977DOI Listing
January 2012

Synchronized release of Doxil and Nutlin-3 by remote degradation of polysaccharide matrices and its possible use in the local treatment of colorectal cancer.

J Drug Target 2011 Dec;19(10):859-73

The Hebrew University of Jerusalem, School of Pharmacy, Research Institute for Drug Research, Jerusalem, Israel.

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http://dx.doi.org/10.3109/1061186X.2011.622401DOI Listing
December 2011

Tumour suppression by p53: the importance of apoptosis and cellular senescence.

J Pathol 2009 Sep;219(1):3-15

Lautenberg Centre for General and Tumour Immunology, The Hebrew University Hadassah Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1002/path.2584DOI Listing
September 2009

Promyelocytic leukemia protein is required for gain of function by mutant p53.

Cancer Res 2009 Jun;69(11):4818-26

Research Division, The Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-08-4010DOI Listing
June 2009

T cell survival and function requires the c-Abl tyrosine kinase.

Cell Cycle 2008 Dec 23;7(24):3847-57. Epub 2008 Dec 23.

Lautenberg Center for General and Tumor Immunology, Hadassah Medical School, The Hebrew University, Jerusalem, Israel.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407662PMC
http://dx.doi.org/10.4161/cc.7.24.7267DOI Listing
December 2008

Importance of p53 for cancer onset and therapy.

Anticancer Drugs 2006 Aug;17(7):725-32

Department of Hematology, Hadassah University Hospital, Jerusalem, Israel.

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http://dx.doi.org/10.1097/01.cad.0000217422.52208.faDOI Listing
August 2006

Celecoxib can induce cell death independently of cyclooxygenase-2, p53, Mdm2, c-Abl and reactive oxygen species.

Anticancer Drugs 2006 Jul;17(6):609-19

Department of Hematology, Hadassah University Hospital, Jerusalem, Israel.

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http://dx.doi.org/10.1097/01.cad.0000215055.40072.42DOI Listing
July 2006

Luminal delivery and dosing considerations of local celecoxib administration to colorectal cancer.

Eur J Pharm Sci 2006 Jun 11;28(3):204-11. Epub 2006 Apr 11.

The Hebrew University of Jerusalem, Faculty of Medicine, School of Pharmacy, P.O. Box 12065, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1016/j.ejps.2006.02.001DOI Listing
June 2006

Mdm2 in growth signaling and cancer.

Growth Factors 2005 Sep;23(3):183-92

The Hebrew University Hadassah Medical School, Lautenberg Center for General and Tumor Immunology, Jerusalem, Israel.

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http://dx.doi.org/10.1080/08977190500196218DOI Listing
September 2005

C-Abl as a modulator of p53.

Biochem Biophys Res Commun 2005 Jun;331(3):737-49

Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1016/j.bbrc.2005.03.152DOI Listing
June 2005