Publications by authors named "Suditi Neekhra"

6 Publications

  • Page 1 of 1

Designing nanoformulation for the nose-to-brain delivery in Parkinson's disease: Advancements and barrier.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2021 Nov 25:e1768. Epub 2021 Nov 25.

Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.

Parkinson's disease (PD), a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons, which results in the loss of motor activity. In the management of PD, the primary aim is to increase the dopamine content in the brain either by delivering the precursors of dopamine or by inhibiting the molecules responsible for dopamine degradation. Due to the low bioavailability, a higher dosage of drugs needs to be administered repeatedly for achieving the desired therapeutic effect. This repeated high dose not only increases the severe side effects but also produces tolerance in the body. Often, direct administration of drugs fails to ameliorate the symptoms as the unmodified drugs cannot cross the blood-brain barrier (BBB). Nanotherapeutic is at the forefront of the alternative treatment against the central nervous system (CNS) disorders due to the ability to circumvents the BBB. Here, all the available treatments for PD have been discussed with their limitation. The current trends of nanotherapeutics for PD have been explored. Suitability and formulation prospects for nasal delivery have been analyzed in detail to explore new research scope. The most effective approach is the nose-to-brain delivery for targeting drugs directly to the brain. This delivery bypasses the BBB and concentrates more drugs at the target site. Thus, developments of nose-to-brain delivery of nanoformulations explicit the new scope to manage PD better. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.
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http://dx.doi.org/10.1002/wnan.1768DOI Listing
November 2021

Designing and Immunomodulating Multiresponsive Nanomaterial for Cancer Theranostics.

Front Chem 2020 29;8:631351. Epub 2021 Jan 29.

Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.

Cancer has been widely investigated yet limited in its manifestation. Cancer treatment holds innovative and futuristic strategies considering high disease heterogeneity. Chemotherapy, radiotherapy and surgery are the most explored pillars; however optimal therapeutic window and patient compliance recruit constraints. Recently evolved immunotherapy demonstrates a vital role of the host immune system to prevent metastasis recurrence, still undesirable clinical response and autoimmune adverse effects remain unresolved. Overcoming these challenges, tunable biomaterials could effectively control the co-delivery of anticancer drugs and immunomodulators. Current status demands a potentially new approach for minimally invasive, synergistic, and combinatorial nano-biomaterial assisted targeted immune-based treatment including therapeutics, diagnosis and imaging. This review discusses the latest findings of engineering biomaterial with immunomodulating properties and implementing novel developments in designing versatile nanosystems for cancer theranostics. We explore the functionalization of nanoparticle for delivering antitumor therapeutic and diagnostic agents promoting immune response. Through understanding the efficacy of delivery system, we have enlightened the applicability of nanomaterials as immunomodulatory nanomedicine further advancing to preclinical and clinical trials. Future and present ongoing improvements in engineering biomaterial could result in generating better insight to deal with cancer through easily accessible immunological interventions.
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http://dx.doi.org/10.3389/fchem.2020.631351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878384PMC
January 2021

Hydrothermal-Assisted Synthesis and Stability of Multifunctional MXene Nanobipyramids: Structural, Chemical, and Optical Evolution.

ACS Appl Mater Interfaces 2021 Jan 7;13(2):3011-3023. Epub 2021 Jan 7.

Department of Biosciences and Bioengineering, Indian Institute of Technology, Bombay (IITB), Powai, Mumbai 400076, India.

Recent advancements in two-dimensional materials have brought MXene (TiC) into attention due to its exciting properties as a very promising material for various applications. In this work, we report a novel TiC nanobipyramid (TiC NB) structure obtained through a three-step process involving exfoliation, delamination, and subsequent hydrothermal treatment. The morphological and textural properties at each step of synthesis were studied using an array of experimental techniques such as transmission electron microscopy, scanning electron microscopy, and atomic force microscopy and the chemical properties through X-ray diffraction, Raman, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy analysis. The TiC NBs exhibit fluorescence with an excitation-dependent emission. Further, the effect of temperature and pH on the fluorescence was also investigated, which opens up its scope in bioanalytical applications. TiC NBs showed a ∼43% increase in photoluminescence intensity from pH 3 to 11 while a ∼38% increase with the temperature from 20 to 80 °C. Usually, MXenes are highly susceptible to oxidation, but the TiC NBs were found to be chemically and optically stable even after 30 days. Bestowed with good hydrophilicity, the material exhibited high biocompatibility on the mouse fibroblast cell line L929. Further, L929 cells also showed good cellular adhesion on a TiC NB-modified glass substrate. These properties pave a way for its multifunctional ability as a sensor for pH and temperature as well as bioimaging.
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http://dx.doi.org/10.1021/acsami.0c18712DOI Listing
January 2021

Design and Development of Axially Chiral Bis(naphthofuran) Luminogens as Fluorescent Probes for Cell Imaging.

Chemistry 2021 Mar 25;27(17):5470-5482. Epub 2021 Feb 25.

Department of Speciality Chemicals Technology, Institute of Chemical Technology (ICT), Mumbai, 400019, India.

Designing chiral AIEgens without aggregation-induced emission (AIE)-active molecules externally tagged to the chiral scaffold remains a long-standing challenge for the scientific community. The inherent aggregation-caused quenching phenomenon associated with the axially chiral (R)-[1,1'-binaphthalene]-2,2'-diol ((R)-BINOL) scaffold, together with its marginal Stokes shift, limits its application as a chiral AIE-active material. Here, in our effort to design chiral luminogens, we have developed a design strategy in which 2-substituted furans, when appropriately fused with the BINOL scaffold, will generate solid-state emissive materials with high thermal and photostability as well as colour-tunable properties. The excellent biocompatibility, together with the high fluorescence quantum yield and large Stokes shift, of one of the luminogens stimulated us to investigate its cell-imaging potential. The luminogen was observed to be well internalised and uniformly dispersed within the cytoplasm of MDA-MB-231 cancer cells, showing high fluorescence intensity.
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http://dx.doi.org/10.1002/chem.202004942DOI Listing
March 2021

Machine-Free Polymerase Chain Reaction with Triangular Gold and Silver Nanoparticles.

J Phys Chem Lett 2020 Dec 4;11(24):10489-10496. Epub 2020 Dec 4.

Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

Photothermal effects of metal nanoparticles (NPs) are used for various biotechnological applications. Although NPs have been used in a polymerase chain reaction (PCR), the effects of shape on the photothermal properties and its efficiency on PCR are less explored. The present study reports the synthesis of triangular gold and silver NPs, which can attain temperatures up to ∼90 °C upon irradiation with 808 nm laser. This photothermal property of synthesized nanoparticles was evaluated using various concentrations, irradiation time, and power to create a temperature profile required for variable-temperature PCR. This study reports a cost-effective, machine-free PCR using both gold and silver triangular NPs, with efficiency similar to that of a commercial PCR machine. Interestingly, addition of triangular NPs increases PCR efficiency in commercial PCR reactions. The higher PCR efficiencies are due to the direct binding and unfolding of double-stranded DNA as suggested by circular dichroism and UV spectroscopy. These findings suggest that triangular NPs can be used to develop cost-effective, robust machine-free PCR modules and can be used in various other photothermal applications.
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http://dx.doi.org/10.1021/acs.jpclett.0c02708DOI Listing
December 2020

Plasmonic carbon nanohybrids for repetitive and highly localized photothermal cancer therapy.

Colloids Surf B Biointerfaces 2018 Dec 28;172:430-439. Epub 2018 Aug 28.

Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India. Electronic address:

Integrating metallic and non-metallic platform for cancer nanomedicine is a challenging task and bringing together multi-functionality of two interfaces is a major hurdle for biomaterial design. Herein, NIR light responsive advanced hybrid plasmonic carbon nanomaterials are synthesized, and their properties toward repetitive and highly localized photothermal cancer therapy are well understood. Graphene oxide nanosheets having thickness of ∼2 nm are synthesized using modified Hummers' method, thereafter functionalized with biodegradable NIR light responsive gold deposited plasmonic polylactic-co-glycolic acid nanoshells (AuPLGA NS, tuned at 808 nm) and NIR dye (IR780) to examine their repetitive and localized therapeutic efficacy as well resulting side effects to nearby healthy cells. It is observed that AuPLGA NS decorated graphene oxide nanosheets (GO-AuPLGA) and IR780 loaded graphene oxide nanosheets (GO-IR780) are capable in standalone complete photothermal ablation of cancer cells within 4 min. of 808 nm NIR laser irradiation and also without the aid of any anticancer drugs. However, GO-AuPLGA having the potential for repetitive photothermal treatment of a big tumor, ablate the cancer cells in highly localized fashion, without having side effects on neighboring healthy cells.
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http://dx.doi.org/10.1016/j.colsurfb.2018.08.054DOI Listing
December 2018
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