Publications by authors named "Suat Ozbek"

56Publications

New Class of Crosslinker-Free Nanofiber Biomaterials from Hydra Nematocyst Proteins.

Sci Rep 2019 12 13;9(1):19116. Epub 2019 Dec 13.

Physical Chemistry of Biosystems, Institute of Physical Chemistry, Heidelberg University, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41598-019-55655-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910907PMC
December 2019

Extracellular matrix and morphogenesis in cnidarians: a tightly knit relationship.

Essays Biochem 2019 09 13;63(3):407-416. Epub 2019 Sep 13.

Department of Molecular Evolution and Genomics, Im Neuenheimer Feld 230, Centre for Organismal Studies, University of Heidelberg, 69120 Heidelberg, Germany

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http://dx.doi.org/10.1042/EBC20190021DOI Listing
September 2019

Spatially resolved photochemical coding of reversibly anchored cysteine-rich domains.

J Mater Chem B 2017 Jul 7;5(25):4993-5000. Epub 2017 Jun 7.

Macromolecular Architectures, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Engesserstraße 18, 76128 Karlsruhe, Germany.

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http://dx.doi.org/10.1039/c7tb00962cDOI Listing
July 2017

Minicollagen cysteine-rich domains encode distinct modes of polymerization to form stable nematocyst capsules.

Sci Rep 2016 05 11;6:25709. Epub 2016 May 11.

University of Heidelberg, Centre for Organismal Studies, Department of Molecular Evolution and Genomics, Im Neuenheimer Feld 329, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/srep25709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863159PMC
May 2016

Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation.

J Biol Chem 2016 Jun 29;291(26):13730-42. Epub 2016 Apr 29.

the Centre of Organismal Studies, Department of Molecular Evolution and Genomics, University of Heidelberg, 69120 Heidelberg, Germany

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http://dx.doi.org/10.1074/jbc.M116.733766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919455PMC
June 2016

The Rise and Fall of TRP-N, an Ancient Family of Mechanogated Ion Channels, in Metazoa.

Genome Biol Evol 2015 Jun 22;7(6):1713-27. Epub 2015 Jun 22.

Institute for Evolution and Biodiversity, University of Muenster, Germany

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http://dx.doi.org/10.1093/gbe/evv091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494053PMC
June 2015

A fast recoiling silk-like elastomer facilitates nanosecond nematocyst discharge.

BMC Biol 2015 Jan 16;13. Epub 2015 Jan 16.

Department of Molecular Evolution and Genomics, University of Heidelberg, Centre for Organismal Studies, Im Neuenheimer Feld 329, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s12915-014-0113-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321713PMC
January 2015

Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis.

Nat Commun 2014 Dec 23;5:5536. Epub 2014 Dec 23.

Department of Molecular Evolution and Genomics, Centre for Organismal Studies (COS), Heidelberg University, Im Neuenheimer Feld 329, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/ncomms6536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284808PMC
December 2014

Nodal signalling determines biradial asymmetry in Hydra.

Nature 2014 Nov 24;515(7525):112-5. Epub 2014 Aug 24.

Department of Molecular Evolution and Genomics, Centre for Organismal Studies (COS), Heidelberg University, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature13666DOI Listing
November 2014

Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity.

BMC Biol 2014 May 30;12:44. Epub 2014 May 30.

Centre for Organismal Studies, Department of Molecular Evolution and Genomics, University of Heidelberg, Im Neuenheimer Feld 329, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1186/1741-7007-12-44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068752PMC
May 2014

The nematocyst: a molecular map of the cnidarian stinging organelle.

Int J Dev Biol 2012 ;56(6-8):577-82

Department for Molecular Evolution and Genomics, Centre for Organismal Studies, University of Heidelberg, Hei-delberg, Germany.

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http://dx.doi.org/10.1387/ijdb.113472abDOI Listing
February 2013

Live imaging of active fluorophore labelled Wnt proteins.

FEBS Lett 2012 Jun 26;586(11):1638-44. Epub 2012 Apr 26.

Zoological Institute II, Karlsruhe Institute of Technology, D-76131 Karlsruhe, Germany.

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http://dx.doi.org/10.1016/j.febslet.2012.04.035DOI Listing
June 2012

Proteome of Hydra nematocyst.

J Biol Chem 2012 Mar 30;287(13):9672-81. Epub 2012 Jan 30.

Department of Molecular Evolution and Genomics, Centre for Organismal Studies, University of Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M111.328203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323026PMC
March 2012

In vivo imaging of basement membrane movement: ECM patterning shapes Hydra polyps.

J Cell Sci 2011 Dec;124(Pt 23):4027-38

Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.

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http://dx.doi.org/10.1242/jcs.087239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244984PMC
December 2011

Signaling pathways and axis formation in the lower metazoa.

Curr Top Dev Biol 2011 ;97:137-77

Department of Molecular Evolution and Genomics, Centre for Organismal Studies, Heidelberg University, Germany.

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http://dx.doi.org/10.1016/B978-0-12-385975-4.00012-7DOI Listing
April 2012

Neurotoxin localization to ectodermal gland cells uncovers an alternative mechanism of venom delivery in sea anemones.

Proc Biol Sci 2012 Apr 2;279(1732):1351-8. Epub 2011 Nov 2.

Department of Molecular Biology and Ecology of Plants, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel.

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http://rspb.royalsocietypublishing.org/content/royprsb/early
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http://rspb.royalsocietypublishing.org/cgi/doi/10.1098/rspb.
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http://dx.doi.org/10.1098/rspb.2011.1731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282367PMC
April 2012

Morphological and molecular analysis of the Nematostella vectensis cnidom.

PLoS One 2011 28;6(7):e22725. Epub 2011 Jul 28.

Department for Molecular Evolution and Genomics, Centre for Organismal Studies, University of Heidelberg, Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022725PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145756PMC
December 2011

Evolution of glycosaminoglycans: Comparative biochemical study.

Commun Integr Biol 2011 Mar;4(2):150-8

Laboratory of Proteoglycan Signaling and Therapeutics; Faculty of Advanced Life Science; Graduate School of Life Science; Hokkaido University; Sapporo, Japan.

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http://dx.doi.org/10.4161/cib.4.2.14547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104567PMC
March 2011

Expression of pancreatitis-associated protein after traumatic brain injury: a mechanism potentially contributing to neuroprotection in human brain.

Cell Mol Neurobiol 2011 Nov 5;31(8):1141-9. Epub 2011 Jun 5.

Translational Research, Hoffmann-LaRoche Ltd, Grenzacherstrasse, 4070 Basel, Switzerland.

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http://dx.doi.org/10.1007/s10571-011-9715-0DOI Listing
November 2011

Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer.

Proc Natl Acad Sci U S A 2011 May 16;108(22):9137-42. Epub 2011 May 16.

Department of Molecular Evolution and Genomics, Heidelberg Institute of Zoology, University of Heidelberg, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1073/pnas.1018109108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107325PMC
May 2011

The evolution of extracellular matrix.

Mol Biol Cell 2010 Dec;21(24):4300-5

Department of Molecular Evolution and Genomics, University of Heidelberg, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1091/mbc.E10-03-0251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002383PMC
December 2010

The cnidarian nematocyst: a miniature extracellular matrix within a secretory vesicle.

Authors:
Suat Ozbek

Protoplasma 2011 Oct 19;248(4):635-40. Epub 2010 Oct 19.

Institute of Zoology, Department of Molecular Evolution and Genomics, University of Heidelberg, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00709-010-0219-4DOI Listing
October 2011

A non-sulfated chondroitin stabilizes membrane tubulation in cnidarian organelles.

J Biol Chem 2010 Aug 9;285(33):25613-23. Epub 2010 Jun 9.

Department of Molecular Evolution and Genomics, Institute of Zoology, Heidelberg University, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.107904
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http://dx.doi.org/10.1074/jbc.M110.107904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919125PMC
August 2010

The dynamic genome of Hydra.

Nature 2010 Mar 14;464(7288):592-6. Epub 2010 Mar 14.

US Department of Energy Joint Genome Institute, Walnut Creek, California 94598, USA.

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http://dx.doi.org/10.1038/nature08830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479502PMC
March 2010

Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin.

Anticancer Res 2009 Jan;29(1):11-8

Karolinska Institutet, Department of Oncology-Pathology, Cancer Center Karolinska R8:01, Karolinska University Hospital, 171 76 Stockholm.

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January 2009

Cnidocyst structure and the biomechanics of discharge.

Toxicon 2009 Dec 13;54(8):1038-45. Epub 2009 Mar 13.

Institute of Zoology, Department of Molecular Evolution and Genomics, Im Neuenheimer Feld 230, 69130 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.toxicon.2009.03.006DOI Listing
December 2009

Wnt/beta-catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra.

Proc Natl Acad Sci U S A 2009 Mar 23;106(11):4290-5. Epub 2009 Feb 23.

Institute of Zoology, Center for Molecular Biosciences, University of Innsbruck, Technikerstrasse 25, Innsbruck, A-6020, Austria.

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http://dx.doi.org/10.1073/pnas.0812847106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646623PMC
March 2009

Multiple Wnts are involved in Hydra organizer formation and regeneration.

Dev Biol 2009 Jun 13;330(1):186-99. Epub 2009 Feb 13.

Department of Molecular Evolution and Genomics, Heidelberg University, Im Neuenheimer Feld 230, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ydbio.2009.02.004DOI Listing
June 2009

Evolution of complex structures: minicollagens shape the cnidarian nematocyst.

Trends Genet 2008 Sep 3;24(9):431-8. Epub 2008 Aug 3.

Department Biologie II, Ludwig-Maximilians-Universität, D-82152 Planegg-Martinsried, Germany.

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http://dx.doi.org/10.1016/j.tig.2008.07.001DOI Listing
September 2008

Minicollagen-15, a novel minicollagen isolated from Hydra, forms tubule structures in nematocysts.

J Mol Biol 2008 Feb 5;376(4):1008-20. Epub 2007 Dec 5.

Institute of Zoology, Department of Molecular Evolution and Genomics, Im Neuenheimer Feld 230, 69130 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jmb.2007.10.090DOI Listing
February 2008

A biological cosmos of parallel universes: does protein structural plasticity facilitate evolution?

Bioessays 2007 Nov;29(11):1095-104

Institute of Molecular Biology and Physiology, August Krogh Building, University of Copenhagen, Universitet sparken 13, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1002/bies.20661DOI Listing
November 2007

Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall.

J Mol Biol 2007 May 24;368(3):718-28. Epub 2007 Feb 24.

Department of Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360700207
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http://dx.doi.org/10.1016/j.jmb.2007.02.026DOI Listing
May 2007

Continuous molecular evolution of protein-domain structures by single amino acid changes.

Curr Biol 2007 Jan;17(2):173-8

Department of Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S096098220602444
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http://dx.doi.org/10.1016/j.cub.2006.10.063DOI Listing
January 2007

The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor.

Biol Chem 2006 Sep;387(9):1255-9

Biochemisches Institut der Christian-Albrechts-Universität Kiel, Olshausenstr. 40, D-24118 Kiel, Germany.

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http://dx.doi.org/10.1515/BC.2006.155DOI Listing
September 2006

Structure/function analysis of spinalin, a spine protein of Hydra nematocysts.

FEBS J 2006 Jul 15;273(14):3230-7. Epub 2006 Jun 15.

Department of Biophysical Chemistry, Biozentrum, University of Basel, Switzerland.

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http://dx.doi.org/10.1111/j.1742-4658.2006.05331.xDOI Listing
July 2006

Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain.

J Biol Chem 2006 Jul 18;281(29):20263-70. Epub 2006 May 18.

Institute of Physiology, Pestalozzistr. 20, University of Basel, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1074/jbc.M601563200DOI Listing
July 2006

Favourable mediation of crystal contacts by cocoamidopropylbetaine (CAPB).

Acta Crystallogr D Biol Crystallogr 2005 Apr 24;61(Pt 4):477-80. Epub 2005 Mar 24.

Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrase 70, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1107/S0907444905001204DOI Listing
April 2005

The glycoprotein NOWA and minicollagens are part of a disulfide-linked polymer that forms the cnidarian nematocyst wall.

J Biol Chem 2004 Dec 4;279(50):52016-23. Epub 2004 Oct 4.

Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1074/jbc.M407613200DOI Listing
December 2004

Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons.

J Biol Chem 2004 Aug 16;279(34):35542-50. Epub 2004 Jun 16.

Institute of Physiology, Vesalgasse 1, University of Basel, 4051 Basel, Switzerland.

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http://dx.doi.org/10.1074/jbc.M405865200DOI Listing
August 2004

The structure of the Cys-rich terminal domain of Hydra minicollagen, which is involved in disulfide networks of the nematocyst wall.

J Biol Chem 2004 Jul 3;279(29):30395-401. Epub 2004 May 3.

Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1074/jbc.M403734200DOI Listing
July 2004

Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias.

J Biol Chem 2004 Jun 9;279(24):25294-8. Epub 2004 Apr 9.

Centers for Biochemistry and Molecular Medicine, Medical Faculty, University of Cologne, Joseph-Stelzmann-Strasse 52, D-50931 Köln, Germany.

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http://dx.doi.org/10.1074/jbc.M403778200DOI Listing
June 2004

Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy.

J Biol Chem 2004 Jan 13;279(1):571-6. Epub 2003 Oct 13.

Biochemisches Institut, Christian-Albrechts-Universität Kiel, Olshausenstrasse 40, 24118 Kiel, Germany.

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http://dx.doi.org/10.1074/jbc.M311019200DOI Listing
January 2004

Characterisation of Drosophila thrombospondin defines an early origin of pentameric thrombospondins.

J Mol Biol 2003 Apr;328(2):479-94

MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, Gower St, London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/s0022-2836(03)00248-1DOI Listing
April 2003

Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3).

EMBO J 2002 Nov;21(22):5960-8

Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137217PMC
http://dx.doi.org/10.1093/emboj/cdf628DOI Listing
November 2002

Structure/function relationships in the minicollagen of Hydra nematocysts.

J Biol Chem 2002 Dec 3;277(51):49200-4. Epub 2002 Oct 3.

Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1074/jbc.M209401200DOI Listing
December 2002

Nowa, a novel protein with minicollagen Cys-rich domains, is involved in nematocyst formation in Hydra.

J Cell Sci 2002 Oct;115(Pt 20):3923-34

Institute of Zoology, Darmstadt University of Technology, 64287 Darmstadt, Germany.

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http://dx.doi.org/10.1242/jcs.00084DOI Listing
October 2002