Su-Jun Lee

Su-Jun Lee

UNVERIFIED PROFILE

Are you Su-Jun Lee?   Register this Author

Register author
Su-Jun Lee

Su-Jun Lee

Publications by authors named "Su-Jun Lee"

Are you Su-Jun Lee?   Register this Author

47Publications

505Reads

45Profile Views

Influences of cytochrome b5 expression and its genetic variant on the activity of CYP2C9, CYP2C19 and CYP3A4.

Drug Metab Pharmacokinet 2019 Jun 1;34(3):201-208. Epub 2019 Apr 1.

Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Republic of Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dmpk.2019.03.001DOI Listing
June 2019

Rifampin Induces Expression of P-glycoprotein on the THP1 Cell-Derived Macrophages, Causing Decrease Intramacrophage Concentration of Prothionamide.

J Pharm Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Pharmacology and Clinical Pharmacology, Pharmacogenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00223549193023
Publisher Site
http://dx.doi.org/10.1016/j.xphs.2019.04.009DOI Listing
April 2019

Inhibition of Cytochrome P450 Activities by Extract and Its Prenylated Flavonoids in Human Liver Microsomes.

Evid Based Complement Alternat Med 2019 13;2019:2673769. Epub 2019 Mar 13.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan 614-735, Republic of Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/2673769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436327PMC
March 2019

Identification of novel CYP4F2 genetic variants exhibiting decreased catalytic activity in the conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).

Prostaglandins Leukot Essent Fatty Acids 2018 04 11;131:6-13. Epub 2018 Mar 11.

Department of Pharmacology and Pharmacogenomics Research Center; Department of Clinical Pharmacology, Inje University College of Medicine, Inje University Busan Paik Hospital, 633-165 Gaegum-dong, Jin-gu, Busan 614-735, South Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.plefa.2018.02.003DOI Listing
April 2018

Identification and characterization of amiodarone metabolites in rats using UPLC-ESI-QTOFMS-based untargeted metabolomics approach.

J Toxicol Environ Health A 2018 11;81(12):481-492. Epub 2018 Apr 11.

a Department of Pharmacology and PharmacoGenomics Research Center , Inje University College of Medicine , Busan , Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15287394.2018.1460783DOI Listing
April 2018

Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma.

Toxicol Appl Pharmacol 2017 09 17;330:100-106. Epub 2017 Jul 17.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, Busan, South Korea. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0041008X173030
Publisher Site
http://dx.doi.org/10.1016/j.taap.2017.07.009DOI Listing
September 2017

Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis.

Arch Biochem Biophys 2017 04 27;620:43-51. Epub 2017 Mar 27.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, Bokji-ro 75, Busanjin-gu, Busan 47392, South Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2017.03.010DOI Listing
April 2017

A Novel Null Mutation in P450 Aromatase Gene (CYP19A1) Associated with Development of Hypoplastic Ovaries in Humans.

J Clin Res Pediatr Endocrinol 2016 Jun 18;8(2):205-10. Epub 2016 Apr 18.

Inje University College of Medicine, Department of Pharmacology, Inje University, Busan, Korea Phone: 82 51 890 86 65 E-mail:

View Article

Download full-text PDF

Source
http://cms.galenos.com.tr/Uploads/Article_1533/JCRPE-8-205.p
Publisher Site
http://dx.doi.org/10.4274/jcrpe.2761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096477PMC
June 2016

Molecular functionality of CYP2C9 polymorphisms and their influence on drug therapy.

Drug Metabol Drug Interact 2014 ;29(4):211-20

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/dmdi-2014-0001DOI Listing
July 2015

Analysis of genetic polymorphism and biochemical characterization of a functionally decreased variant in prostacyclin synthase gene (CYP8A1) in humans.

Arch Biochem Biophys 2015 Mar 23;569:10-8. Epub 2015 Jan 23.

Department of Pharmacology, Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, Busan 614-735, South Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2015.01.012DOI Listing
March 2015

Determination of major UDP-glucuronosyltransferase enzymes and their genotypes responsible for 20-HETE glucuronidation.

J Lipid Res 2014 Nov 23;55(11):2334-42. Epub 2014 Sep 23.

Department of Pharmacology and PharmacoGenomics Research Center Inje University College of Medicine, Busan, South Korea Department of Clinical Pharmacology, Inje University College of Medicine, Busan, South Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M051169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617135PMC
November 2014

Genetic variations in UDP-glucuronosyltransferase 2B15 in a Korean population.

Drug Metab Pharmacokinet 2014 23;29(1):105-9. Epub 2013 Jul 23.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University.

View Article

Download full-text PDF

Source
October 2014

Tumor cells loaded with α-galactosylceramide promote therapeutic NKT-dependent anti-tumor immunity in multiple myeloma.

Immunol Lett 2013 Nov-Dec;156(1-2):132-9. Epub 2013 Oct 19.

Advanced Research Center for Multiple Myeloma, Department of Microbiology and Immunology, Inje University College of Medicine, Busan, Republic of Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2013.10.002DOI Listing
July 2014

Development of a multiplex and cost-effective genotype test toward more personalized medicine for the antiplatelet drug clopidogrel.

Int J Mol Sci 2014 May 5;15(5):7699-710. Epub 2014 May 5.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University, Busan 614-812, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms15057699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057700PMC
May 2014

Single nucleotide polymorphisms in SULT1A1 and SULT1A2 in a Korean population.

Drug Metab Pharmacokinet 2013 29;28(4):372-7. Epub 2013 Jan 29.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, Busan, South Korea.

View Article

Download full-text PDF

Source
April 2014

Multiple cytochrome P450 isoforms are involved in the generation of a pharmacologically active thiol metabolite, whereas paraoxonase 1 and carboxylesterase 1 catalyze the formation of a thiol metabolite isomer from ticlopidine.

Drug Metab Dispos 2014 Jan 29;42(1):141-52. Epub 2013 Oct 29.

Department of Pharmacology and PharmacoGenomics Research Center, College of Medicine (M.-J.K., E.S.J, J.-S.P., S.-J.L., J.L.G, J.-G.S., D.-H.K.), and Department of General Surgery, Busan Paik Hospital (C.-S.C.), Inje University, Busan, South Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.113.053017DOI Listing
January 2014

Simultaneous quantification of caffeine and its three primary metabolites in rat plasma by liquid chromatography-tandem mass spectrometry.

Food Chem 2013 Dec 24;141(3):2735-42. Epub 2013 May 24.

College of Pharmacy, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S030881461300659
Publisher Site
http://dx.doi.org/10.1016/j.foodchem.2013.05.069DOI Listing
December 2013

CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.

Antimicrob Agents Chemother 2013 Nov 19;57(11):5448-56. Epub 2013 Aug 19.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, South Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00843-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811268PMC
November 2013

Comparison of CYP3A4 and CYP3A5: the effects of cytochrome b5 and NADPH-cytochrome P450 reductase on testosterone hydroxylation activities.

Drug Metab Pharmacokinet 2012 12;27(6):663-7. Epub 2012 Jun 12.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, Busan, Korea.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602955PMC
September 2013

Identification of cytochrome P450s involved in the metabolism of arachidonic acid in human platelets.

Prostaglandins Leukot Essent Fatty Acids 2013 Sep 6;89(4):227-34. Epub 2013 Aug 6.

Department of Pharmacology, Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, Busan, South Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.plefa.2013.06.008DOI Listing
September 2013

Glucuronidation of a sarpogrelate active metabolite is mediated by UDP-glucuronosyltransferases 1A4, 1A9, and 2B4.

Drug Metab Dispos 2013 Aug 23;41(8):1529-37. Epub 2013 May 23.

Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, #633-165 Gaegum-Dong, Jin-Gu, Busan 614-735, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.113.051862DOI Listing
August 2013

Expression of arachidonic acid-metabolizing cytochrome P450s in human megakaryocytic Dami cells.

In Vitro Cell Dev Biol Anim 2013 Aug 31;49(7):492-500. Epub 2013 May 31.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, 633-165 Gaegum-dong, Busanjin-gu, Busan, South Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11626-013-9633-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713264PMC
August 2013

In vitro metabolism of obovatol and its effect on cytochrome P450 enzyme activities in human liver microsomes.

Biopharm Drug Dispos 2013 May 26;34(4):195-202. Epub 2013 Mar 26.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bdd.1837DOI Listing
May 2013

Effects of testosterone and 17β-oestradiol on expression of the G protein-coupled receptor P2Y12 in megakaryocytic DAMI cells.

Platelets 2012 2;23(8):579-85. Epub 2012 Jul 2.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, Gaegum-Dong, Jin-Gu, Busan, Korea.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.3109/09537104.2012.67
Publisher Site
http://dx.doi.org/10.3109/09537104.2012.670812DOI Listing
April 2013

Clinical Application of CYP2C19 Pharmacogenetics Toward More Personalized Medicine.

Authors:
Su-Jun Lee

Front Genet 2012 1;3:318. Epub 2013 Feb 1.

Department of Pharmacology, Pharmacogenomics Research Center, Inje University College of Medicine, Inje University Busan, South Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2012.00318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561709PMC
February 2013

Discovery of a novel allelic variant of CYP2C8, CYP2C8*11, in Asian populations and its clinical effect on the rosiglitazone disposition in vivo.

Drug Metab Dispos 2011 Apr 18;39(4):711-6. Epub 2011 Jan 18.

Department of Pharmacology, Inje University College of Medicine, 633-165 Gaegum-Dong, Jin-Gu, Busan 614-735, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.110.035899DOI Listing
April 2011

Identification of P2Y12 single-nucleotide polymorphisms and their influences on the variation in ADP-induced platelet aggregation.

Thromb Res 2011 Mar 8;127(3):220-7. Epub 2011 Jan 8.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University Busan Paik Hospital, Inje University, Busan, South Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thromres.2010.11.023DOI Listing
March 2011

Genetic variations in UDP-glucuronosyltransferase 2B7 gene (UGT2B7) in a Korean population.

Drug Metab Pharmacokinet 2010 ;25(4):398-402

Department of Pharmacology and Pharmacogenomics Research Center, Busan, Korea.

View Article

Download full-text PDF

Source
December 2010

A haplotype of CYP2C9 associated with warfarin sensitivity in mechanical heart valve replacement patients.

Br J Clin Pharmacol 2010 Aug;70(2):213-21

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, Korea.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2125.2010.03688.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2125.2010.03688.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911551PMC
August 2010

Ethnic differences of two non-synonymous single nucleotide polymorphisms in CDA gene.

Drug Metab Pharmacokinet 2009 ;24(6):553-6

Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo 158-8501, Japan.

View Article

Download full-text PDF

Source
April 2010

Identification of CYP19A1 single-nucleotide polymorphisms and their haplotype distributions in a Korean population.

J Hum Genet 2010 Mar 26;55(3):189-93. Epub 2010 Feb 26.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, Busan, South Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/jhg.2010.6DOI Listing
March 2010

Identification of new CYP2C19 variants exhibiting decreased enzyme activity in the metabolism of S-mephenytoin and omeprazole.

Drug Metab Dispos 2009 Nov 6;37(11):2262-9. Epub 2009 Aug 6.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University Busan Paik Hospital, Jin-gu, Busan, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.109.028175DOI Listing
November 2009

Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans.

Drug Metab Dispos 2009 Jul 13;37(7):1464-70. Epub 2009 Apr 13.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, 633-165 Gaegum-Dong, Jin-Gu, Busan 614-735, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.108.022368DOI Listing
July 2009

The CYP3A4*18 allele, the most frequent coding variant in asian populations, does not significantly affect the midazolam disposition in heterozygous individuals.

Drug Metab Dispos 2007 Nov 27;35(11):2095-101. Epub 2007 Aug 27.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University Busan Paik Hospital, Busan, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.107.016733DOI Listing
November 2007

Comparisons of CYP2C19 genetic polymorphisms between Korean and Vietnamese populations.

Ther Drug Monit 2007 Aug;29(4):455-9

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, 655-165 Gaegum-dong, Jin-gu, Busan 614-735, South Korea.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/drug-monitoring/2007/08000/Comp
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/FTD.0b013e31811f383cDOI Listing
August 2007

Identification and functional assessment of BCRP polymorphisms in a Korean population.

Drug Metab Dispos 2007 Apr 19;35(4):623-32. Epub 2007 Jan 19.

Department of Pharmacology, Pharmacogenomics Research Center, College of Medicine, Inje University, 633-165 Gaegum-Dong, Jin-Gu, Busan 614-735, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.106.012302DOI Listing
April 2007

The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system.

Pharmacogenet Genomics 2007 Mar;17(3):169-80

Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e32801152d6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2393551PMC
March 2007

A new CYP3A5 variant, CYP3A5*11, is shown to be defective in nifedipine metabolism in a recombinant cDNA expression system.

Drug Metab Dispos 2007 Jan 11;35(1):67-71. Epub 2006 Oct 11.

Department of Clinical Chemistry, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.106.012310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302370PMC
January 2007

Reduced methylprednisolone clearance causing prolonged pharmacodynamics in a healthy subject was not associated with CYP3A5*3 allele or a change in diet composition.

J Clin Pharmacol 2006 May;46(5):515-26

Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0091270006287588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182867PMC
May 2006

Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests.

Pharmacogenomics 2005 Jun;6(4):357-71

National Institutes of Health, National Institute of Environmental Health Science Center, NC 27709,USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/14622416.6.4.357DOI Listing
June 2005

Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifedipine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A haplotype.

J Pharmacol Exp Ther 2005 Apr 5;313(1):302-9. Epub 2005 Jan 5.

Human Metabolism Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.104.078758DOI Listing
April 2005

Discovery of new potentially defective alleles of human CYP2C9.

Pharmacogenetics 2004 Aug;14(8):527-37

Laboratory of Pharmacology and Chemistry, Human Metabolism Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA, DNA.

View Article

Download full-text PDF

Source
August 2004

Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups.

Pharmacogenetics 2003 Aug;13(8):461-72

Human Metabolism Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.fpc.0000054117.14659.acDOI Listing
August 2003

Cloning, tissue distribution, and functional studies of a new cytochrome P450 3A subfamily member, CYP3A45, from rainbow trout (Oncorhynchus mykiss) intestinal ceca.

Arch Biochem Biophys 2003 Apr;412(1):77-89

Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331-7301, USA.

View Article

Download full-text PDF

Source
April 2003

Functional properties of a rainbow trout CYP3A27 expressed by recombinant baculovirus in insect cells.

Drug Metab Dispos 2002 Dec;30(12):1406-12

Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.30.12.1406DOI Listing
December 2002