Publications by authors named "Su Yeong Kim"

125 Publications

A case of Conradi-Hünermann-Happle syndrome with typical clinical manifestations confirmed by genetic mutation analysis.

Indian J Dermatol Venereol Leprol 2021 Aug 1:1-4. Epub 2021 Aug 1.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.25259/IJDVL_876_20DOI Listing
August 2021

Antecedents and Consequences of Discrepant Perceptions of Racial Socialization between Parents and Adolescents within Mexican-Origin Families.

J Youth Adolesc 2021 Sep 3. Epub 2021 Sep 3.

Department of Human Development and Family Sciences, University of Texas at Austin, Austin, TX, USA.

Parents and adolescents often have different views regarding parental racial socialization practices; however, studies documenting such discrepancies remain scarce. Using a person-centered approach, this study investigated patterns of parent-adolescent discrepant views on racial socialization (i.e., cultural socialization, bias coping, bias awareness) as well as antecedents and consequences of the discrepancy profiles. Participants were 604 adolescents (54% female, M= 12.41, Range = 11-15) and their mothers and fathers. The results showed distinct discrepancy patterns and suggested that more maternal/paternal warmth was associated with profiles that have smaller discrepancies or profiles in which adolescents reported higher socialization than parents. Adolescents who reported higher or similar socialization as parents demonstrated better adjustment. Implications for interventions aimed at strengthening parent-child relationships and communication about race and culture are discussed.
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http://dx.doi.org/10.1007/s10964-021-01487-zDOI Listing
September 2021

Pathways linking ethnic discrimination and drug-using peer affiliation to underage drinking status among Mexican-origin adolescents.

Exp Clin Psychopharmacol 2021 Jul 1. Epub 2021 Jul 1.

Department of Human Development and Family Sciences, University of Texas at Austin.

Using a three-wave longitudinal data set of Mexican-origin adolescents ( = 602, = 12.92, = 0.91 at Wave 1), this study examines parallel pathways from early exposure to ethnic discrimination and drug-using peers, separately, to underage drinking status by late adolescence. Negative affect was expected to mediate the link from ethnic discrimination to underage drinking status (the stress-induced pathway), whereas social alcohol expectancy was expected to mediate the link from drug-using peers to underage drinking status (the socialization pathway). Our findings lend support to the stress-induced pathway while controlling for the socialization pathway. For the stress-induced pathway, we found that early ethnic discrimination experiences were related to higher likelihood of having engaged in underage drinking by late adolescence through elevated negative affect sustained across adolescence. For the socialization pathway, we found no association between affiliation with drug-using peers in early adolescence and underage drinking status, either directly or indirectly. Present findings highlight the unique role of early ethnic discrimination experiences in underage drinking among Mexican-origin adolescents, over and above the effect of drug-using peers. Alcohol use interventions targeting ethnic minority adolescents should account for adolescents' ethnic discrimination experiences by helping adolescents develop adaptive coping strategies to handle negative affect induced by discrimination (e.g., reappraisal) rather than using alcohol to self-medicate. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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http://dx.doi.org/10.1037/pha0000504DOI Listing
July 2021

Wave-controlled aliasing in parallel imaging magnetization-prepared gradient echo (wave-CAIPI MPRAGE) accelerates speed for pediatric brain MRI with comparable diagnostic performance.

Sci Rep 2021 Jun 24;11(1):13296. Epub 2021 Jun 24.

Department of Pediatrics, Chung-Ang University Hospital, Chung-Ang University College of Medicine , 102 Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea.

We aimed to compare accelerated post-contrast magnetization-prepared rapid gradient-echo (MPRAGE) using wave-controlled aliasing in parallel imaging (wave-CAIPI) with conventional MPRAGE as a reliable method to diagnose intracranial lesions in pediatric patients. A total of 23 consecutive pediatric patients who underwent post-contrast wave-CAIPI and conventional MPRAGE (scan time: 2 min 39 s vs. 5 min 46 s) were retrospectively evaluated. Two radiologists independently assessed each image for the presence of intracranial lesions. Quantitative [contrast-to-noise ratio (CNR), contrast rate (CR), and signal-to-noise ratio (SNR)] and qualitative parameters (overall image quality, gray-white matter differentiation, demarcation of basal ganglia and sulci, and motion artifacts) were also surveyed. Wave-CAIPI MPRAGE and conventional MPRAGE detected enhancing and non-enhancing intracranial lesions with 100% agreement. Although wave-CAIPI MPRAGE had a lower SNR (all p < 0.05) and overall image quality (overall analysis, p = 0.02) compared to conventional MPRAGE, other quantitative (CNR and CR) and qualitative parameters (gray-white differentiation, demarcation of basal ganglia and sulci, and motion artifacts) were comparable in the pooled analysis and between both observers (all p > 0.05). Wave-CAIPI MPRAGE was a reliable method for diagnosing intracranial lesions in pediatric patients as conventional MPRAGE at half the scan time.
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http://dx.doi.org/10.1038/s41598-021-92759-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225910PMC
June 2021

Changes in the Occurrence of Gastrointestinal Infections after COVID-19 in Korea.

J Korean Med Sci 2021 Jun 21;36(24):e180. Epub 2021 Jun 21.

Department of Pediatrics, Chung-Ang University Hospital, Seoul, Korea.

Background: After the global epidemic of coronavirus disease 2019 (COVID-19), lifestyle changes to curb the spread of COVID-19 (e.g., wearing a mask, hand washing, and social distancing) have also affected the outbreak of other infectious diseases. However, few studies have been conducted on whether the incidence of gastrointestinal infections has changed over the past year with COVID-19. In this study, we examined how the incidence of gastrointestinal infections has changed since COVID-19 outbreak through open data.

Methods: We summarized the data on the several viruses and bacteria that cause gastrointestinal infections from the open data of the Korea Disease Control and Prevention Agency for 3 years from March 2018 to February 2021 (from Spring 2018 to Winter 2020). Moreover, we confirmed three most common legal gastrointestinal infectious pathogens from March 2016.

Results: From March 2020, when the COVID-19 epidemic was in full swing and social distancing and personal hygiene management were heavily emphasized, the incidence of infection from each virus was drastically decreased. The reduction rates compared to the averages of the last 2 years were as follows: total viruses 31.9%, norovirus 40.2%, group A rotavirus 31.8%, enteric adenovirus 13.4%, astrovirus 7.0%, and sapovirus 12.2%. Among bacterial pathogens, the infection rates of and did not decrease but rather increased in some periods when compared to the average of the last two years. The incidence of nontyphoidal , , or enteropathogenic somewhat decreased but not significantly compared to the previous two years.

Conclusion: The incidence of infection from gastrointestinal viruses, which are mainly caused by the fecal-to-oral route and require direct contact among people, was significantly reduced, whereas the incidence of bacterial pathogens, which have food-mediated transmission as the main cause of infection, did not decrease significantly.
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http://dx.doi.org/10.3346/jkms.2021.36.e180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216988PMC
June 2021

Longitudinal profiles of acculturation and developmental outcomes among Mexican-origin adolescents from immigrant families.

New Dir Child Adolesc Dev 2021 Mar 22;2021(176):205-225. Epub 2021 Feb 22.

Department of Human Development and Family Sciences, The University of Texas at Austin, 108 East Dean Keeton St., Stop A2702, Austin, Texas, 78712, USA.

Prior studies investigating the association between acculturation and adolescent adjustment have often focused on specific acculturation domains rather than examining these domains collectively in a profile typology. Here, we investigate stability and change patterns in Mexican American adolescent acculturation profiles over time, using a two-wave longitudinal dataset spanning 5 years. Using latent profile analysis, three adolescent acculturation profiles were identified at Waves 1 and 2: integrated; moderately integrated; and moderately assimilated. Using latent transition analysis, four acculturation transition profiles were identified across time: stable integrated; stable moderately integrated; progressive; and regressive. Over half of all adolescents were identified as belonging to the stable integrated and stable moderately integrated transition profiles. Adolescents classified in the stable integrated profile reported the highest levels of adjustment (academic competence and socioemotional well-being) relative to those with other transition profiles. Findings from this study contribute to a comprehensive understanding of the dynamic process of acculturation among Mexican American adolescents, and provide useful insights to inform interventions and policies aimed at improving Mexican-origin adolescents' adaption to US culture while maintaining their heritage Mexican culture.
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http://dx.doi.org/10.1002/cad.20396DOI Listing
March 2021

From Diagnosis to Treatment: Recent Advances in Patient-Friendly Biosensors and Implantable Devices.

ACS Nano 2021 02 3;15(2):1960-2004. Epub 2021 Feb 3.

Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.

Patient-friendly medical diagnostics and treatments have been receiving a great deal of interest due to their rapid and cost-effective health care applications with minimized risk of infection, which has the potential to replace conventional hospital-based medical procedures. In particular, the integration of recently developed materials into health care devices allows the rapid development of point-of-care (POC) sensing platforms and implantable devices with special functionalities. In this review, the recent advances in biosensors for patient-friendly diagnosis and implantable devices for patient-friendly treatment are discussed. Comprehensive analysis of portable and wearable biosensing platforms for patient-friendly health monitoring and disease diagnosis is provided, including topics such as materials selection, device structure and integration, and biomarker detection strategies. Moreover, specific challenges related to each biological fluid for wearable biosensor-based POC applications are presented. Also, advances in implantable devices, including recent materials development and wireless communication strategies, are discussed. Furthermore, various patient-friendly surgical and treatment approaches are reviewed, such as minimally invasive insertion and mounting, electrical and optical modulations, and post-operation health monitoring. Finally, the challenges and future perspectives toward the development of the patient-friendly diagnosis and treatment are provided.
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http://dx.doi.org/10.1021/acsnano.0c06688DOI Listing
February 2021

Stress of Language Brokering and Mexican American Adolescents' Adjustment: The Role of Cumulative Risk.

J Early Adolesc 2020 Mar 17;40(3):400-425. Epub 2019 May 17.

The University of Texas at Austin, USA.

This study focused on early adolescents' stress of language brokering and examined the moderating role of family cumulative risk in the relation of language brokering to adjustment problems. Data came from self-reports of 604 low-income Mexican American adolescent language brokers (54% female; ; = 0.97; 75% born in the United States) and their parents (99% foreign-born) in central Texas. Path analyses revealed that brokering stress, but not frequency, was positively associated with adolescents' adjustment problems, including depressive symptoms, anxiety, and delinquency. We also found that the relation between stress of brokering for mothers and adolescents' depressive symptoms was stronger among families with a high cumulative risk. Further, with a high cumulative risk, adolescents exhibited delinquent behaviors regardless of the levels of stress from translating for fathers. Current findings underscore the importance of examining family contexts in assessing the consequences of language brokering for Mexican American early adolescents' well-being.
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http://dx.doi.org/10.1177/0272431619847526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841983PMC
March 2020

Epidemiology of Demyelinating Diseases in Korean Pediatric Patients.

J Child Neurol 2021 02 28;36(2):141-147. Epub 2020 Sep 28.

Department of Pediatrics, 65542Chung-Ang University Hospital, Seoul, Korea.

The epidemiology of demyelinating diseases in the Korean pediatric population has not been reported to date. This study aimed to identify the epidemiology of demyelinating diseases in Korean children by using big data. The subjects were children (0-17 years old) diagnosed with acute-disseminated encephalomyelitis, multiple sclerosis, neuromyelitis optica, and Guillain-Barré syndrome enrolled in the Korean Health Insurance Review and Assessment Service (HIRA) from January 2010 to December 2017.Of 1722 enrolled children, 553 (32.1%) had acute-disseminated encephalomyelitis, 170 (9.9%) had multiple sclerosis, 68 (3.9%) had neuromyelitis optica, and 931 (54.1%) had Guillain-Barré syndrome. The male-female ratios were 1.47:1 in acute-disseminated encephalomyelitis, 1.43:1 in Guillain-Barré syndrome, 1:1.66 in multiple sclerosis, and 1:1.62 in neuromyelitis optica. Demyelinating diseases were most prevalent in summer. The prevalence differed by region, with 545 (31.6%) in Seoul and 298 (17.3%) in Gyeonggi. This study is the first to identify the incidence of demyelinating diseases in South Korea.
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http://dx.doi.org/10.1177/0883073820959543DOI Listing
February 2021

Analysis of the human breast milk microbiome and bacterial extracellular vesicles in healthy mothers.

Exp Mol Med 2020 08 3;52(8):1288-1297. Epub 2020 Aug 3.

Department of Pediatrics, Chung-Ang University Hospital, Seoul, 06973, South Korea.

The microbiota of human breast milk (HBM) contribute to infant gut colonization; however, whether bacterial extracellular vesicles (EVs) are present in HBM or might contribute to this process remains unknown. In this study, we characterized the HBM microbiota of healthy Korean mothers and measured the key bacteria likely affecting infant gut colonization by analyzing both the microbiota and bacterial EVs. A total of 22 HBM samples were collected from lactating mothers. The DNA of bacteria and bacteria-derived EVs was extracted from each sample. In alpha-diversity analyses, bacterial samples showed higher richness and evenness than bacterial EV samples, and beta-diversity analyses showed significant differences between bacteria and bacterial EVs within identical individual samples. Firmicutes accounted for the largest proportion among the phyla, followed by Proteobacteria, Bacteroidetes, and Actinobacteria, in both bacteria and bacterial EV samples. At the genus level, Streptococcus (25.1%) and Staphylococcus (10.7%) were predominant in bacterial samples, whereas Bacteroides (9.1%), Acinetobacter (6.9%), and Lactobacillaceae(f) (5.5%) were prevalent in bacterial EV samples. Several genera, including Bifidobacterium, were significantly positively correlated between the two samples. This study revealed the diverse bacterial communities in the HBM of healthy lactating mothers, and found that gut-associated genera accounted for a high proportion in bacterial EV samples. Our findings suggest the existence of key bacteria with metabolic activity that are independent of the major bacterial populations that inhabit HBM, and the possibility that EVs derived from these bacteria are involved in the vertical transfer of gut microbiota.
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http://dx.doi.org/10.1038/s12276-020-0470-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080581PMC
August 2020

Perceived Discrimination and Risk Behaviors in African American Students: the Potential Moderating Roles of Emotion Regulation and Ethnic Socialization.

J Racial Ethn Health Disparities 2021 04 30;8(2):494-506. Epub 2020 Jun 30.

Department of Educational Psychology, Texas A&M University, College Station, TX, USA.

Prior research has identified perceived discrimination as being a contributing factor in health and mental health disparities. However, there is little research on the relationship between perceived discrimination and behaviors such as hazardous alcohol and illicit substance use and risky sexual behaviors that put people at risk for negative health consequences including HIV. The current research explores the role that cultural factors may play in a tendency for individuals to engage in unhealthy behaviors or an ability to avoid them. A total of 266 college students who self-identified as Black or African American were surveyed on measures of familial ethnic socialization, perceived discrimination, emotion regulation, substance use, and risky sexual behaviors. Findings indicate that perceived discrimination and emotion regulation-suppression were associated with higher levels of hazardous alcohol use, and that emotion regulation-cognitive reappraisal was associated with lower levels of illicit substance use. Implications for intervention and prevention in African American college students are discussed.
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http://dx.doi.org/10.1007/s40615-020-00807-6DOI Listing
April 2021

Bilingual language broker profiles and academic competence in Mexican-origin adolescents.

Dev Psychol 2020 Aug 11;56(8):1582-1595. Epub 2020 Jun 11.

Family and Child Development, School of Family and Consumer Sciences, Texas State University.

We advance a tripartite framework of language use to encompass language skills, the practice of language skills, and the subjective experiences associated with language use among Mexican-origin adolescents who function as language brokers by translating and interpreting for their English-limited parents. Using data collected over 2 waves from a sample of 604 adolescents (Wave 1: Mage = 12.41, SD = 0.97), this study identified 4 types of bilingual language broker profiles that capture the tripartite framework of language use: efficacious, moderate, ambivalent, and nonchalant. All 4 profiles emerged across waves and brokering recipients (i.e., mothers, fathers), except for Wave 1 brokering for mother, in which case only 3 profiles (i.e., efficacious, moderate, and ambivalent) emerged. Three profiles emerged across time: stable efficacious, stable moderate, and other. The efficacious and stable efficacious profiles showed the most consistent relation to adolescents' academic competence. Improving bilingual language proficiency, together with fostering more frequently positive brokering experiences, may be an avenue to improving academic competence among Mexican-origin adolescents in the United States. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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http://dx.doi.org/10.1037/dev0001010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254578PMC
August 2020

Effects of Sedation Performed by an Anesthesiologist on Pediatric Endoscopy: a Single-Center Retrospective Study in Korea.

J Korean Med Sci 2020 Jun 1;35(21):e183. Epub 2020 Jun 1.

Department of Pediatrics, Hanil General Hospital, Seoul, Korea.

Background: Endoscopy is used for diagnosing and treating various digestive diseases in children as well as in adults. However, in pediatric patients, it is recommended that sufficient sedation should be ensured before conducting endoscopy, since insufficient sedation may cause serious complications. However, in Korea, no studies have yet described the types of sedation drugs, effects of sedation, and efficiency of endoscopy with respect to the sedation instructor. Thus, we investigated the effectiveness of sedative procedures performed by anesthesiologists.

Methods: We retrospectively reviewed the medical records of patients aged < 18 years who underwent endoscopy during March 2014-July 2019. Data of sedation instructors, sedation drugs and their doses, complications, and the recovery after sedation were evaluated.

Results: Of 257 patients, 217 underwent esophagogastroduodenoscopy (EGD) and 40 underwent colonoscopies. Before EGD, 29 patients (13.4%) underwent sedation by the pediatric endoscopist and 188 (86.6%) were sedated by the anesthesiologist. The anesthesiologist performed the sedation for all 40 patients who underwent colonoscopy. Endoscopic examinations performed by the anesthesiologist were relatively more time-consuming (401.0 ± 135.1 seconds vs. 274.9 ± 106.1 seconds, < 0.001). We observed that in patients who underwent EGD, there was a difference in the dose of midazolam administered ( = 0.000). When comparing EGD and colonoscopy in patients undergoing sedation by the anesthesiologist, there were no significant differences in the doses of midazolam and ketamine, but the dose of propofol increased for colonoscopy (2.50 ± 0.95 mg/kg vs. 4.71 ± 1.66 mg/kg, = 0.000). The cognitive recovery time according to drug dose was associated with propofol only in EGD with a shorter endoscopy time. The longer cognitive recovery time in colonoscopy and the discharge time of EGD and colonoscopies were not associated with propofol use.

Conclusion: When sedation is performed by an anesthesiologist, various drugs are used with sufficient doses and complications are reduced, but the discharge time does not change. For performing pediatric endoscopy in Korea, anesthesiologists should be considered for inducing anesthesia.
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http://dx.doi.org/10.3346/jkms.2020.35.e183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261697PMC
June 2020

Components of human breast milk: from macronutrient to microbiome and microRNA.

Clin Exp Pediatr 2020 Aug 23;63(8):301-309. Epub 2020 Mar 23.

Department of Pediatrics, Chung-Ang University Hospital, Seoul, Korea.

Human breast milk (HBM) is essential for the infant's growth and development right after birth and is an irreplaceable source of nutrition for early human survival. Various infant formulas have many similarities to HBM in many components, but there is no perfect substitute for HBM. Recently, various breast milk components and their roles have been studied according to the development of various analysis techniques. As is already well known, HBM contains about 87%-88% water, and 124- g/L solid components as macronutrients, including about 7% (60-70 g/L) carbohydrates, 1% (8-10 g/L) protein, and 3.8% (35-40 g/L) fat. The composition may vary depending on the environmental factors, including maternal diet. Colostrum is low in fat but high in protein and relatively rich in immuneprotective components. Although HBM contains enough vitamins to ensure normal growth of the infant, vitamins D and K may be insufficient, and the infant may require their supplementation. Growth factors in HBM also serve as various bioactive proteins and peptides on the intestinal tract, vasculature, nervous system, and endocrine system. In the past, HBM of a healthy mother was thought to be sterile. However, several subsequent studies have confirmed the presence of rich and diverse microbial communities in HBM. Some studies suggested that the genera Staphylococcus and Streptococcus may be universally predominant in HBM, but the origin of microbiota still remains controversial. Lastly, milk is the one of most abundant body fluid of microRNAs, which are known to play a role in various functions, such as immunoprotection and developmental programming, through delivering from HBM and absorption by intestinal epithelial cells. In conclusion, HBM is the most important source of nutrition for infants and includes microbiomes and miRNAs for growth, development, and immunity.
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http://dx.doi.org/10.3345/cep.2020.00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402982PMC
August 2020

Discrimination, language brokering efficacy, and academic competence among adolescent language brokers.

J Adolesc 2020 02 31;79:247-257. Epub 2020 Jan 31.

Department of Human Development and Family Sciences, University of Texas at Austin, USA. Electronic address:

Introduction: Discrimination is detrimental for the development of ethnic minority adolescents' academic competence. To combat the negative effects of discrimination and promote academic success, it is important to understand the mechanisms underlying the association between discrimination and academic competence. Guided by the integrative model of ethnic minority children's development and the adapting cultural systems framework, this study examined whether a culture-specific factor, language brokering efficacy, mediated the relation between adolescents' perceived discrimination and their academic competence.

Method: Data were drawn form a two-wave longitudinal study of 604 Mexican American adolescent language brokers residing in and around a metropolitan city in central Texas, USA (54% female; M = 12.5; SD = 1.0; 75% born in the U.S.). Path analyses were conducted to answer the research questions.

Results: The study revealed that the link between discrimination and academic competence was mediated by language brokering efficacy when translating for fathers and mothers, although the path from language brokering efficacy to academic competence was stronger when brokering for mothers.

Conclusions: The results highlight the importance of incorporating ethnic minority children's adapting cultural experiences in linking the contextual influence with their developmental competence. Implications for interventions aiming to reduce the negative impacts of discrimination are also discussed.
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http://dx.doi.org/10.1016/j.adolescence.2020.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287791PMC
February 2020

Clinically accurate diagnosis of Alzheimer's disease via multiplexed sensing of core biomarkers in human plasma.

Nat Commun 2020 01 8;11(1):119. Epub 2020 Jan 8.

Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon, 305-701, Republic of Korea.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Here we report clinically accurate and ultrasensitive detection of multiple AD core biomarkers (t-tau, p-tau, Aβ, and Aβ) in human plasma using densely aligned carbon nanotubes (CNTs). The closely packed and unidirectionally aligned CNT sensor array exhibits high precision, sensitivity, and accuracy, evidenced by a low coefficient of variation (<6%), a femtomolar-level limit of detection, and a high degree of recovery (>93.0%). By measuring the levels of t-tau/Aβ, p-tau/Aβ, and Aβ/Aβ in clinical blood samples, the sensor array successfully discriminates the clinically diagnosed AD patients from healthy controls with an average sensitivity of 90.0%, a selectivity of 90.0%, and an average accuracy of 88.6%.
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http://dx.doi.org/10.1038/s41467-019-13901-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949261PMC
January 2020

Seasonal distribution of febrile seizure and the relationship with respiratory and enteric viruses in Korean children based on nationwide registry data.

Seizure 2019 Dec 18;73:9-13. Epub 2019 Oct 18.

Department of Pediatrics, Chung-Ang University Hospital, 102, Heukseok-ro, Dongjak-gu, Seoul, South Korea. Electronic address:

Purpose: The seasonal distribution patterns of febrile seizures and of respiratory and enteric viral pathogens are similar. In this study, we analyzed trends in febrile seizures and viral infection in Korean children, using big data from the Korean Health Insurance Review and Assessment Service (HIRA).

Methods: We analyzed children younger than 6 years who visited the hospital and were diagnosed with febrile seizures from 2009 to 2016, using medical records in the HIRA database. A total of 666,136 medical records of children with a main or subdiagnosis of febrile seizure from 2008 to 2016 were included. Of these records, patients younger than 1 month and records before 2009 were excluded. Finally, 558,130 records were extracted.

Results: The medical records included 315,774 male children and 242,356 (43.4%) female children, with a mean age of 2.31 ± 1.31 years. The annual incidence of febrile seizure was 25.4 per 1000 person-years (27.9 for boys and 22.7 for girls). The ratio of male to female children was 1.30: 1, and records of 1-year-old children comprised the highest proportion (n = 210,400, 33.70%). The total monthly number of patients was highest in May (n = 64,969, 11.6%), and peaks were formed from April to July. The fewest patients were seen in October (n = 34,424, 6.17%). The most common viral pathogens were influenza in April and enterovirus during May-July.

Conclusion: The seasonal distribution of febrile seizures was high from late spring to summer, and influenza virus and enterovirus were most frequently associated.
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http://dx.doi.org/10.1016/j.seizure.2019.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111037PMC
December 2019

Influence of proton pump inhibitor therapy on intestinal inflammation assessed by fecal calprotectin in pediatric patients.

Korean J Pediatr 2019 Oct 3;62(10):400-404. Epub 2019 Jul 3.

Department of Pediatrics, Chung-Ang University Hospital, Seoul, Korea.

Background: An increase in the numbers of patients with gastrointestinal symptoms has recently been observed.

Purpose: To investigate the effects of proton pump inhibitor (PPI) therapy on intestinal inflammation in children and adolescents as confirmed by clinical manifestations and objectively assessed by fecal calprotectin (FC) level measurement.

Methods: Consecutive children (aged 3-18 years) who presented with gastrointestinal symptoms and were treated with or without PPI for at least 1 month were enrolled. Patients were divided into PPI and non-PPI groups. The PPI group was further subdivided by treatment duration and type of PPI used. Stool samples were collected for FC evaluation at baseline and after treatment and clinical data and FC levels were compared between the groups.

Results: Fifty-one patients (15 boys, 36 girls) were enrolled in the study. The PPI group included 37 patients, while the non-PPI group included 14 patients. Clinical symptoms were not significantly different. FC levels and laboratory results, including C-reactive protein levels, white blood cell count, and absolute neutrophil count, were not statistically different before versus after PPI treatment. After treatment, FC levels decreased to 8.1 mg/kg (-575.4 to 340.3 mg/kg) in the PPI group and increased to 5.6 mg/kg (-460.0 to 186.9 mg/kg) in the non-PPI group compared to those before treatment (P=0.841). The number of patients with increased FC levels was not significantly different between the 2 groups (48.6% vs. 64.3%, P=0.363), similar to that observed in patients with an FC level > 50 mg/kg (24.3% and 7.1%, P=0.250). PPI therapy type and duration did not affect the FC levels (P=0.811 and P=0.502, respectively).

Conclusion: Although we aimed to confirm the evidence of intestinal inflammation due to PPI use in children and adolescents through clinical symptoms and FC measurement, no significant changes were observed.
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http://dx.doi.org/10.3345/kjp.2019.00115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801199PMC
October 2019

Characteristics of intussusception among children in Korea: a nationwide epidemiological study.

BMC Pediatr 2019 06 28;19(1):211. Epub 2019 Jun 28.

Department of Pediatrics, Chung-Ang University Hospital, 102, Heukseok-ro, Dongjak-gu, Seoul, 06973, Republic of Korea.

Background: Intussusception is a gastrointestinal condition in which early treatment is critical. Although its epidemiology and comorbidities have been studied, few studies have included the entire pediatric population of a country. Therefore, we aimed to analyze the epidemiologic features of pediatric intussusception patients and identify comorbidities associated with intussusception in South Korea, using the public health database.

Methods: We analyzed the data of children below 18 years of age, from the national database of South Korea, who were diagnosed with intussusception and managed such as air reduction or surgical methods from 2008 to 2016. Patients were categorized into six groups based on the comorbid diseases. Patients with structural lesion in gastrointestinal tract were divided diagnosis or diagnosis code.

Results: The number of patients diagnosed with intussusception were 25,023 (16,024 males, 64.0%). Of them, the highest percentage was patients aged between 2 and 36 months (20,703; 82.7%). The incidence per 100,000 individuals aged up to 2 years was 196.7. The number of males were 16,024 (64.0%) and were almost twice the number of 8999 (36.0%) female patients. The maximum number of cases (n = 2517; 10.1%) were seen in September, followed by July (n = 2469; 9.9%). In February, the number of cases was lowest at 1448 (5.8%) patients (P < 0.001). The number of patients with structural lesions of the gastrointestinal tract that could lead to intussusception was 1207 (4.8%), while patients with acute gastrointestinal infectious disease were 4541 (18.1%). Among the structural lesions of the gastrointestinal tract that could be the leading cause of intussusception, lymphadenopathy was the most common, seen in 462 (56.6%) patients and an appendix-related condition was seen in 260 (31.9%) patients. Infectious diseases were more common in the younger children, while systemic diseases were more common in the older.

Conclusion: We confirmed that pediatric intussusception in South Korea shows a seasonal tendency, which is age-dependent and is associated with an exposure to infectious agents. Some infectious pathogens and underlying diseases might play an important role in the pathophysiology of intussusception.
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http://dx.doi.org/10.1186/s12887-019-1592-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598253PMC
June 2019

Parent-Adolescent Acculturation Profiles and Adolescent Language Brokering Experiences in Mexican Immigrant Families.

J Youth Adolesc 2020 Jan 24;49(1):335-351. Epub 2019 Jun 24.

School of Family and Consumer Scienes, Texas State University, San Marcos, TX, USA.

Language brokering is a special form of interpersonal communication that is affected by the cultural and relational settings in which it occurs. The current study explores whether parent-adolescent acculturation status may influence Mexican American adolescent language brokers' translation experiences, including brokering frequency and attitudes. Using data from a two-wave longitudinal study (N = 604; N = 483; M = 12.91; 54.3% female), latent profile analyses were conducted, resulting in four mother-adolescent acculturation profiles as well as three father-adolescent profiles. The adolescent integrated-parent (moderately) separated profiles emerged as the most effective for brokers, as adolescents in this profile generally experienced more positive and less negative brokering attitudes, regardless of their brokering frequency. Parent-adolescent acculturation profiles may be a useful construct in capturing the interplay of cultural and relational settings and their effects on multifaceted language brokering experiences.
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http://dx.doi.org/10.1007/s10964-019-01064-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903809PMC
January 2020

Discordance in parents' and adolescents' reports of parenting: A meta-analysis and qualitative review.

Am Psychol 2020 04 13;75(3):329-348. Epub 2019 Jun 13.

Department of Curriculum and Instruction.

Parents and adolescents often provide discordant reports on parenting. Prior studies are inconsistent regarding the extent, predictors, and consequences of such discordance. The current study aimed to robustly estimate the extent, potential moderators, and consequences of discordance between parent- and adolescent-reported parenting by (a) meta-analyzing a large number of studies involving both parent- and adolescent-reported parenting ( = 313) and (b) qualitatively summarizing the main methods and findings in studies examining how parent-adolescent discordance in reports of parenting relates to adolescent outcomes ( = 36). The meta-analysis demonstrated a small yet statistically significant correlation between parent- and adolescent-reported parenting ( = .276; 95% confidence interval [CI: .262, .290]); parents perceived parenting more positively than did adolescents, with a small but statistically significant mean-level difference ( = .242; 95% CI [.188, .296]). The levels of parent-adolescent discordance were higher for younger (vs. older) and male (vs. female) adolescents; for nonclinical parents (vs. parents with internalizing symptoms); in more individualistic societies such as the United States; and in ethnic minority (vs. White), low (vs. high) socioeconomic status, and nonintact (vs. intact) families among U.S. samples. The qualitative review highlighted current methodological approaches, main findings, and limitations and strengths of each approach. Together, the two components of the current study have important implications for research and clinical practice, including areas of inquiry for future studies and how researchers and clinicians should handle informant discordance. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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http://dx.doi.org/10.1037/amp0000463DOI Listing
April 2020

Macronutrient Analysis of Human Milk according to Storage and Processing in Korean Mother.

Pediatr Gastroenterol Hepatol Nutr 2019 May 23;22(3):262-269. Epub 2019 Apr 23.

Department of Pediatrics, Severance Children's Hospital, Seoul, Korea.

Purpose: As the importance of breastfeeding has been reinforced, human milk is often stored for practical reasons. Therefore, we evaluated optimal storage and processing methods for human milk from a nutritional standpoint.

Methods: Human milk samples were collected between June 2017 and February 2018. Also, data about maternal information were collected. Human milk was analyzed for macronutrients and caloric content. The samples were subdivided into groups for nutrient analysis. The control group (fresh milk) was not stored or processed. The other groups (9 groups) consisted of samples analyzed based on different storage temperatures (room temperature, refrigerated, frozen), defrosting methods (bottle warmer, room temperature thawing, microwave oven), and storage period (1 week, 1 month, 2 months) and compared with the control group.

Results: There was no statistically significant difference in the nutrient content of human milk among the collected samples. A significant change in the content of macronutrients in milk samples was observed under storage condition at different temperatures for 1 week with subsequent thawing with bottle warmer compared to fresh milk. Under storage at -20°C for 1 week with subsequent thawing with different defrosting methods, a significant change in the content of macronutrients in milk samples was observed compared to fresh milk. After storage at -20°C for different periods and thawing with a bottle warmer, a significant change in macronutrient content in milk samples was observed compared to fresh milk regardless of the storage period.

Conclusion: Unlike previous guidelines, changes in macronutrient content in milk samples were observed regardless of the method of storing and thawing. Apparently, it is proposed that mothers should feed fresh human milk to their babies without storing.
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http://dx.doi.org/10.5223/pghn.2019.22.3.262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506430PMC
May 2019

The father's role in risk and resilience among Mexican-American adolescents.

Am J Orthopsychiatry 2020 10;90(1):70-77. Epub 2019 Jan 10.

Department of Human Development and Family Sciences, The University of Texas at Austin.

Research suggests fathers are important to adolescent well-being, yet there is limited information regarding how fathering is associated with adolescent risk and resilience in Mexican American families. This cross-sectional study utilized a structural equation model to examine whether parent-child alienation mediated the relations between parental displays of warmth and hostility and the outcomes of adolescent resilience and delinquency in Mexican American families (N = 272). Results indicated that adolescent-perceived alienation from parents was a significant predictor of both resilience and delinquency. Additionally, alienation mediated the relations between father warmth and resilience and father warmth and delinquency, as well as the relations between mother hostility and adolescent outcomes. Implications for theory and practice are discussed. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
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http://dx.doi.org/10.1037/ort0000394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842255PMC
October 2020

Parenting and Centrality: The Role of Life Meaning as a Mediator for Parenting and Language Broker Role Identity.

J Youth Adolesc 2019 Mar 30;48(3):510-526. Epub 2018 Nov 30.

School of Family and Consumer Sciences, Texas State University, San Marcos, TX, 78666, USA.

Language brokering is a prevalent phenomenon in ethnic minority immigrant populations. Although accruing evidence points to the beneficial impacts of healthy role identity development, research investigating the formation of a language broker role identity in language brokering adolescents is lacking in the literature. In a sample of 604 Latinx adolescents (54.3% female; M at Time 1 = 12.41, SD = .97), structured equation modeling was conducted with maternal warmth and hostility examined as antecedents and adolescents' life meaning as a mediator for language broker role identities. Results revealed that life meaning mediated the positive association from maternal warmth to language broker role identity. However, the negative association from maternal hostility to language broker role identity was no longer significant when accounting for maternal warmth. Corroborating extant findings, reciprocal relations were observed between maternal parenting practices, life meaning and language broker role identity. The results attest to the importance of investigating culturally specific role identity development in immigrant populations and demonstrates the role of maternal parenting practices in affecting adolescents' role identity formation, albeit with contrasting gender effects.
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http://dx.doi.org/10.1007/s10964-018-0963-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391204PMC
March 2019

Parental socialization profiles in Mexican-origin families: Considering cultural socialization and general parenting practices.

Cultur Divers Ethnic Minor Psychol 2019 Jul 1;25(3):439-450. Epub 2018 Nov 1.

Steve Hicks School of Social Work, The University of Texas at Austin.

Objectives: Recognizing that immigrant parents socialize their children in specific ways, the current study examines Mexican-origin families' parental socialization profiles using both parental cultural socialization and general parenting dimensions. We seek to understand how these dimensions interact to form culturally grounded parental socialization profiles in a sample of Mexican-origin parents and adolescents.

Method: There were 604 adolescents, 595 mothers, and 293 fathers within Mexican-origin families self-reporting on 2 cultural socialization dimensions (respeto, independence) and 4 general parenting dimensions (warmth, hostility, monitoring, reasoning). Adolescent outcomes were assessed 1 year later.

Results: Latent profile analysis revealed eight parental socialization profiles representing distinct combinations of cultural socialization and parenting dimensions. Relative to other profiles, the Integrative-Authoritative profile (high on socialization toward respeto and independence; high on warmth, monitoring, and reasoning; and relatively low on hostility) was the most common parenting pattern and was also associated with more optimal adolescent outcomes.

Conclusion: Examining cultural socialization alongside general parenting dimensions can better capture parental socialization strategies among Mexican-origin parents. The various parental socialization profiles that characterize Mexican-origin parents have important implications for adolescent outcomes. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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http://dx.doi.org/10.1037/cdp0000234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494738PMC
July 2019

Bilinear and Multidimensional Cultural Orientations and Indigenous Family Process among Korean Immigrant Mothers and Fathers.

Asian Am J Psychol 2018 Jun 18;9(2):127-139. Epub 2018 Jan 18.

Human Development and Family Sciences, School of Human Ecology, University of Texas at Austin, Austin, TX.

This study examined how parental cultural orientations and family process are related among Korean immigrant parents (272 mothers, and 164 fathers, =436) and how the relationship varies across fathers and mothers. Multiple scales were used to assess bilinear, multidimensional cultural orientation towards both the culture of origin and mainstream culture. The dimensions of language, identity, and cultural participation as well as the number of years living in U.S. were analyzed. The main findings include: (1) parents who maintain heritage culture orientation were more likely to preserve traditional parenting values and practices, (2) parental host culture orientation largely had no impact on traditional parenting but some elements of the host culture orientation were in fact associated with stronger endorsements of traditional parenting, (3) each dimension of acculturation differentially related to traditional parenting, and (4) significant relationships were more pronounced among parenting values than practices. These patterns were largely similar across mothers and fathers. Although some mixed findings suggest the complexity of the hypothesized relationships, the present study findings highlight the importance of bilinear and multidimensional acculturation and core vs. peripheral elements of culture in family process. Implications for practice and future research are discussed.
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http://dx.doi.org/10.1037/aap0000097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193501PMC
June 2018

Burdened or Efficacious? Subgroups of Chinese American Language Brokers, Predictors, and Long-Term Outcomes.

J Youth Adolesc 2019 Jan 1;48(1):154-169. Epub 2018 Sep 1.

Department of Human Development and Family Sciences, University of Texas at Austin, 108 East Dean Keeton Street, Stop A2702, Austin, TX, 78712, USA.

Despite growing research on youth language brokering in immigrant families, evidence regarding its developmental outcomes remains mixed. This study took a person-centered approach, exploring subgroups of language brokers and identifying predictors and long-term outcomes of the subgroup membership. Participants were Chinese American adolescents (N = 350 at Time 1; M = 17.04; SD = 0.72; 59% female) followed over two waves spaced four years apart (longitudinal N = 291). Two distinct subgroups of adolescent language brokers were identified using latent profile analyses on language brokering feelings: efficacious and burdened brokers. Adolescents proficient in both English and Chinese were more likely to be efficacious brokers. Furthermore, burdened brokers reported higher parent-child alienation, and in turn, more depressive symptoms in emerging adulthood, compared to efficacious brokers and non-language-brokers. The current findings inform future interventions that burdened language brokers may be most at risk and that improving parent-child relationships may be one way to promote the well-being of young brokers.
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http://dx.doi.org/10.1007/s10964-018-0916-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360092PMC
January 2019

The Roles of Familism and Emotion Reappraisal in the Relations Between Acculturative Stress and Prosocial Behaviors in Latino/a College Students.

J Lat Psychol 2018 Aug 17;6(3):175-189. Epub 2017 Jul 17.

Department of Human Development and Family Studies, University of Missouri.

Researchers have demonstrated mixed associations between acculturative stress and prosocial behaviors (actions intended to benefit others) among Latino/a adolescents and emerging adults. The current study aimed to examine the relations between acculturative stress and Latino/a young adults' prosocial behaviors via familism values and emotion reappraisal. Participants were 1,527 Latino/a college students ( = 20.35 years, = 3.88; 75.2% women) from universities across the United States. The results demonstrated direct and indirect links between acculturative stress and prosocial behaviors. Specifically, acculturative stress was positively related to familism values, which in turn were positively associated with multiple forms of prosocial behaviors. Additionally, emotion reappraisal was positively associated with specific forms of prosocial behaviors. There was also evidence that familism and emotion reappraisals moderated the associations between acculturative stress and specific forms of prosocial behaviors. Discussion focuses on the interplay of culture-related and emotion-regulation processes associated with Latino/a young adults' positive social outcomes.
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http://dx.doi.org/10.1037/lat0000092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319854PMC
August 2018

Acute salivary cortisol response among Mexican American adolescents in immigrant families.

Cultur Divers Ethnic Minor Psychol 2018 Oct 30;24(4):510-520. Epub 2018 Jul 30.

Department of Human Development and Family Sciences.

Objectives: Though previous research has indicated that language brokering can be stressful, the findings are mixed, pointing to potential moderators of the association. Guided by an ecological perspective, we examined the role of individual, family, and environmental factors in Mexican American adolescents' acute cortisol responses to language brokering.

Method: The study consisted of 46 Mexican American adolescents recruited around a metropolitan city in Central Texas. Participants translated a difficult medical document from English to Spanish for their parents, followed by an arithmetic task (modeled after the Trier Social Stress Test [TSST]). Participants' perceptions (perceived efficacy and parental dependence), parental hostility, and discrimination experiences were assessed via self-report and were examined as moderators of adolescents' responses to the task.

Results: Results revealed differential responses to the task based on individual, family, and environmental factors. High efficacy and low dependence-parental hostility-discrimination related to stress responses characterized by low baselines, steeper reactivity, and faster recovery. Low efficacy and high dependence related to greater baseline stress and a slower recovery. High levels of parental hostility related to a slower recovery. High levels of discrimination related to greater baseline stress.

Conclusions: The study demonstrates that the modified TSST task can elicit an acute hypothalamic-pituitary-adrenal axis response, but the nature of this response is dependent upon participants' perceptions of language brokering (parental dependence and efficacy), parental hostility, and discrimination experiences. Adolescents' individual characteristics and contextual demands remain important considerations in understanding their acute stress responses. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
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http://dx.doi.org/10.1037/cdp0000218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188823PMC
October 2018
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