Su Chi Lim

Su Chi Lim

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Association of central arterial stiffness with the presence and severity of diabetic retinopathy in Asians with type 2 diabetes.

Diab Vasc Dis Res 2019 11 3;16(6):498-505. Epub 2019 May 3.

Department of Ophthalmology and Visual Sciences, Khoo Teck Puat Hospital, Singapore.

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http://dx.doi.org/10.1177/1479164119845904DOI Listing
November 2019

Arterial Stiffness Modulates the Association of Resting Heart Rate With Rapid Renal Function Decline in Individuals With Type 2 Diabetes Mellitus.

Arterioscler Thromb Vasc Biol 2019 Nov 12;39(11):2437-2444. Epub 2019 Sep 12.

Diabetes Centre, Admiralty Medical Centre, Singapore (F.S., S.T., S.C.L.).

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http://dx.doi.org/10.1161/ATVBAHA.119.313163DOI Listing
November 2019

The prevalence of sarcopenic obesity and its association with cognitive performance in type 2 diabetes in Singapore.

Clin Nutr 2019 Nov 4. Epub 2019 Nov 4.

Diabetes Centre, Admiralty Medical Centre, Block 676, Level 4, Kampung Admiralty, Woodlands Drive 71, 730676, Singapore; Clinical Research Unit, Khoo Teck Puat Hospital, 90 Yishun Central, 768828, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, #10-01, 117549, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.clnu.2019.10.019DOI Listing
November 2019

Leucine-rich α-2-glycoprotein predicts proliferative diabetic retinopathy in type 2 diabetes.

J Diabetes Complications 2019 Sep 31;33(9):651-656. Epub 2019 May 31.

Department of ophthalmology and Visual Sciences, Khoo Teck Puat Hospital, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2019.05.021DOI Listing
September 2019

Brown Adipose Tissue: Multimodality Evaluation by PET, MRI, Infrared Thermography, and Whole-Body Calorimetry (TACTICAL-II).

Obesity (Silver Spring) 2019 Sep 13;27(9):1434-1442. Epub 2019 Jul 13.

Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, National University Health System, Singapore.

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http://dx.doi.org/10.1002/oby.22560DOI Listing
September 2019

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Authors:
Alexander Teumer Yong Li Sahar Ghasemi Bram P Prins Matthias Wuttke Tobias Hermle Ayush Giri Karsten B Sieber Chengxiang Qiu Holger Kirsten Adrienne Tin Audrey Y Chu Nisha Bansal Mary F Feitosa Lihua Wang Jin-Fang Chai Massimiliano Cocca Christian Fuchsberger Mathias Gorski Anselm Hoppmann Katrin Horn Man Li Jonathan Marten Damia Noce Teresa Nutile Sanaz Sedaghat Gardar Sveinbjornsson Bamidele O Tayo Peter J van der Most Yizhe Xu Zhi Yu Lea Gerstner Johan Ärnlöv Stephan J L Bakker Daniela Baptista Mary L Biggs Eric Boerwinkle Hermann Brenner Ralph Burkhardt Robert J Carroll Miao-Li Chee Miao-Ling Chee Mengmeng Chen Ching-Yu Cheng James P Cook Josef Coresh Tanguy Corre John Danesh Martin H de Borst Alessandro De Grandi Renée de Mutsert Aiko P J de Vries Frauke Degenhardt Katalin Dittrich Jasmin Divers Kai-Uwe Eckardt Georg Ehret Karlhans Endlich Janine F Felix Oscar H Franco Andre Franke Barry I Freedman Sandra Freitag-Wolf Ron T Gansevoort Vilmantas Giedraitis Martin Gögele Franziska Grundner-Culemann Daniel F Gudbjartsson Vilmundur Gudnason Pavel Hamet Tamara B Harris Andrew A Hicks Hilma Holm Valencia Hui Xian Foo Shih-Jen Hwang M Arfan Ikram Erik Ingelsson Vincent W V Jaddoe Johanna Jakobsdottir Navya Shilpa Josyula Bettina Jung Mika Kähönen Chiea-Chuen Khor Wieland Kiess Wolfgang Koenig Antje Körner Peter Kovacs Holly Kramer Bernhard K Krämer Florian Kronenberg Leslie A Lange Carl D Langefeld Jeannette Jen-Mai Lee Terho Lehtimäki Wolfgang Lieb Su-Chi Lim Lars Lind Cecilia M Lindgren Jianjun Liu Markus Loeffler Leo-Pekka Lyytikäinen Anubha Mahajan Joseph C Maranville Deborah Mascalzoni Barbara McMullen Christa Meisinger Thomas Meitinger Kozeta Miliku Dennis O Mook-Kanamori Martina Müller-Nurasyid Josyf C Mychaleckyj Matthias Nauck Kjell Nikus Boting Ning Raymond Noordam Jeffrey O' Connell Isleifur Olafsson Nicholette D Palmer Annette Peters Anna I Podgornaia Belen Ponte Tanja Poulain Peter P Pramstaller Ton J Rabelink Laura M Raffield Dermot F Reilly Rainer Rettig Myriam Rheinberger Kenneth M Rice Fernando Rivadeneira Heiko Runz Kathleen A Ryan Charumathi Sabanayagam Kai-Uwe Saum Ben Schöttker Christian M Shaffer Yuan Shi Albert V Smith Konstantin Strauch Michael Stumvoll Benjamin B Sun Silke Szymczak E-Shyong Tai Nicholas Y Q Tan Kent D Taylor Andrej Teren Yih-Chung Tham Joachim Thiery Chris H L Thio Hauke Thomsen Unnur Thorsteinsdottir Anke Tönjes Johanne Tremblay André G Uitterlinden Pim van der Harst Niek Verweij Suzanne Vogelezang Uwe Völker Melanie Waldenberger Chaolong Wang Otis D Wilson Charlene Wong Tien-Yin Wong Qiong Yang Masayuki Yasuda Shreeram Akilesh Murielle Bochud Carsten A Böger Olivier Devuyst Todd L Edwards Kevin Ho Andrew P Morris Afshin Parsa Sarah A Pendergrass Bruce M Psaty Jerome I Rotter Kari Stefansson James G Wilson Katalin Susztak Harold Snieder Iris M Heid Markus Scholz Adam S Butterworth Adriana M Hung Cristian Pattaro Anna Köttgen

Nat Commun 2019 Sep 11;10(1):4130. Epub 2019 Sep 11.

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/s41467-019-11576-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739370PMC
September 2019

Association between gain in adiposity and diabetic kidney disease worsening in type 2 diabetes is mediated by deteriorating glycaemic control: A 3-year follow-up analysis.

Diabetes Res Clin Pract 2019 Aug 8;157:107812. Epub 2019 Aug 8.

Clinical Research Unit, Khoo Teck Puat Hospital, Singapore; Diabetes Centre, Admiralty Medical Centre, Khoo Teck Puat Hospital, Singapore; Saw Swee Hock School of Public Health, National University Hospital, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688227193022
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http://dx.doi.org/10.1016/j.diabres.2019.107812DOI Listing
August 2019

Precision medicine for a man presented with diabetes at 2-month old.

Eur J Hum Genet 2019 Jun 19;27(6):989-993. Epub 2019 Mar 19.

Clinical Research Unit, Khoo Teck Puat Hospital (KTPH), Singapore, Singapore.

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http://dx.doi.org/10.1038/s41431-019-0371-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777453PMC
June 2019

A catalog of genetic loci associated with kidney function from analyses of a million individuals.

Authors:
Matthias Wuttke Yong Li Man Li Karsten B Sieber Mary F Feitosa Mathias Gorski Adrienne Tin Lihua Wang Audrey Y Chu Anselm Hoppmann Holger Kirsten Ayush Giri Jin-Fang Chai Gardar Sveinbjornsson Bamidele O Tayo Teresa Nutile Christian Fuchsberger Jonathan Marten Massimiliano Cocca Sahar Ghasemi Yizhe Xu Katrin Horn Damia Noce Peter J van der Most Sanaz Sedaghat Zhi Yu Masato Akiyama Saima Afaq Tarunveer S Ahluwalia Peter Almgren Najaf Amin Johan Ärnlöv Stephan J L Bakker Nisha Bansal Daniela Baptista Sven Bergmann Mary L Biggs Ginevra Biino Michael Boehnke Eric Boerwinkle Mathilde Boissel Erwin P Bottinger Thibaud S Boutin Hermann Brenner Marco Brumat Ralph Burkhardt Adam S Butterworth Eric Campana Archie Campbell Harry Campbell Mickaël Canouil Robert J Carroll Eulalia Catamo John C Chambers Miao-Ling Chee Miao-Li Chee Xu Chen Ching-Yu Cheng Yurong Cheng Kaare Christensen Renata Cifkova Marina Ciullo Maria Pina Concas James P Cook Josef Coresh Tanguy Corre Cinzia Felicita Sala Daniele Cusi John Danesh E Warwick Daw Martin H de Borst Alessandro De Grandi Renée de Mutsert Aiko P J de Vries Frauke Degenhardt Graciela Delgado Ayse Demirkan Emanuele Di Angelantonio Katalin Dittrich Jasmin Divers Rajkumar Dorajoo Kai-Uwe Eckardt Georg Ehret Paul Elliott Karlhans Endlich Michele K Evans Janine F Felix Valencia Hui Xian Foo Oscar H Franco Andre Franke Barry I Freedman Sandra Freitag-Wolf Yechiel Friedlander Philippe Froguel Ron T Gansevoort He Gao Paolo Gasparini J Michael Gaziano Vilmantas Giedraitis Christian Gieger Giorgia Girotto Franco Giulianini Martin Gögele Scott D Gordon Daniel F Gudbjartsson Vilmundur Gudnason Toomas Haller Pavel Hamet Tamara B Harris Catharina A Hartman Caroline Hayward Jacklyn N Hellwege Chew-Kiat Heng Andrew A Hicks Edith Hofer Wei Huang Nina Hutri-Kähönen Shih-Jen Hwang M Arfan Ikram Olafur S Indridason Erik Ingelsson Marcus Ising Vincent W V Jaddoe Johanna Jakobsdottir Jost B Jonas Peter K Joshi Navya Shilpa Josyula Bettina Jung Mika Kähönen Yoichiro Kamatani Candace M Kammerer Masahiro Kanai Mika Kastarinen Shona M Kerr Chiea-Chuen Khor Wieland Kiess Marcus E Kleber Wolfgang Koenig Jaspal S Kooner Antje Körner Peter Kovacs Aldi T Kraja Alena Krajcoviechova Holly Kramer Bernhard K Krämer Florian Kronenberg Michiaki Kubo Brigitte Kühnel Mikko Kuokkanen Johanna Kuusisto Martina La Bianca Markku Laakso Leslie A Lange Carl D Langefeld Jeannette Jen-Mai Lee Benjamin Lehne Terho Lehtimäki Wolfgang Lieb Su-Chi Lim Lars Lind Cecilia M Lindgren Jun Liu Jianjun Liu Markus Loeffler Ruth J F Loos Susanne Lucae Mary Ann Lukas Leo-Pekka Lyytikäinen Reedik Mägi Patrik K E Magnusson Anubha Mahajan Nicholas G Martin Jade Martins Winfried März Deborah Mascalzoni Koichi Matsuda Christa Meisinger Thomas Meitinger Olle Melander Andres Metspalu Evgenia K Mikaelsdottir Yuri Milaneschi Kozeta Miliku Pashupati P Mishra Karen L Mohlke Nina Mononen Grant W Montgomery Dennis O Mook-Kanamori Josyf C Mychaleckyj Girish N Nadkarni Mike A Nalls Matthias Nauck Kjell Nikus Boting Ning Ilja M Nolte Raymond Noordam Jeffrey O'Connell Michelle L O'Donoghue Isleifur Olafsson Albertine J Oldehinkel Marju Orho-Melander Willem H Ouwehand Sandosh Padmanabhan Nicholette D Palmer Runolfur Palsson Brenda W J H Penninx Thomas Perls Markus Perola Mario Pirastu Nicola Pirastu Giorgio Pistis Anna I Podgornaia Ozren Polasek Belen Ponte David J Porteous Tanja Poulain Peter P Pramstaller Michael H Preuss Bram P Prins Michael A Province Ton J Rabelink Laura M Raffield Olli T Raitakari Dermot F Reilly Rainer Rettig Myriam Rheinberger Kenneth M Rice Paul M Ridker Fernando Rivadeneira Federica Rizzi David J Roberts Antonietta Robino Peter Rossing Igor Rudan Rico Rueedi Daniela Ruggiero Kathleen A Ryan Yasaman Saba Charumathi Sabanayagam Veikko Salomaa Erika Salvi Kai-Uwe Saum Helena Schmidt Reinhold Schmidt Ben Schöttker Christina-Alexandra Schulz Nicole Schupf Christian M Shaffer Yuan Shi Albert V Smith Blair H Smith Nicole Soranzo Cassandra N Spracklen Konstantin Strauch Heather M Stringham Michael Stumvoll Per O Svensson Silke Szymczak E-Shyong Tai Salman M Tajuddin Nicholas Y Q Tan Kent D Taylor Andrej Teren Yih-Chung Tham Joachim Thiery Chris H L Thio Hauke Thomsen Gudmar Thorleifsson Daniela Toniolo Anke Tönjes Johanne Tremblay Ioanna Tzoulaki André G Uitterlinden Simona Vaccargiu Rob M van Dam Pim van der Harst Cornelia M van Duijn Digna R Velez Edward Niek Verweij Suzanne Vogelezang Uwe Völker Peter Vollenweider Gerard Waeber Melanie Waldenberger Lars Wallentin Ya Xing Wang Chaolong Wang Dawn M Waterworth Wen Bin Wei Harvey White John B Whitfield Sarah H Wild James F Wilson Mary K Wojczynski Charlene Wong Tien-Yin Wong Liang Xu Qiong Yang Masayuki Yasuda Laura M Yerges-Armstrong Weihua Zhang Alan B Zonderman Jerome I Rotter Murielle Bochud Bruce M Psaty Veronique Vitart James G Wilson Abbas Dehghan Afshin Parsa Daniel I Chasman Kevin Ho Andrew P Morris Olivier Devuyst Shreeram Akilesh Sarah A Pendergrass Xueling Sim Carsten A Böger Yukinori Okada Todd L Edwards Harold Snieder Kari Stefansson Adriana M Hung Iris M Heid Markus Scholz Alexander Teumer Anna Köttgen Cristian Pattaro

Nat Genet 2019 06 31;51(6):957-972. Epub 2019 May 31.

Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.

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http://dx.doi.org/10.1038/s41588-019-0407-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698888PMC
June 2019

Cause-Specific Mortality in Multiethnic South East Asians With Type 2 Diabetes Mellitus.

Asia Pac J Public Health 2019 May 16;31(4):306-314. Epub 2019 May 16.

3 Diabetes Centre, Khoo Teck Puat Hospital, Singapore.

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http://dx.doi.org/10.1177/1010539519849317DOI Listing
May 2019

PAX4 R192H is associated with younger onset of Type 2 diabetes in East Asians in Singapore.

J Diabetes Complications 2019 01 13;33(1):53-58. Epub 2018 Oct 13.

Clinical Research Unit, Khoo Teck Puat Hospital (KTPH), Singapore; Diabetes Center, Khoo Teck Puat Hospital (KTPH), Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183022
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http://dx.doi.org/10.1016/j.jdiacomp.2018.10.002DOI Listing
January 2019

Risk Behavior Patterns and Outcomes of CKD-Potential for Individualizing Behavioral Interventions.

Kidney Int Rep 2019 Jan 24;4(1):11-13. Epub 2018 Nov 24.

Khoo Tech Puat Hospital, National Health Group, Singapore.

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http://dx.doi.org/10.1016/j.ekir.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308905PMC
January 2019

Urine Tricarboxylic Acid Cycle Metabolites Predict Progressive Chronic Kidney Disease in Type 2 Diabetes.

J Clin Endocrinol Metab 2018 12;103(12):4357-4364

Diabetes Centre, Khoo Teck Puat Hospital, Singapore.

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http://dx.doi.org/10.1210/jc.2018-00947DOI Listing
December 2018

Association of plasma osteopontin with diabetic retinopathy in Asians with type 2 diabetes.

Mol Vis 2018 15;24:165-173. Epub 2018 Feb 15.

Department of ophthalmology and Visual Sciences, Khoo Teck Puat Hospital, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815337PMC
November 2018

The role of triglyceride glucose index in development of Type 2 diabetes mellitus.

Diabetes Res Clin Pract 2018 Sep 21;143:43-49. Epub 2018 Jun 21.

Family and Community Medicine, Khoo Teck Puat Hospital, Singapore.

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183028
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http://dx.doi.org/10.1016/j.diabres.2018.06.006DOI Listing
September 2018

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

Diabetes 2018 07 27;67(7):1414-1427. Epub 2018 Apr 27.

Wellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.2337/db17-0914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014557PMC
July 2018

Microvascular endothelial function is an independent predictor for albuminuria progression among Asians with type 2 diabetes-A prospective cohort study.

Microcirculation 2018 05 27;25(4):e12453. Epub 2018 Apr 27.

Department of Medicine, Khoo Teck Puat Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1111/micc.12453DOI Listing
May 2018

Short Leukocyte Telomere Length Predicts Albuminuria Progression in Individuals With Type 2 Diabetes.

Kidney Int Rep 2018 May 16;3(3):592-601. Epub 2017 Dec 16.

Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.

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http://dx.doi.org/10.1016/j.ekir.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976822PMC
May 2018

Discovery and validation of serum creatinine variability as novel biomarker for predicting onset of albuminuria in Type 2 diabetes mellitus.

Diabetes Res Clin Pract 2018 Apr 31;138:8-15. Epub 2018 Jan 31.

Clinical Research Unit, Khoo Teck Puat Hospital, Singapore; Diabetes Centre, Khoo Teck Puat Hospital, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688227173139
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http://dx.doi.org/10.1016/j.diabres.2017.11.003DOI Listing
April 2018

Effect of bariatric surgery on diabetic nephropathy in obese type 2 diabetes patients in a retrospective 2-year study: A local pilot.

Diab Vasc Dis Res 2018 Mar 18;15(2):139-144. Epub 2017 Nov 18.

4 Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.

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http://dx.doi.org/10.1177/1479164117742315DOI Listing
March 2018

Spectrum of mutations in index patients with familial hypercholesterolemia in Singapore: Single center study.

Atherosclerosis 2018 02 27;269:106-116. Epub 2017 Dec 27.

Clinical Research Unit, Khoo Teck Puat Hospital, 768828, Singapore; Diabetes Centre, Admiralty Medical Centre, 730676, Singapore; Division of Endocrinology, Khoo Teck Puat Hospital, 768828, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00219150173146
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http://dx.doi.org/10.1016/j.atherosclerosis.2017.12.028DOI Listing
February 2018

Plasma Leucine-Rich α-2-Glycoprotein 1 Predicts Rapid eGFR Decline and Albuminuria Progression in Type 2 Diabetes Mellitus.

J Clin Endocrinol Metab 2017 10;102(10):3683-3691

Diabetes Centre, Khoo Teck Puat Hospital, Singapore 768828, Singapore.

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http://dx.doi.org/10.1210/jc.2017-00930DOI Listing
October 2017

Association of apolipoprotein-CIII (apoC-III), endothelium-dependent vasodilation and peripheral neuropathy in a multi-ethnic population with type 2 diabetes.

Metabolism 2017 07 2;72:75-82. Epub 2017 Apr 2.

Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828; Diabetes Centre, Khoo Teck Puat Hospital, Singapore 768828; Division of Endocrinology, Department of Medicine, Khoo Teck Puat Hospital, Singapore 768828. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2017.03.016DOI Listing
July 2017

Arterial stiffness is an independent predictor for albuminuria progression among Asians with type 2 diabetes-A prospective cohort study.

J Diabetes Complications 2017 Jun 14;31(6):933-938. Epub 2017 Feb 14.

Diabetes Centre, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore; Department of Medicine, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2017.02.004DOI Listing
June 2017

HbA1c variability in type 2 diabetes is associated with the occurrence of new-onset albuminuria within three years.

Diabetes Res Clin Pract 2017 Jun 14;128:32-39. Epub 2017 Feb 14.

Department of Pharmacy, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.diabres.2017.02.007DOI Listing
June 2017

Baseline predictors of aortic stiffness progression among multi-ethnic Asians with type 2 diabetes.

Atherosclerosis 2017 05 27;260:102-109. Epub 2017 Jan 27.

Diabetes Centre, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore 768828, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.01.031DOI Listing
May 2017

Development and validation of a predictive model for Chronic Kidney Disease progression in Type 2 Diabetes Mellitus based on a 13-year study in Singapore.

Diabetes Res Clin Pract 2017 Jan 22;123:49-54. Epub 2016 Nov 22.

Khoo Teck Puat Hospital, Diabetes Centre, 90 Yishun Central, Singapore 768828, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.diabres.2016.11.008DOI Listing
January 2017

Urinary Haptoglobin Predicts Rapid Renal Function Decline in Asians With Type 2 Diabetes and Early Kidney Disease.

J Clin Endocrinol Metab 2016 10 26;101(10):3794-3802. Epub 2016 Jul 26.

Clinical Research Unit (J.-J.L., S.L., M.D.S.W., R.L.G.) and Diabetes Centre (S.C.L.), Khoo Teck Puat Hospital, Singapore 768828.

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http://dx.doi.org/10.1210/jc.2016-2094DOI Listing
October 2016

Central arterial stiffness is associated with systemic inflammation among Asians with type 2 diabetes.

Diab Vasc Dis Res 2016 07 18;13(4):303-6. Epub 2016 Apr 18.

Diabetes Centre, Khoo Teck Puat Hospital, Singapore, Republic of Singapore Department of Medicine, Khoo Teck Puat Hospital, Singapore, Republic of Singapore

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http://dx.doi.org/10.1177/1479164116635021DOI Listing
July 2016

Profile of the Paraoxonase 1 (PON1) Gene 192Q/R Polymorphism and Clinical Associations among Older Singaporean Chinese with Alzheimer's and Mixed Dementia.

Dement Geriatr Cogn Dis Extra 2016 Jan-Apr;6(1):43-54. Epub 2016 Feb 17.

Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Psychological Medicine, National University Health System, Singapore.

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http://dx.doi.org/10.1159/000442382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899677PMC
June 2016

Health Promotion Board-Ministry of Health Clinical Practice Guidelines: Obesity.

Singapore Med J 2016 Jun;57(6):292-300

Changi General Hospital; College of Family Physicians Singapore; Gleneagles Hospital and Medical Centre; Health Promotion Board; Khoo Teck Puat Hospital; KK Women's and Children's Hospital; National Institute of Education; National University Hospital; Saw Swee Hock School of Public Health, National University of Singapore; Singapore General Hospital; Victoria University, Australia; Yong Loo Lin School of Medicine, National University of Singapore.

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http://dx.doi.org/10.11622/smedj.2016103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971447PMC
June 2016

Circulating and visceral adipose miR-100 is down-regulated in patients with obesity and Type 2 diabetes.

Mol Cell Endocrinol 2016 May 10;427:112-23. Epub 2016 Mar 10.

Clinical Research Unit, Khoo Teck Puat Hospital, 768828, Singapore; Diabetes Centre, Khoo Teck Puat Hospital, 768828, Singapore; Division of Endocrinology, Khoo Teck Puat Hospital, 768828, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2016.03.010DOI Listing
May 2016

Elevated serum leptin, adiponectin and leptin to adiponectin ratio is associated with chronic kidney disease in Asian adults.

PLoS One 2015 20;10(3):e0122009. Epub 2015 Mar 20.

Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, National University of Singapore, Singapore, Singapore; Singapore Eye Research Institute, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122009PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368742PMC
February 2016

MicroRNAs as biomarkers of hepatotoxicity in a randomized placebo-controlled study of simvastatin and ubiquinol supplementation.

Exp Biol Med (Maywood) 2016 Feb 30;241(3):317-30. Epub 2015 Sep 30.

Diabetes Centre, Khoo Teck Puat Hospital, Singapore768828, Singapore Division of Endocrinology, Khoo Teck Puat Hospital, Singapore 768828, Singapore.

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http://dx.doi.org/10.1177/1535370215605588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935448PMC
February 2016

Missed Appointments at a Diabetes Centre: Not a Small Problem.

Ann Acad Med Singapore 2016 Jan;45(1):1-5

Research Laboratory, Khoo Teck Puat Hospital, Singapore.

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January 2016

Ethnic disparity in central arterial stiffness and its determinants among Asians with type 2 diabetes.

Atherosclerosis 2015 Sep 18;242(1):22-8. Epub 2015 Jun 18.

Diabetes Centre, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore; Department of Medicine, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.06.019DOI Listing
September 2015

Chronic kidney disease, cardiovascular disease and mortality: A prospective cohort study in a multi-ethnic Asian population.

Eur J Prev Cardiol 2015 Aug 23;22(8):1018-26. Epub 2014 May 23.

Singapore Eye Research Institute, Singapore Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore Department of Ophthalmology, National University of Singapore, Singapore

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http://cpr.sagepub.com/content/22/8/1018.full.pdf
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http://cpr.sagepub.com/lookup/doi/10.1177/2047487314536873
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http://dx.doi.org/10.1177/2047487314536873DOI Listing
August 2015

Prednisone for community-acquired pneumonia: not yet time.

Lancet 2015 Aug;386(9992):431

Khoo Teck Puat Hospital, Singapore 768828, Singapore.

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http://dx.doi.org/10.1016/S0140-6736(15)61445-3DOI Listing
August 2015

Vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1, is associated with diabetic kidney disease in Asians with type 2 diabetes.

J Diabetes Complications 2015 Jul 28;29(5):707-12. Epub 2015 Feb 28.

Department of Medicine, Khoo Teck Puat Hospital, 768828 Singapore; Diabetes Centre, Khoo Teck Puat Hospital, 768828 Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2015.02.011DOI Listing
July 2015

The role of fibroblast growth factor 21 in diabetes and its complications: A review from clinical perspective.

Diabetes Res Clin Pract 2015 Jun 3;108(3):382-9. Epub 2015 Mar 3.

Diabetes Center, Khoo Teck Puat Hospital, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.diabres.2015.02.032DOI Listing
June 2015

Prevalence of Chronic Kidney Disease in Adults with Type 2 Diabetes Mellitus.

Ann Acad Med Singapore 2015 May;44(5):164-71

Clinical Services, Khoo Teck Puat Hospital, Singapore.

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May 2015

Elevation of a novel angiogenic factor, leucine-rich-α2-glycoprotein (LRG1), is associated with arterial stiffness, endothelial dysfunction, and peripheral arterial disease in patients with type 2 diabetes.

J Clin Endocrinol Metab 2015 Apr 30;100(4):1586-93. Epub 2015 Jan 30.

Clinical Research Unit (S.L.T.P., S.T., S.C.L., K.W., X.N., J.L.), Diabetes Centre (S.T., S.C.L., C.F.S.), and Division of Endocrinology (S.T., S.C.L., C.F.S.), Khoo Teck Puat Hospital, Singapore 768828; Metabolic Disease Research Programme (X.W.), Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 639798; Division of Nephrology (L.Y.Y.), Department of Medicine, Khoo Teck Puat Hospital, Singapore 768828; Institute of Molecular and Cell Biology (X.W.), A*STAR, Singapore 138673; and Institute of Ophthalmology (X.W.), University College London, London EC1V 9EL, United Kingdom.

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http://dx.doi.org/10.1210/jc.2014-3855DOI Listing
April 2015

Diagnosis of diabetes mellitus using HbA1c in Asians: relationship between HbA1c and retinopathy in a multiethnic Asian population.

J Clin Endocrinol Metab 2015 Feb 6;100(2):689-96. Epub 2014 Nov 6.

Singapore Eye Research Institute (C.S., M.K.I., E.L.M., C.Y.C., T.Y.W.), Singapore 169856; Office of Clinical Sciences (C.S., M.K.I., E.L.M., C.Y.C., T.Y.W.), Duke-NUS Graduate Medical School, Singapore 169856; Departments of Ophthalmology (C.S., M.K.I., E.L.M., C.Y.C., T.Y.W.) and Medicine (E.Y.H.K., M.L.S.T., A.-C.T., E.S.T.), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597; Center for Quantitative Medicine (W.K.L.), Duke-NUS Graduate Medical School, Singapore 169856; Department of Epidemiology and Public Health (A.S., J.L.), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597; Department of Medicine (S.C.-L., S.T.), Khoo Teck Puat Hospital, Singapore 768828; and Epidemiology and Disease Control Division (D.H., S.M.), Ministry of Health, Singapore 169854.

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http://dx.doi.org/10.1210/jc.2014-2498DOI Listing
February 2015

Elevated circulating alpha-klotho by angiotensin II receptor blocker losartan is associated with reduction of albuminuria in type 2 diabetic patients.

J Renin Angiotensin Aldosterone Syst 2014 Dec 4;15(4):487-90. Epub 2013 Feb 4.

Diabetes Centre, Khoo Teck Puat Hospital, Republic of Singapore.

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http://dx.doi.org/10.1177/1470320313475905DOI Listing
December 2014

Relationship between circulating irisin, renal function and body composition in type 2 diabetes.

J Diabetes Complications 2014 Mar-Apr;28(2):208-13. Epub 2013 Oct 4.

Diabetes Centre, Khoo Teck Puat Hospital, Republic of Singapore; Department of Medicine, Khoo Teck Puat Hospital, Republic of Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2013.09.011DOI Listing
November 2014

Is chronic kidney disease associated with diabetic retinopathy in Asian adults?

J Diabetes 2014 Nov 24;6(6):556-63. Epub 2014 Apr 24.

Singapore Eye Research Institute, Singapore; Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore; Department of Ophthalmology, National University of Singapore, Singapore.

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http://www.siditalia.it/images/Documenti/riace/17_Journal-of
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http://doi.wiley.com/10.1111/1753-0407.12148
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http://dx.doi.org/10.1111/1753-0407.12148DOI Listing
November 2014

Low-density lipoprotein cholesterol levels in adults with type 2 diabetes: an alternative equation for accurate estimation and improved cardiovascular risk classification.

Diab Vasc Dis Res 2014 Nov 9;11(6):431-9. Epub 2014 Sep 9.

Diabetes Centre, Khoo Teck Puat Hospital, Singapore Division of Endocrinology, Medicine Unit 2, Department of Medicine, Khoo Teck Puat Hospital, Singapore Clinical Research Unit, Khoo Teck Puat Hospital, Singapore

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http://dx.doi.org/10.1177/1479164114547703DOI Listing
November 2014

Obesity is a determinant of arterial stiffness independent of traditional risk factors in Asians with young-onset type 2 diabetes.

Atherosclerosis 2014 Oct 27;236(2):286-91. Epub 2014 Jul 27.

Diabetes Centre, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore; Department of Medicine, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2014.07.017DOI Listing
October 2014

Osteoprotegerin is independently associated with metabolic syndrome and microvascular complications in type 2 diabetes mellitus.

Diab Vasc Dis Res 2014 Sep 7;11(5):359-62. Epub 2014 Jul 7.

Diabetes Centre, Khoo Teck Puat Hospital, Singapore Division of Endocrinology, Khoo Teck Puat Hospital, Singapore.

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http://dvr.sagepub.com/content/11/5/359.full.pdf
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http://dvr.sagepub.com/cgi/doi/10.1177/1479164114539712
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http://dx.doi.org/10.1177/1479164114539712DOI Listing
September 2014

Association of plasma soluble α-klotho with pro-endothelin-1 in patients with type 2 diabetes.

Atherosclerosis 2014 Apr 22;233(2):415-8. Epub 2014 Jan 22.

Diabetes Centre, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore 768828, Republic of Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2014.01.024DOI Listing
April 2014

Lower circulating irisin is associated with type 2 diabetes mellitus.

J Diabetes Complications 2013 Jul-Aug;27(4):365-9. Epub 2013 Apr 22.

Clinical Research Unit, Khoo Teck Puat Hospital, Republic of Singapore.

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https://linkinghub.elsevier.com/retrieve/pii/S10568727130005
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http://dx.doi.org/10.1016/j.jdiacomp.2013.03.002DOI Listing
March 2014

A method comparison study to validate a novel parameter of obesity, the body adiposity index, in Chinese subjects.

Obesity (Silver Spring) 2013 Dec 13;21(12):E634-9. Epub 2013 Aug 13.

Department of Family and Community Medicine, Khoo Teck Puat Hospital, Singapore.

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http://dx.doi.org/10.1002/oby.20504DOI Listing
December 2013

Myopia-related fundus changes in Singapore adults with high myopia.

Am J Ophthalmol 2013 Jun 15;155(6):991-999.e1. Epub 2013 Mar 15.

Duke Eye Center, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.1016/j.ajo.2013.01.016DOI Listing
June 2013

Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics.

J Clin Endocrinol Metab 2013 Jun 30;98(6):E1060-5. Epub 2013 Apr 30.

School of Public Health, National University of Singapore, 16 Medical Drive MD3, Singapore 117597.

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http://dx.doi.org/10.1210/jc.2012-4132DOI Listing
June 2013

Structural changes in the retinal microvasculature and renal function.

Invest Ophthalmol Vis Sci 2013 Apr 26;54(4):2970-6. Epub 2013 Apr 26.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1167/iovs.13-11941DOI Listing
April 2013

Acetyl-keto-β-boswellic acid induces lipolysis in mature adipocytes.

Biochem Biophys Res Commun 2013 Feb 9;431(2):192-6. Epub 2013 Jan 9.

Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828, Republic of Singapore.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X130003
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http://dx.doi.org/10.1016/j.bbrc.2012.12.136DOI Listing
February 2013

Circulating miRNA profiles in patients with metabolic syndrome.

J Clin Endocrinol Metab 2012 Dec 2;97(12):E2271-6. Epub 2012 Oct 2.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, Singapore 117597.

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http://dx.doi.org/10.1210/jc.2012-1996DOI Listing
December 2012

Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.

Mol Cell Endocrinol 2012 Oct 26;362(1-2):227-41. Epub 2012 Jul 26.

Division of Bioengineering, Nanyang Technological University, Singapore 637457, Singapore.

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http://dx.doi.org/10.1016/j.mce.2012.07.002DOI Listing
October 2012

MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus.

PLoS One 2011 1;6(8):e22839. Epub 2011 Aug 1.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022839PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148231PMC
December 2011

Hypertension, hypertension control, and chronic kidney disease in a Malay population in Singapore.

Asia Pac J Public Health 2011 Nov 10;23(6):936-45. Epub 2010 May 10.

Yong Loo Lin School of Medicine, National University of Singapore.

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http://dx.doi.org/10.1177/1010539510361637DOI Listing
November 2011

Ethnic disparities in prevalence and impact of risk factors of chronic kidney disease.

Nephrol Dial Transplant 2010 Aug 25;25(8):2564-70. Epub 2010 Feb 25.

Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore.

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http://dx.doi.org/10.1093/ndt/gfq084DOI Listing
August 2010

Fractal analysis of the retinal vasculature and chronic kidney disease.

Nephrol Dial Transplant 2010 Jul 1;25(7):2252-8. Epub 2010 Feb 1.

Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University Health System, Singapore.

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http://dx.doi.org/10.1093/ndt/gfq007DOI Listing
July 2010

Retinal vessel caliber and peripheral neuropathy in diabetic participants.

Microcirculation 2010 May;17(4):297-302

Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1111/j.1549-8719.2010.00021.xDOI Listing
May 2010

C-reactive protein and microalbuminuria in a multi-ethnic Asian population.

Nephrol Dial Transplant 2010 Apr 13;25(4):1167-72. Epub 2009 Nov 13.

Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1093/ndt/gfp591DOI Listing
April 2010

Chronic kidney disease and intraocular pressure: the Singapore Malay Eye Study.

Ophthalmology 2010 Mar 6;117(3):477-83. Epub 2009 Dec 6.

Singapore Eye Research Institute & Singapore National Eye Center, Singapore.

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http://dx.doi.org/10.1016/j.ophtha.2009.07.029DOI Listing
March 2010

Prevalence of diabetes mellitus, glycemic control, and associated factors in a Malay population in Singapore.

Asia Pac J Public Health 2009 Oct 5;21(4):385-98. Epub 2009 Aug 5.

Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1177/1010539509343958DOI Listing
October 2009

Peripheral artery disease and glaucoma: the singapore malay eye study.

Arch Ophthalmol 2009 Jul;127(7):888-93

Centre for Eye Research Australia, University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1001/archophthalmol.2009.136DOI Listing
July 2009