Stuart H Ralston

Stuart H Ralston

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Stuart H Ralston

Publications by authors named "Stuart H Ralston"

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Long-Term Effects of Teriparatide Followed by Antiresorptive Therapy on Clinical Outcomes in Patients with Severe Spinal Osteoporosis.

Calcif Tissue Int 2019 Aug 21;105(2):148-155. Epub 2019 May 21.

Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1007/s00223-019-00563-8DOI Listing
August 2019

Analysis of Transcriptional Regulation in Bone Cells.

Methods Mol Biol 2019 ;1914:145-167

Rheumatic Diseases Unit, Centre for Genomics and Experimental Medicine, MRC IGMM, Western General Hospital, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1007/978-1-4939-8997-3_8DOI Listing
June 2019

Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice.

EBioMedicine 2019 Jun 29;44:452-466. Epub 2019 May 29.

Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK; Bone and Cancer Group, Edinburgh Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.05.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606522PMC
June 2019

Rare Inherited forms of Paget's Disease and Related Syndromes.

Calcif Tissue Int 2019 May 13;104(5):501-516. Epub 2019 Feb 13.

Howard Hughes Medical Institute and Department of Cell and Molecular Biology, St Jude's Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1007/s00223-019-00520-5DOI Listing
May 2019

Focal and Osteosclerotic Bone Diseases.

Calcif Tissue Int 2019 May 9;104(5):481-482. Epub 2019 May 9.

Division of Bone Diseases, Geneva University Hospitals, 1211, Geneva 14, Switzerland.

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http://dx.doi.org/10.1007/s00223-019-00556-7DOI Listing
May 2019

Disentangling the genetics of lean mass.

Authors:
David Karasik M Carola Zillikens Yi-Hsiang Hsu Ali Aghdassi Kristina Akesson Najaf Amin Inês Barroso David A Bennett Lars Bertram Murielle Bochud Ingrid B Borecki Linda Broer Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos-Obando Jane A Cauley Peggy M Cawthon John C Chambers Zhao Chen Nam H Cho Hyung Jin Choi Wen-Chi Chou Steven R Cummings Lisette C P G M de Groot Phillip L De Jager Ilja Demuth Luda Diatchenko Michael J Econs Gudny Eiriksdottir Anke W Enneman Joel Eriksson Johan G Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Christian Gieger Harald Grallert Vilmundur Gudnason Launer J Lenore Caroline Hayward Albert Hofman Georg Homuth Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Toby Johnson Reiner Biffar Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Daniel L Koller Jaspal S Kooner William E Kraus Stephen Kritchevsky Zoltán Kutalik Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Markus M Lerch Joshua R Lewis Christina Lill Lars Lind Cecilia Lindgren Yongmei Liu Gregory Livshits Östen Ljunggren Ruth J F Loos Mattias Lorentzon Jian'an Luan Robert N Luben Ida Malkin Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Maria Nethander Anne B Newman Jeffery R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Munro Peacock Markus Perola Annette Peters Richard L Prince Bruce M Psaty Katri Räikkönen Stuart H Ralston Samuli Ripatti Fernando Rivadeneira John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Sabine Schipf Chan Soo Shin Albert V Smith Shad B Smith Nicole Soranzo Timothy D Spector Alena Stancáková Kari Stefansson Elisabeth Steinhagen-Thiessen Lisette Stolk Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Patricia Thompson Cynthia A Thomson Gudmar Thorleifsson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah André G Uitterlinden Cornelia M van Duijn Natasja M van Schoor Liesbeth Vandenput Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Nicholas J Wareham Dawn Waterworth Michael N Weedon H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Yanhua Zhou Carrie M Nielson Tamara B Harris Serkalem Demissie Douglas P Kiel Claes Ohlsson

Am J Clin Nutr 2019 Feb;109(2):276-287

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1093/ajcn/nqy272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500901PMC
February 2019

Raman spectroscopy as a predictive tool for monitoring osteoporosis therapy in a rat model of postmenopausal osteoporosis.

J Mater Sci Mater Med 2019 Feb 12;30(2):25. Epub 2019 Feb 12.

Department of Oncology and Metabolism, Medical School, University of Sheffield, Beech Hill Road, Sheffield, UK.

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http://link.springer.com/10.1007/s10856-019-6226-x
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http://dx.doi.org/10.1007/s10856-019-6226-xDOI Listing
February 2019

Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62 mouse model of Paget's disease.

Dis Model Mech 2018 08 23;11(9). Epub 2018 Aug 23.

Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, UK

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http://dx.doi.org/10.1242/dmm.035576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177010PMC
August 2018

Osteoimmunology.

Calcif Tissue Int 2018 05 13;102(5):501-502. Epub 2018 Apr 13.

Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitatsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.

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http://dx.doi.org/10.1007/s00223-018-0421-5DOI Listing
May 2018

Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density.

Ann Rheum Dis 2018 03 23;77(3):378-385. Epub 2017 Nov 23.

Rheumatology and Bone Disease Unit, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1136/annrheumdis-2017-212469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912156PMC
March 2018

Raman spectroscopy predicts the link between claw keratin and bone collagen structure in a rodent model of oestrogen deficiency.

Biochim Biophys Acta Mol Basis Dis 2018 Feb 21;1864(2):398-406. Epub 2017 Oct 21.

Rheumatology and Bone Diseases Unit, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, UK; Department of Oncology and Metabolism, Medical School, University of Sheffield, Beech Hill Road, Sheffield, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.10.020DOI Listing
February 2018

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

Am J Hum Genet 2018 01;102(1):88-102

Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777980PMC
January 2018

Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS.

Bone 2017 Dec 5;105:11-17. Epub 2017 Aug 5.

Bone Center, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2017.08.003DOI Listing
December 2017

Bisphosphonates for Paget's disease of bone in adults.

Cochrane Database Syst Rev 2017 12 1;12:CD004956. Epub 2017 Dec 1.

Internal Medicine Department, Hospital el Bierzo, Gerencia de Asistencia Sanitaria del Bierzo, SACYL, IBSAL, RETICEF, c/Medicos Sin fronteras, 7, Ponferrada, Leon, Spain, 24411.

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http://dx.doi.org/10.1002/14651858.CD004956.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486234PMC
December 2017

How Basic Science Discoveries Have Shaped the Treatment of Bone and Mineral Disorders.

J Bone Miner Res 2017 12 30;32(12):2324-2330. Epub 2017 Nov 30.

Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1002/jbmr.3316DOI Listing
December 2017

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 11 7;8(1):1414. Epub 2017 Nov 7.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676783PMC
November 2017

Autoantibodies to Osteoprotegerin are Associated with Low Hip Bone Mineral Density and History of Fractures in Axial Spondyloarthritis: A Cross-Sectional Observational Study.

Calcif Tissue Int 2017 10 22;101(4):375-383. Epub 2017 May 22.

Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1007/s00223-017-0291-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587630PMC
October 2017

Combined deficiency of the Cnr1 and Cnr2 receptors protects against age-related bone loss by osteoclast inhibition.

Aging Cell 2017 10 28;16(5):1051-1061. Epub 2017 Jul 28.

Bone and Cancer Group, Edinburgh Cancer Research Centre, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XR, UK.

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http://dx.doi.org/10.1111/acel.12638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595693PMC
October 2017

The Reply.

Am J Med 2017 10;130(10):e457

Rheumatology and Bone Diseases Unit, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, UK.

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http://dx.doi.org/10.1016/j.amjmed.2017.05.033DOI Listing
October 2017

Antibody Response to Paramyxoviruses in Paget's Disease of Bone.

Calcif Tissue Int 2017 08 31;101(2):141-147. Epub 2017 Mar 31.

The Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1007/s00223-017-0265-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498588PMC
August 2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 07 19;8(1):80. Epub 2017 Jul 19.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-00031-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517526PMC
July 2017

Long-Term Randomized Trial of Intensive Versus Symptomatic Management in Paget's Disease of Bone: The PRISM-EZ Study.

J Bone Miner Res 2017 Jun 8;32(6):1165-1173. Epub 2017 Feb 8.

Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1002/jbmr.3066DOI Listing
June 2017

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Authors:
Philip C Haycock Stephen Burgess Aayah Nounu Jie Zheng George N Okoli Jack Bowden Kaitlin Hazel Wade Nicholas J Timpson David M Evans Peter Willeit Abraham Aviv Tom R Gaunt Gibran Hemani Massimo Mangino Hayley Patricia Ellis Kathreena M Kurian Karen A Pooley Rosalind A Eeles Jeffrey E Lee Shenying Fang Wei V Chen Matthew H Law Lisa M Bowdler Mark M Iles Qiong Yang Bradford B Worrall Hugh Stephen Markus Rayjean J Hung Chris I Amos Amanda B Spurdle Deborah J Thompson Tracy A O'Mara Brian Wolpin Laufey Amundadottir Rachael Stolzenberg-Solomon Antonia Trichopoulou N Charlotte Onland-Moret Eiliv Lund Eric J Duell Federico Canzian Gianluca Severi Kim Overvad Marc J Gunter Rosario Tumino Ulrika Svenson Andre van Rij Annette F Baas Matthew J Bown Nilesh J Samani Femke N G van t'Hof Gerard Tromp Gregory T Jones Helena Kuivaniemi James R Elmore Mattias Johansson James Mckay Ghislaine Scelo Robert Carreras-Torres Valerie Gaborieau Paul Brennan Paige M Bracci Rachel E Neale Sara H Olson Steven Gallinger Donghui Li Gloria M Petersen Harvey A Risch Alison P Klein Jiali Han Christian C Abnet Neal D Freedman Philip R Taylor John M Maris Katja K Aben Lambertus A Kiemeney Sita H Vermeulen John K Wiencke Kyle M Walsh Margaret Wrensch Terri Rice Clare Turnbull Kevin Litchfield Lavinia Paternoster Marie Standl Gonçalo R Abecasis John Paul SanGiovanni Yong Li Vladan Mijatovic Yadav Sapkota Siew-Kee Low Krina T Zondervan Grant W Montgomery Dale R Nyholt David A van Heel Karen Hunt Dan E Arking Foram N Ashar Nona Sotoodehnia Daniel Woo Jonathan Rosand Mary E Comeau W Mark Brown Edwin K Silverman John E Hokanson Michael H Cho Jennie Hui Manuel A Ferreira Philip J Thompson Alanna C Morrison Janine F Felix Nicholas L Smith Angela M Christiano Lynn Petukhova Regina C Betz Xing Fan Xuejun Zhang Caihong Zhu Carl D Langefeld Susan D Thompson Feijie Wang Xu Lin David A Schwartz Tasha Fingerlin Jerome I Rotter Mary Frances Cotch Richard A Jensen Matthias Munz Henrik Dommisch Arne S Schaefer Fang Han Hanna M Ollila Ryan P Hillary Omar Albagha Stuart H Ralston Chenjie Zeng Wei Zheng Xiao-Ou Shu Andre Reis Steffen Uebe Ulrike Hüffmeier Yoshiya Kawamura Takeshi Otowa Tsukasa Sasaki Martin Lloyd Hibberd Sonia Davila Gang Xie Katherine Siminovitch Jin-Xin Bei Yi-Xin Zeng Asta Försti Bowang Chen Stefano Landi Andre Franke Annegret Fischer David Ellinghaus Carlos Flores Imre Noth Shwu-Fan Ma Jia Nee Foo Jianjun Liu Jong-Won Kim David G Cox Olivier Delattre Olivier Mirabeau Christine F Skibola Clara S Tang Merce Garcia-Barcelo Kai-Ping Chang Wen-Hui Su Yu-Sun Chang Nicholas G Martin Scott Gordon Tracey D Wade Chaeyoung Lee Michiaki Kubo Pei-Chieng Cha Yusuke Nakamura Daniel Levy Masayuki Kimura Shih-Jen Hwang Steven Hunt Tim Spector Nicole Soranzo Ani W Manichaikul R Graham Barr Bratati Kahali Elizabeth Speliotes Laura M Yerges-Armstrong Ching-Yu Cheng Jost B Jonas Tien Yin Wong Isabella Fogh Kuang Lin John F Powell Kenneth Rice Caroline L Relton Richard M Martin George Davey Smith

JAMA Oncol 2017 May;3(5):636-651

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.

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http://dx.doi.org/10.1001/jamaoncol.2016.5945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638008PMC
May 2017

Heavy Cannabis Use Is Associated With Low Bone Mineral Density and an Increased Risk of Fractures.

Am J Med 2017 02 2;130(2):214-221. Epub 2016 Sep 2.

Rheumatology and Bone Diseases Unit, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029343163085
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http://dx.doi.org/10.1016/j.amjmed.2016.07.034DOI Listing
February 2017

Cerebral Small Vessel Disease Burden Is Increased in Systemic Lupus Erythematosus.

Stroke 2016 11 4;47(11):2722-2728. Epub 2016 Oct 4.

From the Centre for Clinical Brain Sciences (S.J.W., M.E.B., C.L.J., G.B., I.F.H., E.S., D.H., J.M.W.) and Centre for Genomic and Experimental Medicine (S.H.R.), University of Edinburgh, United Kingdom; Department of Rheumatology, Western General Hospital, Edinburgh, United Kingdom (E.N.A.); and Division of Cardiovascular and Diabetes Medicine, University of Dundee, United Kingdom (S.T., J.F.F.B.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079231PMC
http://dx.doi.org/10.1161/STROKEAHA.116.014330DOI Listing
November 2016

Raman Spectroscopic Analysis of Fingernail Clippings Can Help Differentiate Between Postmenopausal Women Who Have and Have Not Suffered a Fracture.

Clin Med Insights Arthritis Musculoskelet Disord 2016 31;9:109-16. Epub 2016 May 31.

Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.; Department of Mechanical and Industrial Engineering, Ryerson University, Toronto, ON, Canada.

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http://dx.doi.org/10.4137/CMAMD.S38493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939848PMC
July 2016

A Systematic Review of the Role of Vitamin D on Neuromuscular Remodelling Following Exercise and Injury.

Calcif Tissue Int 2016 May 19;98(5):426-37. Epub 2015 Dec 19.

School of Health Sciences, Queen Margaret University, Edinburgh, EH21 6UU, UK.

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http://dx.doi.org/10.1007/s00223-015-0099-xDOI Listing
May 2016

Cerebrovascular Disease in Rheumatic Diseases: A Systematic Review and Meta-Analysis.

Stroke 2016 Apr 25;47(4):943-50. Epub 2016 Feb 25.

From the Centre for Clinical Brain Sciences, University of Edinburgh (S.J.W., J.M.W.), Centre for Genomic and Experimental Medicine (S.H.R.), University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1161/STROKEAHA.115.012052DOI Listing
April 2016

New Targets and New Treatments: Recent Advances in the Treatment of Musculoskeletal Disease.

Calcif Tissue Int 2016 Apr 17;98(4):317-8. Epub 2016 Mar 17.

Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

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http://dx.doi.org/10.1007/s00223-016-0127-5DOI Listing
April 2016

Biology and Treatment of Paget's Disease of Bone.

J Cell Biochem 2016 Feb 3;117(2):289-99. Epub 2015 Sep 3.

Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU.

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http://dx.doi.org/10.1002/jcb.25291DOI Listing
February 2016

Diagnosis and management of osteoporosis.

Practitioner 2015 Dec;259(1788):15-9, 2

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December 2015

Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget's Disease.

Cell Rep 2015 Nov 29;13(6):1096-1102. Epub 2015 Oct 29.

Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646838PMC
November 2015

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Authors:
Hou-Feng Zheng Vincenzo Forgetta Yi-Hsiang Hsu Karol Estrada Alberto Rosello-Diez Paul J Leo Chitra L Dahia Kyung Hyun Park-Min Jonathan H Tobias Charles Kooperberg Aaron Kleinman Unnur Styrkarsdottir Ching-Ti Liu Charlotta Uggla Daniel S Evans Carrie M Nielson Klaudia Walter Ulrika Pettersson-Kymmer Shane McCarthy Joel Eriksson Tony Kwan Mila Jhamai Katerina Trajanoska Yasin Memari Josine Min Jie Huang Petr Danecek Beth Wilmot Rui Li Wen-Chi Chou Lauren E Mokry Alireza Moayyeri Melina Claussnitzer Chia-Ho Cheng Warren Cheung Carolina Medina-Gómez Bing Ge Shu-Huang Chen Kwangbom Choi Ling Oei James Fraser Robert Kraaij Matthew A Hibbs Celia L Gregson Denis Paquette Albert Hofman Carl Wibom Gregory J Tranah Mhairi Marshall Brooke B Gardiner Katie Cremin Paul Auer Li Hsu Sue Ring Joyce Y Tung Gudmar Thorleifsson Anke W Enneman Natasja M van Schoor Lisette C P G M de Groot Nathalie van der Velde Beatrice Melin John P Kemp Claus Christiansen Adrian Sayers Yanhua Zhou Sophie Calderari Jeroen van Rooij Chris Carlson Ulrike Peters Soizik Berlivet Josée Dostie Andre G Uitterlinden Stephen R Williams Charles Farber Daniel Grinberg Andrea Z LaCroix Jeff Haessler Daniel I Chasman Franco Giulianini Lynda M Rose Paul M Ridker John A Eisman Tuan V Nguyen Jacqueline R Center Xavier Nogues Natalia Garcia-Giralt Lenore L Launer Vilmunder Gudnason Dan Mellström Liesbeth Vandenput Najaf Amin Cornelia M van Duijn Magnus K Karlsson Östen Ljunggren Olle Svensson Göran Hallmans François Rousseau Sylvie Giroux Johanne Bussière Pascal P Arp Fjorda Koromani Richard L Prince Joshua R Lewis Bente L Langdahl A Pernille Hermann Jens-Erik B Jensen Stephen Kaptoge Kay-Tee Khaw Jonathan Reeve Melissa M Formosa Angela Xuereb-Anastasi Kristina Åkesson Fiona E McGuigan Gaurav Garg Jose M Olmos Maria T Zarrabeitia Jose A Riancho Stuart H Ralston Nerea Alonso Xi Jiang David Goltzman Tomi Pastinen Elin Grundberg Dominique Gauguier Eric S Orwoll David Karasik George Davey-Smith Albert V Smith Kristin Siggeirsdottir Tamara B Harris M Carola Zillikens Joyce B J van Meurs Unnur Thorsteinsdottir Matthew T Maurano Nicholas J Timpson Nicole Soranzo Richard Durbin Scott G Wilson Evangelia E Ntzani Matthew A Brown Kari Stefansson David A Hinds Tim Spector L Adrienne Cupples Claes Ohlsson Celia M T Greenwood Rebecca D Jackson David W Rowe Cynthia A Loomis David M Evans Cheryl L Ackert-Bicknell Alexandra L Joyner Emma L Duncan Douglas P Kiel Fernando Rivadeneira J Brent Richards

Nature 2015 Oct 14;526(7571):112-7. Epub 2015 Sep 14.

Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.

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October 2015

Bone Cell-autonomous Contribution of Type 2 Cannabinoid Receptor to Breast Cancer-induced Osteolysis.

J Biol Chem 2015 Sep 20;290(36):22049-60. Epub 2015 Jul 20.

Bone and Cancer Group, Edinburgh Cancer Research Centre, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XR, United Kingdom, From the Academic Unit of Bone Biology, Mellanby Centre for Bone Research, Department of Human Metabolism, Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom,

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September 2015

Autoantibodies to osteoprotegerin are associated with increased bone resorption in rheumatoid arthritis.

Ann Rheum Dis 2015 Aug 29;74(8):1631-2. Epub 2015 Apr 29.

Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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August 2015

Characterisation of osteoprotegerin autoantibodies in coeliac disease.

Calcif Tissue Int 2015 Aug 20;97(2):125-33. Epub 2015 Jun 20.

Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK.

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August 2015

Letter to the Editor: The Endocrine Society Clinical Practice Guidelines on Paget's Disease: Many Recommendations Are Not Evidence Based.

J Clin Endocrinol Metab 2015 Jun;100(6):L45-6

Rheumatology and Bone Disease Unit (S.H.R.), Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh,Western General Hospital, Edinburgh, United Kingdom; Hospital el Bierzo (L.C.-G.), Ponferrada, Spain; Department of Medicine (W.D.F.), University of E Anglia, Norwich, United Kingdom; Department of Internal Medicine (L.G.), Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy; Metabolic Bone Diseases Unit (N.G.), Service of Rheumatology, Hospital Clinic, University of Barcelona, Barcelona, Spain; Institute of Human Development (P.L.S.), Faculty of Medical and Human Sciences, University of Manchester; Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.

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June 2015

Bisphosphonates for the prevention of fractures in osteogenesis imperfecta: meta-analysis of placebo-controlled trials.

J Bone Miner Res 2015 May;30(5):929-33

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

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May 2015

Atypical femoral fracture in osteoporosis pseudoglioma syndrome associated with two novel compound heterozygous mutations in LRP5.

J Bone Miner Res 2015 Apr;30(4):615-20

Rheumatic Diseases Unit, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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April 2015

Predictors of poor clinical outcome following hip fracture in middle aged-patients.

Injury 2015 Apr 15;46(4):709-12. Epub 2014 Nov 15.

Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom.

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April 2015

Emerging impact of skeletal muscle in health and disease.

Calcif Tissue Int 2015 Mar;96(3):181-2

Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA,

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March 2015

Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice.

Ann Rheum Dis 2015 Jan 4;74(1):220-6. Epub 2013 Oct 4.

Molecular Medicine Centre, Institute for Genetics and Molecular Medicine, University of Edinburgh, General Western Hospital, Edinburgh, UK.

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January 2015

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.

Ann Rheum Dis 2014 Dec 29;73(12):2130-6. Epub 2013 Aug 29.

Department of Twin Research & Genetic Epidemiology, King's College London, London, UK Department of Academic Rheumatology, University of Nottingham, Nottingham, UK.

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December 2014

Clinical presentation of Paget's disease: evaluation of a contemporary cohort and systematic review.

Calcif Tissue Int 2014 Nov 27;95(5):385-92. Epub 2014 Aug 27.

Rheumatology and Bone Disease Unit, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.

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November 2014

Prevalence and clinical prediction of osteoporosis in a contemporary cohort of patients with rheumatoid arthritis.

Rheumatology (Oxford) 2014 Oct 24;53(10):1759-66. Epub 2014 Apr 24.

Rheumatology and Bone Disease Unit, Institute of Genetics and Molecular Medicine and Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.

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October 2014

Genetics of Paget's disease of bone.

Curr Osteoporos Rep 2014 Sep;12(3):263-71

Bone and Rheumatology Research Group, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK,

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September 2014

The influence of vitamin C on the outcome of distal radial fractures: a double-blind, randomized controlled trial.

J Bone Joint Surg Am 2014 Sep;96(17):1451-9

Edinburgh Orthopaedic Trauma Unit, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SU, United Kingdom. E-mail address for A.D. Duckworth:

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September 2014

Up-titration of allopurinol in patients with gout.

Semin Arthritis Rheum 2014 Aug 23;44(1):25-30. Epub 2014 Jan 23.

Medicines Monitoring Unit (MEMO), University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK.

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August 2014

Modulation of strain-specific differences in gene expression by cannabinoid type 2 receptor deficiency.

Calcif Tissue Int 2014 Apr 27;94(4):423-32. Epub 2013 Dec 27.

Rheumatology and Bone Research Group, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.

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April 2014

Genetic background modifies the effects of type 2 cannabinoid receptor deficiency on bone mass and bone turnover.

Calcif Tissue Int 2014 Mar 14;94(3):259-68. Epub 2013 Sep 14.

Rheumatic Diseases Unit, Centre for Molecular Medicine, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.

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March 2014

Teriparatide treatment of severe osteoporosis reduces the risk of vertebral fractures compared with standard care in routine clinical practice.

Calcif Tissue Int 2014 Feb 13;94(2):176-82. Epub 2013 Sep 13.

Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.

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February 2014

A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.

J Med Genet 2014 Feb 16;51(2):122-31. Epub 2013 Dec 16.

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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February 2014

Calcified Tissue International-"the times, they are a-changin'".

Calcif Tissue Int 2014 Jan 21;94(1). Epub 2013 Dec 21.

University of Edinburgh, Edinburgh, UK,

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January 2014

Development of triarylsulfonamides as novel anti-inflammatory agents.

Bioorg Med Chem Lett 2013 Feb 29;23(3):816-20. Epub 2012 Nov 29.

Kosterlitz Centre for Therapeutics, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.

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February 2013

Apolipoprotein E isoforms and bone--of mice and men.

Authors:
Stuart H Ralston

J Bone Miner Res 2013 Feb;28(2):234-5

Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.

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February 2013

Casting new light on the sunshine vitamin.

Calcif Tissue Int 2013 Feb 18;92(2):75-6. Epub 2013 Jan 18.

Rheumatic Diseases Unit, University of Edinburgh, Edinburgh, UK.

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February 2013

Clinical practice. Paget's disease of bone.

Authors:
Stuart H Ralston

N Engl J Med 2013 Feb;368(7):644-50

Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.

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February 2013

Role of cannabinoids in the regulation of bone remodeling.

Front Endocrinol (Lausanne) 2012 16;3:136. Epub 2012 Nov 16.

Bone and Cancer Group, Edinburgh Cancer Research Centre, The University of Edinburgh Edinburgh, UK.

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November 2012

Polyarteritis nodosa presenting as haematuria following strenuous exercise.

BMJ Case Rep 2012 Nov 27;2012. Epub 2012 Nov 27.

Department of Urology, Western General Hospital, Edinburgh, UK.

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November 2012

Assessment of gene-by-sex interaction effect on bone mineral density.

J Bone Miner Res 2012 Oct;27(10):2051-64

Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue CT3, Boston,MA 02118, USA.

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October 2012

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

Lancet 2012 Sep 3;380(9844):815-23. Epub 2012 Jul 3.

Wellcome Trust Sanger Institute, Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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September 2012

Pathogenesis of Paget disease of bone.

Calcif Tissue Int 2012 Aug 29;91(2):97-113. Epub 2012 Apr 29.

Rheumatic Diseases Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.

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August 2012

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

Authors:
Karol Estrada Unnur Styrkarsdottir Evangelos Evangelou Yi-Hsiang Hsu Emma L Duncan Evangelia E Ntzani Ling Oei Omar M E Albagha Najaf Amin John P Kemp Daniel L Koller Guo Li Ching-Ti Liu Ryan L Minster Alireza Moayyeri Liesbeth Vandenput Dana Willner Su-Mei Xiao Laura M Yerges-Armstrong Hou-Feng Zheng Nerea Alonso Joel Eriksson Candace M Kammerer Stephen K Kaptoge Paul J Leo Gudmar Thorleifsson Scott G Wilson James F Wilson Ville Aalto Markku Alen Aaron K Aragaki Thor Aspelund Jacqueline R Center Zoe Dailiana David J Duggan Melissa Garcia Natàlia Garcia-Giralt Sylvie Giroux Göran Hallmans Lynne J Hocking Lise Bjerre Husted Karen A Jameson Rita Khusainova Ghi Su Kim Charles Kooperberg Theodora Koromila Marcin Kruk Marika Laaksonen Andrea Z Lacroix Seung Hun Lee Ping C Leung Joshua R Lewis Laura Masi Simona Mencej-Bedrac Tuan V Nguyen Xavier Nogues Millan S Patel Janez Prezelj Lynda M Rose Serena Scollen Kristin Siggeirsdottir Albert V Smith Olle Svensson Stella Trompet Olivia Trummer Natasja M van Schoor Jean Woo Kun Zhu Susana Balcells Maria Luisa Brandi Brendan M Buckley Sulin Cheng Claus Christiansen Cyrus Cooper George Dedoussis Ian Ford Morten Frost David Goltzman Jesús González-Macías Mika Kähönen Magnus Karlsson Elza Khusnutdinova Jung-Min Koh Panagoula Kollia Bente Lomholt Langdahl William D Leslie Paul Lips Östen Ljunggren Roman S Lorenc Janja Marc Dan Mellström Barbara Obermayer-Pietsch José M Olmos Ulrika Pettersson-Kymmer David M Reid José A Riancho Paul M Ridker François Rousseau P Eline Slagboom Nelson L S Tang Roser Urreizti Wim Van Hul Jorma Viikari María T Zarrabeitia Yurii S Aulchenko Martha Castano-Betancourt Elin Grundberg Lizbeth Herrera Thorvaldur Ingvarsson Hrefna Johannsdottir Tony Kwan Rui Li Robert Luben Carolina Medina-Gómez Stefan Th Palsson Sjur Reppe Jerome I Rotter Gunnar Sigurdsson Joyce B J van Meurs Dominique Verlaan Frances M K Williams Andrew R Wood Yanhua Zhou Kaare M Gautvik Tomi Pastinen Soumya Raychaudhuri Jane A Cauley Daniel I Chasman Graeme R Clark Steven R Cummings Patrick Danoy Elaine M Dennison Richard Eastell John A Eisman Vilmundur Gudnason Albert Hofman Rebecca D Jackson Graeme Jones J Wouter Jukema Kay-Tee Khaw Terho Lehtimäki Yongmei Liu Mattias Lorentzon Eugene McCloskey Braxton D Mitchell Kannabiran Nandakumar Geoffrey C Nicholson Ben A Oostra Munro Peacock Huibert A P Pols Richard L Prince Olli Raitakari Ian R Reid John Robbins Philip N Sambrook Pak Chung Sham Alan R Shuldiner Frances A Tylavsky Cornelia M van Duijn Nick J Wareham L Adrienne Cupples Michael J Econs David M Evans Tamara B Harris Annie Wai Chee Kung Bruce M Psaty Jonathan Reeve Timothy D Spector Elizabeth A Streeten M Carola Zillikens Unnur Thorsteinsdottir Claes Ohlsson David Karasik J Brent Richards Matthew A Brown Kari Stefansson André G Uitterlinden Stuart H Ralston John P A Ioannidis Douglas P Kiel Fernando Rivadeneira

Nat Genet 2012 Apr 15;44(5):491-501. Epub 2012 Apr 15.

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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April 2012

Analysis of transcriptional regulation in bone cells.

Methods Mol Biol 2012 ;816:233-47

Kennedy Institute of Rheumatology, London, UK.

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March 2012

A class III semaphorin (Sema3e) inhibits mouse osteoblast migration and decreases osteoclast formation in vitro.

Calcif Tissue Int 2012 Feb 7;90(2):151-62. Epub 2012 Jan 7.

Musculoskeletal Research Programme, School of Medicine & Dentistry, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK.

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February 2012

Genetic determinants of Paget's disease of bone.

Ann N Y Acad Sci 2011 Dec;1240:53-60

Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, United Kingdom.

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December 2011

Signal peptide mutations in RANK prevent downstream activation of NF-κB.

J Bone Miner Res 2011 Aug;26(8):1926-38

Musculoskeletal Research Program, University of Aberdeen Medical School, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom.

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August 2011

The type 2 cannabinoid receptor regulates bone mass and ovariectomy-induced bone loss by affecting osteoblast differentiation and bone formation.

Endocrinology 2011 Jun 29;152(6):2141-9. Epub 2011 Mar 29.

Rheumatic Diseases Unit, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.

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June 2011

Randomized trial of alendronate plus vitamin D3 versus standard care in osteoporotic postmenopausal women with vitamin D insufficiency.

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Rheumatic Diseases Unit, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, UK.

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Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.

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Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.

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The biphenyl-carboxylate derivative ABD328 is a novel orally active antiresorptive agent.

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Rheumatic Diseases Unit, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.

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December 2010

Small molecule inhibitors of IkappaB kinase signaling inhibit osteoclast formation in vitro and prevent ovariectomy-induced bone loss in vivo.

FASEB J 2010 Nov 20;24(11):4545-55. Epub 2010 Jul 20.

Institute of Genetic and Molecular Medicine, University of Edinburgh, General Western Hospital, Edinburgh, UK.

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November 2010

Cannabinoids and bone: friend or foe?

Calcif Tissue Int 2010 Oct 9;87(4):285-97. Epub 2010 Jun 9.

Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Scotland, UK.

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October 2010

Risk of upper gastrointestinal tract events in risedronate users switched to alendronate.

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Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, UK.

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October 2010

Discovery of biphenylketones as dual modulators of inflammation and bone loss.

Bioorg Med Chem Lett 2010 Sep 18;20(18):5548-51. Epub 2010 Jul 18.

School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom.

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September 2010