Stuart H Orkin

Stuart H Orkin

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Stuart H Orkin

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CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis.

Genome Biol 2019 09 9;20(1):192. Epub 2019 Sep 9.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1186/s13059-019-1802-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734249PMC
September 2019

TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.

Mol Cell 2019 Jun 17;74(6):1148-1163.e7. Epub 2019 Apr 17.

Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Wellington Road, Clayton, VIC 3800, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193022
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http://dx.doi.org/10.1016/j.molcel.2019.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671628PMC
June 2019

Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA.

Mol Cell 2019 05 21;74(3):542-554.e5. Epub 2019 Mar 21.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499659PMC
May 2019

Emerging Genetic Therapy for Sickle Cell Disease.

Annu Rev Med 2019 01 24;70:257-271. Epub 2018 Oct 24.

Dana Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA; email:

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https://www.annualreviews.org/doi/10.1146/annurev-med-041817
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http://dx.doi.org/10.1146/annurev-med-041817-125507DOI Listing
January 2019

Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.

Cell Rep 2018 12;25(12):3504-3518.e6

Prostate Oncobiology, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, UK; Belfast-Manchester Movember Centre of Excellence, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183184
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http://dx.doi.org/10.1016/j.celrep.2018.11.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315111PMC
December 2018

Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment.

Sci Rep 2018 09 25;8(1):14335. Epub 2018 Sep 25.

Department of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park, Smithville, Texas, 78957, USA.

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http://www.nature.com/articles/s41598-018-32729-z
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http://dx.doi.org/10.1038/s41598-018-32729-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156232PMC
September 2018

Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments.

Nat Protoc 2018 05 12;13(5):946-986. Epub 2018 Apr 12.

Molecular Pathology Unit and Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.nature.com/doifinder/10.1038/nprot.2018.005
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http://dx.doi.org/10.1038/nprot.2018.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182299PMC
May 2018

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.

Sci Rep 2018 05 22;8(1):8001. Epub 2018 May 22.

Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School Boston, MA, 02115, Boston, USA.

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http://dx.doi.org/10.1038/s41598-018-26123-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964225PMC
May 2018

Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch.

Cell 2018 04 29;173(2):430-442.e17. Epub 2018 Mar 29.

Cancer and Blood Disorders Center, Dana Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183029
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http://dx.doi.org/10.1016/j.cell.2018.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889339PMC
April 2018

Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies.

Br J Haematol 2018 03 28;180(5):630-643. Epub 2017 Nov 28.

Boston Children's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1111/bjh.15038DOI Listing
March 2018

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

Cancer Cell 2018 03 22;33(3):386-400.e5. Epub 2018 Feb 22.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849534PMC
March 2018

Dissecting super-enhancer hierarchy based on chromatin interactions.

Nat Commun 2018 03 5;9(1):943. Epub 2018 Mar 5.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41467-018-03279-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838163PMC
March 2018

Mapping the Mouse Cell Atlas by Microwell-Seq.

Cell 2018 02;172(5):1091-1107.e17

Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; Institute of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Stem Cell Institute, Zhejiang University, Hangzhou 310058, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183011
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http://dx.doi.org/10.1016/j.cell.2018.02.001DOI Listing
February 2018

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

Cancer Res 2017 09 27;77(17):4613-4625. Epub 2017 Jun 27.

Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581676PMC
September 2017

Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells.

Stem Cells 2017 07 24;35(7):1773-1785. Epub 2017 Apr 24.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/stem.2627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532742PMC
July 2017

The 2017 ASPHO distinguished career award goes to Holcombe E. Grier, MD.

Pediatr Blood Cancer 2017 06;64 Suppl 1

Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/pbc.26483DOI Listing
June 2017

Functional interrogation of non-coding DNA through CRISPR genome editing.

Methods 2017 05 10;121-122:118-129. Epub 2017 Mar 10.

Harvard Medical School, Boston, MA 02115, United States; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, United States; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, United States; Howard Hughes Medical Institute, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483188PMC
May 2017

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.

Nat Genet 2017 Apr 20;49(4):625-634. Epub 2017 Feb 20.

Division of Hematology/Oncology, Boston Children's Hospital; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Harvard Stem Cell Institute; and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374001PMC
April 2017

EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent.

Elife 2017 04 10;6. Epub 2017 Apr 10.

Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China.

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http://dx.doi.org/10.7554/eLife.24570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400508PMC
April 2017

The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells.

Nat Immunol 2017 02 19;18(2):184-195. Epub 2016 Dec 19.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA, and Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.3644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247321PMC
February 2017

Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2.

Cancer Discov 2016 11 14;6(11):1237-1247. Epub 2016 Sep 14.

Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096974PMC
November 2016

Hemoglobin genetics: recent contributions of GWAS and gene editing.

Hum Mol Genet 2016 10 23;25(R2):R99-R105. Epub 2016 Jun 23.

Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA Howard Hughes Medical Institute, Boston, MA 02115, USA

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http://dx.doi.org/10.1093/hmg/ddw170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036874PMC
October 2016

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.

Exp Hematol 2016 10 1;44(10):947-63. Epub 2016 Jul 1.

St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.06.250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035604PMC
October 2016

Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease.

Am J Hematol 2016 09 14;91(9):931-7. Epub 2016 Jul 14.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ajh.24449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093908PMC
September 2016

Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype.

Cell Rep 2016 09;16(12):3181-3194

Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Stem Cell Institute, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054719PMC
http://dx.doi.org/10.1016/j.celrep.2016.08.064DOI Listing
September 2016

Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells.

Cell Rep 2016 08 11;16(8):2053-2060. Epub 2016 Aug 11.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001892PMC
August 2016

Interferon-α signaling promotes embryonic HSC maturation.

Blood 2016 07 19;128(2):204-16. Epub 2016 Apr 19.

Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA; Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA; and.

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http://dx.doi.org/10.1182/blood-2016-01-689281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946201PMC
July 2016

An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation.

Cancer Discov 2016 07;6(7):700-2

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Harvard Stem Cell Institute, Cambridge, Massachusetts. Howard Hughes Medical Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0564DOI Listing
July 2016

Analyzing CRISPR genome-editing experiments with CRISPResso.

Nat Biotechnol 2016 07;34(7):695-7

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.3583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242601PMC
July 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells.

Cell 2016 Jun 19;165(6):1389-1400. Epub 2016 May 19.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.04.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893000PMC
June 2016

Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling.

Nat Commun 2016 06 22;7:12047. Epub 2016 Jun 22.

Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/ncomms12047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917962PMC
June 2016

Customizing the genome as therapy for the β-hemoglobinopathies.

Blood 2016 05 6;127(21):2536-45. Epub 2016 Apr 6.

Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA; Department of Pediatrics, Harvard Medical School and Harvard Stem Cell Institute, Harvard University, Boston, MA; and Howard Hughes Medical Institute, Boston, MA.

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http://dx.doi.org/10.1182/blood-2016-01-678128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882803PMC
May 2016

MEDICINE. Paying for future success in gene therapy.

Science 2016 May;352(6289):1059-61

Third Rock Ventures, Boston, MA 02116, USA.

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http://dx.doi.org/10.1126/science.aaf4770DOI Listing
May 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

Recent advances in globin research using genome-wide association studies and gene editing.

Authors:
Stuart H Orkin

Ann N Y Acad Sci 2016 03 11;1368(1):5-10. Epub 2016 Feb 11.

Dana Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1111/nyas.13001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870148PMC
March 2016

Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.

Cell Rep 2016 Mar 18;14(8):1953-65. Epub 2016 Feb 18.

Department of Pediatrics, Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation, University of Colorado Denver, Aurora, CO 80045, USA; Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO 80045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790111PMC
March 2016

Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.

Blood 2016 Feb 12;127(7):839-48. Epub 2016 Jan 12.

Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA; and.

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http://dx.doi.org/10.1182/blood-2015-09-618587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760089PMC
February 2016

Serum-Based Culture Conditions Provoke Gene Expression Variability in Mouse Embryonic Stem Cells as Revealed by Single-Cell Analysis.

Cell Rep 2016 Feb 21;14(4):956-965. Epub 2016 Jan 21.

Division of Pediatric Hematology/Oncology, Dana Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247150154
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http://dx.doi.org/10.1016/j.celrep.2015.12.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740311PMC
February 2016

LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice.

Nat Commun 2015 Dec 2;6:10116. Epub 2015 Dec 2.

Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, 1808 Park Road 1C, Smithville, Texas 78957, USA.

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http://dx.doi.org/10.1038/ncomms10116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686821PMC
December 2015

Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.

Proc Natl Acad Sci U S A 2015 Dec 14;112(52):15988-93. Epub 2015 Dec 14.

Department of Cell Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Laboratory of Epigenetics in Development and Tumorigenesis, Tianjin Research Center of Basic Medical Sciences, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China;

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http://dx.doi.org/10.1073/pnas.1521740112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702963PMC
December 2015

Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.

Exp Hematol 2015 Nov 26;43(11):930-935.e6. Epub 2015 Jun 26.

Center for Cancer and Blood Disorders, Children's Hospital Colorado, and Department of Pediatrics, Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation, University of Colorado Denver, 13123 East 16th Avenue, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1016/j.exphem.2015.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630114PMC
November 2015

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.

Nature 2015 Nov 16;527(7577):192-7. Epub 2015 Sep 16.

Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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https://pdfs.semanticscholar.org/1ddb/3d38167d122b418b8d6968
Web Search
http://www.nature.com/doifinder/10.1038/nature15521
Publisher Site
http://dx.doi.org/10.1038/nature15521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644101PMC
November 2015

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.

Blood 2015 Oct 28;126(16):1930-9. Epub 2015 Aug 28.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA;

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http://dx.doi.org/10.1182/blood-2015-06-649087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608240PMC
October 2015

PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells.

Cell Rep 2015 Sep 20;12(9):1456-70. Epub 2015 Aug 20.

Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute (DFCI), Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute (HHMI), Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.07.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384103PMC
September 2015

Failure to replicate the STAP cell phenomenon.

Nature 2015 Sep;525(7570):E6-9

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature15513DOI Listing
September 2015

Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.

Curr Opin Genet Dev 2015 Aug 14;33:62-70. Epub 2015 Sep 14.

Boston Children's Hospital, Boston, MA 02115, United States; Dana-Farber Cancer Institute, Boston, MA 02115, United States; Harvard Medical School, Boston, MA 02115, United States; Harvard Stem Cell Institute, Cambridge, MA 02138, United States; Howard Hughes Medical Institute, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705561PMC
August 2015

Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.

Mol Cell Proteomics 2015 Jun 13;14(6):1435-46. Epub 2015 Feb 13.

From the ‡Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02143;

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http://dx.doi.org/10.1074/mcp.M114.044586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458711PMC
June 2015

Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2.

J Neurosci 2015 Jun;35(22):8640-52

Waisman Center, Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin 53705, and

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http://dx.doi.org/10.1523/JNEUROSCI.2257-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452560PMC
June 2015

Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence.

J Exp Med 2015 May 13;212(5):633-48. Epub 2015 Apr 13.

Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute; Howard Hughes Medical Institute, Harvard Stem Cell Institute; Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute; Howard Hughes Medical Institute, Harvard Stem Cell Institute; Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute; Howard Hughes Medical Institute, Harvard Stem Cell Institute; Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute; and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115

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http://www.jem.org/lookup/doi/10.1084/jem.20141514
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http://dx.doi.org/10.1084/jem.20141514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419355PMC
May 2015

Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation.

Cell Stem Cell 2015 May 16;16(5):504-16. Epub 2015 Apr 16.

Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909150011
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http://dx.doi.org/10.1016/j.stem.2015.03.007DOI Listing
May 2015

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.

Sci Signal 2015 Apr 14;8(372):ra34. Epub 2015 Apr 14.

Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Division of Hematology-Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.aaa5903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402725PMC
April 2015

Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence.

EMBO J 2015 Mar 6;34(6):759-77. Epub 2015 Jan 6.

Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, CA, USA

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http://dx.doi.org/10.15252/embj.201490542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369313PMC
March 2015

2014 William Allan Award: A hematologist's pursuit of hemoglobin genetics.

Authors:
Stuart H Orkin

Am J Hum Genet 2015 Mar;96(3):354-60

Dana Farber Cancer Institute - Boston Children's Hospital Cancer and Blood Disorders Center, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375649PMC
March 2015

Generation of genomic deletions in mammalian cell lines via CRISPR/Cas9.

J Vis Exp 2015 Jan 3(95):e52118. Epub 2015 Jan 3.

Harvard Medical School; Division of Hematology/Oncology, Boston Children's Hospital; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Howard Hughes Medical Institute;

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http://dx.doi.org/10.3791/52118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279820PMC
January 2015

Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions.

Mol Cell 2015 Jan 8;57(2):304-316. Epub 2015 Jan 8.

Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765140095
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http://dx.doi.org/10.1016/j.molcel.2014.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305004PMC
January 2015

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production.

Genes Dev 2014 Dec 13;28(23):2597-612. Epub 2014 Nov 13.

Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19014, USA;

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http://dx.doi.org/10.1101/gad.253302.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248291PMC
December 2014

A comparative encyclopedia of DNA elements in the mouse genome.

Authors:
Feng Yue Yong Cheng Alessandra Breschi Jeff Vierstra Weisheng Wu Tyrone Ryba Richard Sandstrom Zhihai Ma Carrie Davis Benjamin D Pope Yin Shen Dmitri D Pervouchine Sarah Djebali Robert E Thurman Rajinder Kaul Eric Rynes Anthony Kirilusha Georgi K Marinov Brian A Williams Diane Trout Henry Amrhein Katherine Fisher-Aylor Igor Antoshechkin Gilberto DeSalvo Lei-Hoon See Meagan Fastuca Jorg Drenkow Chris Zaleski Alex Dobin Pablo Prieto Julien Lagarde Giovanni Bussotti Andrea Tanzer Olgert Denas Kanwei Li M A Bender Miaohua Zhang Rachel Byron Mark T Groudine David McCleary Long Pham Zhen Ye Samantha Kuan Lee Edsall Yi-Chieh Wu Matthew D Rasmussen Mukul S Bansal Manolis Kellis Cheryl A Keller Christapher S Morrissey Tejaswini Mishra Deepti Jain Nergiz Dogan Robert S Harris Philip Cayting Trupti Kawli Alan P Boyle Ghia Euskirchen Anshul Kundaje Shin Lin Yiing Lin Camden Jansen Venkat S Malladi Melissa S Cline Drew T Erickson Vanessa M Kirkup Katrina Learned Cricket A Sloan Kate R Rosenbloom Beatriz Lacerda de Sousa Kathryn Beal Miguel Pignatelli Paul Flicek Jin Lian Tamer Kahveci Dongwon Lee W James Kent Miguel Ramalho Santos Javier Herrero Cedric Notredame Audra Johnson Shinny Vong Kristen Lee Daniel Bates Fidencio Neri Morgan Diegel Theresa Canfield Peter J Sabo Matthew S Wilken Thomas A Reh Erika Giste Anthony Shafer Tanya Kutyavin Eric Haugen Douglas Dunn Alex P Reynolds Shane Neph Richard Humbert R Scott Hansen Marella De Bruijn Licia Selleri Alexander Rudensky Steven Josefowicz Robert Samstein Evan E Eichler Stuart H Orkin Dana Levasseur Thalia Papayannopoulou Kai-Hsin Chang Arthur Skoultchi Srikanta Gosh Christine Disteche Piper Treuting Yanli Wang Mitchell J Weiss Gerd A Blobel Xiaoyi Cao Sheng Zhong Ting Wang Peter J Good Rebecca F Lowdon Leslie B Adams Xiao-Qiao Zhou Michael J Pazin Elise A Feingold Barbara Wold James Taylor Ali Mortazavi Sherman M Weissman John A Stamatoyannopoulos Michael P Snyder Roderic Guigo Thomas R Gingeras David M Gilbert Ross C Hardison Michael A Beer Bing Ren

Nature 2014 Nov;515(7527):355-64

Ludwig Institute for Cancer Research and University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nature13992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266106PMC
November 2014