Stuart A Lipton

Stuart A Lipton

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Stuart A Lipton

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NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model.

Neurobiol Dis 2019 07 27;127:390-397. Epub 2019 Mar 27.

Scintillon Institute, San Diego, CA 92121, USA; Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA; Neuroscience Translational Center, Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.03.029DOI Listing
July 2019

Novel Direct Conversion of Microglia to Neurons.

Trends Mol Med 2019 02 2;25(2):72-74. Epub 2019 Jan 2.

Neuroscience Translational Center and Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Neurosciences, School of Medicine, University of California-San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384091PMC
February 2019

The mouse as a model for neuropsychiatric drug development.

Curr Biol 2018 Sep;28(17):R909-R914

Departments of Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2018.07.046DOI Listing
September 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

'SNO'-Storms Compromise Protein Activity and Mitochondrial Metabolism in Neurodegenerative Disorders.

Trends Endocrinol Metab 2017 12 30;28(12):879-892. Epub 2017 Oct 30.

Neuroscience Translational Center, and Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121, USA; Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701818PMC
December 2017

Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease.

Nat Commun 2017 11 10;8(1):1403. Epub 2017 Nov 10.

Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1038/s41467-017-01096-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680235PMC
November 2017

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models.

Cell Rep 2017 Nov;21(8):2171-2182

Departments of Molecular Medicine and Neuroscience and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Neurodegenerative Disease Center, Scintillon Institute, San Diego, CA 92121, USA; Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705204PMC
November 2017

Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency.

Invest Ophthalmol Vis Sci 2017 07;58(9):3741-3749

Neuroscience and Aging Research Center and Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States 2Neurodegenerative Disease Center, Scintillon Institute, San Diego, California, United States 3Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California, United States 4Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, United States.

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http://dx.doi.org/10.1167/iovs.17-21767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525556PMC
July 2017

MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress.

Proc Natl Acad Sci U S A 2017 05 1;114(20):E4048-E4056. Epub 2017 May 1.

Neuroscience and Aging Research Center and Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037;

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http://dx.doi.org/10.1073/pnas.1613067114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441815PMC
May 2017

S-Nitrosylation Induces Structural and Dynamical Changes in a Rhodanese Family Protein.

J Mol Biol 2016 09 27;428(19):3737-51. Epub 2016 Jul 27.

Laboratory of Physical Chemistry, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093 Zürich, Switzerland; Structural Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260856PMC
September 2016

Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities.

Lancet Neurol 2016 09 8;15(10):1089-102. Epub 2016 Aug 8.

INSERM U919, University of Caen Normandy, Caen, France. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(16)30165-XDOI Listing
September 2016

Levetiracetam inhibits oligomeric Aβ-induced glutamate release from human astrocytes.

Neuroreport 2016 06;27(9):705-9

aNeurodegenerative Disease Center, Scintillon Institute bDepartment of Neurosciences, School of Medicine, University of California, San Diego cDel E. Webb Center for Neuroscience, Aging and Stem Cell Research, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1097/WNR.0000000000000601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874889PMC
June 2016

Partnering with Big Pharma-What Academics Need to Know.

Cell 2016 Apr;165(3):512-5

Eli Lilly and Company, Indianapolis, IN 46285, USA.

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http://www.cell.com/cell/pdf/S0092-8674(16)30412-3.pdf
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http://dx.doi.org/10.1016/j.cell.2016.04.021DOI Listing
April 2016

Nitrosative Stress in the Nervous System: Guidelines for Designing Experimental Strategies to Study Protein S-Nitrosylation.

Neurochem Res 2016 Mar 29;41(3):510-4. Epub 2015 Jun 29.

Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1007/s11064-015-1640-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695327PMC
March 2016

Differential Effects of Pharmacologic and Genetic Modulation of NMDA Receptor Activity on HIV/gp120-Induced Neuronal Damage in an In Vivo Mouse Model.

J Mol Neurosci 2016 Jan 15;58(1):59-65. Epub 2015 Sep 15.

Center for Neuroscience and Aging Research, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.

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http://link.springer.com/10.1007/s12031-015-0651-1
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http://dx.doi.org/10.1007/s12031-015-0651-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821006PMC
January 2016

Protein S-Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases.

Trends Pharmacol Sci 2016 Jan 17;37(1):73-84. Epub 2015 Dec 17.

Scintillon Institute, San Diego, CA 92121, USA; Department of Neurosciences, University of California, San Diego School of Medicine, La Jolla, CA 92039, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2015.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698225PMC
January 2016

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation.

Nat Commun 2016 Jan 8;7:10242. Epub 2016 Jan 8.

Center for Neuroscience and Aging Research, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Avenue, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/ncomms10242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729876PMC
January 2016

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases.

Neurobiol Dis 2015 Dec 18;84:99-108. Epub 2015 Mar 18.

Neuroscience and Aging Research Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Biomedical Sciences Graduate Program, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Neurosciences, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575233PMC
December 2015

Granulocyte-colony stimulating factor as a treatment for diabetic neuropathy in rat.

Mol Cell Endocrinol 2015 Oct 17;414:64-72. Epub 2015 Jul 17.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, CA, USA; Department of Neurosciences, School of Medicine, University of California at San Diego, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2015.07.014DOI Listing
October 2015

Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress.

Sci Rep 2015 Oct 8;5:14812. Epub 2015 Oct 8.

Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.

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http://dx.doi.org/10.1038/srep14812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597200PMC
October 2015

S-Nitrosylation in neurogenesis and neuronal development.

Biochim Biophys Acta 2015 Aug 18;1850(8):1588-93. Epub 2014 Dec 18.

Neuroscience and Aging Research Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2014.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441575PMC
August 2015

Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid.

J Neurochem 2015 Jun 11;133(6):898-908. Epub 2015 Mar 11.

Neuroscience and Aging Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1111/jnc.13074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465065PMC
June 2015

Transcriptional profiling of MEF2-regulated genes in human neural progenitor cells derived from embryonic stem cells.

Genom Data 2015 Mar;3:24-27

Neuroscience and Aging Research Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1016/j.gdata.2014.10.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255278PMC
March 2015

Zonarol, a sesquiterpene from the brown algae Dictyopteris undulata, provides neuroprotection by activating the Nrf2/ARE pathway.

Biochem Biophys Res Commun 2015 Feb 23;457(4):718-22. Epub 2015 Jan 23.

Department of Anti-Aging Food Research, School of Bioscience and Biotechnology, Tokyo University of Technology, Hachioji 192-0982, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.01.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577281PMC
February 2015

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease.

Mol Neurodegener 2014 Nov 14;9:48. Epub 2014 Nov 14.

Neuroscience and Aging Research Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1186/1750-1326-9-48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237769PMC
November 2014

Stephen F. Heinemann: 1939-2014.

Cell 2014 Oct;159(2):231-2

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http://dx.doi.org/10.1016/j.cell.2014.09.042DOI Listing
October 2014

Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells.

J Comp Neurol 2014 Aug 7;522(12):2845-56. Epub 2014 May 7.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California, 92037.

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http://dx.doi.org/10.1002/cne.23617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388243PMC
August 2014

Differential effects of synaptic and extrasynaptic NMDA receptors on Aβ-induced nitric oxide production in cerebrocortical neurons.

J Neurosci 2014 Apr;34(14):5023-8

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037.

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http://dx.doi.org/10.1523/JNEUROSCI.2907-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972726PMC
April 2014

ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage.

J Neurosci 2014 Mar;34(13):4640-53

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, and Proteomics Facility, Sanford-Burnham Medical Research Institute, La Jolla, California 92037.

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http://dx.doi.org/10.1523/JNEUROSCI.2510-12.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965787PMC
March 2014

Reprint of: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs.

Free Radic Biol Med 2014 Jan 18;66:45-57. Epub 2013 Nov 18.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849130149
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http://dx.doi.org/10.1016/j.freeradbiomed.2013.11.002DOI Listing
January 2014

Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells.

Cell Res 2014 Jan 3;24(1):126-9. Epub 2013 Dec 3.

Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1038/cr.2013.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879704PMC
January 2014

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs.

Free Radic Biol Med 2013 Dec 25;65:645-657. Epub 2013 Jul 25.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849130036
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http://dx.doi.org/10.1016/j.freeradbiomed.2013.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859717PMC
December 2013

S-nitrosylation of dynamin-related protein 1 mediates mutant huntingtin-induced mitochondrial fragmentation and neuronal injury in Huntington's disease.

Antioxid Redox Signal 2013 Oct 20;19(11):1173-84. Epub 2013 Jun 20.

1 Sanford-Burnham Medical Research Institute , Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, La Jolla, California.

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http://dx.doi.org/10.1089/ars.2012.4928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785802PMC
October 2013

Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites.

J Neurosci 2013 Aug;33(35):14170-83

Del E. Web Center for Neuroscience, Aging, and Stem Cell Research, and Bioinformatics Shared Resource, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4646-10.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756761PMC
August 2013

Aberrant protein s-nitrosylation in neurodegenerative diseases.

Neuron 2013 May;78(4):596-614

Del E. Web Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712898PMC
May 2013

Genetic deletion of NR3A accelerates glutamatergic synapse maturation.

PLoS One 2012 1;7(8):e42327. Epub 2012 Aug 1.

Curriculum in Neurobiology, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042327PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411625PMC
February 2013

S-nitrosylation of Cdk5: potential implications in amyloid-β-related neurotoxicity in Alzheimer disease.

Prion 2012 Sep-Oct;6(4):364-70. Epub 2012 Aug 9.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.

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http://www.tandfonline.com/doi/abs/10.4161/pri.21250
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http://dx.doi.org/10.4161/pri.21250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609065PMC
February 2013

S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke.

Proc Natl Acad Sci U S A 2013 Feb 4;110(8):3137-42. Epub 2013 Feb 4.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1215501110
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http://dx.doi.org/10.1073/pnas.1215501110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581884PMC
February 2013

Emerging role of protein-protein transnitrosylation in cell signaling pathways.

Antioxid Redox Signal 2013 Jan 9;18(3):239-49. Epub 2012 Jul 9.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1089/ars.2012.4703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518546PMC
January 2013

Dysfunctional Mitochondrial Dynamics in the Pathophysiology of Neurodegenerative Diseases.

J Cell Death 2013 ;6:27-35

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, CA.

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http://journals.sagepub.com/doi/10.4137/JCD.S10847
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http://dx.doi.org/10.4137/JCD.S10847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935363PMC
January 2013

Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases.

Exp Neurol 2012 Nov 5;238(1):12-21. Epub 2012 Jul 5.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.expneurol.2012.06.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645978PMC
November 2012

Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration.

Invest Ophthalmol Vis Sci 2012 Nov 27;53(12):7847-54. Epub 2012 Nov 27.

Del E Web Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1167/iovs.12-10793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508754PMC
November 2012

High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons.

J Neurosci 2012 Nov;32(45):15837-42

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3735-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513396PMC
November 2012

Redox Regulation of Protein Function via Cysteine S-Nitrosylation and Its Relevance to Neurodegenerative Diseases.

Int J Cell Biol 2012 16;2012:463756. Epub 2012 Aug 16.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.hindawi.com/journals/ijcb/2012/463756/
Publisher Site
http://dx.doi.org/10.1155/2012/463756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431077PMC
September 2012

MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model.

PLoS One 2011 25;6(8):e24027. Epub 2011 Aug 25.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162026PMC
April 2012

Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors.

Proc Natl Acad Sci U S A 2012 Jan 17;109(5):1737-42. Epub 2012 Jan 17.

Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada T2N 4N1.

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http://dx.doi.org/10.1073/pnas.1110789109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277185PMC
January 2012

Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions.

Cell Stem Cell 2011 Aug 28;9(2):113-8. Epub 2011 Jul 28.

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.stem.2011.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567246PMC
August 2011

S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide.

Proc Natl Acad Sci U S A 2011 Aug 15;108(34):14330-5. Epub 2011 Aug 15.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1105172108
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http://dx.doi.org/10.1073/pnas.1105172108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161554PMC
August 2011

Direct reprogramming of mouse fibroblasts to neural progenitors.

Proc Natl Acad Sci U S A 2011 May 26;108(19):7838-43. Epub 2011 Apr 26.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1103113108
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http://dx.doi.org/10.1073/pnas.1103113108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093517PMC
May 2011

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation.

Mol Neurodegener 2011 May 19;6:34. Epub 2011 May 19.

Department of Pathology & Anatomical Sciences, Center for Translational Neuroscience, University of Missouri-Columbia School of Medicine, Columbia, MO, USA.

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http://dx.doi.org/10.1186/1750-1326-6-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120712PMC
May 2011

S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases.

Antioxid Redox Signal 2011 Apr 8;14(8):1479-92. Epub 2011 Jan 8.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1089/ars.2010.3570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061195PMC
April 2011

Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes.

Antioxid Redox Signal 2011 Apr 28;14(8):1421-4. Epub 2011 Feb 28.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom.

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http://www.liebertpub.com/doi/10.1089/ars.2010.3573
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April 2011

Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases.

Apoptosis 2010 Nov;15(11):1354-63

Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/s10495-010-0476-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978885PMC
November 2010

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration.

Mol Neurodegener 2010 Nov 10;5:49. Epub 2010 Nov 10.

Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA.

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http://dx.doi.org/10.1186/1750-1326-5-49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992530PMC
November 2010

Mitochondrial dynamics in cell death and neurodegeneration.

Cell Mol Life Sci 2010 Oct 25;67(20):3435-47. Epub 2010 Jun 25.

Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://link.springer.com/10.1007/s00018-010-0435-2
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October 2010

S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration.

Mitochondrion 2010 Aug 4;10(5):573-8. Epub 2010 May 4.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.mito.2010.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918703PMC
August 2010

Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses.

J Neurosci 2010 Aug;30(33):11246-50

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.2488-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932667PMC
August 2010

Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits.

J Neurosci 2010 Aug;30(34):11501-5

Molecular Neurobiology Laboratory, Salk Institute, and Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1593-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941801PMC
August 2010

Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death.

Mol Cell 2010 Jul;39(2):184-95

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924818PMC
July 2010

Redox reactions induced by nitrosative stress mediate protein misfolding and mitochondrial dysfunction in neurodegenerative diseases.

Mol Neurobiol 2010 Jun 25;41(2-3):55-72. Epub 2010 Mar 25.

Department of Pathology and Anatomical Sciences, University of Missouri-Columbia School of Medicine, One Hospital Drive, Columbia, MO 65212, USA.

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http://dx.doi.org/10.1007/s12035-010-8113-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586261PMC
June 2010

Protection of retinal ganglion cells by caspase substrate-binding peptide IQACRG from N-methyl-D-aspartate receptor-mediated excitotoxicity.

Invest Ophthalmol Vis Sci 2010 Feb 8;51(2):1198-207. Epub 2009 Oct 8.

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1167/iovs.09-4102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868456PMC
February 2010

Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies.

Cell Calcium 2010 Feb 8;47(2):190-7. Epub 2010 Jan 8.

Center for Neuroscience, Aging and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.ceca.2009.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875138PMC
February 2010

Type C botulinum toxin causes degeneration of motoneurons in vivo.

Neuroreport 2010 Jan;21(1):14-18

Center for Neuroscience, Aging and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California, USA.

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http://dx.doi.org/10.1097/WNR.0b013e328330dccaDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351749PMC
January 2010

Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke. Laboratory investigation.

J Neurosurg 2009 Jul;111(1):164-70

Department of Neurosurgery, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229, USA.

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http://dx.doi.org/10.3171/2009.2.JNS081199DOI Listing
July 2009

According to GOSPEL: filling in the GAP(DH) of NO-mediated neurotoxicity.

Neuron 2009 Jul;63(1):3-6

Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.neuron.2009.06.013DOI Listing
July 2009

S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.

Science 2009 Apr;324(5923):102-5

Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.sciencemag.org/lookup/doi/10.1126/science.1171091
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http://dx.doi.org/10.1126/science.1171091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823371PMC
April 2009

Neuroprotection by the NR3A subunit of the NMDA receptor.

J Neurosci 2009 Apr;29(16):5260-5

Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1067-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703294PMC
April 2009