Stuart A Cook

Stuart A Cook

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Stuart A Cook

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Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.

Gastroenterology 2019 09 9;157(3):777-792.e14. Epub 2019 May 9.

Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore; National Heart and Lung Institute, Imperial College London, London, UK; MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London, UK. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.05.002DOI Listing
September 2019

Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins.

Circulation 2019 Sep 9;140(11):937-951. Epub 2019 Jul 9.

Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore (S.C., S.S., E.A., S.V., A.W., S.L., M.W., G.D., S.G.S., B.L.G., S.L., E.Y.C., E.C., J.D., S.A.C., O.J.L.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039596DOI Listing
September 2019

The Translational Landscape of the Human Heart.

Cell 2019 Jun 30;178(1):242-260.e29. Epub 2019 May 30.

Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347 Berlin, Germany; Berlin Institute of Health (BIH), 10178 Berlin, Germany; Charité-Universitätsmedizin, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.05.010DOI Listing
June 2019

Sudden Death and Left Ventricular Involvement in Arrhythmogenic Cardiomyopathy.

Circulation 2019 Apr;139(15):1786-1797

Cardiology Clinical Academic Group, St George's University Hospitals' NHS Foundation Trust and Molecular and Clinical Sciences Institute, St George's University of London, United Kingdom (C.M., G.F., M.P., B.G., J.W., B.E., J.B., G.P.-W., E.P. C.P., A.M., A.A., M.T., S.S., E.R.B., M.N.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467560PMC
April 2019

Using High-Resolution Variant Frequencies Empowers Clinical Genome Interpretation and Enables Investigation of Genetic Architecture.

Am J Hum Genet 2019 Jan;104(1):187-190

Cardiovascular Genetics and Genomics, National Heart and Lung Institute, Imperial College Centre for Translational and Experimental Medicine, London, W12 0NN, UK; National Institute for Health Research Royal Brompton Cardiovascular Research Centre, Royal Brompton and Harefield National Health Service Foundation Trust, London, SW7 2AZ, UK; Medical Research Council London Institute of Medical Sciences, Imperial College London, London, W12 0NN, UK; Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323549PMC
January 2019

Fractal Analysis of Right Ventricular Trabeculae in Pulmonary Hypertension.

Radiology 2018 08 5;288(2):386-395. Epub 2018 Jun 5.

From the MRC London Institute of Medical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Rd, London W12 0HS, England (T.J.W.D., M.Q., A.d.M., P.J.O., P.F.T., S.A.C., D.P.O.); National Heart and Lung Institute (T.J.W.D., J.S.R.G., S.A.C.), and Division of Experimental Medicine, Department of Medicine (G.M.J.W., J.W., M.R.W.), Imperial College London, London, England; National Heart Centre Singapore, Singapore, and Duke-NUS Graduate Medical School, Singapore (J.C., S.A.C.); and Department of Cardiology, National Pulmonary Hypertension Service, Imperial College Healthcare NHS Trust, London, England (L.S.G.E.H., J.S.R.G.).

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http://dx.doi.org/10.1148/radiol.2018172821DOI Listing
August 2018

Role of titin in cardiomyopathy: from DNA variants to patient stratification.

Nat Rev Cardiol 2018 04 14;15(4):241-252. Epub 2017 Dec 14.

National Heart and Lung Institute, Imperial College London, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.

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http://dx.doi.org/10.1038/nrcardio.2017.190DOI Listing
April 2018

Three-dimensional cardiovascular imaging-genetics: a mass univariate framework.

Bioinformatics 2018 01;34(1):97-103

Cardiovascular Magnetic Resonance Imaging and Genetics, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK.

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http://dx.doi.org/10.1093/bioinformatics/btx552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870605PMC
January 2018

Using high-resolution variant frequencies to empower clinical genome interpretation.

Genet Med 2017 10 18;19(10):1151-1158. Epub 2017 May 18.

Cardiovascular Genetics and Genomics, National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/gim.2017.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563454PMC
October 2017

Phenotype and Clinical Outcomes of Titin Cardiomyopathy.

J Am Coll Cardiol 2017 Oct;70(18):2264-2274

National Heart Lung Institute, Imperial College London, London, United Kingdom; Cardiovascular Research Centre, Royal Brompton Hospital, London, United Kingdom; Medical Research Council London Institute of Medical Sciences, Imperial College London, London, United Kingdom; National Heart Centre, Singapore; Duke-NUS Medical School, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.08.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666113PMC
October 2017

Novel Index of Maladaptive Myocardial Remodeling in Hypertension.

Circ Cardiovasc Imaging 2017 Sep;10(9)

From the Department of Internal Medicine, Singapore General Hospital, Singapore (V.J.G.); Department of Cardiology, National Heart Centre Singapore (T.-T.L., J.B., J.I.W., B.S., C.J.P., C.P.Y.S., B.A., S.A.C., C.W.L.C.); National University Heart Centre Singapore (C.-H.L.); Duke-NUS Medical School, Singapore, Singapore (S.A.C., C.W.L.C.); and Depatrment of Laboratory Medicine, Changi General Hospital, Singapore (T.C.A.).

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http://dx.doi.org/10.1161/CIRCIMAGING.117.006840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617557PMC
September 2017

Machine Learning of Three-dimensional Right Ventricular Motion Enables Outcome Prediction in Pulmonary Hypertension: A Cardiac MR Imaging Study.

Radiology 2017 05 16;283(2):381-390. Epub 2017 Jan 16.

From the MRC Clinical Sciences Centre, Du Cane Rd, London W12 0NN, England (T.J.W.D., A.d.M., W.S., T.F., S.A.C., D.P.O.); Division of Experimental Medicine, Department of Medicine (T.J.W.D, T.F., G.M.J.W., J.W., C.J.R., M.R.W.), Department of Computing (W.S., D.R.), and National Heart and Lung Institute (J.S.R.G.), Imperial College London, London, England; National Heart Centre Singapore, Singapore and Duke-NUS Graduate Medical School, Singapore (S.A.C.); and Department of Cardiology, National Pulmonary Hypertension Service, Imperial College Healthcare NHS Trust, London, England (L.S.G.E.H., J.S.R.G.).

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http://dx.doi.org/10.1148/radiol.2016161315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398374PMC
May 2017

Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients With Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction.

Circulation 2017 May 28;135(22):2106-2115. Epub 2017 Mar 28.

From National Institute for Health Research Cardiovascular Biomedical Research Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's College London and Department of Cardiology, Guy's and St Thomas' Hospital, London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.026910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444425PMC
May 2017

Genetics and genomics of dilated cardiomyopathy and systolic heart failure.

Genome Med 2017 02 22;9(1):20. Epub 2017 Feb 22.

National Heart Lung Institute, Imperial College London, Cale Street, London, SW3 6LY, UK.

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http://dx.doi.org/10.1186/s13073-017-0410-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322656PMC
February 2017

Issues and Challenges in Diagnostic Sequencing for Inherited Cardiac Conditions.

Clin Chem 2017 Jan 22;63(1):116-128. Epub 2016 Nov 22.

National Heart and Lung Institute, Imperial College London, London, UK;

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http://dx.doi.org/10.1373/clinchem.2016.254698DOI Listing
January 2017

Truncating Variants in Filamin C: The Challenges of Genotype-Phenotype Correlations in Cardiomyopathies.

J Am Coll Cardiol 2016 12;68(22):2452-2453

National Heart and Lung Institute, Imperial College, London, United Kingdom; National Heart Centre, Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.05.105DOI Listing
December 2016

Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy.

J Am Coll Cardiol 2016 Dec;68(25):2871-2886

Department of Genetics, Harvard Medical School, Boston, Massachusetts; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Howard Hughes Medical Institute, Chevy Chase, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.08.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843375PMC
December 2016

Pulmonary Artery Stiffness Is Independently Associated with Right Ventricular Mass and Function: A Cardiac MR Imaging Study.

Radiology 2016 Aug 24;280(2):398-404. Epub 2016 Feb 24.

From the Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, England (T.J.W.D., A.d.M., R.B., P.T., M.Q., G.D., T.D., L.M.G., S.A.C., D.P.O'R.); Department of Cardiology, Imperial College NHS Healthcare Trust, London, England (A.G.); and Sorbonne Universités, UPMC Univ Paris 06, INSERM UMR_S 1146, CNRS UMR 7371, Lib, Paris, France (A.d.C.);

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http://dx.doi.org/10.1148/radiol.2016151527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976460PMC
August 2016

Moderate Physical Activity in Healthy Adults Is Associated With Cardiac Remodeling.

Circ Cardiovasc Imaging 2016 08;9(8)

From the MRC Clinical Sciences Centre (CSC), London, United Kingdom (T.J.W.D., B.C., A.d.M., J.S.W., S.A.C., D.P.O.); Division of Experimental Medicine, Department of Medicine, Imperial College London, United Kingdom (S.C.); NIHR Royal Brompton Cardiovascular Biomedical Research Unit and the National Heart & Lung Institute at Imperial College London, United Kingdom (R.W., J.S.W., S.A.C.); National Heart Centre and Duke-National University of Singapore (S.A.C.).

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http://dx.doi.org/10.1161/CIRCIMAGING.116.004712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991346PMC
August 2016

The Authors Reply.

JACC Cardiovasc Imaging 2016 06 9;9(6):763-4. Epub 2016 Mar 9.

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http://dx.doi.org/10.1016/j.jcmg.2015.12.005DOI Listing
June 2016

The Diagnosis and Evaluation of Dilated Cardiomyopathy.

J Am Coll Cardiol 2016 06;67(25):2996-3010

Department of Cardiology, Royal Brompton Hospital, London, United Kingdom; Department of Cardiovascular Medicine, National Heart & Lung Institute, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jacc.2016.03.590DOI Listing
June 2016

Relationship between body composition and left ventricular geometry using three dimensional cardiovascular magnetic resonance.

J Cardiovasc Magn Reson 2016 05 31;18(1):32. Epub 2016 May 31.

Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK.

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http://dx.doi.org/10.1186/s12968-016-0251-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888671PMC
May 2016

Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients.

Int J Cardiol 2015 1;189:105-7. Epub 2015 Apr 1.

INSERM, UMR_S 1166, F-75013 Paris, France; ICAN Institute for Cardiometabolism and Nutrition, F-75013 Paris, France; Hôpital Ambroise Paré AP-HP, Paris, France; Université de Versailles Saint Quentin en Yvelines, Versailles, France.

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http://dx.doi.org/10.1016/j.ijcard.2015.04.003DOI Listing
April 2016

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart.

Circ Res 2016 Feb 15;118(3):433-8. Epub 2015 Dec 15.

From the Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands (E.E.C., A.B., H.W.M.D., I.M., N.E.G., M.E.A., C.R.B., Y.M.P.); Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands (A.P.U., R.E., R.A.); National Heart and Lung Institute, Imperial College, London, United Kingdom (S.A.C.); Cardiovascular and Metabolic Sciences, Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany (N.H.); and Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands (J.V.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307082DOI Listing
February 2016

Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies.

N Engl J Med 2016 Jan 6;374(3):233-41. Epub 2016 Jan 6.

From the Department of Genetics, Harvard Medical School (J.S.W., E.M., C.M.Y., C.E.S., J.G.S.), the Howard Hughes Medical Institute (C.E.S.), and the Cardiovascular Division, Brigham and Women's Hospital (J.S.W., E.M., C.E.S., J.G.S.) - all in Boston; the Cardiovascular Institute and the Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (J.L., T.D., T.P.C., Z.A.), the Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh (I.H., J.P., K.H.-Y., J.G., D.M.M.), and Penn State Hershey Medical Center, Hershey (J.B.) - all in Pennsylvania; the National Institute for Health Research Royal Brompton Cardiovascular Biomedical Research Unit (J.S.W., F.M., S.K.P.) and the National Heart and Lung Institute (J.S.W., F.M., S.A.C., S.K.P.), Imperial College London, London; the Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York (E.J.T.), and the University of Rochester, Rochester (J.A.) - both in New York; the Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany (D.H.-K.); the Department of Perinatology and Gynecology, the National Cerebral and Cardiovascular Center, Osaka, Japan (C.A.K.); the National Heart Center and Duke-National University of Singapore, Singapore (S.A.C.); the Intermountain Medical Center, Murray, Utah (R.A.); Vanderbilt University, Nashville (J.D.); Cleveland Clinic, Cleveland (E.H.); University of Southern California, Los Angeles (U.E.); McGill University and Jewish General Hospital, Montreal (R.S.), University of Calgary, Calgary, AB (A.K.), and University of Toronto, Toronto (P.L.) - all in Canada; University of Maryland, College Park (G.R.), and Johns Hopkins Hospital, Baltimore (I.S.W.) - both in Maryland; Morristown Hospital, Morristown (J.S.), and Newark Beth Israel Medical Center, Newark (M.J.Z.) - both in New Jersey; Truman Medical Center, University of Missouri, Kansas City (D.F.P.); and Wa

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http://dx.doi.org/10.1056/NEJMoa1505517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797319PMC
January 2016

A bi-ventricular cardiac atlas built from 1000+ high resolution MR images of healthy subjects and an analysis of shape and motion.

Med Image Anal 2015 Dec 1;26(1):133-45. Epub 2015 Sep 1.

Biomedical Image Analysis Group, Department of Computing, Imperial College London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S13618415150013
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http://dx.doi.org/10.1016/j.media.2015.08.009DOI Listing
December 2015

Precursors of Hypertensive Heart Phenotype Develop in Healthy Adults: A High-Resolution 3D MRI Study.

JACC Cardiovasc Imaging 2015 Nov 14;8(11):1260-9. Epub 2015 Oct 14.

Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2015.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639392PMC
November 2015

Genetic modifiers to the PLN L39X mutation in a patient with DCM and sustained ventricular tachycardia?

Glob Cardiol Sci Pract 2015 3;2015(2):29. Epub 2015 Jul 3.

Qatar Cardiovascular Research Center (QCRC), Qatar Foundation, Doha, Qatar. ; NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.5339/gcsp.2015.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614339PMC
November 2015

Alternative Splicing Signatures in RNA-seq Data: Percent Spliced in (PSI).

Curr Protoc Hum Genet 2015 Oct 6;87:11.16.1-14. Epub 2015 Oct 6.

Cardiovascular and Metabolic Sciences, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1002/0471142905.hg1116s87DOI Listing
October 2015

HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.

Science 2015 Aug;349(6251):982-6

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.1126/science.aaa5458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618316PMC
August 2015

Translational regulation shapes the molecular landscape of complex disease phenotypes.

Nat Commun 2015 May 26;6:7200. Epub 2015 May 26.

Cardiovascular and Metabolic Sciences, Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association, Robert-Rossle-Strasse 10, 13125 Berlin, Germany.

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http://www.nature.com/articles/ncomms8200
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http://dx.doi.org/10.1038/ncomms8200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455061PMC
May 2015

Bayesian models for syndrome- and gene-specific probabilities of novel variant pathogenicity.

Genome Med 2015 28;7(1). Epub 2015 Jan 28.

NIHR Biomedical Research Unit in Cardiovascular Disease at Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK ; National Heart and Lung Institute, Imperial College, London, UK ; National Heart Centre, Singapore, Singapore ; Duke-National University, Singapore, Singapore.

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http://genomemedicine.com/content/7/1/5
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http://dx.doi.org/10.1186/s13073-014-0120-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308924PMC
February 2015

Osteoglycin prevents cardiac dilatation and dysfunction after myocardial infarction through infarct collagen strengthening.

Circ Res 2015 Jan 17;116(3):425-36. Epub 2014 Dec 17.

From the Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Catholic University of Leuven, Leuven, Belgium (L.N.L.V.A., P.C., A.-P.P., S.H.); Department of Cardiology (L.N.L.V.A., M.S.) and Department of Pathology (E.V.), University Hospitals Leuven, Leuven, Belgium; Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany (S.V., H.N., C.T., H.M.); Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), University Hospital Maastricht, Maastricht, The Netherlands (P.C., R.V.L., S.S.-v.W., L.E., H.-P.B.-L.R., A.-P.P., S.H.); Department of Pediatrics, Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V.); Department of Molecular Cell Biology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands (F.K.V.); National Heart and Lung Institute, Cardiovascular Genetics and Genomics, London, United Kingdom (S.A.C.); National Heart Centre Singapore, Department of Cardiology, Singapore (S.A.C.); Duke-NUS Graduate Medical School, Singapore (S.A.C.); Department of Cardiology, University Hospital Basel, Basel, Switzerland (H.-P.B.-L.R.); and ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (S.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.304599DOI Listing
January 2015

Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking.

Stem Cells Transl Med 2014 May 19;3(5):586-98. Epub 2014 Mar 19.

Epigenetics and Cell Fates Laboratory, A*STAR Institute of Molecular and Cell Biology, Singapore; Research and Development Unit, National Heart Centre Singapore, Singapore; Stem Cell and Developmental Biology, Genome Institute of Singapore, and Bioinformatics Institute, A*STAR, Singapore; Center for Individualized Medicine, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA; Health Sciences Authority, Singapore; Centre for Biomedical and Life Sciences, Singapore Polytechnic, Singapore; Department of Paediatrics, University Children's Medical Institute, National University Hospital, Singapore; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA; Department of Biochemistry, Yong Loo Lin School of Medicine, Department of Biological Sciences, and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore; Duke-NUS Graduate Medical School, Singapore; Royal Brompton Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.5966/sctm.2013-0195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006490PMC
May 2014

FineSplice, enhanced splice junction detection and quantification: a novel pipeline based on the assessment of diverse RNA-Seq alignment solutions.

Nucleic Acids Res 2014 Apr 25;42(8):e71. Epub 2014 Feb 25.

Cardiovascular Development and Repair Department, Centro Nacional de Investigaciones Cardiovasculares, Madrid, 28029, Spain, Bioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares, Madrid, 28029, Spain, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK, Cardiovascular Biomedical Research Unit, NIHR Royal Brompton and Harefield NHS Foundation Trust, London SW3 6NP, UK, Department of Cardiology, National Heart Centre Singapore, Singapore 168752, Singapore and Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.

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http://dx.doi.org/10.1093/nar/gku166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005686PMC
April 2014

Population-based studies of myocardial hypertrophy: high resolution cardiovascular magnetic resonance atlases improve statistical power.

J Cardiovasc Magn Reson 2014 Feb 3;16:16. Epub 2014 Feb 3.

From the Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1186/1532-429X-16-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914701PMC
February 2014

Paralogue annotation identifies novel pathogenic variants in patients with Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia.

J Med Genet 2014 Jan 17;51(1):35-44. Epub 2013 Oct 17.

NIHR Royal Brompton Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, UK.

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http://dx.doi.org/10.1136/jmedgenet-2013-101917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888601PMC
January 2014

NECTAR: a database of codon-centric missense variant annotations.

Nucleic Acids Res 2014 Jan 1;42(Database issue):D1013-9. Epub 2013 Dec 1.

NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London SW3 6NP, UK, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK, National Heart Centre Singapore, Singapore 168752, Singapore and Cardiovascular & Metabolic Disorders, Duke National University of Singapore, Singapore 169857, Singapore.

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http://dx.doi.org/10.1093/nar/gkt1245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965063PMC
January 2014

The prevalence and prognostic significance of right ventricular systolic dysfunction in nonischemic dilated cardiomyopathy.

Circulation 2013 Oct 21;128(15):1623-33. Epub 2013 Aug 21.

Royal Brompton Hospital, London, United Kingdom (A.G., T.F.I., A.J., F.A., K.G., N.A.I., S.R., J.K., T.D.H.B., K.M., E.L., M.R., R.W., T.C.P., R.S., J.-P.C., S.A.C., M.R.C., R.G.A., D.J.P., S.K.P.); Ealing Hospital, London, United Kingdom (R.G.A.); National Heart & Lung Institute, Imperial College, London, United Kingdom (T.F.I., K.G., R.S., J.-.P.C., S.A.C., M.R.C., D.J.P., S.K.P.); and National Heart Centre Singapore, Singapore (S.A.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002518DOI Listing
October 2013

Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells.

Int J Cardiol 2013 Oct 15;168(6):5277-86. Epub 2013 Aug 15.

Research and Development Unit (RDU), National Heart Centre Singapore, Singapore.

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http://dx.doi.org/10.1016/j.ijcard.2013.08.015DOI Listing
October 2013

Investigating stable chest pain of suspected cardiac origin.

BMJ 2013 Jul 22;347:f3940. Epub 2013 Jul 22.

Robert Steiner MRI Unit, MRC Clinical Sciences Centre, London W12 0NN, UK.

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http://dx.doi.org/10.1136/bmj.f3940DOI Listing
July 2013

Body fat is associated with reduced aortic stiffness until middle age.

Hypertension 2013 Jun 22;61(6):1322-7. Epub 2013 Apr 22.

MRC Clinical Sciences Centre, Robert Steiner MRI Unit, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, Du Cane Rd, London W12 0NN, UK.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.113.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.01177DOI Listing
June 2013

Salvage assessment with cardiac MRI following acute myocardial infarction underestimates potential for recovery of systolic strain.

Eur Radiol 2013 May 24;23(5):1210-7. Epub 2012 Nov 24.

Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1007/s00330-012-2715-8DOI Listing
May 2013

Integrative genomics in cardiovascular medicine.

Cardiovasc Res 2013 Mar 27;97(4):623-30. Epub 2012 Sep 27.

MRC Clinical Sciences Centre, Imperial Centre for Translational and Experimental Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1093/cvr/cvs303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583255PMC
March 2013

Paralogous annotation of disease-causing variants in long QT syndrome genes.

Hum Mutat 2012 Aug 7;33(8):1188-1191. Epub 2012 Jun 7.

Medical Research Council Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1002/humu.22114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640174PMC
August 2012

Remodeling after acute myocardial infarction: mapping ventricular dilatation using three dimensional CMR image registration.

J Cardiovasc Magn Reson 2012 Jun 21;14:41. Epub 2012 Jun 21.

Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

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http://jcmr-online.biomedcentral.com/articles/10.1186/1532-4
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http://dx.doi.org/10.1186/1532-429X-14-41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411469PMC
June 2012

Republished review: Next generation sequencing for clinical diagnostics and personalised medicine: implications for the next generation cardiologist.

Postgrad Med J 2012 Apr;88(1038):234-9

Molecular Cardiology, Medical Research Council Clinical Sciences Centre, Imperial College London, London, UK.

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http://dx.doi.org/10.1136/pgmj.2011.300742repDOI Listing
April 2012