Stig Omholt

Stig Omholt

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Stig Omholt

Publications by authors named "Stig Omholt"

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Cardiovascular models for personalised medicine: Where now and where next?

Med Eng Phys 2019 Oct;72:38-48

Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.

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http://dx.doi.org/10.1016/j.medengphy.2019.08.007DOI Listing
October 2019

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow.

Proc Natl Acad Sci U S A 2017 09 28;114(37):9894-9899. Epub 2017 Aug 28.

GliaLab and Letten Centre, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway;

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http://dx.doi.org/10.1073/pnas.1706942114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604020PMC
September 2017

Disentangling genetic and epigenetic determinants of ultrafast adaptation.

Mol Syst Biol 2016 Dec 15;12(12):892. Epub 2016 Dec 15.

Centre for Integrative Genetics (CIGENE), Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Ås, Norway

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199126PMC
http://dx.doi.org/10.15252/msb.20166951DOI Listing
December 2016

A novel role for pigment genes in the stress response in rainbow trout (Oncorhynchus mykiss).

Sci Rep 2016 07 4;6:28969. Epub 2016 Jul 4.

Centre for Integrative Genetics, Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, NO-1430 Ås, Norway.

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http://dx.doi.org/10.1038/srep28969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931468PMC
July 2016

Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.

Mol Biol Evol 2015 Jan 27;32(1):153-61. Epub 2014 Oct 27.

Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden Centre for Integrative Genetics (CIGENE), Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences (UMB), Ås, Norway

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http://dx.doi.org/10.1093/molbev/msu285DOI Listing
January 2015

150 years of the mass action law.

PLoS Comput Biol 2015 Jan 8;11(1):e1004012. Epub 2015 Jan 8.

Department of Engineering Cybernetics, Norwegian University of Science & Technology, Trondheim, Norway.

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http://dx.doi.org/10.1371/journal.pcbi.1004012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288704PMC
January 2015

A computational pipeline for quantification of mouse myocardial stiffness parameters.

Comput Biol Med 2014 Oct 2;53:65-75. Epub 2014 Aug 2.

Department of Animal and Aquacultural Sciences, Centre for Integrative Genetics, Norwegian University of Life Sciences, P.O. Box 5003, N-1432 Ås, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.compbiomed.2014.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625543PMC
October 2014

Electrodiffusive model for astrocytic and neuronal ion concentration dynamics.

PLoS Comput Biol 2013 19;9(12):e1003386. Epub 2013 Dec 19.

Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, Ås, Norway.

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http://dx.doi.org/10.1371/journal.pcbi.1003386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868551PMC
August 2014

The evolution and functional divergence of the beta-carotene oxygenase gene family in teleost fish--exemplified by Atlantic salmon.

Gene 2014 Jun 26;543(2):268-74. Epub 2014 Feb 26.

Centre for Integrative Genetics (CIGENE), Dept. of Animal and Aquacultural Sciences, Norwegian University of Life Sciences (UMB), P.O. Box 5003, N-1432 As, Norway.

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https://linkinghub.elsevier.com/retrieve/pii/S03781119140023
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http://dx.doi.org/10.1016/j.gene.2014.02.042DOI Listing
June 2014

Evolution evolves: physiology returns to centre stage.

J Physiol 2014 Jun;592(11):2237-44

Norwegian University of Science and Technology, Faculty of Medicine, Trondheim, Norway.

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http://dx.doi.org/10.1113/jphysiol.2014.273151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048083PMC
June 2014

Arterial stiffening provides sufficient explanation for primary hypertension.

PLoS Comput Biol 2014 May 22;10(5):e1003634. Epub 2014 May 22.

Department of Circulation and Medical Imaging, Cardiac Exercise Research Group, NTNU Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1371/journal.pcbi.1003634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031054PMC
May 2014

Effect of regulatory architecture on broad versus narrow sense heritability.

PLoS Comput Biol 2013 9;9(5):e1003053. Epub 2013 May 9.

Centre for Integrative Genetics (CIGENE), Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Ås, Norway.

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http://dx.doi.org/10.1371/journal.pcbi.1003053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649986PMC
March 2014

A computational analysis of the long-term regulation of arterial pressure.

F1000Res 2013 8;2:208. Epub 2013 Oct 8.

Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.12688/f1000research.2-208.v2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886803PMC
February 2014

Monotonicity is a key feature of genotype-phenotype maps.

Front Genet 2013 7;4:216. Epub 2013 Nov 7.

Centre for Integrative Genetics (CIGENE), Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences Ås, Norway.

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http://dx.doi.org/10.3389/fgene.2013.00216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819525PMC
November 2013

Life-history evolution and the polyphenic regulation of somatic maintenance and survival.

Q Rev Biol 2013 Sep;88(3):185-218

Institut für Populationsgenetik, Vetmeduni Vienna, A-1210 Vienna, Austria.

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September 2013

Propagation of genetic variation in gene regulatory networks.

Physica D 2013 Aug;256-257:7-20

Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, P.O. Box 5003, N - 1432 Ås, Norway ; CIGENE (Centre for Integrative Genetics), Norwegian University of Life Sciences, N - 1432 Ås, Norway.

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http://dx.doi.org/10.1016/j.physd.2013.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752980PMC
August 2013

Understanding the melanocyte distribution in human epidermis: an agent-based computational model approach.

PLoS One 2012 9;7(7):e40377. Epub 2012 Jul 9.

Centre for Integrative Genetics (CIGENE), Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, Ås, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040377PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392240PMC
April 2013

From sequence to consequence and back.

Authors:
Stig W Omholt

Prog Biophys Mol Biol 2013 Apr 25;111(2-3):75-82. Epub 2012 Sep 25.

Centre for Ecological and Evolutionary Synthesis, Department of Biology, University of Oslo, P.O. Box 1066, Blindern, N-0316 Oslo, Norway.

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http://dx.doi.org/10.1016/j.pbiomolbio.2012.09.003DOI Listing
April 2013

Bridging the genotype-phenotype gap: what does it take?

J Physiol 2013 Apr 11;591(8):2055-66. Epub 2013 Feb 11.

Centre for Integrative Genetics, Department of Mathematical and Technological Sciences, Norwegian University of Life Sciences, Norway.

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http://dx.doi.org/10.1113/jphysiol.2012.248864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634519PMC
April 2013

Ancient evolutionary trade-offs between yeast ploidy states.

PLoS Genet 2013 Mar 21;9(3):e1003388. Epub 2013 Mar 21.

Centre for Integrative Genetics, Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, UMB, Ås, Norway.

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http://gup.ub.gu.se/records/fulltext/176504/176504.pdf
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http://dx.plos.org/10.1371/journal.pgen.1003388
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http://dx.doi.org/10.1371/journal.pgen.1003388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605057PMC
March 2013

Genotype-Phenotype Map Characteristics of an In silico Heart Cell.

Front Physiol 2011 28;2:106. Epub 2011 Dec 28.

Department of Mathematical Sciences and Technology, Centre for Integrative Genetics, Norwegian University of Life Sciences Ås, Norway.

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http://dx.doi.org/10.3389/fphys.2011.00106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246639PMC
October 2012

Parameters in dynamic models of complex traits are containers of missing heritability.

PLoS Comput Biol 2012 5;8(4):e1002459. Epub 2012 Apr 5.

Centre for Integrative Genetics, Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Ås, Norway.

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https://pdfs.semanticscholar.org/674c/ef556adfeb24ad54a56c9d
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http://dx.plos.org/10.1371/journal.pcbi.1002459
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http://dx.doi.org/10.1371/journal.pcbi.1002459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320574PMC
August 2012

Life history shapes trait heredity by accumulation of loss-of-function alleles in yeast.

Mol Biol Evol 2012 Jul 20;29(7):1781-9. Epub 2012 Jan 20.

Centre for Integrative Genetics, Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, UMB, Ås, Norway.

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http://dx.doi.org/10.1093/molbev/mss019DOI Listing
July 2012

Multi-way metamodelling facilitates insight into the complex input-output maps of nonlinear dynamic models.

BMC Syst Biol 2012 Jul 20;6:88. Epub 2012 Jul 20.

Centre for Integrative Genetics (CIGENE), Dept, of Mathematical Sciences and Technology, Norwegian University of Life Sciences, Ås, Norway.

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http://dx.doi.org/10.1186/1752-0509-6-88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483253PMC
July 2012

Dependence of spontaneous neuronal firing and depolarisation block on astroglial membrane transport mechanisms.

J Comput Neurosci 2012 Feb 11;32(1):147-65. Epub 2011 Jun 11.

Centre for Integrative Genetics (CIGENE), Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, 1430 Ås, Norway.

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http://dx.doi.org/10.1007/s10827-011-0345-9DOI Listing
February 2012

Towards a quantitative understanding of the MITF-PIAS3-STAT3 connection.

BMC Syst Biol 2012 Feb 8;6:11. Epub 2012 Feb 8.

Centre for Integrative Genetics, Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, 1430 Ås, Norway.

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http://dx.doi.org/10.1186/1752-0509-6-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341200PMC
February 2012

A dense SNP-based linkage map for Atlantic salmon (Salmo salar) reveals extended chromosome homeologies and striking differences in sex-specific recombination patterns.

BMC Genomics 2011 Dec 19;12:615. Epub 2011 Dec 19.

Centre for Integrative Genetics and Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, N-1432, Ås, Norway.

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http://dx.doi.org/10.1186/1471-2164-12-615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261913PMC
December 2011

Hierarchical cluster-based partial least squares regression (HC-PLSR) is an efficient tool for metamodelling of nonlinear dynamic models.

BMC Syst Biol 2011 Jun 1;5:90. Epub 2011 Jun 1.

Centre for Integrative Genetics, Dept. of Mathematical Sciences and Technology, Norwegian University of Life Sciences, N-1432 Ås, Norway.

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http://dx.doi.org/10.1186/1752-0509-5-90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127793PMC
June 2011

Methods for and results from the study of design principles in molecular systems.

Math Biosci 2011 May 15;231(1):3-18. Epub 2011 Feb 15.

Departament de Ciencies Mèdiques Bàsiques, Universitat de Lleida and IRBLleida, Lleida, Spain.

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http://dx.doi.org/10.1016/j.mbs.2011.02.005DOI Listing
May 2011

Characterisation of a novel paralog of scavenger receptor class B member I (SCARB1) in Atlantic salmon (Salmo salar).

BMC Genet 2011 May 30;12:52. Epub 2011 May 30.

Centre for Integrative Genetics, Dept. of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, 1432 Aas, Norway.

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http://dx.doi.org/10.1186/1471-2156-12-52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118963PMC
May 2011

Assessing the complex architecture of polygenic traits in diverged yeast populations.

Mol Ecol 2011 Apr 25;20(7):1401-13. Epub 2011 Jan 25.

Centre for Genetics and Genomics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1111/j.1365-294X.2011.05005.xDOI Listing
April 2011

Sequencing the genome of the Atlantic salmon (Salmo salar).

Genome Biol 2010 30;11(9):403. Epub 2010 Sep 30.

Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby BC, V5A 1S6, Canada.

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http://dx.doi.org/10.1186/gb-2010-11-9-403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965382PMC
February 2011

Phenomics: the next challenge.

Nat Rev Genet 2010 Dec;11(12):855-66

Department of Biological Science, Florida State University, Tallahassee, 32306-4295, USA.

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http://dx.doi.org/10.1038/nrg2897DOI Listing
December 2010

Allele interaction--single locus genetics meets regulatory biology.

PLoS One 2010 Feb 23;5(2):e9379. Epub 2010 Feb 23.

Centre for Integrative Genetics, Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, As, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009379PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826424PMC
February 2010

The genotype-phenotype relationship in multicellular pattern-generating models--the neglected role of pattern descriptors.

BMC Syst Biol 2009 Sep 4;3:87. Epub 2009 Sep 4.

Centre for Integrative Genetics (CIGENE), Norwegian University of Life Sciences, N-1432 As, Norway.

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http://dx.doi.org/10.1186/1752-0509-3-87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749810PMC
September 2009

The mathematics of tanning.

BMC Syst Biol 2009 Jun 9;3:60. Epub 2009 Jun 9.

Centre for Integrative Genetics (CIGENE), Norwegian University of Life Sciences (UMB), PO Box 5003, 1432 As, Norway.

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http://dx.doi.org/10.1186/1752-0509-3-60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714304PMC
June 2009

Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space.

PLoS Comput Biol 2009 Jan 23;5(1):e1000272. Epub 2009 Jan 23.

Centre for Integrative Genetics, Norwegian University of Life Sciences, As, Norway.

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http://dx.doi.org/10.1371/journal.pcbi.1000272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613522PMC
January 2009

When parameters in dynamic models become phenotypes: a case study on flesh pigmentation in the chinook salmon (Oncorhynchus tshawytscha).

Genetics 2008 Jun 27;179(2):1113-8. Epub 2008 May 27.

Centre for Integrative Genetics (CIGENE) and Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, N-1432 As, Norway.

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http://dx.doi.org/10.1534/genetics.108.087064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429864PMC
June 2008

Threshold-dominated regulation hides genetic variation in gene expression networks.

BMC Syst Biol 2007 Dec 6;1:57. Epub 2007 Dec 6.

Department of Animal Science and Aquaculture, Norwegian University of Life Sciences, 1432 As, Norway.

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http://dx.doi.org/10.1186/1752-0509-1-57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238762PMC
December 2007

Nonlinear regulation enhances the phenotypic expression of trans-acting genetic polymorphisms.

BMC Syst Biol 2007 Jul 25;1:32. Epub 2007 Jul 25.

Centre for Integrative Genetics (CIGENE), Norwegian University of Life Sciences, As, Norway.

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http://dx.doi.org/10.1186/1752-0509-1-32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994684PMC
July 2007

Statistical epistasis is a generic feature of gene regulatory networks.

Genetics 2007 Jan 8;175(1):411-20. Epub 2006 Oct 8.

Centre for Integrative Genetics and Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, N-1432 Aas, Norway.

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http://dx.doi.org/10.1534/genetics.106.058859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774990PMC
January 2007

Genetic variation in putative regulatory loci controlling gene expression in breast cancer.

Proc Natl Acad Sci U S A 2006 May 9;103(20):7735-40. Epub 2006 May 9.

Department of Genetics, Institute of Cancer Research, Rikshospitalet-Radiumhospitalet Medical Center, Montebello, 0310 Oslo, Norway.

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http://dx.doi.org/10.1073/pnas.0601893103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458617PMC
May 2006

Carotenoid dynamics in Atlantic salmon.

BMC Biol 2006 Apr 18;4:10. Epub 2006 Apr 18.

Centre for Integrative Genetics (CIGENE) and Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences (UMB), 1430 As, Norway.

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http://dx.doi.org/10.1186/1741-7007-4-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479383PMC
April 2006

Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect.

FEBS Lett 2005 Sep;579(22):4961-5

Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.febslet.2005.07.085DOI Listing
September 2005

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

Mech Ageing Dev 2005 Mar;126(3):439-43

Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK.

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http://dx.doi.org/10.1016/j.mad.2004.09.008DOI Listing
March 2005

Epigenetic regulation of aging in honeybee workers.

Sci Aging Knowledge Environ 2004 Jun 30;2004(26):pe28. Epub 2004 Jun 30.

Centre for Integrative Genetics and Department of Animal Science, Agricultural University of Norway, 1432 Aas, Norway.

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http://dx.doi.org/10.1126/sageke.2004.26.pe28DOI Listing
June 2004

Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees.

Exp Gerontol 2004 May;39(5):767-73

Department of Animal Science, Centre for Integrative Genetics, Agricultural University of Norway, P.O. Box 5025, 1432 Aas, Norway.

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http://dx.doi.org/10.1016/j.exger.2004.02.010DOI Listing
May 2004

Targeted reduction of complex models with time scale hierarchy--a case study.

Math Biosci 2003 Oct;185(2):123-52

Department of Mathematical Sciences, Agricultural University of Norway, P.O. Box 5035, 1432 As, Norway.

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http://izt.ciens.ucv.ve/ecologia/Archivos/ECOLOGIA_DE%20_POB
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October 2003

The hive bee to forager transition in honeybee colonies: the double repressor hypothesis.

J Theor Biol 2003 Aug;223(4):451-64

Department of Animal Science, Agricultural University of Norway, P.O. Box 5025, Aas 1432, Norway.

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http://dx.doi.org/10.1016/s0022-5193(03)00121-8DOI Listing
August 2003

The gene csd is the primary signal for sexual development in the honeybee and encodes an SR-type protein.

Cell 2003 Aug;114(4):419-29

Martin-Luther-Universität Halle/Wittenberg, Institut für Zoologie, Biozentrum, Weinberg Weg 22, 06120, Halle, Germany.

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http://dx.doi.org/10.1016/s0092-8674(03)00606-8DOI Listing
August 2003

Social exploitation of vitellogenin.

Proc Natl Acad Sci U S A 2003 Feb 3;100(4):1799-802. Epub 2003 Feb 3.

Centre for Integrative Genetics and Department of Animal Science, Agricultural University of Norway, Box 5025, N-1432 Aas, Norway.

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http://dx.doi.org/10.1073/pnas.0333979100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149913PMC
February 2003

Disruption of vitellogenin gene function in adult honeybees by intra-abdominal injection of double-stranded RNA.

BMC Biotechnol 2003 Jan 20;3. Epub 2003 Jan 20.

Centre for Integrative Genetics and Department of Animal Science, Agricultural University of Norway, N-1432 Aas, Norway.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149360PMC
January 2003

The regulatory anatomy of honeybee lifespan.

J Theor Biol 2002 May;216(2):209-28

Department of Animal Science, Agricultural University of Norway, 1432 Aas, Norway.

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http://linkinghub.elsevier.com/retrieve/pii/S002251930292545
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http://dx.doi.org/10.1006/jtbi.2002.2545DOI Listing
May 2002

The regulatory basis of melanogenic switching.

J Theor Biol 2002 Apr;215(4):449-68

Department of Mathematical Sciences, Agricultural University of Norway, 1432 As, Norway.

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http://dx.doi.org/10.1006/jtbi.2001.2521DOI Listing
April 2002