Stig Linder

Stig Linder

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Stig Linder

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Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug.

Biochimie 2019 Jul 1;162:46-54. Epub 2019 Apr 1.

Department of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden; Department of Medical and Health Sciences, Linköping University, SE-581 83, Linköping, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03009084193008
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http://dx.doi.org/10.1016/j.biochi.2019.03.015DOI Listing
July 2019

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment.

Oxid Med Cell Longev 2019 10;2019:1659468. Epub 2019 Jun 10.

Department of Oncology-Pathology, Karolinska Institutet, SE-17176 Stockholm, Sweden.

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https://www.hindawi.com/journals/omcl/2019/1659468/
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http://dx.doi.org/10.1155/2019/1659468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590552PMC
June 2019

Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation.

Cancer Lett 2019 Apr 13;448:70-83. Epub 2019 Feb 13.

Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835193006
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http://dx.doi.org/10.1016/j.canlet.2019.02.003DOI Listing
April 2019

Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer.

Int J Mol Sci 2019 Jan 8;20(1). Epub 2019 Jan 8.

Masonic Cancer Center and Department of Obstetrics, Gynecology and Women's Heath, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.3390/ijms20010229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337358PMC
January 2019

The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage.

Biochem Pharmacol 2018 10 25;156:291-301. Epub 2018 Aug 25.

Department of Oncology-Pathology, Karolinska Institutet, SE-171 77 Stockholm, Sweden; Division of Drug Research, Department of Medical and Health Sciences, Linköping University, SE-751 85 Linköping, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.08.039DOI Listing
October 2018

A drug screening assay on cancer cells chronically adapted to acidosis.

Cancer Cell Int 2018 25;18:147. Epub 2018 Sep 25.

1Cancer Center Karolinska, R8:00, Department of Oncology-Pathology, Karolinska Institute, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1186/s12935-018-0645-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156858PMC
September 2018

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group.

Cancer Chemother Pharmacol 2018 03 28;81(3):427-441. Epub 2017 Dec 28.

School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK.

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http://dx.doi.org/10.1007/s00280-017-3502-7DOI Listing
March 2018

Proteasome-associated deubiquitinases and cancer.

Cancer Metastasis Rev 2017 12;36(4):635-653

Department of Medical and Health Sciences, Linköping University, SE-581 83, Linköping, Sweden.

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http://dx.doi.org/10.1007/s10555-017-9697-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721125PMC
December 2017

MYC is downregulated by a mitochondrial checkpoint mechanism.

Oncotarget 2017 Oct 6;8(52):90225-90237. Epub 2017 Oct 6.

Department of Medical and Health Sciences, Linköping University, SE-581 83 Linköping, Sweden.

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http://dx.doi.org/10.18632/oncotarget.21653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685744PMC
October 2017

Iron chelators target both proliferating and quiescent cancer cells.

Sci Rep 2016 12 7;6:38343. Epub 2016 Dec 7.

Department of Medical Sciences, Division of Cancer Pharmacology and Computational Medicine, Uppsala University, SE-751 85 Uppsala, Sweden.

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http://dx.doi.org/10.1038/srep38343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141479PMC
December 2016

Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics.

Trends Cancer 2016 11 11;2(11):657-663. Epub 2016 Nov 11.

Department of Medical and Health Sciences, Linköping University, SE-581 83 Linköping, Sweden; Department of Oncology-Pathology, Karolinska Institute, SE-171 76 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2016.10.009DOI Listing
November 2016

Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?

Drug Resist Updat 2015 Jul-Aug;21-22:20-9. Epub 2015 Jul 6.

Department of Medical and Health Sciences, Linköping University, Linköping, SE-581 85, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.drup.2015.06.001DOI Listing
June 2016

[Handling of misconduct in Swedish research must be improved. More strict investigative procedures, tougher punishments and withdrawals are required].

Authors:
Stig Linder

Lakartidningen 2015 Dec 15;112. Epub 2015 Dec 15.

Linköping University - Medicine and Health Linköping, Sweden Linköping University - Medicine and Health Linköping, Sweden.

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December 2015

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments.

Nat Commun 2014 ;5:3295

1] Department of Oncology-Pathology, Karolinska Institute, Stockholm S-171 76, Sweden [2] Division of Clinical Pharmacology, Department of Medical Sciences, Uppsala University, Uppsala S-751 85, Sweden.

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http://dx.doi.org/10.1038/ncomms4295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929804PMC
November 2015

Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15.

Chem Biol Drug Des 2015 Nov 27;86(5):1036-48. Epub 2015 May 27.

Department of Medical and Health Sciences, Linköping University, S-581 83, Linköping, Sweden.

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http://dx.doi.org/10.1111/cbdd.12571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846425PMC
November 2015

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors.

Int J Mol Sci 2015 Nov 13;16(11):27313-26. Epub 2015 Nov 13.

Department of Medical and Health Sciences, Linköping University, SE-581 83 Linköping, Sweden.

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http://dx.doi.org/10.3390/ijms161126020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661878PMC
November 2015

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer.

Mol Cancer Ther 2015 Jun 24;14(6):1504-16. Epub 2015 Apr 24.

Department of Medical Sciences, Division of Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-14
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http://dx.doi.org/10.1158/1535-7163.MCT-14-0792DOI Listing
June 2015

Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study.

Nutrients 2015 Jun 19;7(6):4978-94. Epub 2015 Jun 19.

Department of Laboratory Medicine, Division of Pathology F46, Karolinska Institutet, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.3390/nu7064978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488827PMC
June 2015

Deubiquitinase inhibition as a cancer therapeutic strategy.

Pharmacol Ther 2015 Mar 6;147:32-54. Epub 2014 Nov 6.

Department of Medical and Health Sciences, Linköping University, SE-58183 Linköping, Sweden; Department of Oncology and Pathology, Karolinska Institute, SE-171 76 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2014.11.002DOI Listing
March 2015

Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress.

Antioxid Redox Signal 2014 Dec 17;21(17):2271-85. Epub 2013 Oct 17.

1 Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute , Stockholm, Sweden .

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http://dx.doi.org/10.1089/ars.2013.5322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241954PMC
December 2014

Molecular pathways: translational potential of deubiquitinases as drug targets.

Clin Cancer Res 2014 Aug;20(15):3908-14

Department of Oncology-Pathology, Karolinska Institute, Stockholm and Department of Medical Sciences, Division of Clinical Pharmacology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0568DOI Listing
August 2014

The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.

Mol Pharmacol 2014 Jun 8;85(6):932-45. Epub 2014 Apr 8.

Department of Oncology and Pathology, Cancer Center Karolinska (X.W., M.M., S.B., X.Z., P.D., S.L.), and Division of Biochemistry, Department of Medical Biochemistry and Biophysics (W.S., E.S.J.A.), Karolinska Institute, Stockholm, Sweden; and Division of Clinical Pharmacology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden (M.F., J.G., R.L., S.L.).

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http://molpharm.aspetjournals.org/content/85/6/932.full.pdf
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http://molpharm.aspetjournals.org/content/early/2014/04/08/m
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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.113.09
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http://dx.doi.org/10.1124/mol.113.091322DOI Listing
June 2014

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: implications for cancer therapies.

Autophagy 2014 Apr 31;10(4):562-71. Epub 2014 Jan 31.

Cancer Center Karolinska; Department of Oncology-Pathology; Karolinska Institute; Stockholm, Sweden.

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http://dx.doi.org/10.4161/auto.27901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984580PMC
April 2014

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter.

Autophagy 2014 Jan 1;10(1):57-69. Epub 2013 Jan 1.

Uppsala University; Department of Medical Sciences; Cancer Pharmacology and Computational Medicine; University Hospital; Uppsala, Sweden.

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http://dx.doi.org/10.4161/auto.26678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872480PMC
January 2014

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.

Blood 2014 Jan 6;123(5):706-16. Epub 2013 Dec 6.

Jerome Lipper Multiple Myeloma Center and LeBow Institute for Myeloma Therapeutics, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and.

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http://dx.doi.org/10.1182/blood-2013-05-500033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907756PMC
January 2014

A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells.

Cancer Immunol Immunother 2013 Aug 21;62(8):1359-68. Epub 2013 May 21.

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, R8:01, 171 76, Stockholm, Sweden.

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http://link.springer.com/content/pdf/10.1007%2Fs00262-013-14
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http://link.springer.com/10.1007/s00262-013-1439-1
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http://dx.doi.org/10.1007/s00262-013-1439-1DOI Listing
August 2013

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system.

Invest New Drugs 2013 Jun 20;31(3):587-98. Epub 2012 Nov 20.

Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Center, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s10637-012-9902-yDOI Listing
June 2013

Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells.

Virology 2013 May 16;440(1):41-50. Epub 2013 Mar 16.

Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway.

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http://dx.doi.org/10.1016/j.virol.2013.01.024DOI Listing
May 2013

A natural anticancer agent thaspine targets human topoisomerase IB.

Anticancer Agents Med Chem 2013 Feb;13(2):356-63

Department of Biology, University of Rome Tor Vergata, Via Della Ricerca Scientifica, Rome 00133, Italy.

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February 2013

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells.

Biochem Biophys Res Commun 2013 Feb 11;431(2):117-23. Epub 2013 Jan 11.

Department of Medical Sciences, Division of Clinical Pharmacology, Uppsala University, S-751 85 Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2013.01.017DOI Listing
February 2013

Proteasome deubiquitinases as novel targets for cancer therapy.

Int J Biochem Cell Biol 2012 Nov 20;44(11):1729-38. Epub 2012 Jul 20.

Institute for Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, 17176 Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S13572725120025
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http://dx.doi.org/10.1016/j.biocel.2012.07.011DOI Listing
November 2012

Autophagy is a protective mechanism for human melanoma cells under acidic stress.

J Biol Chem 2012 Aug 3;287(36):30664-76. Epub 2012 Jul 3.

Department of Therapeutic Research and Medicines Evaluation, Unit of Antitumor Drugs, Istituto Superiore di Sanità, Rome 00161, Italy.

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http://dx.doi.org/10.1074/jbc.M112.339127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436311PMC
August 2012

Determination of cell death modes using circulating biomarkers.

Liver Int 2012 Feb 2;32(2):347-8; author reply 347. Epub 2011 Dec 2.

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http://dx.doi.org/10.1111/j.1478-3231.2011.02690.xDOI Listing
February 2012

Inhibition of proteasome deubiquitinating activity as a new cancer therapy.

Nat Med 2011 Nov 6;17(12):1636-40. Epub 2011 Nov 6.

Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nm.2536DOI Listing
November 2011

Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer.

Eur J Cancer 2011 Jan 6;47(1):131-7. Epub 2010 Sep 6.

Clinical Proteomics, Karolinska Biomics Center, Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.ejca.2010.08.006DOI Listing
January 2011

Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis.

Mol Biosyst 2010 May 9;6(5):767-74. Epub 2010 Feb 9.

Department of Oncology-Pathology, Cancer Center Karolinska, R8:00, Karolinska Institute, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1039/b920805dDOI Listing
May 2010

Utilization of cytokeratin-based biomarkers for pharmacodynamic studies.

Expert Rev Mol Diagn 2010 Apr;10(3):353-9

Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute and Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1586/erm.10.14DOI Listing
April 2010

Screening of natural products for therapeutic activity against solid tumors.

Indian J Exp Biol 2010 Mar;48(3):258-64

Department of Pharmacognosy, Pharmaceutical Sciences Division, National Research Centre, Dokki, Giza 12622, Egypt.

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March 2010

Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model.

Int J Cancer 2009 Nov;125(10):2450-5

Department of Oncology and Pathology, Karolinska Institute and Hospital, Cancer Center Karolinska, Stockholm, Sweden.

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http://doi.wiley.com/10.1002/ijc.24627
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http://dx.doi.org/10.1002/ijc.24627DOI Listing
November 2009

Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation.

Free Radic Biol Med 2009 Jun 26;46(12):1607-13. Epub 2009 Mar 26.

Department of Oncology-Pathology, CCK, Karolinska Institute, S-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.freeradbiomed.2009.03.015DOI Listing
June 2009

Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.

J Chem Biol 2009 Jun 31;2(2):81-7. Epub 2009 Mar 31.

Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute and Hospital, Cancer Center Karolinska, R8:00, S-171 76, Stockholm, Sweden.

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http://link.springer.com/10.1007/s12154-009-0017-7
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http://dx.doi.org/10.1007/s12154-009-0017-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701489PMC
June 2009

Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines.

Scand J Urol Nephrol 2009 ;43(2):98-103

Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1080/00365590802475904DOI Listing
May 2009

Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system.

Int J Cancer 2009 Mar;124(6):1463-9

Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ijc.24004DOI Listing
March 2009

Serum efficacy biomarkers for oncology.

Biomark Med 2009 Feb;3(1):47-54

Department of Oncology - Pathology, Cancer Center Karolinska, Karolinska Institute, S-171 76 Stockholm, Sweden.

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https://www.futuremedicine.com/doi/10.2217/17520363.3.1.47
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http://dx.doi.org/10.2217/17520363.3.1.47DOI Listing
February 2009

Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin.

Anticancer Res 2009 Jan;29(1):11-8

Karolinska Institutet, Department of Oncology-Pathology, Cancer Center Karolinska R8:01, Karolinska University Hospital, 171 76 Stockholm.

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January 2009

Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II.

BMC Chem Biol 2008 Aug 1;8. Epub 2008 Aug 1.

Cancer Center Karolinska, Department of Oncology-Pathology, Karolinska Institute, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1186/1472-6769-8-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518916PMC
August 2008

Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir.

Int J Cancer 2008 Jul;123(2):476-483

Department of Oncology-Pathology, Karolinska Institute, S-171 76 Stockholm, Sweden.

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http://doi.wiley.com/10.1002/ijc.23525
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http://dx.doi.org/10.1002/ijc.23525DOI Listing
July 2008

The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity.

Lab Invest 2008 Mar 14;88(3):256-63. Epub 2008 Jan 14.

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute and Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/labinvest.3700718DOI Listing
March 2008

Target specificity and off-target effects as determinants of cancer drug efficacy.

Expert Opin Drug Metab Toxicol 2008 Mar;4(3):273-80

Cancer Center Karolinska, Department of Oncology-Pathology, Karolinska Institute, S-171 76 Stockholm, Sweden.

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http://www.tandfonline.com/doi/full/10.1517/17425255.4.3.273
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http://dx.doi.org/10.1517/17425255.4.3.273 DOI Listing
March 2008

Screening for compounds that induce apoptosis of cancer cells grown as multicellular spheroids.

J Biomol Screen 2008 Jan 26;13(1):1-8. Epub 2007 Nov 26.

Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute and Hospital, Stockholm, Sweden.

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http://jbx.sagepub.com/cgi/doi/10.1177/1087057107310442
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http://dx.doi.org/10.1177/1087057107310442DOI Listing
January 2008

Cytokeratin markers come of age.

Authors:
Stig Linder

Tumour Biol 2007 23;28(4):189-95. Epub 2007 Aug 23.

Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute and Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1159/000107582DOI Listing
October 2007

Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?

Mini Rev Med Chem 2007 Oct;7(10):1035-9

Cancer Canter Karolinska, Department of Oncology and Pathology, Karolinska, Institute and Hospital, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.2174/138955707782110196DOI Listing
October 2007

The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival.

Lung Cancer 2007 Jun 20;56(3):399-404. Epub 2007 Feb 20.

Biochemistry Department of Medical School of Uludag University, Bursa, Turkey, and Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute and Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.lungcan.2007.01.015DOI Listing
June 2007

Large-scale proteomics analysis of human ovarian cancer for biomarkers.

J Proteome Res 2007 Apr 22;6(4):1440-50. Epub 2007 Feb 22.

Department of Protein Technology, Lund University, 221 84 Lund, Sweden.

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http://pubs.acs.org/doi/abs/10.1021/pr060593y
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http://dx.doi.org/10.1021/pr060593yDOI Listing
April 2007

Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA.

Int J Cancer 2007 Jan;120(1):175-80

Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ijc.22132DOI Listing
January 2007

Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses.

Expert Opin Drug Discov 2006 Nov;1(6):585-94

Dept. of Oncology-Pathology, Karolinska Institute, Cancer Center Karolinska, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1517/17460441.1.6.585DOI Listing
November 2006

Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1.

Exp Cell Res 2006 May 9;312(9):1581-9. Epub 2006 Mar 9.

Department Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute R8:03, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.yexcr.2006.01.023DOI Listing
May 2006

Is translational research compatible with preclinical publication strategies?

Radiat Oncol 2006 Mar 24;1. Epub 2006 Mar 24.

Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute and Hospital, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1186/1748-717X-1-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459183PMC
March 2006

Clinical cancer proteomics: promises and pitfalls.

J Proteome Res 2005 Jul-Aug;4(4):1213-22

Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, P.O. Box 3354 Riyadh 11211 (MBC#03), Saudi Arabia.

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http://dx.doi.org/10.1021/pr050149fDOI Listing
October 2005

Lysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy.

Drug Resist Updat 2005 Aug 1;8(4):199-204. Epub 2005 Aug 1.

R8:03, Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute and Hospital, S-171 76 Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S13687646050004
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http://dx.doi.org/10.1016/j.drup.2005.06.004DOI Listing
August 2005

Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis.

FEBS Lett 2005 Jun;579(14):3090-4

Cancer Center Karolinska, Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.febslet.2005.04.067DOI Listing
June 2005

Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis.

Proc Natl Acad Sci U S A 2005 Jan 23;102(1):192-7. Epub 2004 Dec 23.

Cancer Center Karolinska, Department of Oncology-Pathology, Karolinska Institute and Hospital, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1073/pnas.0408592102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544072PMC
January 2005

Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker.

Cancer Lett 2004 Oct;214(1):1-9

Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and Hospital, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.canlet.2004.06.032DOI Listing
October 2004

Processing of pulmonary surfactant protein B by napsin and cathepsin H.

J Biol Chem 2004 Apr 6;279(16):16178-84. Epub 2004 Feb 6.

Cancer Center Karolinska, Department of Oncology-Pathology, Karolinska Institute and Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M312029200DOI Listing
April 2004

Induction of endoplasmic reticulum stress by ellipticine plant alkaloids.

Mol Cancer Ther 2004 Apr;3(4):489-97

Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and Hospital, Stockholm, Sweden.

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April 2004

Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line.

Exp Cell Res 2003 Oct;289(2):256-64

Cancer Center Karolinska, Department of Oncology-Pathology, Karolinska Institute, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/s0014-4827(03)00264-7DOI Listing
October 2003

Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling.

J Biol Chem 2003 Mar 31;278(11):9100-6. Epub 2002 Dec 31.

Department of Oncology-Pathology, CancerCenterKarolinska, Karolinska Institute and Hospital, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M210284200DOI Listing
March 2003

A novel high-through-put assay for screening of pro-apoptotic drugs.

Invest New Drugs 2002 Aug;20(3):253-9

Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute and Hospital, Stockholm, Sweden.

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http://link.springer.com/content/pdf/10.1023/A:1016249728664
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August 2002

Expression of UPA and UPAR is associated with the clinical course of urinary bladder neoplasms.

Int J Cancer 2002 Jun;99(5):721-6

Cancer Center Karolinska, Karolinska Institute and Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ijc.10426DOI Listing
June 2002