Publications by authors named "Steven Whitebread"

20Publications

Secondary pharmacology: screening and interpretation of off-target activities - focus on translation.

Drug Discov Today 2016 08 29;21(8):1232-42. Epub 2016 Apr 29.

Preclinical Safety, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA. Electronic address:

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August 2016

A screening pattern recognition method finds new and divergent targets for drugs and natural products.

ACS Chem Biol 2014 Jul 2;9(7):1622-31. Epub 2014 Jun 2.

Novartis Institutes for Biomedical Research Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

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July 2014

Matched molecular pair analysis: significance and the impact of experimental uncertainty.

J Med Chem 2014 May 16;57(9):3786-802. Epub 2014 Apr 16.

Department of Theoretical Chemistry, Faculty for Chemistry and Pharmacy, Center for Molecular Biosciences Innsbruck (CMBI), Leopold-Franzens University Innsbruck , Innrain 80/82, A-6020 Innsbruck, Austria.

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May 2014

In vitro safety pharmacology profiling: what else beyond hERG?

Future Med Chem 2009 Jul;1(4):645-65

Center for Proteomic Chemistry, Novartis Pharma AG, Forum 1, 4002 Basel, Switzerland.

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July 2009

Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis.

J Chem Inf Model 2009 Feb;49(2):308-17

Lead Discovery Informatics and Preclinical Safety Profiling, CPC, Novartis Institutes for Biomedical Research, 250 Massachussetts Avenue, Cambridge, Massachusetts 02139, USA.

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February 2009

Mapping adverse drug reactions in chemical space.

J Med Chem 2009 May;52(9):3103-7

Lead Discovery Informatics, CPC, Novartis Institutes for Biomedical Research, 250 Massachussetts Avenue, Cambridge, Massachusetts 02139, USA.

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May 2009

Modeling promiscuity based on in vitro safety pharmacology profiling data.

ChemMedChem 2007 Jun;2(6):874-80

CPC/LFP/MLI, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Postfach, 4002 Basel, Switzerland.

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June 2007

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure.

ChemMedChem 2007 Jun;2(6):861-73

Lead Finding Platform, Novartis Institutes for BioMedical Research Inc. 250 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.

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June 2007

Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development.

Drug Discov Today 2005 Nov;10(21):1421-33

PreClinical Profiling, Lead Discovery Center, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

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November 2005