Steven W Paugh

Steven W Paugh

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Steven W Paugh

Steven W Paugh

Publications by authors named "Steven W Paugh"

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24Publications

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Inflammasome-mediated glucocorticoid resistance: The receptor rheostat.

Mol Cell Oncol 2016 Jan 11;3(1):e1065947. Epub 2015 Nov 11.

Hematological Malignancies Program, and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital , Memphis, TN, USA.

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http://dx.doi.org/10.1080/23723556.2015.1065947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845245PMC
January 2016

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

N Engl J Med 2014 Sep;371(11):1005-15

From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children's Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) - all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children's Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) - all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) - all in Texas; Maine Children's Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein

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http://dx.doi.org/10.1056/NEJMoa1403088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900PMC
September 2014

Mathematical modeling of folate metabolism.

Wiley Interdiscip Rev Syst Biol Med 2013 Sep-Oct;5(5):603-13. Epub 2013 May 22.

Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1002/wsbm.1227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745816PMC
March 2014

A guide to the current Web-based resources in pharmacogenomics.

Methods Mol Biol 2013 ;1015:293-310

Queensland Institute of Medical Research, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1007/978-1-62703-435-7_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795434PMC
February 2014

Pharmacogenomics in pediatric leukemia.

Curr Opin Pediatr 2010 Dec;22(6):703-10

Hematological Malignancies Program and Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1097/MOP.0b013e32833fde85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612020PMC
December 2010

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.

FASEB J 2008 Aug 24;22(8):2629-38. Epub 2008 Mar 24.

Department of Biochemistry and Molecular Biology and the Massey Cancer Center, VCU School of Medicine, 1101 E. Marshall St., Richmond, VA 23298, USA.

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http://dx.doi.org/10.1096/fj.08-107169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493451PMC
August 2008

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

Blood 2008 Aug 29;112(4):1382-91. Epub 2008 May 29.

Departments ofBiochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine and Massey Cancer Center, Richmond, VA 23298-0614, USA.

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http://dx.doi.org/10.1182/blood-2008-02-138958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515133PMC
August 2008

"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.

Pharmacol Rev 2008 Jun 13;60(2):181-95. Epub 2008 Jun 13.

Department of Surgery, Division of Surgical Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1124/pr.107.07113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695666PMC
June 2008

EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells.

FASEB J 2008 Feb 12;22(2):455-65. Epub 2007 Sep 12.

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine/Massey Cancer Center, Richmond, VA 23298, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752832PMC
http://dx.doi.org/10.1096/fj.07-8276comDOI Listing
February 2008

Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin.

Cancer Res 2007 Nov;67(21):10466-74

Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298-0614, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-07-2090DOI Listing
November 2007

Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases.

Biochim Biophys Acta 2006 Dec 18;1758(12):2016-26. Epub 2006 Aug 18.

Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E. Marshall St., Richmond, VA 23298-0614, USA.

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http://dx.doi.org/10.1016/j.bbamem.2006.08.007DOI Listing
December 2006

Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.

Mol Pharmacol 2006 Jul 29;70(1):41-50. Epub 2006 Mar 29.

Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, 1112 East Clay Street, Box 980524, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1124/mol.105.020552DOI Listing
July 2006

Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.

FEBS Lett 2005 Oct;579(24):5313-7

Department of Biochemistry, Virginia Commonwealth University, School of Medicine, Richmond, 23298-0614, USA.

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http://doi.wiley.com/10.1016/j.febslet.2005.08.055
Publisher Site
http://dx.doi.org/10.1016/j.febslet.2005.08.055DOI Listing
October 2005

The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.

FEBS Lett 2003 Nov;554(1-2):189-93

Department of Biochemistry, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1016/s0014-5793(03)01168-2DOI Listing
November 2003