Steven T Pals

Steven T Pals

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Steven T Pals

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MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance.

Gastroenterology 2019 10 27;157(4):1153-1155.e1. Epub 2019 Jun 27.

Amsterdam University Medical Centers, University of Amsterdam, Department of Pathology, Cancer Center Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.06.029DOI Listing
October 2019

Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options.

Leukemia 2019 05 15;33(5):1063-1075. Epub 2019 Feb 15.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41375-019-0404-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756057PMC
May 2019

Human Fetal TNF-α-Cytokine-Producing CD4 Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life.

Immunity 2019 02 12;50(2):462-476.e8. Epub 2019 Feb 12.

Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam University Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands; Department of Pediatrics, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam 1105 AZ, the Netherlands; Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg 20251, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183053
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http://dx.doi.org/10.1016/j.immuni.2018.12.010DOI Listing
February 2019

Acute lymphoblastic leukemia during the third trimester of pregnancy.

Leuk Lymphoma 2018 05 15;59(5):1274-1276. Epub 2017 Sep 15.

e Department of Hematology , Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.

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https://www.tandfonline.com/doi/full/10.1080/10428194.2017.1
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http://dx.doi.org/10.1080/10428194.2017.1375104DOI Listing
May 2018

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins.

Blood 2018 03 6;131(9):982-994. Epub 2017 Dec 6.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2017-07
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http://dx.doi.org/10.1182/blood-2017-07-797050DOI Listing
March 2018

MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.

Gastroenterology 2017 10 14;153(4):1040-1053.e4. Epub 2017 Jul 14.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.07.008DOI Listing
October 2017

Targeting cell adhesion and homing as strategy to cure Waldenström's macroglobulinemia.

Best Pract Res Clin Haematol 2016 06 7;29(2):161-168. Epub 2016 Sep 7.

Department of Pathology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands; Lymphoma and Myeloma Center Amsterdam - LYMMCARE, The Netherlands.

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http://dx.doi.org/10.1016/j.beha.2016.08.019DOI Listing
June 2016

Ibrutinib and idelalisib target B cell receptor- but not CXCL12/CXCR4-controlled integrin-mediated adhesion in Waldenström macroglobulinemia.

Haematologica 2016 Mar 3;101(3):e111-5. Epub 2015 Dec 3.

Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands Lymphoma and Myeloma Center Amsterdam - LYMMCARE, The Netherlands

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http://dx.doi.org/10.3324/haematol.2015.137265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815740PMC
March 2016

Effective treatment of Bing-Neel Syndrome with oral fludarabine: a case series of four consecutive patients.

Br J Haematol 2016 Feb 5;172(3):461-4. Epub 2015 May 5.

Department of Haematology, UMC Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1111/bjh.13483DOI Listing
February 2016

The forkhead transcription factor FOXP1 represses human plasma cell differentiation.

Blood 2015 Oct 19;126(18):2098-109. Epub 2015 Aug 19.

Department of Pathology, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Academic Medical Center, Amsterdam, The Netherlands;

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http://dx.doi.org/10.1182/blood-2015-02-626176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626252PMC
October 2015

Ibrutinib and idelalisib synergistically target BCR-controlled adhesion in MCL and CLL: a rationale for combination therapy.

Blood 2015 Apr;125(14):2306-9

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Lymphoma and Myeloma Center Amsterdam - LYMMCARE, Amsterdam, The Netherlands.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-12-61
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http://dx.doi.org/10.1182/blood-2014-12-619163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416940PMC
April 2015

Hepatosplenic T-Cell Lymphoma: A Population-Based Study Assessing Incidence and Association With Immune-Mediated Disease.

Gastroenterol Hepatol (N Y) 2015 Mar;11(3):160-3

Dr Montgomery is the executive medical director at Incyte Corporation in Wilmington, Delaware. At the time of the study, he was a director at Janssen Biotech in Horsham, Pennsylvania. Ms van Santen is a surgical pathologist at the Academic Medical Center of the University of Amsterdam in Amsterdam, The Netherlands. Dr Biemond is an internist-hematologist in the Department of Haematology at the Academic Medical Center of the University of Amsterdam. Dr Diamond is the vice president of medical affairs at BTG International, Inc, in West Conshohocken, Pennsylvania. At the time of the study, he was the lead medical director at Janssen Biotech. Dr Pals is a professor of pathology at the Academic Medical Center of the University of Amsterdam.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836585PMC
March 2015

FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells.

Blood 2014 Nov 29;124(23):3431-40. Epub 2014 Sep 29.

Department of Pathology and Lymphoma and Myeloma Center Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;

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http://dx.doi.org/10.1182/blood-2014-01-553412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246697PMC
November 2014

CD44-deficiency attenuates the immunologic responses to LPS and delays the onset of endotoxic shock-induced renal inflammation and dysfunction.

PLoS One 2013 23;8(12):e84479. Epub 2013 Dec 23.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands ; Department of Pathology, Radboud University Nijmegen Center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084479PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871539PMC
October 2014

Opposite role of CD44-standard and CD44-variant-3 in tubular injury and development of renal fibrosis during chronic obstructive nephropathy.

Kidney Int 2014 Sep 9;86(3):558-69. Epub 2014 Apr 9.

1] Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands [2] Department of Pathology, Radboud University Nijmegen Center, Nijmegen, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00852538153033
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http://dx.doi.org/10.1038/ki.2014.87DOI Listing
September 2014

Aberrant humoral immune reactivity in DOCK8 deficiency with follicular hyperplasia and nodal plasmacytosis.

Clin Immunol 2013 Oct 19;149(1):25-31. Epub 2013 Jun 19.

Department of Experimental Immunology, Academic Medical Center (AMC), Amsterdam, The Netherlands; Emma Children's Hospital, AMC, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2013.06.002DOI Listing
October 2013

Heparan sulfate proteoglycans in the control of B cell development and the pathogenesis of multiple myeloma.

FEBS J 2013 May 4;280(10):2180-93. Epub 2013 Mar 4.

Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1111/febs.12180
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http://dx.doi.org/10.1111/febs.12180DOI Listing
May 2013

Distinct CD44 splice variants differentially affect collateral artery growth.

Curr Vasc Pharmacol 2013 Jan;11(1):13-20

Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

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January 2013

Memory CD4(+)CCR5(+) T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1.

Blood 2012 Nov 1;120(22):4383-90. Epub 2012 Oct 1.

Departments of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children’s Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2012-06-437566DOI Listing
November 2012

The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia.

Blood 2012 Mar 25;119(11):2590-4. Epub 2012 Jan 25.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2011-11-390989DOI Listing
March 2012

WNT signaling controls expression of pro-apoptotic BOK and BAX in intestinal cancer.

Biochem Biophys Res Commun 2011 Mar 22;406(1):1-6. Epub 2010 Dec 22.

Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bbrc.2010.12.070DOI Listing
March 2011

The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.

Biochim Biophys Acta 2010 Dec 22;1806(2):208-19. Epub 2010 Jul 22.

Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.bbcan.2010.07.006DOI Listing
December 2010

Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma.

Blood 2010 Jan 13;115(3):601-4. Epub 2009 Nov 13.

Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2009-02-204396DOI Listing
January 2010

The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation.

Cancer Res 2010 Jan 12;70(2):719-29. Epub 2010 Jan 12.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, and Department of Pathology, Academic Medical Center, 1105AZ Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1820DOI Listing
January 2010

Instant conditional transgenesis in the mouse hematopoietic compartment.

J Immunol Methods 2008 Dec 13;339(2):259-63. Epub 2008 Sep 13.

Academic Medical Center, Department of Pathology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jim.2008.08.009DOI Listing
December 2008

Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis.

Cancer Res 2008 May;68(10):3655-61

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-07-2940DOI Listing
May 2008

The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells.

Blood 2008 Apr 28;111(7):3364-72. Epub 2008 Jan 28.

Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2007-08-106583DOI Listing
April 2008

Lymphoma dissemination: the other face of lymphocyte homing.

Blood 2007 Nov 26;110(9):3102-11. Epub 2007 Jul 26.

Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2007-05-075176DOI Listing
November 2007

The B cell antigen receptor controls AP-1 and NFAT activity through Ras-mediated activation of Ral.

J Immunol 2007 Feb;178(3):1405-14

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.178.3.1405DOI Listing
February 2007

Bruton's tyrosine kinase and phospholipase Cgamma2 mediate chemokine-controlled B cell migration and homing.

Immunity 2007 Jan;26(1):93-104

Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.immuni.2006.11.012DOI Listing
January 2007

Urothelial CD44 facilitates Escherichia coli infection of the murine urinary tract.

J Immunol 2006 Nov;177(10):7225-32

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.177.10.7225DOI Listing
November 2006

No evidence for an association of ocular adnexal lymphoma with Chlamydia psittaci in a cohort of patients from the Netherlands.

Leuk Res 2006 Oct 18;30(10):1305-7. Epub 2006 Jan 18.

Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.leukres.2005.12.003DOI Listing
October 2006

Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma.

Mod Pathol 2006 Sep 16;19(9):1270-6. Epub 2006 Jun 16.

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/modpathol.3800650DOI Listing
September 2006

CD44 disruption prevents degeneration of the capillary network in obstructive nephropathy via reduction of TGF-beta1-induced apoptosis.

J Am Soc Nephrol 2006 Mar 1;17(3):746-53. Epub 2006 Feb 1.

Department of Pathology, Academic Medical Center, Room M2-108, PO Box 22668, 1100 DD Amsterdam, The Netherlands.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2005080808
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http://dx.doi.org/10.1681/ASN.2005080808DOI Listing
March 2006

Protection against renal ischemia reperfusion injury by CD44 disruption.

J Am Soc Nephrol 2005 Jul 18;16(7):2034-43. Epub 2005 May 18.

Department of Pathology, Academic Medical Center, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1681/ASN.2005010054DOI Listing
July 2005

Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity.

J Exp Med 2005 Apr;201(8):1229-41

Department of Pathology, Academic Medical Center, Netherlands Cncer Institute, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1084/jem.20050068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213160PMC
April 2005

Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator.

Blood 2004 Oct 1;104(7):2172-5. Epub 2004 Jun 1.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2003-12-4386DOI Listing
October 2004

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells.

Proc Natl Acad Sci U S A 2004 Apr 5;101(16):6122-7. Epub 2004 Apr 5.

Department of Pathology, Academic Medical Center, University of Amsterdam, 1105AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1073/pnas.0305855101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395933PMC
April 2004

The B cell antigen receptor controls integrin activity through Btk and PLCgamma2.

J Exp Med 2003 Nov 10;198(10):1539-50. Epub 2003 Nov 10.

Dept. of Pathology, Academic Medical Center, Meibergdreef 9 1105 AZ Amsterdam, Netherlands.

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http://dx.doi.org/10.1084/jem.20011866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194118PMC
November 2003

CD44 is a macrophage binding site for Mycobacterium tuberculosis that mediates macrophage recruitment and protective immunity against tuberculosis.

J Clin Invest 2003 Mar;111(5):681-9

Laboratory of Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1172/JCI16936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151898PMC
March 2003

c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination.

J Immunol 2002 Oct;169(7):3793-800

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.169.7.3793DOI Listing
October 2002

Hepatocyte growth factor triggers signaling cascades mediating vascular smooth muscle cell migration.

Biochem Biophys Res Commun 2002 Oct;298(1):80-6

Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/s0006-291x(02)02397-5DOI Listing
October 2002

Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer.

Cancer Res 2002 Sep;62(18):5126-8

Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.

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September 2002

CD44 is exposed to the extracellular matrix at invasive sites in basal cell carcinomas.

Lab Invest 2002 Mar;82(3):313-22

Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands.

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March 2002

Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.

Blood 2002 Feb;99(4):1405-10

Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood.v99.4.1405DOI Listing
February 2002

CD44 expression in IgA nephropathy.

Am J Kidney Dis 2002 Feb;39(2):407-14

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1053/ajkd.2002.30563DOI Listing
February 2002