Publications by authors named "Steven Sacks"

100Publications

Rationale for targeting complement in COVID-19.

EMBO Mol Med 2020 08 12;12(8):e12642. Epub 2020 Jul 12.

MRC Centre of Transplantation, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, Guy's Hospital, King's College London, London, UK.

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http://dx.doi.org/10.15252/emmm.202012642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323084PMC
August 2020

Fucose as a new therapeutic target in renal transplantation.

Pediatr Nephrol 2020 May 29. Epub 2020 May 29.

MRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, UK.

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http://dx.doi.org/10.1007/s00467-020-04588-2DOI Listing
May 2020

l-Fucose prevention of renal ischaemia/reperfusion injury in Mice.

FASEB J 2020 01 27;34(1):822-834. Epub 2019 Nov 27.

MRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, UK.

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http://dx.doi.org/10.1096/fj.201901582RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972607PMC
January 2020

The C5a/C5aR1 axis promotes progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia/reperfusion injury.

Kidney Int 2019 07 4;96(1):117-128. Epub 2019 Mar 4.

Medical Research Council Centre for Transplantation, King's College London, Guy's Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2019.01.039DOI Listing
July 2019

Collectin-11 (CL-11) Is a Major Sentinel at Epithelial Surfaces and Key Pattern Recognition Molecule in Complement-Mediated Ischaemic Injury.

Front Immunol 2018 6;9:2023. Epub 2018 Sep 6.

MRC Centre for Transplantation, School of Immunology and Microbial Sciences, King's College London, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2018.02023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136055PMC
September 2019

Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient.

Transplant Rev (Orlando) 2018 07 10;32(3):119-126. Epub 2018 Feb 10.

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trre.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497150PMC
July 2018

Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy.

Nephrol Dial Transplant 2018 08;33(8):1323-1332

Division of Nephrology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong.

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http://dx.doi.org/10.1093/ndt/gfx336DOI Listing
August 2018

C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli.

JCI Insight 2017 12 21;2(24). Epub 2017 Dec 21.

Medical Research Council (MRC) Centre for Transplantation, King's College London, Guy's Hospital, United Kingdom (UK).

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http://dx.doi.org/10.1172/jci.insight.97626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752266PMC
December 2017

Collectin-11 Promotes the Development of Renal Tubulointerstitial Fibrosis.

J Am Soc Nephrol 2018 01 15;29(1):168-181. Epub 2017 Nov 15.

Medical Research Council Centre for Transplantation, Division of Transplantation Immunology and Mucosa Biology, King's College London, Guy's Hospital, London, United Kingdom; and

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http://dx.doi.org/10.1681/ASN.2017050544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748920PMC
January 2018

Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress.

Sci Rep 2017 11 7;7(1):14625. Epub 2017 Nov 7.

MRC Centre for Transplantation, King's College London and Guy's and St Thomas' NHS Trust, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1038/s41598-017-15212-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677091PMC
November 2017

Structural and functional diversity of collectins and ficolins and their relationship to disease.

Semin Immunopathol 2018 01 11;40(1):75-85. Epub 2017 Sep 11.

MRC Centre for Transplantation, King's College London, Guy's Hospital, 5th Floor Tower Wing, Great Maze Pond, London, SE1 9RT, UK.

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http://dx.doi.org/10.1007/s00281-017-0642-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794833PMC
January 2018

Complement Recognition Pathways in Renal Transplantation.

J Am Soc Nephrol 2017 Sep 29;28(9):2571-2578. Epub 2017 Jun 29.

Medical Research Council Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London, National Health Service Guy's and St. Thomas' Trust, London, United Kingdom.

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http://www.jasn.org/lookup/doi/10.1681/ASN.2017010079
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http://dx.doi.org/10.1681/ASN.2017010079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576943PMC
September 2017

Erratum to: Methods for evaluating medical tests and biomarkers.

Authors:
Gowri Gopalakrishna Miranda Langendam Rob Scholten Patrick Bossuyt Mariska Leeflang Anna Noel-Storr James Thomas Iain Marshall Byron Wallace Penny Whiting Clare Davenport Mariska Leeflang Gowri GopalaKrishna Isabel de Salis Sue Mallett Robert Wolff Penny Whiting Richard Riley Marie Westwood Jos Kleinen Gary Collins Hans Reitsma Karel Moons Antonia Zapf Annika Hoyer Katharina Kramer Oliver Kuss J Ensor J J Deeks E C Martin R D Riley Gerta Rücker Susanne Steinhauser Martin Schumacher Richard Riley Joie Ensor Kym Snell Brian Willis Thomas Debray Karel Moons Jon Deeks Gary Collins Lavinia Ferrante di Ruffano Brian Willis Clare Davenport Sue Mallett Sian Taylor-Phillips Chris Hyde Jon Deeks Sue Mallett Stuart A Taylor Gauraang Batnagar Sian Taylor-Phillips Lavinia Ferrante Di Ruffano Farah Seedat Aileen Clarke Jon Deeks Sarah Byron Frances Nixon Rebecca Albrow Thomas Walker Carla Deakin Chris Hyde Zhivko Zhelev Harriet Hunt Lavinia Ferrante di Ruffano Yaling Yang Lucy Abel James Buchanan Thomas Fanshawe Bethany Shinkins Laure Wynants Jan Verbakel Sabine Van Huffel Dirk Timmerman Ben Van Calster Mariska Leeflang Aeliko Zwinderman Patrick Bossuyt Jason Oke Jack O'Sullivan Rafael Perera Brian Nicholson Hannah L Bromley Tracy E Roberts Adele Francis Denniis Petrie G Bruce Mann Kinga Malottki Holly Smith Jon Deeks Lucinda Billingham Alice Sitch Sue Mallett Jon Deeks Oke Gerke Mie Holm-Vilstrup Eivind Antonsen Segtnan Ulrich Halekoh Poul Flemming Høilund-Carlsen Bernard G Francq Jon Deeks Alice Sitch Jac Dinnes Julie Parkes Walter Gregory Jenny Hewison Doug Altman William Rosenberg Peter Selby Julien Asselineau Paul Perez Aïssatou Paye Emilie Bessede Cécile Proust-Lima Christiana Naaktgeboren Joris de Groot Anne Rutjes Patrick Bossuyt Johannes Reitsma Karel Moons Gary Collins Emmanuel Ogundimu Jonathan Cook Yannick Le Manach Doug Altman Laure Wynants Yvonne Vergouwe Sabine Van Huffel Dirk Timmerman Ben Van Calster Romin Pajouheshnia Rolf Groenwold Karen Moons Johannes Reitsma Linda Peelen Ben Van Calster Daan Nieboer Yvonne Vergouwe Bavo De Cock Micael J Pencina Ewout W Steyerberg Jennifer Cooper Sian Taylor-Phillips Nick Parsons Chris Stinton Steve Smith Andy Dickens Rachel Jordan Alexandra Enocson David Fitzmaurice Alice Sitch Peymane Adab Bernard G Francq Charles Boachie Gaj Vidmar Karoline Freeman Martin Connock Sian Taylor-Phillips Rachel Court Aileen Clarke Joris de Groot Christiana Naaktgeboren Hans Reitsma Carl Moons Jessica Harris Andrew Mumford Zoe Plummer Kurtis Lee Barnaby Reeves Chris Rogers Veerle Verheyden Gianni D Angelini Gavin J Murphy Jeremy Huddy Melody Ni Katherine Good Graham Cooke Patrick Bossuyt George Hanna Jie Ma Doug Altman Gary Collins K G M Carl Moons Joris A H de Groot Sue Mallett Doug G Altman Johannes B Reitsma Gary S Collins Karel G M Moons Douglas G Altman Johannes B Reitsma Gary S Collins Adina Najwa Kamarudin Ruwanthi Kolamunnage-Dona Trevor Cox Melody Ni Jeremy Huddy Simone Borsci George Hanna Teresa Pérez M Carmen Pardo Angel Candela-Toha Alfonso Muriel Javier Zamora Sabina Sanghera Syed Mohiuddin Richard Martin Jenny Donovan Joanna Coast Mikyung Kelly Seo John Cairns Elizabeth Mitchell Alison Smith Judy Wright Peter Hall Michael Messenger Nicola Calder Nyantara Wickramasekera Karen Vinall-Collier Andrew Lewington Romin Pajouheshnia Johanna Damen Rolf Groenwold Karel Moons Linda Peelen Michael Messenger David Cairns Alison Smith Michelle Hutchinson Judy Wright Peter Hall Nicola Calder Cathie Sturgeon Liz Mitchel Rebecca Kift Sofia Christakoudi Manohursingh Rungall Paula Mobillo Rosa Montero Tjir-Li Tsui Sui Phin Kon Beatriz Tucker Steven Sacks Chris Farmer Terry Strom Paramit Chowdhury Irene Rebollo-Mesa Maria Hernandez-Fuentes Johanna A A G Damen Thomas P A Debray Pauline Heus Lotty Hooft Karel G M Moons Romin Pajouheshnia Johannes B Reitsma Rob J P M Scholten Johanna A A G Damen Lotty Hooft Ewoud Schuit Thomas P A Debray Gary S Collins Ioanna Tzoulaki Camille M Lassale George C M Siontis Virginia Chiocchia Corran Roberts Michael Maia Schlüssel Stephen Gerry James A Black Pauline Heus Yvonne T van der Schouw Linda M Peelen Karel G M Moons Johanna A A G Damen Thomas P A Debray Pauline Heus Lotty Hooft Karel G M Moons Romin Pajouheshnia Johannes B Reitsma Rob J P M Scholten Jie Ma Doug Altman Gary Collins Graeme Spence David McCartney Ann van den Bruel Daniel Lasserson Gail Hayward Werner Vach Antoinette de Jong Coreline Burggraaff Otto Hoekstra Josée Zijlstra Henrica de Vet Harriet Hunt Chris Hyde Sara Graziadio Joy Allen Louise Johnston Rachel O'Leary Michael Power Joy Allen Sara Graziadio Louise Johnson Rachel O'Leary Michael Power Ray Waters John Simpson Louise Johnston Joy Allen Sara Graziadio Rachel O'Leary Ray Waters Michael Power Sue Mallett Thomas R Fanshawe Peter Phillips Andrew Plumb Emma Helbren Steve Halligan Stuart A Taylor Alastair Gale Sue Mallett Peggy Sekula Douglas G Altman Willi Sauerbrei Sue Mallett Thomas R Fanshawe Julia R Forman Susan J Dutton Yemisi Takwoingi Elizabeth M Hensor Thomas E Nichols Bethany Shinkins Yaling Yang Lucy Abel Lavinia Ferrante Di Ruffano Thomas Fanshawe Emmanuelle Kempf Raphael Porcher Jennifer de Beyer Karel Moons Douglas Altman Hans Reitsma Sally Hopewell Willi Sauerbrei Gary Collins John Dennis Beverley Shields Angus Jones William Henley Ewan Pearson Andrew Hattersley Pauline Heus Johanna A A G Damen Romin Pajouheshnia Rob J P M Scholten Johannes B Reitsma Gary S Collins Douglas G Altman Karel G M Moons Lotty Hooft Beverley Shields John Dennis Angus Jones William Henley Ewan Pearson Andrew Hattersley Fueloep Scheibler Anne Rummer Sibylle Sturtz Robert Großelfinger Katie Banister Craig Ramsay Augusto Azuara-Blanco Jonathan Cook Charles Boachie Jennifer Burr Manjula Kumarasamy Rupert Bourne Ijeoma Uchegbu Simone Borsci Jennifer Murphy George Hanna Ijeoma Uchegbu Alex Carter Jen Murphy Melody Ni Joachim Marti Julie Eatock Ijeoma Uchegbu Julie Robotham Maria Dudareva Mark Gilchrist Alison Holmes Ijeoma Uchegbu Simone Borsci Phillip Monaghan Sarah Lord Andrew StJohn Sverre Sandberg Christa Cobbaert Lieselotte Lennartz Wilma Verhagen-Kamerbeek Christoph Ebert Patrick Bossuyt Andrea Horvath Kevin Jenniskens Christiana Naaktgeboren Johannes Reitsma Karel Moons Joris de Groot Chris Hyde Jaime Peters Bogdan Grigore Jaime Peters Chris Hyde Chris Hyde Obi Ukoumunne Jaime Peters Zhivko Zhelev Brooke Levis Andrea Benedetti Alexander W Levis John P A Ioannidis Ian Shrier Pim Cuijpers Simon Gilbody Lorie A Kloda Dean McMillan Scott B Patten Russell J Steele Roy C Ziegelstein Charles H Bombardier Flavia de Lima Osório Jesse R Fann Dwenda Gjerdingen Femke Lamers Manote Lotrakul Sonia R Loureiro Bernd Löwe Juwita Shaaban Lesley Stafford Henk C P M van Weert Mary A Whooley Linda S Williams Karin A Wittkampf Albert S Yeung Brett D Thombs Jaime Peters Chris Cooper James Buchanan Tom Nieto Claire Smith Olga Tucker Janine Dretzke Andrew Beggs Nirmala Rai Clare Davenport Sue Bayliss Simon Stevens Kym Snell Sue Mallet Jon Deeks Sudha Sundar Emma Hall Nuria Porta David Lorente Estelles Johann de Bono

Diagn Progn Res 2017 30;1:11. Epub 2017 Mar 30.

278The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1186/s41512-017-0011-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460744PMC
March 2017

The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis.

Kidney Int 2016 09 28;90(3):540-54. Epub 2016 Jun 28.

Medical Research Council Centre for Transplantation, King's College London, Guy's Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996631PMC
September 2016

Role of the lectin complement pathway in kidney transplantation.

Immunobiology 2016 10 24;221(10):1068-72. Epub 2016 May 24.

MRC Centre for Transplantation, Division of Transplantation Immunology & Mucosal Biology, King's College London School of Medicine at Guy's, King's College and St. Thomas's Hospitals, London, United Kingdom.

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http://dx.doi.org/10.1016/j.imbio.2016.05.004DOI Listing
October 2016

Systematic assessment of the influence of complement gene polymorphisms on kidney transplant outcome.

Immunobiology 2016 Apr 12;221(4):528-34. Epub 2015 Dec 12.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.imbio.2015.12.006DOI Listing
April 2016

Kinetics of mast cell migration during transplantation tolerance.

Transpl Immunol 2015 Jan 18;32(1):40-5. Epub 2014 Oct 18.

MRC Centre for Transplantation, King's College London School of Medicine at Guy's, King's and St Thomas' Hospitals, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.trim.2014.10.004DOI Listing
January 2015

Control of innate immunological mechanisms as a route to drug minimization.

Curr Opin Organ Transplant 2014 Aug;19(4):342-7

MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London School of Medicine, Guy's Hospital, London, UK.

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http://pdfs.journals.lww.com/co-transplantation/2014/08000/C
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MOT.0000000000000094DOI Listing
August 2014

Mechanisms of rejection: role of complement.

Curr Opin Organ Transplant 2014 Feb;19(1):8-13

Division of Transplantation Immunology & Mucosal Biology, MRC Centre for Transplantation, King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals, London, United Kingdom.

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http://dx.doi.org/10.1097/MOT.0000000000000037DOI Listing
February 2014

The innate immune system and transplantation.

Cold Spring Harb Perspect Med 2013 Oct 1;3(10):a015479. Epub 2013 Oct 1.

MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London School of Medicine at Guy's, King's College and St. Thomas' Hospitals, London SE1 9RT, United Kingdom.

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http://perspectivesinmedicine.cshlp.org/content/3/10/a015479
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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a015479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784815PMC
October 2013

C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage.

PLoS One 2013 26;8(8):e72059. Epub 2013 Aug 26.

Department of Clinical Research, University of Bern, Bern, Switzerland ; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072059PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753343PMC
April 2014

C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation.

Blood 2013 Nov 22;122(20):3473-81. Epub 2013 Jul 22.

Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Guy's Hospital, London, United Kingdom;

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http://www.bloodjournal.org/content/122/20/3473.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-05-50
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http://dx.doi.org/10.1182/blood-2013-05-502229DOI Listing
November 2013

The use of eculizumab in renal transplantation.

Clin Transplant 2013 May-Jun;27(3):E216-29. Epub 2013 Mar 21.

Renal and Transplant Department, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/ctr.12102DOI Listing
January 2014

Targeting complement at the time of transplantation.

Adv Exp Med Biol 2013 ;735:247-55

Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, 5th Floor, Tower Wing, Great Maze Pond, Guy's Hospital, London SE1 9RT, UK.

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http://link.springer.com/content/pdf/10.1007/978-1-4614-4118
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http://dx.doi.org/10.1007/978-1-4614-4118-2_17DOI Listing
March 2013

Which pathways trigger the role of complement in ischaemia/reperfusion injury?

Front Immunol 2012 19;3:341. Epub 2012 Nov 19.

MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals London, UK.

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http://dx.doi.org/10.3389/fimmu.2012.00341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500775PMC
November 2012

Donor specific transplant tolerance is dependent on complement receptors.

Transpl Int 2013 Jan 20;26(1):99-108. Epub 2012 Nov 20.

MRC Centre for Transplantation, King's College London, School of Medicine at Guy's, King's and St. Thomas' Hospitals, London, UK.

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http://dx.doi.org/10.1111/tri.12006DOI Listing
January 2013

Licenced to transplant: UK overkill on EU Organ Directive provides golden opportunity for research.

J Med Ethics 2012 Oct 8;38(10):593-5. Epub 2012 Aug 8.

NIHR Biomedical Research Centre, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1136/medethics-2012-100872DOI Listing
October 2012

C3a and C5a promote renal ischemia-reperfusion injury.

J Am Soc Nephrol 2012 Sep 12;23(9):1474-85. Epub 2012 Jul 12.

MRC Centre for Transplantation, King's College London, London SE1 9RT, United Kingdom.

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http://dx.doi.org/10.1681/ASN.2011111072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431410PMC
September 2012

The role of complement in the early immune response to transplantation.

Nat Rev Immunol 2012 May 25;12(6):431-42. Epub 2012 May 25.

MRC Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London School of Medicine at Guy's, King's and St Thomas' Hospitals, London SE1 9RT, UK.

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http://dx.doi.org/10.1038/nri3225DOI Listing
May 2012

Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury.

FASEB J 2012 Feb 31;26(2):799-807. Epub 2011 Oct 31.

Medical Research Council Centre for Transplantation, Division of Transplantation Immunology and Mucosal Biology, King's College London School of Medicine at Guy's, King's College, and St. Thomas' Hospitals, Guy's Hospital, London, United Kingdom.

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http://www.fasebj.org/content/26/2/799.full.pdf
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http://www.fasebj.org/cgi/doi/10.1096/fj.11-195396
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http://dx.doi.org/10.1096/fj.11-195396DOI Listing
February 2012

Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a.

Immunobiology 2012 Jan 5;217(1):65-73. Epub 2011 Aug 5.

King's College London, MRC Centre for Transplantation, NIHR Comprehensive Biomedical Research Centre, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1016/j.imbio.2011.07.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234345PMC
January 2012

Complement UK--how and why it started.

Immunobiology 2012 Feb 5;217(2):125-6. Epub 2011 May 5.

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https://linkinghub.elsevier.com/retrieve/pii/S01712985110009
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http://dx.doi.org/10.1016/j.imbio.2011.05.001DOI Listing
February 2012

Expression of complement components, receptors and regulators by human dendritic cells.

Mol Immunol 2011 May 23;48(9-10):1121-7. Epub 2011 Mar 23.

King's College London, MRC Centre for Transplantation, NIHR Comprehensive Biomedical Research Centre, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1016/j.molimm.2011.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084445PMC
May 2011

Tertiary lymphoid organs in renal allografts can be associated with donor-specific tolerance rather than rejection.

Eur J Immunol 2011 Jan 11;41(1):89-96. Epub 2010 Nov 11.

MRC Centre for Transplantation, King's College London School of Medicine at Guy's, King's and St. Thomas' Hospitals, London, UK.

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http://dx.doi.org/10.1002/eji.201040759DOI Listing
January 2011

Genomics in human renal transplantation.

Curr Opin Immunol 2010 Oct;22(5):689-93

MRC Centre for Transplantation and the National Institute for Health Research Comprehensive Biomedical Research Centre, Guys' and St. Thomas' NHS Foundation Trust and King's College, London, United Kingdom.

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http://dx.doi.org/10.1016/j.coi.2010.08.016DOI Listing
October 2010

Deficiency of C5aR prolongs renal allograft survival.

J Am Soc Nephrol 2010 Aug 22;21(8):1344-53. Epub 2010 Jul 22.

Department of Nephrology and Transplantation, MRC Centre for Transplantation, King's College London, School of Medicine at Guy's Hospital, London, UK.

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http://jasn.asnjournals.org/content/early/2010/07/22/ASN.200
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http://www.jasn.org/cgi/doi/10.1681/ASN.2009090977
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http://dx.doi.org/10.1681/ASN.2009090977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938594PMC
August 2010

Complement in organ transplantation.

Curr Opin Organ Transplant 2010 Aug;15(4):486-91

MRC Centre for Transplantation, King's College London, Guy's Hospital, Great Maze Pond, London, UK.

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https://insights.ovid.com/crossref?an=00075200-201008000-000
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http://dx.doi.org/10.1097/MOT.0b013e32833b9cb7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100572PMC
August 2010

Toll-like receptor 4 stimulation triggers crescentic glomerulonephritis by multiple mechanisms including a direct effect on renal cells.

Am J Pathol 2010 Aug 21;177(2):644-53. Epub 2010 Jun 21.

Medical Research Council Centre for Transplantation, King's College London School of Medicine, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00029440106012
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http://dx.doi.org/10.2353/ajpath.2010.091279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912109PMC
August 2010

Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction.

Kidney Int 2010 Aug 16;78(4):351-62. Epub 2010 Jun 16.

MRC Centre for Transplantation, King's College London School of Medicine at Guy's, King's and St Thomas' Hospitals, London, UK.

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http://dx.doi.org/10.1038/ki.2010.177DOI Listing
August 2010

Endogenous ligands for TLR2 and TLR4 are not involved in renal injury following ureteric obstruction.

Nephron Exp Nephrol 2010 28;115(4):e122-30. Epub 2010 Apr 28.

Department of Nephrology and Transplantation, King's College London, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1159/000313493DOI Listing
November 2010

Complement fragments C3a and C5a: the salt and pepper of the immune response.

Authors:
Steven H Sacks

Eur J Immunol 2010 Mar;40(3):668-70

MRC Centre for Transplantation, King's College London, London, UK.

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http://dx.doi.org/10.1002/eji.201040355DOI Listing
March 2010

Dendritic cell function in allostimulation is modulated by C5aR signaling.

J Immunol 2009 Nov 28;183(10):6058-68. Epub 2009 Oct 28.

Complement Laboratory, MRC Centre for Transplantation, King's College London, School of Medicine at Guy's Hospital, London, UK.

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http://dx.doi.org/10.4049/jimmunol.0804186DOI Listing
November 2009

The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses.

Inflamm Allergy Drug Targets 2009 Jul;8(3):236-46

Complement Laboratory, MRC Centre for Transplantation, King's College London, School of Medicine at Guy's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.2174/187152809788681038DOI Listing
July 2009

Locally produced and activated complement as a mediator of alloreactive T cells.

Front Biosci (Schol Ed) 2009 Jun 1;1:117-24. Epub 2009 Jun 1.

Institute of Pathology, Case Western Reserve University, Cleveland OH 44106 USA.

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June 2009

The role of complement in regulating the alloresponse.

Curr Opin Organ Transplant 2009 Feb;14(1):10-5

MRC Centre for Transplantation, King's College London, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1097/MOT.0b013e32831ec551DOI Listing
February 2009

Synergy between type 1 fimbriae expression and C3 opsonisation increases internalisation of E. coli by human tubular epithelial cells.

BMC Microbiol 2009 Mar 31;9:64. Epub 2009 Mar 31.

Complement Laboratory, Medical Research Council (MRC) Centre for Transplantation, Guy's Hospital, King's College London, London, UK.

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http://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-
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http://dx.doi.org/10.1186/1471-2180-9-64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670304PMC
March 2009

C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy.

J Am Soc Nephrol 2009 Mar 21;20(3):593-603. Epub 2009 Jan 21.

King's College London, Department of Nephrology and Transplantation, Guy's Hospital London, London, UK.

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http://dx.doi.org/10.1681/ASN.2008040434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653680PMC
March 2009

Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation.

Blood 2008 Dec 23;112(13):5084-94. Epub 2008 Sep 23.

Complement Laboratory, Medical Research Centre (MRC) Centre for Transplantation, King's College London School of Medicine at Guy's Hospital, London, United Kingdom.

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http://dx.doi.org/10.1182/blood-2008-05-156646DOI Listing
December 2008

Long-term tacrolimus versus long-term ciclosporin in renal transplant recipients with poor graft function.

Nat Clin Pract Nephrol 2008 Nov 16;4(11):598-9. Epub 2008 Sep 16.

National Institute for Health Research Biomedical Research Centre, King's College London and Guy's and St Thomas' NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1038/ncpneph0944DOI Listing
November 2008

Extensive and bidirectional transfer of major histocompatibility complex class II molecules between donor and recipient cells in vivo following solid organ transplantation.

FASEB J 2008 Nov 16;22(11):3776-84. Epub 2008 Jul 16.

MRC Center for Transplantation, Fifth Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.

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http://www.fasebj.org/doi/10.1096/fj.08-107441
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November 2008

Homeostatic proliferation of lymphocytes results in augmented memory-like function and accelerated allograft rejection.

J Immunol 2008 Mar;180(6):3910-8

Department of Nephrology and Transplantation, King's College London School of Medicine at Guy's, King's and St. Thomas' Hospital, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.180.6.3910DOI Listing
March 2008

New boundaries for complement in renal disease.

J Am Soc Nephrol 2008 Oct 6;19(10):1865-9. Epub 2008 Feb 6.

MRC Centre for Transplantation, King's College London, United Kingdom.

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http://dx.doi.org/10.1681/ASN.2007101121DOI Listing
October 2008

Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction.

Blood 2008 Feb 4;111(4):2452-61. Epub 2007 Dec 4.

Medical Research Council Centre for Transplantation, Department of Nephrology and Transplantation, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1182/blood-2007-06-095018DOI Listing
February 2008

Synthesis of complement protein C3 in the kidney is an important mediator of local tissue injury.

FASEB J 2008 Apr 26;22(4):1065-72. Epub 2007 Nov 26.

King's College London, Department of Nephrology and Transplantation, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1096/fj.07-8719comDOI Listing
April 2008

Ultra-localization of Foxp3+ T cells within renal allografts shows infiltration of tubules mimicking rejection.

Am J Pathol 2007 Dec 8;171(6):1915-22. Epub 2007 Nov 8.

Department of Nephrology and Transplantation, King's College London School of Medicine at Guy's, King's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.2353/ajpath.2007.070396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2111114PMC
December 2007

The classical complement pathway plays a critical role in the opsonisation of uropathogenic Escherichia coli.

Mol Immunol 2008 Feb 17;45(4):954-62. Epub 2007 Sep 17.

King's College London, Department of Nephrology and Transplantation, Guy's Hospital London, London SE1 9RT, UK.

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http://dx.doi.org/10.1016/j.molimm.2007.07.037DOI Listing
February 2008

The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies.

Mol Immunol 2007 Sep;44(16):3866-74

MRC Centre for Transplantation and Department of Nephrology and Transplantation, King's College London School of Medicine at Guy's Hospital, London, UK.

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http://dx.doi.org/10.1016/j.molimm.2007.06.006DOI Listing
September 2007

Graft-derived complement as a mediator of transplant injury.

Curr Opin Immunol 2007 Oct 30;19(5):569-76. Epub 2007 Aug 30.

MRC Centre for Transplantation, King's College London, UK.

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http://dx.doi.org/10.1016/j.coi.2007.07.007DOI Listing
October 2007

The role of complement and Toll-like receptors in organ transplantation.

Transpl Int 2007 Jun;20(6):481-9

Department of Nephrology and Transplantation, King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals, London, UK.

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http://doi.wiley.com/10.1111/j.1432-2277.2006.00448.x
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June 2007

Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody-mediated glomerulonephritis via CXCL1 and CXCL2.

J Am Soc Nephrol 2007 Jun 25;18(6):1732-9. Epub 2007 Apr 25.

Department of Nephrology and Transplantation, 5th Floor Thomas Guy House, Guy's Hospital, St. Thomas Street, London, UK.

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June 2007

Mechanisms of disease: the complement system in renal injury--new ways of looking at an old foe.

Nat Clin Pract Nephrol 2007 May;3(5):277-86

King's College London, Guy's Hospital, London, UK.

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http://www.nature.com/articles/ncpneph0465
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May 2007

Controlling the generation and function of human CD8+ memory T cells in vitro with immunosuppressants.

Transplantation 2006 Nov;82(10):1352-61

Department of Nephrology and Transplantation, King's College London School of Medicine at Guy's Hospital, London, UK.

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http://dx.doi.org/10.1097/01.tp.0000241077.83511.beDOI Listing
November 2006

Rapamycin at subimmunosuppressive levels inhibits mesangial cell proliferation and extracellular matrix production.

Am J Physiol Renal Physiol 2007 Jan 8;292(1):F76-81. Epub 2006 Aug 8.

Department of Nephrology and Transplantation, King's College London School of Medicine, London, United Kingdom.

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http://www.physiology.org/doi/10.1152/ajprenal.00128.2006
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January 2007

CD46 (membrane cofactor protein) acts as a human epithelial cell receptor for internalization of opsonized uropathogenic Escherichia coli.

J Immunol 2006 Aug;177(4):2543-51

Department of Nephrology and Transplantation, Guy's Hospital, King's College London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.177.4.2543DOI Listing
August 2006

Role of dendritic cell synthesis of complement in the allospecific T cell response.

Mol Immunol 2007 Jan 25;44(1-3):57-63. Epub 2006 Jul 25.

King's College London School of Medicine at Guy's, King's College and St. Thomas' Hospitals, Department of Nephrology and Transplantation, London, SE1 9RT, UK.

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http://dx.doi.org/10.1016/j.molimm.2006.06.012DOI Listing
January 2007

TLR2 stimulation of intrinsic renal cells in the induction of immune-mediated glomerulonephritis.

J Immunol 2006 Aug;177(3):1925-31

Department of Nephrology and Transplantation, King's College London School of Medicine, Guy's Hospital, London, UK.

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http://dx.doi.org/10.4049/jimmunol.177.3.1925DOI Listing
August 2006

Toll-like receptor 2 agonists exacerbate accelerated nephrotoxic nephritis.

J Am Soc Nephrol 2006 Jul 31;17(7):1931-9. Epub 2006 May 31.

Department of Nephrology and Transplantation, King's College London School of Medicine, Guy's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.1681/ASN.2005111167DOI Listing
July 2006

Influence of donor C3 allotype on late renal-transplantation outcome.

N Engl J Med 2006 May;354(19):2014-23

Department of Nephrology and Transplantation, King's College London, Guy's Hospital, London, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa052825DOI Listing
May 2006

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

Am J Pathol 2006 Apr;168(4):1241-8

Department of Nephrology and Transplantation, 5th Floor, Thomas Guy House, Guy's Hospital, St. Thomas St., London SE1 9RT, UK.

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http://dx.doi.org/10.2353/ajpath.2006.050360DOI Listing
April 2006

Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype.

J Immunol 2006 Mar;176(6):3330-41

Department of Nephrology and Transplantation, King's College London School of Medicine at Guy's, King's College and St. Thomas' Hospitals, London SE1 9RT, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.176.6.3330DOI Listing
March 2006

Therapeutic strategy with a membrane-localizing complement regulator to increase the number of usable donor organs after prolonged cold storage.

J Am Soc Nephrol 2006 Apr 1;17(4):1102-11. Epub 2006 Mar 1.

Department of Nephrology and Transplantation, 5th Floor, Thomas Guy House, Guy's Hospital, London SE1 9RT, UK.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2005101116
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April 2006

Accumulation of immune complexes in glomerular disease is independent of locally synthesized c3.

J Am Soc Nephrol 2006 Mar 1;17(3):686-96. Epub 2006 Feb 1.

Department of Nephrology and Transplantation, Guy's Hospital, King's College London, UK.

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http://dx.doi.org/10.1681/ASN.2004070515DOI Listing
March 2006

Local extravascular pool of C3 is a determinant of postischemic acute renal failure.

FASEB J 2006 Feb;20(2):217-26

King's College London School of Medicine at Guy's, King's College and St. Thomas' Hospitals, Department of Nephrology & Transplantation, London.

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http://dx.doi.org/10.1096/fj.05-4747comDOI Listing
February 2006

Haplotype analysis of tumour necrosis factor receptor genes in 1p36: no evidence for association with systemic lupus erythematosus.

Eur J Hum Genet 2006 Jan;14(1):69-78

Rheumatology Section, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK.

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http://www.nature.com/articles/5201527
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January 2006

Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells.

Blood 2006 Mar 22;107(6):2461-9. Epub 2005 Nov 22.

Department of Nephrology and Transplantation, King's College London School of Medicine at Guy's Hospital, London, SE1 9RT, United Kingdom.

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http://dx.doi.org/10.1182/blood-2005-08-3144DOI Listing
March 2006

RNA interference--a new experimental and therapeutic tool.

Curr Opin Nephrol Hypertens 2005 Nov;14(6):558-60

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http://dx.doi.org/10.1097/01.mnh.0000168937.41270.34DOI Listing
November 2005

Allograft rejection: effect of local synthesis of complement.

Springer Semin Immunopathol 2005 Nov 11;27(3):332-44. Epub 2005 Nov 11.

Department of Nephrology and Transplantation, King's College London School of Medicine at Guy's, St Thomas Hospitals, 5th Floor Thomas Guy House, Guy's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.1007/s00281-005-0005-0DOI Listing
November 2005

Minireview: functions of the renal tract epithelium in coordinating the innate immune response to infection.

Kidney Int 2004 Oct;66(4):1334-44

Department of Nephrology and Transplantation, Guy's Hospital, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1111/j.1523-1755.2004.00896.xDOI Listing
October 2004

Complement activation regulates the capacity of proximal tubular epithelial cell to stimulate alloreactive T cell response.

J Am Soc Nephrol 2004 Sep;15(9):2414-22

Department of Nephrology and Transplantation, 5th Floor, Thomas Guy House, Guy's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.1097/01.ASN.0000135974.06478.7BDOI Listing
September 2004

Independent pathways of P-selectin and complement-mediated renal ischemia/reperfusion injury.

Am J Pathol 2004 Jan;164(1):133-41

Department of Nephrology and Transplantation, Guy's Hospital, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602227PMC
http://dx.doi.org/10.1016/S0002-9440(10)63104-5DOI Listing
January 2004

Gene microarrays in transplantation.

Curr Opin Nephrol Hypertens 2003 Nov;12(6):577-9

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http://dx.doi.org/10.1097/00041552-200311000-00001DOI Listing
November 2003