Publications by authors named "Steven R Little"

69Publications

Evaluating inflammation in an obstruction-based chronic rhinosinusitis model in rabbits.

Int Forum Allergy Rhinol 2020 Nov 8. Epub 2020 Nov 8.

Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

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http://dx.doi.org/10.1002/alr.22729DOI Listing
November 2020

A thermoresponsive hydrogel system for long-acting corticosteroid delivery into the paranasal sinuses.

J Control Release 2020 Nov 4. Epub 2020 Nov 4.

Department of Chemical Engineering, University of Pittsburgh, 940 Benedum Hall, 3700 O'Hara Street, Pittsburgh, PA, 15213, United States of America; Department of Bioengineering, University of Pittsburgh, 302 Benedum Hall, 3700 O'Hara Street, Pittsburgh, PA 15213, United States of America; Department of Clinical and Translational Science, University of Pittsburgh, Forbes Tower, Suite 7057, Pittsburgh, PA 15213, United States of America; McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Suite 300, Pittsburgh, PA 15219, United States of America; Department of Immunology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, United States of America; Department of Pharmaceutical Science, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15213, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2020.10.062DOI Listing
November 2020

TRI microparticles prevent inflammatory arthritis in a collagen-induced arthritis model.

PLoS One 2020 23;15(9):e0239396. Epub 2020 Sep 23.

Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239396PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510963PMC
November 2020

Cranberry extract-based formulations for preventing bacterial biofilms.

Drug Deliv Transl Res 2020 Aug 11. Epub 2020 Aug 11.

Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA.

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http://dx.doi.org/10.1007/s13346-020-00837-xDOI Listing
August 2020

Tuning of thermoresponsive pNIPAAm hydrogels for the topical retention of controlled release ocular therapeutics.

J Mater Chem B 2019 02 25;7(8):1276-1283. Epub 2019 Jan 25.

Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA.

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http://dx.doi.org/10.1039/C8TB02976HDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437675PMC
February 2019

The current status and future directions of CRS Focus Groups.

Authors:
Steven R Little

J Control Release 2019 04 27;300:46-51. Epub 2019 Feb 27.

Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, United States of America; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States of America; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, United States of America; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, United States of America; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, United States of America; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193009
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http://dx.doi.org/10.1016/j.jconrel.2019.02.020DOI Listing
April 2019

Correction to: Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis.

Biomed Microdevices 2018 05 8;20(2):39. Epub 2018 May 8.

Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/s10544-018-0283-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828244PMC
May 2018

Controlled release of an HDAC inhibitor for reduction of inflammation in dry eye disease.

Acta Biomater 2018 04 9;71:261-270. Epub 2018 Mar 9.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, United States; Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15216, United States; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, United States; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, United States; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, United States. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2018.03.002DOI Listing
April 2018

Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis.

Biomed Microdevices 2018 02 14;20(1):18. Epub 2018 Feb 14.

Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/s10544-018-0264-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813085PMC
February 2018

TRI Microspheres prevent key signs of dry eye disease in a murine, inflammatory model.

Sci Rep 2017 12 13;7(1):17527. Epub 2017 Dec 13.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA.

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http://dx.doi.org/10.1038/s41598-017-17869-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727478PMC
December 2017

A biocompatible betaine-functionalized polycation for coacervation.

Soft Matter 2018 Jan;14(3):387-395

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1039/c7sm01763dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771809PMC
January 2018

Monomer sequence in PLGA microparticles: Effects on acidic microclimates and in vivo inflammatory response.

Acta Biomater 2018 Jan 31;65:259-271. Epub 2017 Oct 31.

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2017.10.043DOI Listing
January 2018

Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation.

Adv Healthc Mater 2017 Dec 16;6(23). Epub 2017 Oct 16.

Department of Chemical Engineering, Department of Bioengineering, Department of Ophthalmology, Department of Immunology, Department of Pharmaceutical Sciences, The McGowan Institute for Regenerative Medicine, 940 Benedum Hall 3700 O'Hara Street, Pittsburgh, PA, 15261, USA.

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http://dx.doi.org/10.1002/adhm.201700733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915344PMC
December 2017

An Inexpensive, Point-of-Care Urine Test for Bladder Cancer in Patients Undergoing Hematuria Evaluation.

Adv Healthc Mater 2017 Nov 8;6(22). Epub 2017 Sep 8.

Department of Chemical and Petroleum Engineering, University of Pittsburgh, 15213, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1002/adhm.201700808DOI Listing
November 2017

Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop.

Sci Rep 2017 08 17;7(1):8639. Epub 2017 Aug 17.

UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, USA.

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http://dx.doi.org/10.1038/s41598-017-09379-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561248PMC
August 2017

In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis.

J Control Release 2017 09 8;261:223-233. Epub 2017 Jul 8.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, United States; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, United States; Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261, United States; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, United States; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, United States; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.07.006DOI Listing
September 2017

Treg-recruiting microspheres prevent inflammation in a murine model of dry eye disease.

J Control Release 2017 07 10;258:208-217. Epub 2017 May 10.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15216, United States; Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15216, United States; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.05.007DOI Listing
July 2017

The impact of monomer sequence and stereochemistry on the swelling and erosion of biodegradable poly(lactic-co-glycolic acid) matrices.

Biomaterials 2017 02 24;117:66-76. Epub 2016 Nov 24.

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.11.037DOI Listing
February 2017

One-step synthesis of fluorescently labelled, single-walled carbon nanotubes.

Chem Commun (Camb) 2015 Dec;51(97):17233-6

Department of Bioengineering, University of Pittsburgh, USA. and The McGowan Institute of Regenerative Medicine, University of Pittsburgh, USA.

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http://dx.doi.org/10.1039/c5cc05573cDOI Listing
December 2015

Stapled endosome disrupting alginate particles for cytosolic delivery of cations.

J Drug Target 2015 ;23(7-8):690-7

a Department of Chemical and Petroleum Engineering , University of Pittsburgh , Pittsburgh , PA , USA.

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http://dx.doi.org/10.3109/1061186X.2015.1048517DOI Listing
July 2016

Positive Charge of "Sticky" Peptides and Proteins Impedes Release From Negatively Charged PLGA Matrices.

J Mater Chem B 2015 Jun;3(23):4723-4734

Department of Bioengineering, University of Pittsburgh, PA, USA ; McGowan Institute for Regenerative Medicine, University of Pittsburgh, PA, USA ; Department of Chemical Engineering, University of Pittsburgh, PA, USA ; Department of Immunology, University of Pittsburgh, PA, USA.

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http://dx.doi.org/10.1039/C5TB00515ADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465798PMC
June 2015

A systems approach to modeling drug release from polymer microspheres to accelerate in vitro to in vivo translation.

J Control Release 2015 Aug 20;211:74-84. Epub 2015 May 20.

Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.04.045DOI Listing
August 2015

Micro and nanoparticle drug delivery systems for preventing allotransplant rejection.

Clin Immunol 2015 Sep 1;160(1):24-35. Epub 2015 May 1.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; The McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554802PMC
September 2015

Non-Brownian particle-based materials with microscale and nanoscale hierarchy.

Angew Chem Int Ed Engl 2015 May 17;54(20):5854-8. Epub 2015 Apr 17.

Chemical and Petroleum Engineering, University of Pittsburgh, 3700 O'Hara St, Pittsburgh PA 15261 (USA).

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http://dx.doi.org/10.1002/anie.201500273DOI Listing
May 2015

Strategies to direct the enrichment, expansion, and recruitment of regulatory cells for the treatment of disease.

Ann Biomed Eng 2015 Mar 23;43(3):593-602. Epub 2014 Sep 23.

Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/s10439-014-1125-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370807PMC
March 2015

Collagenase-labile polyurethane urea synthesis and processing into hollow fiber membranes.

Biomacromolecules 2014 Aug 28;15(8):2924-32. Epub 2014 Jul 28.

McGowan Institute for Regenerative Medicine, ‡Department of Surgery, §Department of Chemical & Petroleum Engineering, and ∥Department of Bioengineering, University of Pittsburgh , Pittsburgh, Pennsylvania 15219, United States.

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http://dx.doi.org/10.1021/bm500552fDOI Listing
August 2014

28-day intraocular pressure reduction with a single dose of brimonidine tartrate-loaded microspheres.

Exp Eye Res 2014 Aug 28;125:210-6. Epub 2014 Jun 28.

UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop St., Pittsburgh, PA 15213, USA; Department of Chemical Engineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara St., Pittsburgh, PA 15261, USA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara St., Pittsburgh, PA 15261, USA; Department of Immunology, University of Pittsburgh, 3700 O'Hara St., Pittsburgh, PA 15261, USA; The McGowan Institute for Regenerative Medicine of UPMC and University of Pittsburgh, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2014.06.013DOI Listing
August 2014

Fabrication and characterization of non-Brownian particle-based crystals.

Langmuir 2015 Jan 15;31(3):898-905. Epub 2014 Jul 15.

Department of Chemical and Petroleum Engineering, ‡Ophthalmology, §Bioengineering, ∥Immunology, ⊥McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania 15261, United States.

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http://dx.doi.org/10.1021/la501511sDOI Listing
January 2015

In vitro characterization of a sustained-release formulation for enfuvirtide.

Antimicrob Agents Chemother 2014 23;58(3):1797-9. Epub 2013 Dec 23.

Qrono, Inc., Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1128/AAC.02440-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957899PMC
October 2014

Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes.

Proc Natl Acad Sci U S A 2013 Nov 28;110(46):18525-30. Epub 2013 Oct 28.

Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261.

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http://dx.doi.org/10.1073/pnas.1302829110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831997PMC
November 2013

"Zero-dimensional" single-walled carbon nanotubes.

Angew Chem Int Ed Engl 2013 Oct 5;52(43):11308-12. Epub 2013 Sep 5.

Department of Chemical and Petroleum Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA 15261 (USA) http://littlelab.pitt.edu.

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http://dx.doi.org/10.1002/anie.201305526DOI Listing
October 2013

All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacities.

J Leukoc Biol 2013 Nov 29;94(5):981-9. Epub 2013 Jul 29.

3.720 Rutland Ave, Room 755A, Baltimore, MD 21205, USA. or University of Pittsburgh, 3700 O'Hara St., 440 Benedum Hall, Pittsburgh, PA 15261, USA. E-mail: Twitter:

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http://dx.doi.org/10.1189/jlb.0312167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800062PMC
November 2013

A retrospective mathematical analysis of controlled release design and experimentation.

Mol Pharm 2012 Nov 10;9(11):3003-11. Epub 2012 Oct 10.

Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.

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http://dx.doi.org/10.1021/mp300388wDOI Listing
November 2012

The effect of monomer order on the hydrolysis of biodegradable poly(lactic-co-glycolic acid) repeating sequence copolymers.

J Am Chem Soc 2012 Oct 21;134(39):16352-9. Epub 2012 Sep 21.

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

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http://dx.doi.org/10.1021/ja306866wDOI Listing
October 2012

Bioinspired controlled release of CCL22 recruits regulatory T cells in vivo.

Adv Mater 2012 Sep 23;24(35):4735-8. Epub 2012 Jul 23.

360B CNBIO, 300 Technology Drive, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA-15219, USA.

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http://dx.doi.org/10.1002/adma.201202513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491880PMC
September 2012

Biomimetic delivery with micro- and nanoparticles.

Adv Mater 2012 Jul 23;24(28):3757-78. Epub 2012 Apr 23.

Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261 USA.

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http://dx.doi.org/10.1002/adma.201200224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627374PMC
July 2012

Reorienting our view of particle-based adjuvants for subunit vaccines.

Authors:
Steven R Little

Proc Natl Acad Sci U S A 2012 Jan 17;109(4):999-1000. Epub 2012 Jan 17.

Departments of Chemical Engineering, Bioengineering, and Immunology, and The McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1073/pnas.1120993109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268319PMC
January 2012

Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells.

J Control Release 2012 Apr 21;159(1):78-84. Epub 2012 Jan 21.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, United States.

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http://dx.doi.org/10.1016/j.jconrel.2012.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706997PMC
April 2012

A mathematical model for release of biologics from porous hollow fibers.

J Biomed Mater Res A 2012 Apr 24;100(4):817-26. Epub 2012 Jan 24.

Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1002/jbm.a.34013DOI Listing
April 2012

Patchy, anisotropic microspheres with soft protein islets.

Angew Chem Int Ed Engl 2011 Sep 1;50(37):8706-8. Epub 2011 Aug 1.

Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1002/anie.201101217DOI Listing
September 2011

Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle.

Mol Med 2011 Sep-Oct;17(9-10):917-24. Epub 2011 May 20.

Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.2119/molmed.2010.00256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188871PMC
March 2012

Modeling the self-assembly of lipids and nanotubes in solution: forming vesicles and bicelles with transmembrane nanotube channels.

ACS Nano 2011 Jun 31;5(6):4769-82. Epub 2011 May 31.

Chemical Engineering Department, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.

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http://dx.doi.org/10.1021/nn201260rDOI Listing
June 2011

Sequential delivery of basic fibroblast growth factor and platelet-derived growth factor for angiogenesis.

Tissue Eng Part A 2011 May 17;17(9-10):1181-9. Epub 2011 Jan 17.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1089/ten.TEA.2010.0551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120092PMC
May 2011

Forming transmembrane channels using end-functionalized nanotubes.

Nanoscale 2011 Jan 26;3(1):240-50. Epub 2010 Oct 26.

Chemical Engineering Department, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1039/c0nr00578aDOI Listing
January 2011

Non-viral eNOS gene delivery and transfection with stents for the treatment of restenosis.

Biomed Eng Online 2010 Sep 27;9:56. Epub 2010 Sep 27.

Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/1475-925X-9-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955648PMC
September 2010

Protein bioactivity and polymer orientation is affected by stabilizer incorporation for double-walled microspheres.

J Control Release 2010 Jan 11;141(2):168-76. Epub 2009 Sep 11.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1016/j.jconrel.2009.09.003DOI Listing
January 2010

In vitro and in vivo studies of local arterial gene delivery and transfection using lipopolyplexes-embedded stents.

J Biomed Mater Res A 2010 Apr;93(1):325-36

Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1002/jbm.a.32488DOI Listing
April 2010

A unified mathematical model for the prediction of controlled release from surface and bulk eroding polymer matrices.

Biomaterials 2009 Mar 19;30(8):1657-64. Epub 2008 Dec 19.

Department of Chemical Engineering, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15203, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2008.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864484PMC
March 2009

Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells.

Cancer Chemother Pharmacol 2009 Mar 11;63(4):711-22. Epub 2008 Jul 11.

Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s00280-008-0790-yDOI Listing
March 2009

Biodistribution and pharmacokinetic analysis of Paclitaxel and ceramide administered in multifunctional polymer-blend nanoparticles in drug resistant breast cancer model.

Mol Pharm 2008 Jul-Aug;5(4):516-26. Epub 2008 Jul 11.

Department of Pharmaceutical Sciences, Northeastern University, Department of Orthopedic Surgery, Massachusetts General Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/mp800030kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646668PMC
October 2008

Synthesis of poly(beta-amino ester)s with thiol-reactive side chains for DNA delivery.

J Am Chem Soc 2006 Oct;128(39):12726-34

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building E25-342, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1021/ja061570nDOI Listing
October 2006

Nonviral delivery of cancer genetic vaccines.

Adv Biochem Eng Biotechnol 2005 ;99:93-118

Department of Chemical Engineering and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02142, USA.

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http://dx.doi.org/10.1007/10_004DOI Listing
June 2006

A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery.

Angew Chem Int Ed Engl 2005 Oct;44(41):6704-8

Department of Chemical Engineering, Room 66-546, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://doi.wiley.com/10.1002/anie.200502152
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http://dx.doi.org/10.1002/anie.200502152DOI Listing
October 2005

Formulation and characterization of poly (beta amino ester) microparticles for genetic vaccine delivery.

J Control Release 2005 Oct;107(3):449-62

Department of Chemical Engineering and Center for Cancer Research, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1016/j.jconrel.2005.04.022DOI Listing
October 2005

pH-triggered microparticles for peptide vaccination.

J Immunol 2004 Aug;173(4):2578-85

Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Pediatric Hematology/Oncology, Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.4049/jimmunol.173.4.2578DOI Listing
August 2004

Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines.

Proc Natl Acad Sci U S A 2004 Jun 21;101(26):9534-9. Epub 2004 Jun 21.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0403549101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC470709PMC
June 2004