Steven P Gygi

Steven P Gygi

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Steven P Gygi

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mTMT: An Alternative, Nonisobaric, Tandem Mass Tag Allowing for Precursor-Based Quantification.

Anal Chem 2019 Oct 20;91(19):12167-12172. Epub 2019 Sep 20.

Department of Cell Biology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acs.analchem.9b03162DOI Listing
October 2019

Evaluating False Transfer Rates from the Match-between-Runs Algorithm with a Two-Proteome Model.

J Proteome Res 2019 Oct 2. Epub 2019 Oct 2.

Department of Cell Biology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acs.jproteome.9b00492DOI Listing
October 2019

Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.

Cell Metab 2019 Sep 27;30(3):539-555.e11. Epub 2019 Jun 27.

Graduate Program in Virology, Division of Medical Sciences, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720460PMC
September 2019

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation.

Cell Syst 2019 Sep 11;9(3):258-270.e6. Epub 2019 Sep 11.

Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.07.006DOI Listing
September 2019

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis.

Cell Stem Cell 2019 Sep 27. Epub 2019 Sep 27.

Department of Molecular Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Harvard Stem Cell Institute, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.08.018DOI Listing
September 2019

PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression.

Mol Cell 2019 Aug 3;75(3):620-630.e9. Epub 2019 Jul 3.

Division of Newborn Medicine and Epigenetics Program, Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193040
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http://dx.doi.org/10.1016/j.molcel.2019.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688901PMC
August 2019

Therapy-Induced MHC I Ligands Shape Neo-Antitumor CD8 T Cell Responses during Oncolytic Virus-Based Cancer Immunotherapy.

J Proteome Res 2019 Jun 29;18(6):2666-2675. Epub 2019 May 29.

Department of Cell Biology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acs.jproteome.9b00173DOI Listing
June 2019

Targeted Degradation of Glucose Transporters Protects against Arsenic Toxicity.

Mol Cell Biol 2019 May 30;39(10). Epub 2019 Apr 30.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

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http://dx.doi.org/10.1128/MCB.00559-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497993PMC
May 2019

Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility.

Cell 2019 May 2;177(6):1480-1494.e19. Epub 2019 May 2.

Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA; Department of Gynecology and Obstetrics, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193034
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http://dx.doi.org/10.1016/j.cell.2019.03.047DOI Listing
May 2019

Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program.

Proc Natl Acad Sci U S A 2019 May 9;116(21):10382-10391. Epub 2019 May 9.

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132;

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http://dx.doi.org/10.1073/pnas.1804013116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534978PMC
May 2019

Proteomic profiling of yeast heterochromatin connects direct physical and genetic interactions.

Curr Genet 2019 Apr 12;65(2):495-505. Epub 2018 Oct 12.

Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, 12801 E. 17th Ave, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1007/s00294-018-0889-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421107PMC
April 2019

Active Instrument Engagement Combined with a Real-Time Database Search for Improved Performance of Sample Multiplexing Workflows.

J Proteome Res 2019 Mar 4;18(3):1299-1306. Epub 2019 Feb 4.

Department of Cell Biology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00899
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http://dx.doi.org/10.1021/acs.jproteome.8b00899DOI Listing
March 2019

Web-Based Search Tool for Visualizing Instrument Performance Using the Triple Knockout (TKO) Proteome Standard.

J Proteome Res 2019 Feb 27;18(2):687-693. Epub 2018 Nov 27.

Department of Cell Biology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acs.jproteome.8b00737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358484PMC
February 2019

TomahaqCompanion: A Tool for the Creation and Analysis of Isobaric Label Based Multiplexed Targeted Assays.

J Proteome Res 2019 Feb 12;18(2):594-605. Epub 2018 Dec 12.

Department of Microchemistry, Proteomics and Lipidomics , Genentech , South San Francisco , California 94080 , United States.

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http://dx.doi.org/10.1021/acs.jproteome.8b00767DOI Listing
February 2019

Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation.

Cell 2019 Feb;176(5):1014-1025.e12

Institute for Transformative Molecular Medicine and Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.01.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559381PMC
February 2019

TKO6: A Peptide Standard To Assess Interference for Unit-Resolved Isobaric Labeling Platforms.

J Proteome Res 2019 Jan 6;18(1):565-570. Epub 2018 Dec 6.

Department of Cell Biology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00902
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http://dx.doi.org/10.1021/acs.jproteome.8b00902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465125PMC
January 2019

The effects of nonignorable missing data on label-free mass spectrometry proteomics experiments.

Ann Appl Stat 2018 Dec 13;12(4):2075-2095. Epub 2018 Nov 13.

Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA, 02115, USA; Department of Biostatistics, University of North Carolina at Chapel Hill, 135 Dauer Drive, 3101 McGavran-Greenberg Hall, CB 7420, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics University of North Carolina at Chapel Hill 120 Mason Farm Rd, Campus Box 7260 Chapel Hill, NC 27599 USA.

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https://projecteuclid.org/euclid.aoas/1542078037
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http://dx.doi.org/10.1214/18-AOAS1144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249692PMC
December 2018

ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly.

Mol Cell 2018 08;71(4):567-580.e4

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA; Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183051
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http://dx.doi.org/10.1016/j.molcel.2018.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104058PMC
August 2018

The NAD Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis.

Cell Rep 2018 08;24(9):2381-2391.e5

Department of Pathology, Dalhousie University, Halifax, NS, Canada; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada; Centre for Innovative and Collaborative Health Services Research, IWK Health Centre, Halifax, NS, Canada; Department of Biology, Dalhousie University, Halifax, NS, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183121
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http://dx.doi.org/10.1016/j.celrep.2018.07.086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402325PMC
August 2018

An Internal Standard for Assessing Phosphopeptide Recovery from Metal Ion/Oxide Enrichment Strategies.

J Am Soc Mass Spectrom 2018 07 18;29(7):1505-1511. Epub 2018 Apr 18.

Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s13361-018-1946-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004253PMC
July 2018

Isobaric Tag-Based Protein Profiling of a Nicotine-Treated Alpha7 Nicotinic Receptor-Null Human Haploid Cell Line.

Proteomics 2018 06 15;18(11):e1700475. Epub 2018 May 15.

Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1002/pmic.201700475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990481PMC
June 2018

Characterization of Plasmodium falciparum Atypical Kinase PfPK7 Dependent Phosphoproteome.

J Proteome Res 2018 06 30;17(6):2112-2123. Epub 2018 Apr 30.

Division of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences , University of Central Florida , Orlando , Florida 32826 , United States.

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http://dx.doi.org/10.1021/acs.jproteome.8b00062DOI Listing
June 2018

Proteome-Wide Evaluation of Two Common Protein Quantification Methods.

J Proteome Res 2018 05 19;17(5):1934-1942. Epub 2018 Apr 19.

Department of Cell Biology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acs.jproteome.8b00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984592PMC
May 2018

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins.

Cell Rep 2018 05;23(5):1387-1398

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.009DOI Listing
May 2018

Proteome-Wide Protein Expression Profiling Across Five Pancreatic Cell Lines.

Pancreas 2017 May/Jun;46(5):690-698

From the *Department of Cell Biology, Harvard Medical School; and †Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1097/MPA.0000000000000800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398936PMC
March 2018

Filter-Based Protein Digestion (FPD): A Detergent-Free and Scaffold-Based Strategy for TMT Workflows.

J Proteome Res 2018 03 13;17(3):1227-1234. Epub 2018 Feb 13.

Department of Cell Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.jproteome.7b00840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984590PMC
March 2018

Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice.

J Biol Chem 2018 02 22;293(6):2183-2194. Epub 2017 Dec 22.

From the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006-Oviedo, Spain,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M117.788430
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http://dx.doi.org/10.1074/jbc.M117.788430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808777PMC
February 2018

OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling.

Mol Cell 2018 02;69(3):505-516.e5

Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis MO, 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.01.009DOI Listing
February 2018

BioPlex Display: An Interactive Suite for Large-Scale AP-MS Protein-Protein Interaction Data.

J Proteome Res 2018 01 31;17(1):722-726. Epub 2017 Oct 31.

Department of Cell Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.jproteome.7b00572DOI Listing
January 2018

The skeletal phenotype of achondrogenesis type 1A is caused exclusively by cartilage defects.

Development 2018 01 8;145(1). Epub 2018 Jan 8.

Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, MA 02115, USA

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http://dev.biologists.org/lookup/doi/10.1242/dev.156588
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http://dx.doi.org/10.1242/dev.156588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825869PMC
January 2018

Compositional Proteomics: Effects of Spatial Constraints on Protein Quantification Utilizing Isobaric Tags.

J Proteome Res 2018 01 15;17(1):590-599. Epub 2017 Dec 15.

Department of Cell Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.jproteome.7b00699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806995PMC
January 2018

Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.

Cell 2018 01 14;172(1-2):106-120.e21. Epub 2017 Dec 14.

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766360PMC
January 2018

Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the egg.

Proc Natl Acad Sci U S A 2017 12 28;114(50):E10838-E10847. Epub 2017 Nov 28.

Department of Systems Biology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1709207114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740657PMC
December 2017

Improved Method for Determining Absolute Phosphorylation Stoichiometry Using Bayesian Statistics and Isobaric Labeling.

J Proteome Res 2017 11;16(11):4217-4226

Department of Cell Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.jproteome.7b00571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301010PMC
November 2017

SAMTOR is an -adenosylmethionine sensor for the mTORC1 pathway.

Science 2017 11;358(6364):813-818

Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/science.aao3265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747364PMC
November 2017

Pseudomonas aeruginosa Proteome under Hypoxic Stress Conditions Mimicking the Cystic Fibrosis Lung.

J Proteome Res 2017 10 31;16(10):3917-3928. Epub 2017 Aug 31.

Department of Chemistry and Biomolecular Sciences, Macquarie University , Sydney 2109, Australia.

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http://dx.doi.org/10.1021/acs.jproteome.7b00561DOI Listing
October 2017

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.

Mol Cell 2017 Aug 27;67(3):512-527.e4. Epub 2017 Jul 27.

Department of Pharmacology, Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698809PMC
August 2017

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.

J Cell Biol 2017 07 31;216(7):2027-2045. Epub 2017 May 31.

Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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http://dx.doi.org/10.1083/jcb.201702058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496626PMC
July 2017

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism.

Nat Commun 2017 07 3;8:15965. Epub 2017 Jul 3.

Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncomms15965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500878PMC
July 2017

Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription.

Nature 2017 07 22;547(7664):463-467. Epub 2017 Jun 22.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nature23267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576860PMC
July 2017

Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells.

Sci Rep 2017 07 6;7(1):4780. Epub 2017 Jul 6.

KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.

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http://dx.doi.org/10.1038/s41598-017-04979-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500592PMC
July 2017

Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients.

Cell Rep 2017 06;19(11):2244-2256

Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653973PMC
June 2017

Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P.

Sci Rep 2017 06 29;7(1):4391. Epub 2017 Jun 29.

Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, D-13353, Germany.

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http://dx.doi.org/10.1038/s41598-017-04586-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491492PMC
June 2017

Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2).

J Bacteriol 2017 05 11;199(9). Epub 2017 Apr 11.

Cryo-EM Structural Biology Laboratory, Van Andel Research Institute, Grand Rapids, Michigan, USA

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http://dx.doi.org/10.1128/JB.00846-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388811PMC
May 2017

DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.

Cell Stem Cell 2017 05 30;20(5):706-719.e7. Epub 2017 Mar 30.

Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524993PMC
May 2017

A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells.

Cell Rep 2017 05;19(7):1479-1493

Division of Infectious Disease, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA; Harvard Virology Program, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446956PMC
May 2017

Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling.

Cell 2017 04;169(2):338-349.e11

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173034
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http://dx.doi.org/10.1016/j.cell.2017.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514552PMC
April 2017

Protein Kinase C Controls Binding of Igo/ENSA Proteins to Protein Phosphatase 2A in Budding Yeast.

J Biol Chem 2017 03 18;292(12):4925-4941. Epub 2017 Jan 18.

From the Department of Molecular, Cell and Developmental Biology, University of California at Santa Cruz, Santa Cruz, California 95064,

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http://dx.doi.org/10.1074/jbc.M116.753004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377806PMC
March 2017

Scaffold-mediated gating of Cdc42 signalling flux.

Elife 2017 03 17;6. Epub 2017 Mar 17.

University of Bordeaux, CNRS, European Institute of Chemistry and Biology, IBGC, UMR 5095, Pessac, France.

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http://dx.doi.org/10.7554/eLife.25257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386590PMC
March 2017

Neutral Loss Is a Very Common Occurrence in Phosphotyrosine-Containing Peptides Labeled with Isobaric Tags.

J Proteome Res 2017 02 30;16(2):1069-1076. Epub 2016 Dec 30.

Department of Cell Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479408PMC
February 2017

Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony.

Nat Microbiol 2017 Feb 17;2:17017. Epub 2017 Feb 17.

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, 651 Huntington Avenue, FXB, Room 202, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nmicrobiol.2017.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328244PMC
February 2017

Nicotine-induced protein expression profiling reveals mutually altered proteins across four human cell lines.

Proteomics 2017 01 21;17(1-2). Epub 2016 Dec 21.

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/pmic.201600319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540149PMC
January 2017

LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency.

Nat Cell Biol 2017 Jan 19;19(1):60-67. Epub 2016 Dec 19.

Stem Cell Transplantation Program, Division of Hematology/Oncology, Manton Center for Orphan Disease Research, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncb3453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182091PMC
January 2017

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer.

Cell 2016 Dec;167(7):1705-1718.e13

Department of Medicine, Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.11.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390486PMC
December 2016