Dr. Steven McKinney, Ph.D. - British Columbia Cancer Research Centre - Research Scientist

Dr. Steven McKinney

Ph.D.

British Columbia Cancer Research Centre

Research Scientist

Vancouver, BC | Canada

Main Specialties: Statistics

Additional Specialties: Statistics

Dr. Steven McKinney, Ph.D. - British Columbia Cancer Research Centre - Research Scientist

Dr. Steven McKinney

Ph.D.

Introduction

Primary Affiliation: British Columbia Cancer Research Centre - Vancouver, BC , Canada

Specialties:

Additional Specialties:

Publications

25Publications

877Reads

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2291PubMed Central Citations

A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

Mol Oncol 2015 Jan 8;9(1):115-27. Epub 2014 Aug 8.

Cancer Research UK, Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK; Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK; Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK; Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286124PMC
January 2015
185 Reads
6 Citations
5.331 Impact Factor

Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.

J Pathol 2014 Nov 28;234(3):386-97. Epub 2014 Aug 28.

Department of Molecular Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/path.4404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882165PMC
November 2014
22 Reads
5 Citations
7.430 Impact Factor

TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.

Clin Cancer Res 2014 Jul 6;20(13):3569-80. Epub 2014 May 6.

Authors' Affiliations: Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet; The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine;

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2943DOI Listing
July 2014
30 Reads
52 Citations
8.722 Impact Factor

Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation.

J Biol Chem 2013 Sep 24;288(39):27940-50. Epub 2013 Jun 24.

From the Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.

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http://dx.doi.org/10.1074/jbc.M113.475301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784708PMC
September 2013
14 Reads
5 Citations
4.573 Impact Factor

Mll5 is required for normal spermatogenesis.

PLoS One 2011 1;6(11):e27127. Epub 2011 Nov 1.

Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027127PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206077PMC
March 2012
30 Reads
15 Citations
3.234 Impact Factor

Nucleic acid quantity and quality from paraffin blocks: defining optimal fixation, processing and DNA/RNA extraction techniques.

Exp Mol Pathol 2012 Feb 21;92(1):33-43. Epub 2011 Sep 21.

The Centre of Translation and Applied Genomics, BC Cancer Agency, Provincial Health Services Authority, Vancouver, BC, Canada V5Z 4E6.

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http://dx.doi.org/10.1016/j.yexmp.2011.09.013DOI Listing
February 2012
55 Reads
27 Citations
2.710 Impact Factor

P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer.

Mod Pathol 2011 Jan 17;24(1):64-81. Epub 2010 Sep 17.

Molecular Oncology Department, BC Cancer Research Centre, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/modpathol.2010.189DOI Listing
January 2011
8 Reads
12 Citations
6.190 Impact Factor

Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas.

Cancer Res 2010 Nov 19;70(21):8770-81. Epub 2010 Oct 19.

Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1093DOI Listing
November 2010
86 Reads
22 Citations
9.330 Impact Factor

Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development.

Breast Cancer Res 2010 21;12(3):R38. Epub 2010 Jun 21.

Cancer Genetics and Developmental Biology, British Columbia Cancer Agency, 675 West 10th Ave., Vancouver, BC, Canada.

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http://dx.doi.org/10.1186/bcr2592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917033PMC
November 2010
11 Reads
6 Citations

Identification of sister chromatids by DNA template strand sequences.

Nature 2010 Jan 16;463(7277):93-7. Epub 2009 Dec 16.

Terry Fox Laboratory, B.C. Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.

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http://dx.doi.org/10.1038/nature08644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757939PMC
January 2010
19 Reads
36 Citations
42.351 Impact Factor

Columnar cell lesions, mammographic density and breast cancer risk.

Breast Cancer Res Treat 2009 Jun 28;115(3):561-71. Epub 2008 Jun 28.

Molecular Oncology and Breast Cancer Program, BC Cancer Research Centre, 675 W 10th Avenue, Vancouver, Canada.

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http://dx.doi.org/10.1007/s10549-008-0099-xDOI Listing
June 2009
9 Reads
6 Citations
3.940 Impact Factor

Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.

Blood 2009 Feb 14;113(7):1432-43. Epub 2008 Oct 14.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1182/blood-2008-06-162263DOI Listing
February 2009
11 Reads
42 Citations
10.452 Impact Factor

Ovarian carcinoma subtypes are different diseases: implications for biomarker studies.

PLoS Med 2008 Dec;5(12):e232

Department of Pathology, Genetic Pathology Evaluation Centre of the Prostate Research Centre, Vancouver General Hospital and British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1371/journal.pmed.0050232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592352PMC
December 2008
3 Reads
211 Citations

Intensity calibration and automated cell cycle gating for high-throughput image-based siRNA screens of mammalian cells.

Cytometry A 2008 Oct;73(10):904-17

Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada, V5Z1L3.

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http://dx.doi.org/10.1002/cyto.a.20624DOI Listing
October 2008
5 Reads
6 Citations
2.930 Impact Factor

Transcriptome analysis of the normal human mammary cell commitment and differentiation process.

Cell Stem Cell 2008 Jul;3(1):109-18

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada.

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http://dx.doi.org/10.1016/j.stem.2008.05.018DOI Listing
July 2008
3 Reads
133 Citations

Amplification of 11q13 in ovarian carcinoma.

Genes Chromosomes Cancer 2008 Jun;47(6):481-9

Department of Pathology, Vancouver Coastal Health Research Institute, Genetic Pathology Evaluation Centre, British Columbia Cancer Agency, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/gcc.20549DOI Listing
June 2008
13 Reads
50 Citations
4.041 Impact Factor

Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype.

Clin Cancer Res 2008 Mar;14(5):1368-76

Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1658DOI Listing
March 2008
51 Reads
331 Citations
8.722 Impact Factor

Evidence from multiplex molecular assays for complex multipathogen interactions in acute respiratory infections.

J Clin Microbiol 2008 Jan 31;46(1):97-102. Epub 2007 Oct 31.

Centre for Translational and Applied Genomics, PHSA Labs, Children's and Women's Health Centre of BC, PHSA, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1128/JCM.01117-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224244PMC
January 2008
6 Reads
33 Citations
3.993 Impact Factor

Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma.

BMC Med 2007 Nov 15;5:33. Epub 2007 Nov 15.

Molecular Oncology and Breast Cancer Program, British Columbia Cancer Research Centre and Department of Pathology, University ofBritish Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1186/1741-7015-5-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200658PMC
November 2007
2 Reads
20 Citations
7.250 Impact Factor

Temporal heterogeneity of regional pulmonary perfusion is spatially clustered

Journal of Applied Physiology 10/1995; 79(3):986-1001

Journal of Applied Physiology

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October 1995
4 Reads