Steven Le Gouill

Steven Le Gouill

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Steven Le Gouill

Publications by authors named "Steven Le Gouill"

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Post-treatment positron emission tomography-computed tomography is highly predictive of outcome in Plasmablastic lymphoma.

Eur J Nucl Med Mol Imaging 2018 09 20;45(10):1705-1709. Epub 2018 Apr 20.

Department of Hematology, University Hospital of Montpellier, UMR CNRS 5235, Montpellier, France.

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http://dx.doi.org/10.1007/s00259-018-4020-5DOI Listing
September 2018

Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma.

N Engl J Med 2018 09;379(10):934-947

From Université Lille, Centre Hospitalier Universitaire (CHU), Groupe de Recherche sur les formes Injectables et les Technologies Associées, Lille (F.M.), CHU Régional de Nancy, Service d'Hématologie, Vandoeuvre lès Nancy (P.F.), Institut Paoli-Calmettes (R.B.) and Department of Pathology, Institut Paoli-Calmettes, Centre de Recherche en Cancerologie de Marseille, INSERM, Centre National de la Recherche Scientifique, Aix-Marseille Université (L.X.), Marseille, Centre Henri Becquerel, Unité 1245 and Département d'Hématologie, Université de Rouen, Rouen (H.T.), Institut d'Hématologie de Basse Normandie, Caen (C.F.), CHU Le Bocage Service d'Hématologie Clinique, Dijon (R.-O.C.), Hôpital Henri Mondor Unité Hémopathies Lymphoïdes, Créteil (C.H.), Centre Hospitalier Départemental Vendée Service d'Onco-Hématologie, La Roche sur Yon (H.M.), Institut Universitaire du Cancer de Toulouse Oncopole Service d'Hématologie, Toulouse (L.Y.), CHU Bordeaux, Service d'Hématologie, Bordeaux (K.B.), Hôpital Saint Louis Service d'Onco-Hématologie, Paris (P.B.), Gustave Roussy Cancer, Villejuif (V.R.), Centre Hospitalier Annecy Genevois Service, Annecy (N.D.), CHU de Nantes-Hôtel Dieu Service d'Hématologie Clinique, Centre de Recherche en Cancerologie et Immunologie, INSERM, Centre National de la Recherche Scientifique, Université de Nantes, Nantes (S.L.G.), Centre Hospitalier Métropole Savoie Service Hématologie, Chambery (G.M.P.), Department of Hematology, CHU Montpellier, University of Montpellier, Montpellier (G.C.), and Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, University of Lyon, Pierre-Benite (G.A.S.) - all in France; the Department of Lymphoma and Myeloma, University of Texas M.D. Anderson Cancer Center, Houston (N.H.F.); the Department of Medicine, Memorial Sloan Kettering Cancer Center, New York (M.L.P.); the Department of Medicine, Division of Medical Oncology, University of Washington, Seattle (E.N.L.); Sarah Cannon Research Institute-Tennessee Oncology, Nashville (I.W.F.); Washington University School of Medicine, Siteman Cancer Center, St. Louis (N.L.B.); the Department of Hematology, Hospital Universitario de Salamanca and Instituto de Investigación Biomédica de Salamanca, Centro de Investigación Biomédica en Red de Cáncer, Salamanca (A.M.G.-S.), and the Department of Hematology, Hospital Clinic de Barcelona, Barcelona (A.L.-G.) - both in Spain; CHU de Québec, Hôpital de l'Enfant-Jésus, Quebec (J.-F.L.), and British Columbia Cancer Centre for Lymphoid Cancer, University of British Columbia, Vancouver (L.H.S.) - both in Canada; the Department of Hematology and Oncology, Tokai University Hospital, Kanagawa, Japan (K.A.); Instituto Português de Oncologia Lisboa Francisco Gentil Departamento de Hematologia, Lisbon (M.G.S.); the Department of Hematology, CHU Université Catholique de Louvain Namur, Yvoir (M.A.), and the Department of Hematology, Ziekenhuis Netwerk Antwerpen Stuivenberg, Antwerp (P.Z.) - both in Belgium; the Department of Hematology, National Cancer Center Hospital, Tokyo, Japan (K.T.); and Celgene, Summit, NJ (D.L., J.W.).

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http://www.nejm.org/doi/10.1056/NEJMoa1805104
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http://dx.doi.org/10.1056/NEJMoa1805104DOI Listing
September 2018

Rationale for targeting tumor cells in their microenvironment for mantle cell lymphoma treatment.

Leuk Lymphoma 2018 05 31;59(5):1064-1072. Epub 2017 Jul 31.

a CRCINA, INSERM, CNRS , Université de Nantes, Université d'Angers , Nantes , France.

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http://dx.doi.org/10.1080/10428194.2017.1357177DOI Listing
May 2018

Survival benefit of mantle cell lymphoma patients enrolled in clinical trials; a joint study from the LYSA group and French cancer registries.

J Cancer Res Clin Oncol 2018 Apr 11;144(4):629-635. Epub 2017 Oct 11.

Registre des hémopathies malignes de Côte d'Or, Faculté des Sciences de Santé, Inserm UMR 1231, Université de Bourgogne F-Comté, 7 Bd Jeanne d'Arc, 21079, Dijon Cedex, France.

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http://dx.doi.org/10.1007/s00432-017-2529-9DOI Listing
April 2018

Plerixafor in poor mobilizers with non-Hodgkin's lymphoma: a multi-center time-motion analysis.

Bone Marrow Transplant 2018 03 18;53(3):246-254. Epub 2017 Dec 18.

Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/s41409-017-0033-0DOI Listing
March 2018

Fungal Prophylaxis with a Gastro-Resistant Posaconazole Tablet for Patients with Hematological Malignancies in the POSANANTES Study.

Antimicrob Agents Chemother 2018 02 25;62(2). Epub 2018 Jan 25.

Service d'Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Centre Hospitalier et Universitaire (CHU) de Nantes, CHU Hotel-Dieu, Nante, France.

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http://dx.doi.org/10.1128/AAC.01746-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786819PMC
February 2018

BH3 profiling as a tool to identify acquired resistance to venetoclax in multiple myeloma.

Br J Haematol 2017 11 29;179(4):684-688. Epub 2016 Jul 29.

CRCNA, CNRS, INSERM, Centre Hospitalier Universitaire de Nantes, Université d'Angers, Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1111/bjh.14251DOI Listing
November 2017

Rituximab after Autologous Stem-Cell Transplantation in Mantle-Cell Lymphoma.

N Engl J Med 2017 09;377(13):1250-1260

From Service d'Hématologie Clinique (S.L.G., T.G.), Service d'Anatomopathologie (A.M.), and Service d'Hématologie Biologique (M.C.B.), Hôtel-Dieu Centre Hospitalier Universitaire (CHU) de Nantes, and Centre de Recherche en Cancérologie et Immunologie (S.L.G., M.C.B.) and Faculté de Médecine (S.L.G.), Université de Nantes, Nantes, Hemato-Oncologie, Assistance Publique-Hôpitaux de Paris (APHP), Hôpital Saint-Louis, Université Diderot Sorbonne Paris-Cité (C.T.), Université Descartes (C.T.), Département d'Hématologie, Faculté de Médecine, Université Paris-Sud (V.R.), Département d'Anatomopathologie (D.C.) and Département d'Hématologie (O.H.), Necker Hospital, APHP, Sorbonne Paris-Cité, and INSERM Unité 1163 et Centre National de la Recherche Scientifique (CNRS) Équipe de Recherche Labellisée 8654, Imagine Institute (O.H.), Paris, Département d'Hématologie, Institut Universitaire du Cancer-Oncopole de Toulouse, Toulouse (L.O.), Service d'Hématologie Clinique et Thérapie Cellulaire, CHU de Bordeaux, Bordeaux (K.B.), Service d'Hématologie et Thérapie Cellulaire, CHU de Tours, Tours (C.D.), Service d'Hématologie, CHU d'Amiens, Amiens (G.D.), INSERM, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif (V.R.), Département d'Hématologie, CHU de Nancy, Nancy (P.F.), INSERM Unité 954, Vandoeuvre (P.F.), Service d'Hématologie Clinique, CHU de Dijon, and INSERM Unité Mixte de Recherche 1231, Dijon (O.C.), Service d'Hématologie, Centre Hospitalier d'Avignon, Avignon (H.Z.), Lymphoid Malignancies Unit, Hôpital Henri Mondor, APHP, Créteil (C.H.), Service d'Hématologie du Centre Hospitalier de Vendée, La Roche-sur-Yon (H.M.), Service Hématologie Clinique (R.H.) and Département d'Hématologie (T.L.), CHU de Rennes, INSERM Unité 917 (R.H.), and INSERM Unité 1236 (T.L.), Rennes, Département d'Hematology, Centre Henri-Becquerel et Université de Normandie Unité 1245, Rouen (F.J., H.T.), Service d'Hématologie Clinique Adulte et de Thérapie Cellulaire, CHU de Clermont-Ferrand et Université Clermont Auvergne, Clermont-Ferrand (O.T.), Service d'Hématologie, Clinique Victor Hugo, Le Mans (K.L.D.), Department of Hematology, Université de Lille, Groupe de Recherche sur les Formes Injectables et les Technologies Associées, and CHU de Lille, Lille (F.M.), Département d'Hématologie Clinique, CHU de Montpellier, CNRS UMR 5235, Montpellier (G.C.), Service d'Oncologie et d'Hématologie, Hôpitaux Universitaires de Strasbourg, Strasbourg (L.-M.F.), INSERM 1209, CNRS UMR 5309, Faculté de Médecine, Université Grenoble Alpes (M.C., R.G.), Institute for Advanced Biosciences (M.C.), and Laboratoire de Génétique Onco-hématologie (M.C.) and Faculté de Médecine (R.G.), CHU de Grenoble Alpes, Grenoble, Service d'Hématologie, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite (G.S.), and Université Claude Bernard Lyon 1 and Cancer Research Center of Lyon, INSERM 1052 CNRS 5286 Lyon, Lyon (G.S.) - all in France; and Département d'Hématologie, Cliniques Universitaires Saint-Luc-Université Catholique de Louvain, Brussels (E.V.D.N.).

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http://dx.doi.org/10.1056/NEJMoa1701769DOI Listing
September 2017

Interim PET-driven strategy in de novo diffuse large B-cell lymphoma: do we trust the driver?

Blood 2017 06 17;129(23):3059-3070. Epub 2017 Apr 17.

Department of Hematology, CHU de Dijon, University Hospital of Dijon, Dijon, France; and.

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http://dx.doi.org/10.1182/blood-2016-05-672196DOI Listing
June 2017

Rational targeted therapies to overcome microenvironment-dependent expansion of mantle cell lymphoma.

Blood 2016 12 3;128(24):2808-2818. Epub 2016 Oct 3.

Centre de Recherche en Cancérologie Nantes-Angers, INSERM, Centre National de la Recherche Scientifique (CNRS), Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1182/blood-2016-06-720490DOI Listing
December 2016

Successful treatment of acute promyelocytic leukemia with arsenic trioxide and all-trans retinoic acid in a double lung and kidney transplanted patient.

Ann Hematol 2016 Oct 27;95(10):1737-8. Epub 2016 Jul 27.

Service d'Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Centre Hospitalier et Universitaire (CHU) de Nantes, CHU Hotel-Dieu, Place A. Ricordeau, 44093, Nantes Cedex, France.

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http://dx.doi.org/10.1007/s00277-016-2754-3DOI Listing
October 2016

Higher Early Monocyte and Total Lymphocyte Counts Are Associated with Better Overall Survival after Standard Total Body Irradiation, Cyclophosphamide, and Fludarabine Reduced-Intensity Conditioning Double Umbilical Cord Blood Allogeneic Stem Cell Transplantation in Adults.

Biol Blood Marrow Transplant 2016 08 24;22(8):1473-1479. Epub 2016 Apr 24.

Centre Hospitalier et Universitaire de Nantes, Département d'Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Nantes, France; Université de Nantes and INSERM CRNCA UMR 892, Nantes, France.

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http://dx.doi.org/10.1016/j.bbmt.2016.04.015DOI Listing
August 2016

T-cell defect in diffuse large B-cell lymphomas involves expansion of myeloid-derived suppressor cells.

Blood 2016 08 23;128(8):1081-92. Epub 2016 Jun 23.

Pôle Biologie and INSERM, Unité Mixte de Recherche U917, Equipe Labellisée Ligue Contre le Cancer, Rennes, France; Université Rennes 1, Unité Mixte de Recherche U917, Rennes, France; Etablissement Français du Sang Bretagne, Rennes, France;

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http://dx.doi.org/10.1182/blood-2015-08-662783DOI Listing
August 2016

Brentuximab vedotin in refractory or relapsed peripheral T-cell lymphomas: the French named patient program experience in 56 patients.

Haematologica 2016 Mar 24;101(3):e103-6. Epub 2015 Dec 24.

Département de Pathologie, Groupe Henri-Mondor Albert-Chenevier, Assistance Publique - Hôpitaux de Paris, Créteil, France Unité INSERM U955, Créteil, France Université Paris Est, Créteil, France

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http://dx.doi.org/10.3324/haematol.2015.135400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815738PMC
March 2016

Prognosis and outcome of stem cell transplantation for mantle cell lymphoma.

Expert Rev Hematol 2015 Aug 19;8(4):493-504. Epub 2015 Jun 19.

Hematology Department, Necker Hospital, Paris Descartes - Sorbonne Paris Cité University, INSERM U1163 CNRS ERL8654, Imagine Institute, Paris, France.

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http://dx.doi.org/10.1586/17474086.2015.1047759DOI Listing
August 2015

Reduced-toxicity conditioning with fludarabine, once-daily intravenous busulfan, and antithymocyte globulins prior to allogeneic stem cell transplantation: results of a multicenter prospective phase 2 trial.

Cancer 2015 Feb 3;121(4):562-9. Epub 2014 Oct 3.

Hematology Department, Nantes University Medical Center, Nantes, France; Cancerologie Reserch Center Nantes Angers, INSERM 892, CNRS 6299, University of Nantes School of Medicine, Nantes, France; Center for Clinical Investigation of Cancer, Nantes University Medical Center, Nantes, France; Hematology Department, AP-HP, Paris University 6, Saint Antoine Hospital, Paris, France.

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http://dx.doi.org/10.1002/cncr.29087DOI Listing
February 2015

Human herpesvirus 6 reactivation before engraftment is strongly predictive of graft failure after double umbilical cord blood allogeneic stem cell transplantation in adults.

Exp Hematol 2014 Nov 26;42(11):945-54. Epub 2014 Jul 26.

Centre Hospitalier et Universitaire de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie, Nantes, France; Université de Nantes et INSERM Centre Régional de Recherche en Cancérologie Nantes/Angers Unite Mixte de Recherche 892, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.07.264DOI Listing
November 2014

PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance.

Blood 2014 Sep 8;124(10):1626-36. Epub 2014 Jul 8.

INSERM, Unité Mixte de Recherche 892, Nantes, France; Université de Nantes, Nantes, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6299, Nantes, France; Service d'Hématologie, Centre Hospitalo-Universitaire Nantes, Nantes, France;

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http://dx.doi.org/10.1182/blood-2014-01-548800DOI Listing
September 2014

Mantle cell lymphoma epidemiology: a population-based study in France.

Ann Hematol 2014 Aug 25;93(8):1327-33. Epub 2014 Apr 25.

Service d'Évaluation Médicale et d'Épidémiologie, Centre Hospitalier Universitaire de Nantes, Nantes, France.

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http://dx.doi.org/10.1007/s00277-014-2049-5DOI Listing
August 2014

Fractionated ⁹⁰Y-ibritumomab tiuxetan radioimmunotherapy as an initial therapy of follicular lymphoma: an international phase II study in patients requiring treatment according to GELF/BNLI criteria.

J Clin Oncol 2014 Jan 2;32(3):212-8. Epub 2013 Dec 2.

Tim M. Illidge, Sam Mayes, John A. Radford, W. David J. Ryder, Manchester Academic Health Science Centre, University of Manchester; Jill Tipping, Maureen Zivanovic, Christie Hospital NHS Foundation Trust, Manchester; Ruth Pettengell, St. George's, University of London, London; Andrew T. Bates, Southampton University Hospitals NHS Foundation Trust, Southampton; Mike Bayne, Poole Hospital NHS Foundation Trust, Dorset, United Kingdom; Steven Le Gouill, Centre Hospitalier Universitaire Nantes; Françoise Kraeber-Bodere, Caroline Bodet-Milin, University Hospital-ICO-CRCNA INSERM U892, Nantes; Emmanuel Malek, Damien Huglo, Hospitalier Universitaire Lille; Franck Morschhauser, Centre Hospitalier Universitaire, Lille; Fabrice Jardin, Centre Henri Becquerel, Rouen; Manuel Bardies, Centre de Recherche en Cancérologie de Toulouse, Faculté de Médecine de Toulouse-Rangueil, Toulouse, France.

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http://dx.doi.org/10.1200/JCO.2013.50.3110DOI Listing
January 2014

ABT-737 is highly effective against molecular subgroups of multiple myeloma.

Blood 2011 Oct 11;118(14):3901-10. Epub 2011 Aug 11.

Inserm, Unité Mixte de Recherche_S892, Institut de Recherche Thérapeutique de l'Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1182/blood-2010-11-317438DOI Listing
October 2011

Allogeneic stem cell transplantation in mantle cell lymphoma: where are we now and which way should we go?

Semin Hematol 2011 Jul;48(3):227-39

Service d'hématologie clinique du CHU de Nantes, Nantes, France.

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http://dx.doi.org/10.1053/j.seminhematol.2011.03.009DOI Listing
July 2011