Steven Hersch

Steven Hersch

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Steven Hersch

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Double Tubular Contractile Structure of the Type VI Secretion System Displays Striking Flexibility and Elasticity.

J Bacteriol 2019 Dec 6;202(1). Epub 2019 Dec 6.

Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

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http://dx.doi.org/10.1128/JB.00425-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932242PMC
December 2019

The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting.

Future Sci OA 2019 Jun 28;5(6):FSO398. Epub 2019 Jun 28.

Department of Neurology McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.

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http://dx.doi.org/10.2144/fsoa-2019-0026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609901PMC
June 2019

Double Tubular Contractile Structure of the Type VI Secretion System Displays Striking Flexibility and Elasticity.

J Bacteriol 2019 Dec 6;202(1). Epub 2019 Dec 6.

Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

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http://dx.doi.org/10.1128/JB.00425-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932242PMC
December 2019

Electrocardiogram Abnormalities Suggest Aberrant Cardiac Conduction in Huntington's Disease.

Mov Disord Clin Pract 2018 May-Jun;5(3):306-311. Epub 2018 Apr 11.

Departments of Neurology Center for Neuro-imaging of Aging and Neurodegenerative Diseases.

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http://dx.doi.org/10.1002/mdc3.12596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174483PMC
April 2018

Motor, cognitive, and functional declines contribute to a single progressive factor in early HD.

Neurology 2017 Dec 15;89(24):2495-2502. Epub 2017 Nov 15.

From F. Hoffman-La Roche, Ltd (S.A.S., G.P., O.S.K., D.T., J.J.S.), Roche Innovation Center, Basel, Switzerland; University of Rochester (P.A., S.M., E.R.D., K.D.K.), NY; University of Iowa (J.D.L., D.R.L.), Iowa City; Massachusetts General Hospital and Harvard Medical School (M.C., S.H.), Boston; CHDI Management/Foundation (C.S.), Princeton, NJ; University of British Columbia, Vancouver, Canada (B.R.L.); and University College London (S.J.T.), UK.

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http://dx.doi.org/10.1212/WNL.0000000000004743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729794PMC
December 2017

The CREST-E study of creatine for Huntington disease: A randomized controlled trial.

Neurology 2017 Aug 12;89(6):594-601. Epub 2017 Jul 12.

From the Department of Neurology (S.M.H., H.D.R.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Neurology and Biostatistics (G.S., D.O.), University of Rochester Medical Center, NY; Department of Pediatrics (A.-L.B.), Medical University of South Carolina, Charleston; and NIH (C.M.M., R.N.), National Center for Complementary and Integrative Health, Bethesda, MD.

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http://dx.doi.org/10.1212/WNL.0000000000004209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562960PMC
August 2017

LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington's Disease.

J Huntingtons Dis 2016 12;5(4):347-355

Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.3233/JHD-160226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181668PMC
December 2016

Rho Kinase Pathway Alterations in the Brain and Leukocytes in Huntington's Disease.

Mol Neurobiol 2016 May 5;53(4):2132-40. Epub 2015 May 5.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School, Massachusetts General Hospital, East, Bldg 114, Room 2005, Charlestown, MA, 02129-4404, USA.

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http://dx.doi.org/10.1007/s12035-015-9147-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823347PMC
May 2016

Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials.

Authors:
Kevin Michael Biglan Ira Shoulson Karl Kieburtz David Oakes Elise Kayson M Aileen Shinaman Hongwei Zhao Megan Romer Anne Young Steven Hersch Jack Penney Karen Marder Jane Paulsen Kimberly Quaid Eric Siemers Caroline Tanner William Mallonee Greg Suter Richard Dubinsky Carolyn Gray Martha Nance Scott Bundlie Dawn Radtke Sandra Kostyk Corrine Baic James Caress Francis Walker Victoria Hunt Christine O'Neill Sylvain Chouinard Stewart Factor Timothy Greenamyre Cathy Wood-Siverio Jody Corey-Bloom David Song Guerry Peavy Carol Moskowitz Melissa Wesson Ali Samii Thomas Bird Hillary Lipe Karen Blindauer Frederick Marshall Carol Zimmerman Jody Goldstein Diana Rosas Peter Novak John Caviness Charles Adler Amy Duffy Vicki Wheelock Teresa Tempkin David Richman Lauren Seeberger Roger Albin Kelvin L Chou Brad Racette Joel S Perlmutter Susan Perlman Yvette Bordelon Wayne Martin Marguerite Wieler Blair Leavitt Lynn Raymond Joji Decolongon Lorne Clarke Joseph Jankovic Christine Hunter Robert A Hauser Juan Sanchez-Ramos Sarah Furtado Oksana Suchowersky Mary Lou Klimek Mark Guttman Rustom Sethna Andrew Feigin Marie Cox Barbara Shannon Alan Percy Leon Dure Madaline Harrison William Johnson Donald Higgins Eric Molho Constance Nickerson Sharon Evans Douglas Hobson Carlos Singer Nestor Galvez-Jimenez Kathleen Shannon Cynthia Comella Christopher Ross Marie H Saint-Hilaire Claudia Testa Adam Rosenblatt Penelope Hogarth William Weiner Peter Como Rajeev Kumar Candace Cotto Julie Stout Alicia Brocht Arthur Watts Shirley Eberly Christine Weaver Tatiana Foroud James Gusella Marcy MacDonald Richard Myers Stanley Fahn Clifford Shults

JAMA Neurol 2016 Jan;73(1):102-10

Department of Neuroscience, University of California, San Diego, La Jolla.

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http://dx.doi.org/10.1001/jamaneurol.2015.2736DOI Listing
January 2016

A systems-level "misunderstanding": the plasma metabolome in Huntington's disease.

Ann Clin Transl Neurol 2015 Jul 28;2(7):756-68. Epub 2015 May 28.

Department of Neurology Boston, Massachusetts ; MassGeneral Institutes for Neurodegenerative Disease, Laboratory of Neurodegeneration and Neurotherapeutics, Boston University Boston, Massachusetts.

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http://dx.doi.org/10.1002/acn3.214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531058PMC
July 2015

Altered selenium status in Huntington's disease: neuroprotection by selenite in the N171-82Q mouse model.

Neurobiol Dis 2014 Nov 8;71:34-42. Epub 2014 Jul 8.

Department of Veterinary Sciences, University of Wyoming, Laramie, WY 82070, USA; Neuroscience Graduate Program, University of Wyoming, Laramie, WY 82070, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.06.022DOI Listing
November 2014

Translation initiation rate determines the impact of ribosome stalling on bacterial protein synthesis.

J Biol Chem 2014 Oct 22;289(41):28160-71. Epub 2014 Aug 22.

From the Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada and

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http://dx.doi.org/10.1074/jbc.M114.593277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192472PMC
October 2014

Iron accumulates in Huntington's disease neurons: protection by deferoxamine.

PLoS One 2013 11;8(10):e77023. Epub 2013 Oct 11.

Department of Veterinary Sciences and Neuroscience Graduate Program, University of Wyoming, Laramie, Wyoming, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077023PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795666PMC
August 2014

EF-P dependent pauses integrate proximal and distal signals during translation.

PLoS Genet 2014 Aug 21;10(8):e1004553. Epub 2014 Aug 21.

Department of Microbiology and The Center for RNA Biology, Ohio State University, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140641PMC
August 2014

PRECREST: a phase II prevention and biomarker trial of creatine in at-risk Huntington disease.

Neurology 2014 Mar 7;82(10):850-7. Epub 2014 Feb 7.

From the Departments of Neurology (H.D.R., S.G., K.M., M.R., T.D.T., P.J.W., S.M.H.), Center for Neuro-imaging of Aging and Neurodegenerative Diseases (H.D.R., S.G., K.M., M.R., J.-P.C., T.D.T., P.J.W., D.H.S.), Athinoula A. Martinos Center for Biomedical Imaging (H.D.R., S.G., K.M., M.R., T.D.T., P.J.W., D.H.S.), and Radiology (H.D.R., M.R.), Massachusetts General Hospital and Harvard Medical School, Boston; Department of Biostatistics (G.D.), School of Public Health, Boston University, Boston; Harvard-MIT Division of Health Sciences and Technology (J.-P.C.), Cambridge; and Geriatric Research Education Clinical Center (W.M.), New England Veterans Administration, Bedford, MA.

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http://dx.doi.org/10.1212/WNL.0000000000000187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959748PMC
March 2014

HTRF analysis of soluble huntingtin in PHAROS PBMCs.

Neurology 2013 Sep 21;81(13):1134-40. Epub 2013 Aug 21.

From the Massachusetts General Hospital (M.M.-L., R.E.G., J.J.R., H.D.R., S.M., A.B.Y., S.M.H.), MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, MA; University of Rochester Medical Center (S.E., D.O.), Department of Biostatistics and Computational Biology, Rochester, NY; Veterans Administration Hospital (W.M.), Bedford, MA; and Program for Regulatory Science & Medicine (I.S.), Georgetown University, Washington, DC.

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http://dx.doi.org/10.1212/WNL.0b013e3182a55edeDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795598PMC
September 2013

Alterations in brain transition metals in Huntington disease: an evolving and intricate story.

Arch Neurol 2012 Jul;69(7):887-93

Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, 02129, USA.

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http://dx.doi.org/10.1001/archneurol.2011.2945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652228PMC
July 2012

Loss of elongation factor P disrupts bacterial outer membrane integrity.

J Bacteriol 2012 Jan 11;194(2):413-25. Epub 2011 Nov 11.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1128/JB.05864-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256640PMC
January 2012

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.

Hum Mol Genet 2011 Oct 26;20(20):3986-96. Epub 2011 Jul 26.

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/hmg/ddr326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203628PMC
October 2011

Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse.

Proc Natl Acad Sci U S A 2011 Oct 3;108(41):17141-6. Epub 2011 Oct 3.

Laboratory for Neurogenomics, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1104409108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193232PMC
October 2011

Microtiter plate quantification of mutant and wild-type huntingtin normalized to cell count.

Anal Biochem 2011 Mar 4;410(2):304-6. Epub 2010 Dec 4.

Neuroscience Discovery, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.ab.2010.11.044DOI Listing
March 2011

Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease.

PLoS Curr 2010 Dec 29;2:RRN1205. Epub 2010 Dec 29.

Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; Novartis Institutes for Biomedical Research, Neuroscience; Boston University; Massachusetts General Hospital/Harvard Medical School; Massachusetts General Hospital; Neuroscience Research, Head Neurodegeneration at Novartis, Basel, Switzerland; Novartis Institutes for Biomedical Research and AC Immune SA.

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http://dx.doi.org/10.1371/currents.RRN1205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015780PMC
December 2010

Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease.

Biochim Biophys Acta 2010 Jul-Aug;1802(7-8):673-81. Epub 2010 May 9.

Geriatric Research Education Clinical Center, New England Veterans Administration VISN 1, Bedford, MA 01730, USA.

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http://dx.doi.org/10.1016/j.bbadis.2010.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893277PMC
August 2010

Complexity and heterogeneity: what drives the ever-changing brain in Huntington's disease?

Ann N Y Acad Sci 2008 Dec;1147:196-205

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1196/annals.1427.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813569PMC
December 2008

Linking SNPs to CAG repeat length in Huntington's disease patients.

Nat Methods 2008 Nov 19;5(11):951-3. Epub 2008 Oct 19.

Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA.

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http://dx.doi.org/10.1038/nmeth.1261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587014PMC
November 2008

Metabolite identification using a nanoelectrospray LC-EC-array-MS integrated system.

Anal Chem 2008 Aug 25;80(15):5912-23. Epub 2008 Jun 25.

Barnett Institute and Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/ac800507yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657231PMC
August 2008

Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity.

Brain 2008 Apr 12;131(Pt 4):1057-68. Epub 2008 Mar 12.

Center for Neuro-imaging of Aging and Neurodegenerative Diseases, 149 13th Street Room 2275, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/brain/awn025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657201PMC
April 2008

Neuroprotection for Huntington's disease: ready, set, slow.

Neurotherapeutics 2008 Apr;5(2):226-36

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129-4404, USA.

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http://dx.doi.org/10.1016/j.nurt.2008.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359156PMC
April 2008

Drug targeting of dysregulated transcription in Huntington's disease.

Prog Neurobiol 2007 Nov 23;83(4):249-59. Epub 2007 Feb 23.

Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1016/j.pneurobio.2007.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110959PMC
November 2007

A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.

Proc Natl Acad Sci U S A 2007 Oct 9;104(42):16685-9. Epub 2007 Oct 9.

Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.0707842104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034257PMC
October 2007

Monitoring reportable events and unanticipated problems: the PHAROS and PREDICT studies of Huntington disease.

IRB 2007 May-Jun;29(3):11-6

Department of Family and Community Medicine, University of Texas, Houston Medical School, USA.

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September 2007

Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models.

Hum Mol Genet 2007 Jun 4;16(11):1293-306. Epub 2007 Apr 4.

Department of Neurology, MassGeneral Institute for NeurodegenerativeDisease, Massachusetts General Hospital, B114-2000, 114 16th Street, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1093/hmg/ddm078DOI Listing
June 2007

Mechanisms of copper ion mediated Huntington's disease progression.

PLoS One 2007 Mar 28;2(3):e334. Epub 2007 Mar 28.

Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000334PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828629PMC
March 2007

Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measures.

Mov Disord 2006 Sep;21(9):1317-25

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.20979DOI Listing
September 2006

Discovery of bioactive small-molecule inhibitor of poly adp-ribose polymerase: implications for energy-deficient cells.

Chem Biol 2006 Jul;13(7):765-70

Massachusetts General Institute for Neurodegenerative Disease and Harvard Medical School, Department of Neurology, Massachusetts General Hospital, Charlestown, 02129, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S107455210600180
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http://dx.doi.org/10.1016/j.chembiol.2006.05.012DOI Listing
July 2006

Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective.

J Biol Chem 2006 Jun 4;281(24):16672-80. Epub 2006 Apr 4.

Massachusetts General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1074/jbc.M511648200DOI Listing
June 2006

The therapeutic role of creatine in Huntington's disease.

Pharmacol Ther 2005 Nov 1;108(2):193-207. Epub 2005 Aug 1.

Experimental Neuropathology Unit and Translational Therapeutics Laboratory, Geriatric Research Education Clinical Center, Bedford VA Medical Center, MA 01730, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2005.04.008DOI Listing
November 2005

Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice.

J Comp Neurol 2005 Oct;490(4):354-70

Geriatric Research Education and Clinical Center, Bedford Veterans Administration Medical Center, Bedford, Massachusetts 01730, USA.

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http://dx.doi.org/10.1002/cne.20680DOI Listing
October 2005

Demonstration of nondeclarative sequence learning in mice: development of an animal analog of the human serial reaction time task.

Learn Mem 2004 Nov-Dec;11(6):720-3. Epub 2004 Nov 10.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/lm.85404DOI Listing
March 2005

Anti-inflammatory treatment with acetylsalicylate or rofecoxib is not neuroprotective in Huntington's disease transgenic mice.

Neurobiol Dis 2004 Nov;17(2):319-25

MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.nbd.2004.07.011DOI Listing
November 2004

Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation.

J Neurochem 2004 Oct;91(2):413-22

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02726.xDOI Listing
October 2004

Translating therapies for Huntington's disease from genetic animal models to clinical trials.

NeuroRx 2004 Jul;1(3):298-306

Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534928PMC
http://dx.doi.org/10.1602/neurorx.1.3.298DOI Listing
July 2004

Using advances in neuroimaging to detect, understand, and monitor disease progression in Huntington's disease.

NeuroRx 2004 Apr;1(2):263-72

Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534942PMC
http://dx.doi.org/10.1602/neurorx.1.2.263DOI Listing
April 2004

Minocycline is protective in a mouse model of Huntington's disease.

Ann Neurol 2003 Dec;54(6):841; author reply 842-3

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http://dx.doi.org/10.1002/ana.21891DOI Listing
December 2003

Huntington's disease: prospects for neuroprotective therapy 10 years after the discovery of the causative genetic mutation.

Authors:
Steven M Hersch

Curr Opin Neurol 2003 Aug;16(4):501-6

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1097/01.wco.0000084229.82329.03DOI Listing
August 2003

Cytochrome C and caspase-9 expression in Huntington's disease.

Neuromolecular Med 2002 ;1(3):183-95

Geriatric Research Education and Clinical Center, Bedford VA Medical Center, MA 01730, USA.

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http://dx.doi.org/10.1385/NMM:1:3:183DOI Listing
January 2003

Therapeutic effects of cystamine in a murine model of Huntington's disease.

J Neurosci 2002 Oct;22(20):8942-50

Geriatric Research Education and Clinical Center, Bedford Veterans Affairs Medical Center, Bedford, Massachusetts 01730, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757687PMC
October 2002

Cellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic mice.

J Comp Neurol 2002 Jul;449(3):241-69

Department of Anatomy and Neurobiology, The Health Science Center, University of Tennessee-Memphis, 855 Monroe Avenue, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1002/cne.10295DOI Listing
July 2002

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

Science 2002 Jun 2;296(5576):2238-43. Epub 2002 May 2.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Center for Aging, Genetics and Neurodegeneration, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1126/science.1072613DOI Listing
June 2002

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

J Neurosci 2002 Mar;22(5):1592-9

Geriatric Research Education and Clinical Center, Bedford Veterans Administration Medical Center, Bedford, Massachusetts 01730, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758854PMC
March 2002