Dr. Steven H Zeisel, MD, PhD - University of North Carolina at Chapel Hill - Professor

Dr. Steven H Zeisel

MD, PhD

University of North Carolina at Chapel Hill

Professor

Chapel Hill, NC | United States

Dr. Steven H Zeisel, MD, PhD - University of North Carolina at Chapel Hill - Professor

Dr. Steven H Zeisel

MD, PhD

Introduction

Primary Affiliation: University of North Carolina at Chapel Hill - Chapel Hill, NC , United States

Publications

100Publications

1302Reads

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2530PubMed Central Citations

Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism.

FASEB J 2015 Feb 10;29(2):418-32. Epub 2014 Nov 10.

*Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid, Spain; Unidad 761, Centro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU San Pablo, Boadilla del Monte, Madrid, Spain; Hospital Clínico Veterinario, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain; University of North Carolina at Chapel Hill, Nutrition Research Institute, Kannapolis, North Carolina, USA; Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain; and Instituto de Investigación Sanitaria La Paz, Madrid, Spain.

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http://dx.doi.org/10.1096/fj.14-259283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314232PMC
February 2015
38 Reads
10 Citations
5.043 Impact Factor

Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study.

Am J Clin Nutr 2014 Sep 18;100(3):778-86. Epub 2014 Jun 18.

From the Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC (CAM, KDC, SZ, XZ, TB, BJB, AO, and SHZ), and the Department of Nutrition, School of Public Health and School of Medicine (K-AdC and SHZ) and Departments of Medicine (JAG) and Genetics (BJB), University of North Carolina at Chapel Hill, Chapel Hill, NC.

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http://dx.doi.org/10.3945/ajcn.114.087692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135488PMC
September 2014
27 Reads
36 Citations
6.770 Impact Factor

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.

FASEB J 2014 Jul 26;28(7):2970-8. Epub 2014 Mar 26.

Department of Nutrition, School of Public Health, School of Medicine, and Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA

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http://dx.doi.org/10.1096/fj.14-249557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062831PMC
July 2014
7 Reads
11 Citations
5.043 Impact Factor

Spectral deconvolution for gas chromatography mass spectrometry-based metabolomics: current status and future perspectives.

Comput Struct Biotechnol J 2013 28;4:e201301013. Epub 2013 Jun 28.

Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, United States.

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http://dx.doi.org/10.5936/csbj.201301013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962095PMC
June 2014
6 Reads
8 Citations

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles.

Nat Commun 2014 Apr 29;5:3746. Epub 2014 Apr 29.

MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street, London WC1E 7HT, UK.

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http://dx.doi.org/10.1038/ncomms4746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015319PMC
April 2014
90 Reads
102 Citations
10.742 Impact Factor

Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability.

Nutr Res 2013 Nov 16;33(11):897-904. Epub 2013 Sep 16.

Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nutres.2013.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815698PMC
November 2013
4 Reads
14 Citations
2.585 Impact Factor

Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption.

FASEB J 2013 Sep 24;27(9):3583-93. Epub 2013 May 24.

Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, North Carolina 28081, USA.

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http://dx.doi.org/10.1096/fj.13-231860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752538PMC
September 2013
9 Reads
34 Citations
5.043 Impact Factor

A targeted metabolomic protocol for short-chain fatty acids and branched-chain amino acids.

Metabolomics 2013 Aug;9(4):818-827

Center for Translational Medicine, and Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

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http://dx.doi.org/10.1007/s11306-013-0500-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756605PMC
August 2013
24 Reads
16 Citations
3.860 Impact Factor

Choline's role in maintaining liver function: new evidence for epigenetic mechanisms.

Curr Opin Clin Nutr Metab Care 2013 May;16(3):339-45

Nutrition Research Institute at Kannapolis, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1097/MCO.0b013e3283600d46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729018PMC
May 2013
6 Reads
8 Citations
3.990 Impact Factor

Nutrition in pregnancy: the argument for including a source of choline.

Authors:
Steven H Zeisel

Int J Womens Health 2013 22;5:193-9. Epub 2013 Apr 22.

Nutrition Research Institute at Kannapolis, Department of Nutrition, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.

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http://dx.doi.org/10.2147/IJWH.S36610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639110PMC
May 2013
7 Reads
15 Citations

A brief history of choline.

Authors:
Steven H Zeisel

Ann Nutr Metab 2012 26;61(3):254-8. Epub 2012 Nov 26.

UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA. Steven_Zeisel @ unc.edu

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http://dx.doi.org/10.1159/000343120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422379PMC
April 2013
1 Read
8 Citations
2.620 Impact Factor

Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.

FASEB J 2013 Apr 4;27(4):1674-89. Epub 2013 Jan 4.

University of North Carolina at Chapel Hill Nutrition Research Institute, Kannapolis, NorthCarolina 28081, USA.

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http://dx.doi.org/10.1096/fj.12-219097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606533PMC
April 2013
25 Reads
10 Citations
5.043 Impact Factor

Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research.

JPEN J Parenter Enteral Nutr 2013 Mar 5;37(2):190-200. Epub 2012 Oct 5.

University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.

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http://dx.doi.org/10.1177/0148607112462401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593226PMC
March 2013
33 Reads
2 Citations
3.151 Impact Factor

Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis.

Authors:
Steven H Zeisel

Clin Chem Lab Med 2013 Mar;51(3):467-75

University of North Carolina at Chapel Hill, Nutrition Research Institute, Kannapolis, NC 28081, USA.

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http://dx.doi.org/10.1515/cclm-2012-0518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624053PMC
March 2013
5 Reads
17 Citations
2.960 Impact Factor

Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial.

Am J Clin Nutr 2012 Dec 7;96(6):1465-72. Epub 2012 Nov 7.

Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 28081, USA.

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http://dx.doi.org/10.3945/ajcn.112.037184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497930PMC
December 2012
4 Reads
14 Citations
6.770 Impact Factor

The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic.

Toxicol Appl Pharmacol 2012 Nov 31;264(3):439-50. Epub 2012 Aug 31.

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.taap.2012.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478409PMC
November 2012
9 Reads
16 Citations
3.705 Impact Factor

Homocysteinemia in mice with genetic betaine homocysteine S-methyltransferase deficiency is independent of dietary folate intake.

J Nutr 2012 Nov 26;142(11):1964-7. Epub 2012 Sep 26.

Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.3945/jn.112.166835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497933PMC
November 2012
11 Reads
9 Citations
3.880 Impact Factor

The nutrigenetics and nutrigenomics of the dietary requirement for choline.

Prog Mol Biol Transl Sci 2012 ;108:159-77

University of North Carolina at Chapel Hill, Nutrition Research Institute, Kannapolis, North Carolina, USA.

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http://dx.doi.org/10.1016/B978-0-12-398397-8.00007-1DOI Listing
October 2012
6 Reads
2 Citations
3.490 Impact Factor

Choline intake and risk of lethal prostate cancer: incidence and survival.

Am J Clin Nutr 2012 Oct 5;96(4):855-63. Epub 2012 Sep 5.

Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.3945/ajcn.112.039784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441112PMC
October 2012
3 Reads
12 Citations
6.770 Impact Factor

A grand challenge for nutrigenomics.

Authors:
Steven H Zeisel

Front Genet 2010 13;1. Epub 2010 Dec 13.

UNC Nutrition Research Institute at Kannapolis, University of North Carolina at Chapel Hill Kannapolis, NC, USA.

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http://dx.doi.org/10.3389/fgene.2010.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268351PMC
October 2012
1 Read
1 Citation

Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.

Authors:
Steven H Zeisel

Ann Nutr Metab 2012 15;60 Suppl 3:19-25. Epub 2012 May 15.

Nutrition Research Institute, University of North Carolina at Chapel Hill, 500 Laureate Way, Kannapolis, N.C. 28081, USA.

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http://dx.doi.org/10.1159/000337310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894784PMC
September 2012
11 Reads
5 Citations
2.620 Impact Factor

Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function.

PLoS One 2012 27;7(4):e36047. Epub 2012 Apr 27.

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036047PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338626PMC
September 2012
9 Reads
10 Citations
3.234 Impact Factor

Mouse betaine-homocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue.

J Biol Chem 2012 May 23;287(20):16187-98. Epub 2012 Feb 23.

Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M111.303255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351280PMC
May 2012
4 Reads
15 Citations
4.573 Impact Factor

Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones.

Authors:
Steven H Zeisel

Mutat Res 2012 May 20;733(1-2):34-8. Epub 2011 Oct 20.

Nutrition Research Institute, School of Public Health and School of Medicine, The University of North Carolina at Chapel Hill, Kannapolis, NC 28081, United States. steven

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http://dx.doi.org/10.1016/j.mrfmmm.2011.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319504PMC
May 2012
9 Reads
18 Citations
3.680 Impact Factor

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression.

Curr Opin Gastroenterol 2012 Mar;28(2):159-65

University of North Carolina at Chapel Hill, Nutrition Research Institute, Kannapolis, North Carolina, USA.

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http://dx.doi.org/10.1097/MOG.0b013e32834e7b4bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601486PMC
March 2012
25 Reads
49 Citations
4.290 Impact Factor

Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas.

J Biol Chem 2011 Oct 30;286(42):36258-67. Epub 2011 Aug 30.

Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M111.265348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196139PMC
October 2011
2 Reads
52 Citations
4.573 Impact Factor

What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders.

Authors:
Steven H Zeisel

Mol Neurobiol 2011 Oct 25;44(2):185-91. Epub 2011 Jan 25.

Department of Nutrition, UNC Nutrition Research Institute at Kannapolis, University of North Carolina at Chapel Hill, 500 Laureate Way, Room 2218, Kannapolis, NC 28081, USA.

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http://dx.doi.org/10.1007/s12035-011-8165-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605552PMC
October 2011
2 Reads
19 Citations
5.140 Impact Factor

The supply of choline is important for fetal progenitor cells.

Authors:
Steven H Zeisel

Semin Cell Dev Biol 2011 Aug 12;22(6):624-8. Epub 2011 Jun 12.

Nutrition Research Institute, School of Public Health and School of Medicine, The University of North Carolina at Chapel Hill, Kannapolis, NC 28081, United States.

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http://dx.doi.org/10.1016/j.semcdb.2011.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188336PMC
August 2011
4 Reads
12 Citations
6.265 Impact Factor

Choline: clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements.

Authors:
Steven H Zeisel

J Nutrigenet Nutrigenomics 2010 6;3(4-6):209-19. Epub 2011 Apr 6.

Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 28081, USA.

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http://dx.doi.org/10.1159/000324357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085526PMC
August 2011
36 Reads
5 Citations
2.000 Impact Factor

Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans.

Am J Clin Nutr 2011 May 16;93(5):968-74. Epub 2011 Mar 16.

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.3945/ajcn.110.011064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076652PMC
May 2011
19 Reads
13 Citations
6.770 Impact Factor

Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency.

Gastroenterology 2011 Mar 1;140(3):976-86. Epub 2010 Dec 1.

Department of Bioinformatics and Genomics, University of North Carolina, Charlotte, North Carolina 28223, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.11.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049827PMC
March 2011
7 Reads
106 Citations
16.720 Impact Factor

Nutritional genomics: defining the dietary requirement and effects of choline.

Authors:
Steven H Zeisel

J Nutr 2011 Mar 26;141(3):531-4. Epub 2011 Jan 26.

Nutrition Research Institute, School of Public Health, The University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA.

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http://dx.doi.org/10.3945/jn.110.130369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040911PMC
March 2011
10 Reads
21 Citations
3.880 Impact Factor

Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.

J Biol Chem 2011 Jan 8;286(2):1649-58. Epub 2010 Nov 8.

Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M110.106922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020773PMC
January 2011
14 Reads
28 Citations
4.573 Impact Factor

Dietary choline requirements of women: effects of estrogen and genetic variation.

Am J Clin Nutr 2010 Nov 22;92(5):1113-9. Epub 2010 Sep 22.

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.3945/ajcn.2010.30064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954445PMC
November 2010
22 Reads
17 Citations
6.770 Impact Factor

Adiponectin lowers glucose production by increasing SOGA.

Am J Pathol 2010 Oct 2;177(4):1936-45. Epub 2010 Sep 2.

Departments of Nutrition, School of Medicine and Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.2353/ajpath.2010.100363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947288PMC
October 2010
6 Reads
13 Citations
4.591 Impact Factor

Nutrition in medicine: nutrition education for medical students and residents.

Nutr Clin Pract 2010 Oct;25(5):471-80

Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599-7461, USA.

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http://dx.doi.org/10.1177/0884533610379606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594871PMC
October 2010
28 Reads
18 Citations
2.060 Impact Factor

Nutrition education in U.S. medical schools: latest update of a national survey.

Acad Med 2010 Sep;85(9):1537-42

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7461, USA.

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http://dx.doi.org/10.1097/ACM.0b013e3181eab71bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042309PMC
September 2010
3 Reads
30 Citations
2.934 Impact Factor

Choline: clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements.

Authors:
Steven H Zeisel

World Rev Nutr Diet 2010 30;101:73-83. Epub 2010 Apr 30.

Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USA.

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http://dx.doi.org/10.1159/000314512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601485PMC
August 2010
6 Reads
3 Citations

Evidence-based criteria in the nutritional context.

Nutr Rev 2010 Aug;68(8):478-84

Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/j.1753-4887.2010.00307.xDOI Listing
August 2010
14 Reads
26 Citations
6.080 Impact Factor

Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma.

Am J Clin Nutr 2010 Aug 9;92(2):336-46. Epub 2010 Jun 9.

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 28081, USA.

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http://dx.doi.org/10.3945/ajcn.2010.29459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904035PMC
August 2010
6 Reads
23 Citations
6.770 Impact Factor

Deletion of murine choline dehydrogenase results in diminished sperm motility.

FASEB J 2010 Aug 6;24(8):2752-61. Epub 2010 Apr 6.

Department of Nutrition, Nutrition Research Institute, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1096/fj.09-153718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909292PMC
August 2010
4 Reads
22 Citations
5.043 Impact Factor

Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus.

Proc Natl Acad Sci U S A 2010 Jul 12;107(29):12834-9. Epub 2010 Jul 12.

University of North Carolina Nutrition Research Institute at Kannapolis, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA.

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http://dx.doi.org/10.1073/pnas.0914328107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919920PMC
July 2010
46 Reads
33 Citations
9.810 Impact Factor

Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain.

J Nutr 2010 Jun 14;140(6):1162-6. Epub 2010 Apr 14.

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.3945/jn.110.122044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869500PMC
June 2010
22 Reads
13 Citations
3.880 Impact Factor

Are dietary choline and betaine intakes determinants of total homocysteine concentration?

Am J Clin Nutr 2010 May 10;91(5):1303-10. Epub 2010 Mar 10.

Department of Food and Nutrition, Sookmyung Women's University, Seoul, Republic of Korea.

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http://dx.doi.org/10.3945/ajcn.2009.28456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854904PMC
May 2010
21 Reads
7 Citations
6.770 Impact Factor

Choline and betaine intake and the risk of colorectal cancer in men.

Cancer Epidemiol Biomarkers Prev 2010 Mar 16;19(3):884-7. Epub 2010 Feb 16.

Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-1295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882060PMC
March 2010
32 Reads
15 Citations
4.125 Impact Factor

Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene.

FASEB J 2010 Jan 14;24(1):184-95. Epub 2009 Sep 14.

UNC Nutrition Research Institute at Kannapolis, University of North Carolina, 500 Laureate Way, Kannapolis, NC 28081, USA.

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http://dx.doi.org/10.1096/fj.09-140145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797040PMC
January 2010
1 Read
46 Citations
5.043 Impact Factor

The betaine content of sweat from adolescent females.

J Int Soc Sports Nutr 2010 Jan 22;7(1). Epub 2010 Jan 22.

Danisco A/S, Elmsford, NY, USA.

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http://dx.doi.org/10.1186/1550-2783-7-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822829PMC
January 2010
35 Reads
1 Citation
1.910 Impact Factor

Dietary docosahexaenoic acid supplementation modulates hippocampal development in the Pemt-/- mouse.

J Biol Chem 2010 Jan 4;285(2):1008-15. Epub 2009 Nov 4.

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M109.017137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801227PMC
January 2010
14 Reads
13 Citations
4.573 Impact Factor

High intakes of choline and betaine reduce breast cancer mortality in a population-based study.

FASEB J 2009 Nov 27;23(11):4022-8. Epub 2009 Jul 27.

Department of Community and Preventive Medicine, Box 1057, Mt. Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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November 2009
11 Reads
19 Citations
5.043 Impact Factor

Choline: an essential nutrient for public health.

Nutr Rev 2009 Nov;67(11):615-23

Department of Nutrition at the Nutrition Research Institute, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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November 2009
19 Reads
87 Citations
6.080 Impact Factor

Understanding the role of nutrition in the brain and behavioral development of toddlers and preschool children: identifying and addressing methodological barriers.

Nutr Neurosci 2009 Oct;12(5):190-202

Global Research and Development, Mead Johnson Nutritionals, Evansville, Indiana, USA.

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October 2009
18 Reads
14 Citations
2.114 Impact Factor

BRCA1 promoter methylation is associated with increased mortality among women with breast cancer.

Breast Cancer Res Treat 2009 May 3;115(2):397-404. Epub 2008 Jun 3.

Department of Community and Preventive Medicine, Mount Sinai School of Medicine, P.O. Box 1043, One Gustave L. Levy Place, New York, NY 10029, USA.

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May 2009
10 Reads
29 Citations
3.940 Impact Factor

Epigenetic mechanisms for nutrition determinants of later health outcomes.

Authors:
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Am J Clin Nutr 2009 May 4;89(5):1488S-1493S. Epub 2009 Mar 4.

Nutrition Research Institute, the University of North Carolina, Chapel Hill, NC, USA.

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May 2009
2 Reads
46 Citations
6.770 Impact Factor

Importance of methyl donors during reproduction.

Authors:
Steven H Zeisel

Am J Clin Nutr 2009 Feb 30;89(2):673S-7S. Epub 2008 Dec 30.

Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

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February 2009
5 Reads
58 Citations
6.770 Impact Factor

Is maternal diet supplementation beneficial? Optimal development of infant depends on mother's diet.

Authors:
Steven H Zeisel

Am J Clin Nutr 2009 Feb 30;89(2):685S-7S. Epub 2008 Dec 30.

Nutrition Research Institute, and the Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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February 2009
6 Reads
15 Citations
6.770 Impact Factor

Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study.

Nutr J 2009 Feb 20;8:14. Epub 2009 Feb 20.

Cardiovascular Research Institute and Department of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, GA, USA.

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February 2009
9 Reads
24 Citations
2.600 Impact Factor

Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans.

Toxicol Sci 2009 Jan 23;107(1):220-6. Epub 2008 Oct 23.

Department of Nutrition, School of Public Health and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7461, USA.

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January 2009
5 Reads
1 Citation

Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models.

Authors:
Steven H Zeisel

Brain Res 2008 Oct 3;1237:5-11. Epub 2008 Sep 3.

Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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October 2008
5 Reads
17 Citations
2.843 Impact Factor

Choline metabolism and risk of breast cancer in a population-based study.

FASEB J 2008 Jun 29;22(6):2045-52. Epub 2008 Jan 29.

Department of Community and Preventive Medicine, Mt. Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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June 2008
9 Reads
44 Citations
5.043 Impact Factor

Perspectives from the symposium: The role of nutrition in infant and toddler brain and behavioral development.

Nutr Neurosci 2008 Jun;11(3):135-43

Global Research and Development, Mead Johnson Nutritionals, Evansville, Indiana 47721, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562682PMC
June 2008
7 Reads
5 Citations
2.114 Impact Factor

Is there a new component of the Mediterranean diet that reduces inflammation?

Authors:
Steven H Zeisel

Am J Clin Nutr 2008 Feb;87(2):277-8

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February 2008
4 Reads
3 Citations
6.770 Impact Factor

The association between betaine and choline intakes and the plasma concentrations of homocysteine in women.

Am J Clin Nutr 2007 Oct;86(4):1073-81

Department of Nutrition, Harvard School of Public Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/ajcn/86.4.1073DOI Listing
October 2007
14 Reads
26 Citations
6.770 Impact Factor

Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline.

Authors:
Steven H Zeisel

Am J Clin Nutr 2007 Sep;86(3):542-8

Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1093/ajcn/86.3.542DOI Listing
September 2007
2 Reads
14 Citations
6.770 Impact Factor

Dietary choline and betaine and the risk of distal colorectal adenoma in women.

J Natl Cancer Inst 2007 Aug 8;99(16):1224-31. Epub 2007 Aug 8.

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA.

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August 2007
11 Reads
37 Citations
12.583 Impact Factor

Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes.

FASEB J 2007 Aug 24;21(10):2622-32. Epub 2007 Apr 24.

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA.

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August 2007
27 Reads
53 Citations
5.043 Impact Factor

Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study.

BMC Cardiovasc Disord 2007 Jul 13;7:20. Epub 2007 Jul 13.

Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA.

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July 2007
7 Reads
40 Citations
1.500 Impact Factor

Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not.

Am J Clin Nutr 2007 Jul;86(1):230-9

Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA.

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July 2007
7 Reads
4 Citations
6.770 Impact Factor

Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline.

Authors:
Steven H Zeisel

IUBMB Life 2007 Jun;59(6):380-7

Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599, USA.

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June 2007
6 Reads
19 Citations
3.143 Impact Factor

Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared with those who do not.

J Nutr Biochem 2007 Jun 8;18(6):380-90. Epub 2006 Sep 8.

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, NC 27599-7461, USA.

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June 2007
14 Reads
21 Citations
3.794 Impact Factor

Sex and menopausal status influence human dietary requirements for the nutrient choline.

Am J Clin Nutr 2007 May;85(5):1275-85

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA.

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http://dx.doi.org/10.1093/ajcn/85.5.1275DOI Listing
May 2007
19 Reads
75 Citations
6.770 Impact Factor

GSTM1, GSTT1, GSTP1, and GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans.

J Nutr 2007 Apr;137(4):904-9

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.

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http://dx.doi.org/10.1093/jn/137.4.904DOI Listing
April 2007
18 Reads
22 Citations
3.880 Impact Factor

Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells.

Toxicol Sci 2007 Apr 4;96(2):321-6. Epub 2007 Jan 4.

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599-7461, USA.

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April 2007
2 Reads
3 Citations

The betaine and choline content of a whole wheat flour compared to other mill streams.

J Cereal Sci 2007 ;46(1):93-95

Department of Grain Science & Industry, Kansas State University, Manhattan, KS 66506, USA.

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January 2007
7 Reads
5 Citations
2.094 Impact Factor

The fetal origins of memory: the role of dietary choline in optimal brain development.

Authors:
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J Pediatr 2006 Nov;149(5 Suppl):S131-6

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

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November 2006
3 Reads
35 Citations
3.790 Impact Factor

Choline: critical role during fetal development and dietary requirements in adults.

Authors:
Steven H Zeisel

Annu Rev Nutr 2006 ;26:229-50

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1146/annurev.nutr.26.061505.111156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441939PMC
October 2006
17 Reads
133 Citations
8.360 Impact Factor

Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus.

FASEB J 2006 Aug;20(10):1635-40

Department of Nutrition, School of Public Health and Medicine, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599-7461, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574370PMC
August 2006
14 Reads
3 Citations
5.043 Impact Factor

Common genetic polymorphisms affect the human requirement for the nutrient choline.

FASEB J 2006 Jul;20(9):1336-44

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, CB# 7461, Chapel Hill, North Carolina 27599, USA.

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July 2006
4 Reads
74 Citations
5.043 Impact Factor

Choline deficiency increases lymphocyte apoptosis and DNA damage in humans.

Am J Clin Nutr 2006 Jul;84(1):88-94

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1093/ajcn/84.1.88DOI Listing
July 2006
8 Reads
28 Citations
6.770 Impact Factor

Perinatal choline influences brain structure and function.

Nutr Rev 2006 Apr;64(4):197-203

Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, 27599-7416, USA.

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http://dx.doi.org/10.1111/j.1753-4887.2006.tb00202.xDOI Listing
April 2006
4 Reads
41 Citations
6.080 Impact Factor

Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study.

Am J Clin Nutr 2006 Apr;83(4):905-11

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/ajcn/83.4.905DOI Listing
April 2006
9 Reads
57 Citations
6.770 Impact Factor

Status of nutrition education in medical schools.

Am J Clin Nutr 2006 Apr;83(4):941S-944S

Department of Nutrition, School of Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1093/ajcn/83.4.941SDOI Listing
April 2006
13 Reads
17 Citations
6.770 Impact Factor

The evolution of Nutrition in Medicine, a computer-assisted nutrition curriculum.

Am J Clin Nutr 2006 Apr;83(4):956S-962S

Department of Nutrition, School of Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1093/ajcn/83.4.956SDOI Listing
April 2006
9 Reads
6 Citations
6.770 Impact Factor

Betaine supplementation and blood lipids: fact or artifact?

Authors:
Steven H Zeisel

Nutr Rev 2006 Feb;64(2 Pt 1):77-9

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina, USA.

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February 2006
2 Reads
3 Citations
6.080 Impact Factor

Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains.

FASEB J 2006 Jan;20(1):43-9

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina, 27599-7461 USA.

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http://dx.doi.org/10.1096/fj.05-4707comDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635129PMC
January 2006
5 Reads
112 Citations
5.043 Impact Factor

Homocysteine metabolism in ZDF (type 2) diabetic rats.

Diabetes 2005 Nov;54(11):3245-51

Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.

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http://dx.doi.org/10.2337/diabetes.54.11.3245DOI Listing
November 2005
20 Reads
16 Citations
8.100 Impact Factor

Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans.

Proc Natl Acad Sci U S A 2005 Nov 18;102(44):16025-30. Epub 2005 Oct 18.

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1073/pnas.0504285102DOI Listing
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November 2005
34 Reads
56 Citations
9.810 Impact Factor

Choline, homocysteine, and pregnancy.

Authors:
Steven H Zeisel

Am J Clin Nutr 2005 Oct;82(4):719-20

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October 2005
2 Reads
8 Citations
6.770 Impact Factor

Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus.

Brain Res Dev Brain Res 2005 Oct;159(2):149-54

Department of Nutrition, CB#7461, Room 2212 McGavran-Greenberg Hall, School of Public Health and School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.devbrainres.2005.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592522PMC
October 2005
18 Reads
20 Citations

Regulation of choline deficiency apoptosis by epidermal growth factor in CWSV-1 rat hepatocytes.

Cell Physiol Biochem 2005 ;15(1-4):59-68

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7461, USA.

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August 2005
6 Reads
17 Citations
2.880 Impact Factor

Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD).

FASEB J 2005 Aug;19(10):1266-71

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599-7461, USA .

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1256033PMC
August 2005
5 Reads
54 Citations
5.043 Impact Factor

Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice.

Brain Res Mol Brain Res 2005 Apr;134(2):239-55

Department of Nutrition, CB #7461, School of Public Health, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

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April 2005
5 Reads
4 Citations

Ad libitum choline intake in healthy individuals meets or exceeds the proposed adequate intake level.

J Nutr 2005 Apr;135(4):826-9

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA.

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http://dx.doi.org/10.1093/jn/135.4.826DOI Listing
April 2005
17 Reads
15 Citations
3.880 Impact Factor

Gene expression profiling of choline-deprived neural precursor cells isolated from mouse brain.

Brain Res Mol Brain Res 2005 Apr 9;134(2):309-22. Epub 2004 Dec 9.

Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, 2212 McGavran-Greenberg Hall, Chapel Hill, NC 27599-7461, USA.

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April 2005
3 Reads
22 Citations

Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load.

Am J Clin Nutr 2005 Feb;81(2):440-4

Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1093/ajcn.81.2.440DOI Listing
February 2005
2 Reads
41 Citations
6.770 Impact Factor