Steven H Seeholzer

Steven H Seeholzer

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Steven H Seeholzer

Steven H Seeholzer

Publications by authors named "Steven H Seeholzer"

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Stability and bioactivity of pepCD47 attachment on stainless steel surfaces.

Acta Biomater 2020 Mar 11;104:231-240. Epub 2020 Jan 11.

Division of Cardiology-Department of Pediatrics, The Children's Hospital of Philadelphia, United States; Perelman School of Medicine, The University of Pennsylvania, United States. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2019.12.039DOI Listing
March 2020

The E3 ubiquitin ligase Itch restricts antigen-driven B cell responses.

J Exp Med 2019 Sep 16;216(9):2170-2183. Epub 2019 Jul 16.

Children's Hospital of Philadelphia, Philadelphia, PA

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http://dx.doi.org/10.1084/jem.20181953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719427PMC
September 2019

SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-κB Activation.

Cell Rep 2019 Jul;28(2):434-448.e6

Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Division of Protective Immunity and Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662646PMC
July 2019

Integrative proteomics reveals an increase in non-degradative ubiquitylation in activated CD4 T cells.

Nat Immunol 2019 06 6;20(6):747-755. Epub 2019 May 6.

Division of Protective Immunity, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41590-019-0381-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007700PMC
June 2019

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Dev Cell 2019 04 28;49(1):10-29. Epub 2019 Mar 28.

Department of Biomedical Informatics, University of Cincinnati College of Medicine, and Cincinnati Children's Hospital Medical Center, Division of Biomedical Informatics, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.devcel.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616346PMC
April 2019

Population pharmacokinetics of exendin-(9-39) and clinical dose selection in patients with congenital hyperinsulinism.

Br J Clin Pharmacol 2018 03 6;84(3):520-532. Epub 2017 Dec 6.

The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/bcp.13463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809353PMC
March 2018

Reply to: Medication contaminants as a potential cause of anaphylaxis to vincristine: What about drug specific antigens?

Pediatr Blood Cancer 2018 02 19;65(2). Epub 2017 Oct 19.

Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/pbc.26868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739934PMC
February 2018

Medication contaminants as a potential cause of anaphylaxis to vincristine.

Pediatr Blood Cancer 2018 Jan 22;65(1). Epub 2017 Aug 22.

Department of Pediatrics, Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/pbc.26761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978699PMC
January 2018

Identifying Host Factors Associated with DNA Replicated During Virus Infection.

Mol Cell Proteomics 2017 Dec 2;16(12):2079-2097. Epub 2017 Oct 2.

From the ‡Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania;

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http://www.mcponline.org/lookup/doi/10.1074/mcp.M117.067116
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http://dx.doi.org/10.1074/mcp.M117.067116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724173PMC
December 2017

The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK.

Mar Drugs 2017 Aug 7;15(8). Epub 2017 Aug 7.

Department of Pediatrics, Division of Neurology, Research Institute, Children's Hospital of Philadelphia, Room 814, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.3390/md15080246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577601PMC
August 2017

Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.

J Neurosci 2017 06 18;37(24):5870-5884. Epub 2017 May 18.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, and

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http://dx.doi.org/10.1523/JNEUROSCI.2705-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473205PMC
June 2017

Improved surfaceome coverage with a label-free nonaffinity-purified workflow.

Proteomics 2017 04 6;17(7). Epub 2017 Mar 6.

Protein and Proteomics Core Facility, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/pmic.201600344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518111PMC
April 2017

Integrated analysis of proteome and transcriptome changes in the mucopolysaccharidosis type VII mouse hippocampus.

Mol Genet Metab 2016 May 7;118(1):41-54. Epub 2016 Mar 7.

Research Institute of the Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; W. F. Goodman Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2016.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832927PMC
May 2016

Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.

Nat Commun 2016 Apr 18;7:11226. Epub 2016 Apr 18.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ncomms11226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837450PMC
April 2016

The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation.

J Biol Chem 2016 Feb 22;291(7):3595-612. Epub 2015 Dec 22.

From the Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 and the Cell and Molecular Biology Graduate Group, the Department of Pathology and Laboratory Medicine, and the Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104

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http://dx.doi.org/10.1074/jbc.M115.692442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751398PMC
February 2016

Unconventional N-Linked Glycosylation Promotes Trimeric Autotransporter Function in Kingella kingae and Aggregatibacter aphrophilus.

mBio 2015 Aug 25;6(4). Epub 2015 Aug 25.

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/mBio.01206-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550697PMC
August 2015

The diabetes susceptibility gene Clec16a regulates mitophagy.

Cell 2014 Jun;157(7):1577-90

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine and the Institute for Diabetes, Obesity and Metabolism of the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184276PMC
June 2014

Quaternary arrangement of an active, native group II intron ribonucleoprotein complex revealed by small-angle X-ray scattering.

Nucleic Acids Res 2014 Apr 24;42(8):5347-60. Epub 2014 Feb 24.

Department of Biochemistry & Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6059, USA, Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA, Wadsworth Center, NYS Department of Health, Albany, NY 12201, USA, Department of Biological Sciences and RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA, SUNY Downstate Medical Center, University Hospital, Brooklyn, NY 11203, USA and Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA.

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http://nar.oxfordjournals.org/content/early/2014/02/23/nar.g
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gku140
Publisher Site
http://dx.doi.org/10.1093/nar/gku140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005650PMC
April 2014

A liquid chromatography-mass spectrometry assay for quantification of Exendin[9-39] in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Feb 16;947-948:186-91. Epub 2013 Dec 16.

Protein and Proteomics Core Facility, The Children's Hospital of Philadelphia Research Institute, 3615 Civic Center Boulevard, Abramson Research Center, 816a, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2013.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518449PMC
February 2014

Site specific identification of endogenous S-nitrosocysteine proteomes.

J Proteomics 2013 Oct 5;92:195-203. Epub 2013 Jun 5.

Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2013.05.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818367PMC
October 2013

Quantitative phosphoproteomics reveals extensive cellular reprogramming during HIV-1 entry.

Cell Host Microbe 2013 May;13(5):613-623

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2013.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104530PMC
May 2013

The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide.

J Biol Chem 2012 Nov 25;287(46):38449-59. Epub 2012 Sep 25.

Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.391482
Publisher Site
http://dx.doi.org/10.1074/jbc.M112.391482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493890PMC
November 2012

Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain.

J Neurosci 2012 Aug;32(32):11082-94

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0064-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430387PMC
August 2012

Quantitative phosphoproteomics of CXCL12 (SDF-1) signaling.

PLoS One 2011 20;6(9):e24918. Epub 2011 Sep 20.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024918PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176801PMC
January 2012

Hb Baden: structural and functional characterization.

Am J Hematol 2010 Nov;85(11):848-52

Department of Pediatrics (Hematology), University of Pennsylvania School of Medicine, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/ajh.21831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618950PMC
November 2010

Quantitative mass spectrometry-based proteomics reveals the dynamic range of primary mouse astrocyte protein secretion.

J Proteome Res 2010 May;9(5):2764-74

Department of Pediatrics, The Children's Hospital of Philadelphia Research Institute and The University of Pennsylvania Philadelphia, Pennsylvania 19104, USA.

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http://pubs.acs.org/doi/abs/10.1021/pr100134n
Publisher Site
http://dx.doi.org/10.1021/pr100134nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866110PMC
May 2010

Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping.

Dev Dyn 2008 Dec;237(12):3577-90

Department of Pediatrics, USF/ACH-Children's Research Institute, St. Petersburg, Florida 33701, USA.

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http://dx.doi.org/10.1002/dvdy.21645DOI Listing
December 2008

Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM.

J Immunol 2008 May;180(9):6094-106

Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.4049/jimmunol.180.9.6094DOI Listing
May 2008

Analyzing alkaline proteins in human colon crypt proteome.

J Proteome Res 2004 Jul-Aug;3(4):821-33

Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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http://dx.doi.org/10.1021/pr049942jDOI Listing
January 2005

A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma.

Proteomics 2003 May;3(5):601-9

Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Jefferson Center for Biomedical Research, Doylestown, PA 18901, USA.

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http://dx.doi.org/10.1002/pmic.200300399DOI Listing
May 2003

The synthesis and radiolabeling of 2-nitroimidazole derivatives of cyclam and their preclinical evaluation as positive markers of tumor hypoxia.

J Nucl Med 2002 Jun;43(6):837-50

Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.

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June 2002