Publications by authors named "Steven G Rozen"

49Publications

Mutational selection in normal urothelium.

Authors:
Steven G Rozen

Science 2020 10;370(6512):34-35

Centre for Computational Biology and Programme in Cancer and Stem Cell Biology, Duke-National University of Singapore (NUS) Medical School, 169857 Singapore.

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http://dx.doi.org/10.1126/science.abe0955DOI Listing
October 2020

A tumor-associated splice-isoform of drives dedifferentiation in MBNL1-low cancers via JNK activation.

Proc Natl Acad Sci U S A 2020 07 29;117(28):16391-16400. Epub 2020 Jun 29.

Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 165897 Singapore, Singapore;

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http://dx.doi.org/10.1073/pnas.2002499117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368273PMC
July 2020

Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma.

Theranostics 2020 21;10(12):5578-5580. Epub 2020 Apr 21.

Duke-NUS Centre for Computational Biology,Duke-NUS Medical School, 8 College Road, 169857 Singapore.

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http://dx.doi.org/10.7150/thno.46489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196294PMC
April 2020

DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial.

Eur J Cancer 2019 12 23;123:48-57. Epub 2019 Oct 23.

Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Biomedical Research Council, Agency for Science, Technology and Research, Singapore; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.09.016DOI Listing
December 2019

Experimental Delineation of Mutational Signatures Is an Essential Tool in Cancer Epidemiology and Prevention.

Chem Res Toxicol 2019 11 11;32(11):2153-2155. Epub 2019 Sep 11.

Duke-NUS Centre for Computational Biology and Cancer and Stem Cell Biology Program , Duke-NUS Medical School Singapore , 8 College Road , Singapore 169857 , Republic of Singapore.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00339DOI Listing
November 2019

SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events.

BMC Genomics 2019 Aug 30;20(1):685. Epub 2019 Aug 30.

Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1186/s12864-019-6041-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717374PMC
August 2019

Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.

Breast Cancer Res 2018 03 22;20(1):22. Epub 2018 Mar 22.

Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

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http://dx.doi.org/10.1186/s13058-018-0949-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863852PMC
March 2018

A formalin-fixed paraffin-embedded (FFPE)-based prognostic signature to predict metastasis in clinically low risk stage I/II microsatellite stable colorectal cancer.

Cancer Lett 2017 09 15;403:13-20. Epub 2017 Jun 15.

Department of Colorectal Surgery, Singapore General Hospital, 169856, Singapore; SingHealth Duke-NUS Surgery Academic Clinical Programme, Office of Clinical, Academic and Faculty Affairs, Duke-NUS Medical School, National University of Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.05.031DOI Listing
September 2017

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.

Mol Cell 2017 Jun 25;66(5):684-697.e9. Epub 2017 May 25.

Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate School of Biomedical Sciences, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.04.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521213PMC
June 2017

Wnt proteins synergize to activate β-catenin signaling.

J Cell Sci 2017 05 13;130(9):1532-1544. Epub 2017 Mar 13.

Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, 169857 Singapore

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http://dx.doi.org/10.1242/jcs.198093DOI Listing
May 2017

Differentially Expressed miRNAs in Hepatocellular Carcinoma Target Genes in the Genetic Information Processing and Metabolism Pathways.

Sci Rep 2016 Jan 28;6:20065. Epub 2016 Jan 28.

NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.

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http://dx.doi.org/10.1038/srep20065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730185PMC
January 2016

Inherited breast cancer predisposition in Asians: multigene panel testing outcomes from Singapore.

NPJ Genom Med 2016 13;1:15003. Epub 2016 Jan 13.

Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore, Singapore.

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http://dx.doi.org/10.1038/npjgenmed.2015.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685290PMC
January 2016

MSIseq: Software for Assessing Microsatellite Instability from Catalogs of Somatic Mutations.

Sci Rep 2015 Aug 26;5:13321. Epub 2015 Aug 26.

Centre for Computational Biology, Duke-NUS Graduate Medical School, Singapore, 169857, Singapore.

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http://dx.doi.org/10.1038/srep13321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549793PMC
August 2015

Mutation signatures implicate aristolochic acid in bladder cancer development.

Genome Med 2015 28;7(1):38. Epub 2015 Apr 28.

Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore, 169857 Singapore ; Centre for Computational Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore, 169857 Singapore.

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http://dx.doi.org/10.1186/s13073-015-0161-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443665PMC
May 2015

Pathogenesis of cholangiocarcinoma: From genetics to signalling pathways.

Best Pract Res Clin Gastroenterol 2015 Apr 17;29(2):233-44. Epub 2015 Feb 17.

Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bpg.2015.02.002DOI Listing
April 2015

Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas.

Eur Urol 2015 Jul 14;68(1):77-83. Epub 2015 Jan 14.

Centre for Computational Biology, Duke-NUS Graduate Medical School, Singapore; Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2014.12.040DOI Listing
July 2015

Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion.

J Clin Endocrinol Metab 2015 Feb 11;100(2):E360-4. Epub 2014 Nov 11.

Laboratory of Cancer Epigenome (W.Y., H.L.H., A.G., D.H., S.L.P., C.K.O., B.T.T.), Division of Medical Sciences, National Cancer Centre Singapore, 169610 Singapore; Division of Cancer and Stem Cell Biology (W.Y., J.R.M., H.L.H., D.H., S.L.P., C.K.O., S.G.R., P.T., B.T.T.), Duke-National University of Singapore Graduate Medical School, 169857 Singapore; National University of Singapore Graduate School for Integrative Sciences and Engineering (W.Y.), 117456 Singapore; Academic Endocrine Unit, Nuffield Department of Clinical Medicine (M.S., P.N., R.V.T.), Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, OX3 7LJ Oxford, United Kingdom; Department of Pathology (R.v.E., D.R., T.v.W., H.M.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Molecular Endocrinology Group, Molecular Pathobiology Research Centre Unit (U.I.P.M.) (B.C.) of the Portuguese Institute of Oncology from Lisbon Francisco Gentil (IPOLFG) and Chronic Diseases Research Centre (CEDOC), Faculty of Medical Sciences (FCM), New University of Lisbon (UNL), 1099-023 Lisbon, Portugal; Genome Institute of Singapore (P.T.), 138672 Singapore; and Cancer Science Institute of Singapore (P.T., B.T.T.), National University of Singapore, 117599 Singapore.

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http://dx.doi.org/10.1210/jc.2014-3238DOI Listing
February 2015

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.

Nat Genet 2014 Aug 20;46(8):877-80. Epub 2014 Jul 20.

1] Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore. [2] Division of Cancer and Stem Cell Biology, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore. [3] Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1038/ng.3037DOI Listing
August 2014

Mutation signatures of carcinogen exposure: genome-wide detection and new opportunities for cancer prevention.

Genome Med 2014 31;6(3):24. Epub 2014 Mar 31.

Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore ; Duke-NUS Centre for Computational Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.

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http://dx.doi.org/10.1186/gm541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062065PMC
July 2014

The NF1 gene revisited - from bench to bedside.

Oncotarget 2014 Aug;5(15):5873-92

Cancer Therapeutics Laboratory, Centre for Personalised Cancer Medicine, University of Adelaide, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171599PMC
http://dx.doi.org/10.18632/oncotarget.2194DOI Listing
August 2014

Evaluation and optimisation of indel detection workflows for ion torrent sequencing of the BRCA1 and BRCA2 genes.

BMC Genomics 2014 Jun 24;15:516. Epub 2014 Jun 24.

Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1186/1471-2164-15-516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079958PMC
June 2014

Lipidomics identifies a requirement for peroxisomal function during influenza virus replication.

J Lipid Res 2014 07 27;55(7):1357-65. Epub 2014 May 27.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456 NUS Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore, Singapore 117456 Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland Department of Biological Sciences, National University of Singapore, Singapore 117597.

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http://dx.doi.org/10.1194/jlr.M049148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076098PMC
July 2014

Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers.

Nat Genet 2013 Dec 3;45(12):1474-8. Epub 2013 Nov 3.

1] Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore. [2] Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore. [3] Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. [4].

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http://www.nature.com/articles/ng.2806
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http://dx.doi.org/10.1038/ng.2806DOI Listing
December 2013

Primer3--new capabilities and interfaces.

Nucleic Acids Res 2012 Aug 22;40(15):e115. Epub 2012 Jun 22.

Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1093/nar/gks596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424584PMC
August 2012