Steven G Deeks

Steven G Deeks

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Steven G Deeks

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Risk to Nonparticipants in HIV Remission Studies With Treatment Interruption: A Symposium.

J Infect Dis 2019 Jul;220(Supplement_1):S1-S4

Department of Medicine, University of California, San Francisco.

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http://dx.doi.org/10.1093/infdis/jiz173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603969PMC
July 2019

How Unavoidable Are Analytical Treatment Interruptions in HIV Cure-Related Studies?

J Infect Dis 2019 Jul;220(Supplement_1):S24-S26

Department of Medicine, University of California-San Francisco.

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http://dx.doi.org/10.1093/infdis/jiz222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636248PMC
July 2019

Carnitine Is Associated With Atherosclerotic Risk and Myocardial Infarction in HIV -Infected Adults.

J Am Heart Assoc 2019 May;8(9):e011037

3 Division of Cardiology Department of Medicine San Francisco General Hospital University of California, San Francisco San Francisco CA.

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http://dx.doi.org/10.1161/JAHA.118.011037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512101PMC
May 2019

Unusual Cysteine Content in V1 Region of gp120 From an Elite Suppressor That Produces Broadly Neutralizing Antibodies.

Front Immunol 2019 15;10:1021. Epub 2019 May 15.

Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530427PMC
May 2019

HIV "cure": A shot in the arm?

EBioMedicine 2019 Apr 11;42:3-5. Epub 2019 Apr 11.

Global Health Discovery & Translational Sciences, The Bill & Melinda Gates Foundation, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491910PMC
April 2019

Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial.

Clin Pharmacol Ther 2019 Mar 9;105(3):692-702. Epub 2018 Oct 9.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1002/cpt.1220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379104PMC
March 2019

Stimulant Use and Viral Suppression in the Era of Universal Antiretroviral Therapy.

J Acquir Immune Defic Syndr 2019 Jan;80(1):89-93

Department of Medicine, University of California, San Francisco School of Medicine, San Francisco, CA.

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http://Insights.ovid.com/crossref?an=00126334-201901010-0001
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http://dx.doi.org/10.1097/QAI.0000000000001867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289664PMC
January 2019

Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency.

PLoS Pathog 2019 01 15;15(1):e1007498. Epub 2019 Jan 15.

Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1007498
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http://dx.doi.org/10.1371/journal.ppat.1007498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333332PMC
January 2019

Unique Circulating MicroRNA Profiles in HIV Infection.

J Acquir Immune Defic Syndr 2018 Dec;79(5):644-650

Division of Cardiology and the Center of Excellence in Vascular Research, San Francisco General Hospital, University of California, San Francisco, CA.

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http://Insights.ovid.com/crossref?an=00126334-900000000-9657
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http://dx.doi.org/10.1097/QAI.0000000000001851DOI Listing
December 2018

HIV control: Is getting there the same as staying there?

PLoS Pathog 2018 11 1;14(11):e1007222. Epub 2018 Nov 1.

Department of Medicine, University of California, San Francisco, California, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1007222
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http://dx.doi.org/10.1371/journal.ppat.1007222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211749PMC
November 2018

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.

PLoS Pathog 2018 11 15;14(11):e1007357. Epub 2018 Nov 15.

San Francisco Veterans Affairs (VA) Medical Center and University of California, San Francisco (UCSF), San Francisco, CA, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237391PMC
November 2018

Ethical issues in HIV remission trials.

Curr Opin HIV AIDS 2018 09;13(5):422-427

Department of Medicine, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1097/COH.0000000000000489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112842PMC
September 2018

Maximising the global health impact of future HIV cure-related interventions through advance planning.

J Virus Erad 2018 Jul 1;4(3):182-185. Epub 2018 Jul 1.

Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038126PMC
July 2018

Detection of HIV-1-specific gastrointestinal tissue resident CD8 T-cells in chronic infection.

Mucosal Immunol 2018 05 15;11(3):909-920. Epub 2017 Nov 15.

Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California, USA.

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http://www.nature.com/doifinder/10.1038/mi.2017.96
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http://dx.doi.org/10.1038/mi.2017.96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953759PMC
May 2018

Differential Expression of CD8 T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection.

J Immunol 2018 03 19;200(5):1876-1888. Epub 2018 Jan 19.

Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA 95616;

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http://dx.doi.org/10.4049/jimmunol.1701532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821568PMC
March 2018

Association of HIV-1 Gag-Specific IgG Antibodies With Natural Control of HIV-1 Infection in Individuals Not Carrying HLA-B*57: 01 Is Only Observed in Viremic Controllers.

J Acquir Immune Defic Syndr 2017 11;76(3):e90-e92

*School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia †Division of Clinical Epidemiology, University of California, San Francisco, CA ‡School of Medicine, University of California, San Francisco, CA §Stem Cell Unit, Institute of Respiratory Health, Perth, Western Australia, Australia ‖Department of Microbiology and Infectious Diseases, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Western Australia, Australia ¶School of Biomedical Sciences, Curtin University, Perth, Western Australia, Australia #Medical School, University of Western Australia, Perth, Western Australia, Australia **Department of Clinical Immunology, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1097/QAI.0000000000001477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634911PMC
November 2017

The end of HIV: Still a very long way to go, but progress continues.

PLoS Med 2017 Nov 30;14(11):e1002466. Epub 2017 Nov 30.

Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1371/journal.pmed.1002466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708775PMC
November 2017

Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers.

Retrovirology 2017 Aug 22;14(1):41. Epub 2017 Aug 22.

Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1186/s12977-017-0365-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568399PMC
August 2017

Signature of the Sleeper Cell: A Biomarker of HIV Latency Revealed.

Trends Immunol 2017 07 13;38(7):457-458. Epub 2017 May 13.

Positive Health Program, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.it.2017.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091624PMC
July 2017

p16INK4a Expression and Immunologic Aging in Chronic HIV Infection.

PLoS One 2016 18;11(11):e0166759. Epub 2016 Nov 18.

Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166759PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115792PMC
June 2017

SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.

Cell Host Microbe 2017 May;21(5):569-579.e6

Gladstone Institute for Virology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490666PMC
May 2017

High-Sequence Diversity and Rapid Virus Turnover Contribute to Higher Rates of Coreceptor Switching in Treatment-Experienced Subjects with HIV-1 Viremia.

AIDS Res Hum Retroviruses 2017 03 12;33(3):234-245. Epub 2016 Oct 12.

1 Department of Immunology and Microbial Science, IMM-7, The Scripps Research Institute , La Jolla, California.

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http://dx.doi.org/10.1089/AID.2016.0153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333564PMC
March 2017

Measuring the Size of the Latent Human Immunodeficiency Virus Reservoir: The Present and Future of Evaluating Eradication Strategies.

J Infect Dis 2017 03;215(suppl_3):S134-S141

Blood Systems Research Institute and Department of Laboratory Medicine, University of California, San Francisco.

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http://dx.doi.org/10.1093/infdis/jiw648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410981PMC
March 2017

Psoriasis risk SNPs and their association with HIV-1 control.

Hum Immunol 2017 Feb 31;78(2):179-184. Epub 2016 Oct 31.

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2016.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253078PMC
February 2017

Mucosal Microbes Mitigate Maladies.

Immunity 2017 01;46(1):1-3

University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613163052
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http://dx.doi.org/10.1016/j.immuni.2016.12.019DOI Listing
January 2017

Role of T-Cell Dysfunction, Inflammation, and Coagulation in Microvascular Disease in HIV.

J Am Heart Assoc 2016 12 20;5(12). Epub 2016 Dec 20.

Division of Cardiology, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA

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http://dx.doi.org/10.1161/JAHA.116.004243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210441PMC
December 2016

Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents.

Open Forum Infect Dis 2016 Oct 7;3(4):ofw189. Epub 2016 Oct 7.

Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts.

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http://dx.doi.org/10.1093/ofid/ofw189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066458PMC
October 2016

The Benefits of Early Antiretroviral Therapy for HIV Infection: How Early is Early Enough?

EBioMedicine 2016 Sep 5;11:7-8. Epub 2016 Aug 5.

University of California San Francisco, CA, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049928PMC
http://dx.doi.org/10.1016/j.ebiom.2016.08.009DOI Listing
September 2016

Endothelin-1 Predicts Hemodynamically Assessed Pulmonary Arterial Hypertension in HIV Infection.

PLoS One 2016 11;11(1):e0146355. Epub 2016 Jan 11.

San Francisco General Hospital Cardiology Division, University of California San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146355PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709102PMC
July 2016

Persistent HIV-1 replication during antiretroviral therapy.

Curr Opin HIV AIDS 2016 07;11(4):417-23

aAIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona, Badalona bUniversity of Vic-Central University of Catalonia (UVic-UCC), Vic cInstitució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain dDepartment of Medicine, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1097/COH.0000000000000287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900428PMC
July 2016

Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4+ T cells in HIV-infected individuals on antiretroviral therapy.

AIDS 2016 06;30(10):1511-20

aThe Peter Doherty Institute for Infection and Immunity, University of MelbournebDepartment of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, AustraliacDepartment of Microbiology, Infectiology and Immunology, Université de Montréal, Faculty of Medicine, and Centre de Recherche du CHUM, Montréal, Quebec, CanadadDepartment of MedicineeDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889535PMC
June 2016

Immunologic profiles distinguish aviremic HIV-infected adults.

AIDS 2016 06;30(10):1553-62

aDepartment of Biostatistics, University of California at Los Angeles, Los AngelesbDepartment of Medicine, University of California at San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679214PMC
June 2016

When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries: A Prospective Observational Study.

J Acquir Immune Defic Syndr 2016 Jun;72(2):214-21

1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; 2University College London, London, United Kingdom; 3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA; 4Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France; 5Assistance Publique-Hopitaux de Paris (AP-HP), Hopital Antoine Béclère, Service de Médecine Interne, Clamart, France; 6University of Alabama at Birmingham, Birmingham, AL; 7Université Paris Sud, INSERM CESP U1018, and AP-HP, Hopital de Bicêtre, Service de Santé Publique, le Kremlin Bicêtre, France; 8Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, WA; 9Bordeaux University, ISPED, INSERM U897 CHU de Bordeaux, Bordeaux, France; 10INSERM U897, Centre Inserm Epidémiologie et Biostatistique, Université de Bordeaux, and Department of Internal Medicine, Bordeaux University Hospital, Bordeaux, France; 11School of Medicine, Johns Hopkins University, Baltimore, MD; 12Stichting HIV Monitoring, Amsterdam, Netherlands; Academic Medical Center, Department of Global Health and Division of Infectious Diseases, University of Amsterdam, and Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands; 13Stichting HIV Monitoring, Amsterdam, Netherlands; 14Internal Medicine, Johns Hopkins University, Baltimore, MD; 15National Centre of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain; Consorcio de Investigación Biomédica de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; 16Ramón y Cajal Hospital, IRYCIS, Madrid, Spain, University of Alcalá de Henares, Madrid, Spain; 17Positive Health Program, San Francisco General Hospital, San Francisco, CA; 18Servei de Medicina Interna, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain; 19Fenway Health, Boston, MA; 20Hospital Universitari d

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http://dx.doi.org/10.1097/QAI.0000000000000956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866894PMC
June 2016

Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People?

J Acquir Immune Defic Syndr 2016 06;72(2):206-213

*Department of Medicine, Boston University School of Medicine, Boston, MA; †Section of General Internal Medicine, VA Connecticut Healthcare System, West Haven, CT; ‡Department of Internal Medicine, Yale University School of Medicine, New Haven, CT; §Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA; ‖Hamad Healthcare Quality Institute, Hamad Medical Corporation, Doha, Qatar; ¶Department of Medicine, Weill Cornell Medical College, Doha, Qatar and New York, NY; #Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii-Manoa, Honolulu, HI; **Medical Service/Infectious Diseases, VA Medical Center, Washington, DC; ††Department of Medicine, George Washington University Medical Center, Washington, DC; ‡‡Infectious Diseases Section, VA Greater Los Angeles Healthcare System, Los Angeles, CA; §§Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; ‖‖Medical Service, VA Medical Center, Atlanta, GA; ¶¶Medical Service, Emory University School of Medicine, Atlanta, GA; ##Infectious Diseases Section, Michael E. DeBakey VA Medical Center, Houston, TX; ***Infectious Diseases Section, Baylor College of Medicine, Houston, TX; †††Department of Medicine, Los Angeles Biomedical Research Institute, Torrance, CA; ‡‡‡Section of General Internal Medicine, Boston University School of Medicine, Boston, MA; §§§Department of Community Health Sciences, Boston University School of Public Health, Boston, MA; ‖‖‖Department of General Internal Medicine, Boston Medical Center, Boston, MA; ¶¶¶Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA; ###Department of Medicine, Positive Health Program, San Francisco General Hospital, San Francisco, CA; ****Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Washington, Seattle, WA; ††††Departments of Pathology and Laboratory Medicine and Biochemistry, College of Medicine, University of Vermont, Burlington, VT; ‡‡‡‡Department of Medicine, University of Washington School of Medicine, Seattle, WA; §§§§Department of Medicine, Baltimore VA Medical Center, Baltimore, MD; ‖‖‖‖Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD; ¶¶¶¶Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; and ####Geriatric Research, Education, and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, TN.

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http://dx.doi.org/10.1097/QAI.0000000000000954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867134PMC
June 2016

Post-Treatment Controllers: Role in HIV "Cure" Research.

Curr HIV/AIDS Rep 2016 Feb;13(1):1-9

HIV/AIDS Division, San Francisco General Hospital, University of California, 995 Potrero Avenue, San Francisco, CA, 94110, USA.

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http://dx.doi.org/10.1007/s11904-016-0296-xDOI Listing
February 2016