Publications by authors named "Steven G Deeks"

100Publications

Filgotinib suppresses HIV-1-driven gene transcription by inhibiting HIV-1 splicing and T cell activation.

J Clin Invest 2020 Jun 23. Epub 2020 Jun 23.

Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, United States of America.

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http://dx.doi.org/10.1172/JCI137371DOI Listing
June 2020

'Rinse and Replace': Boosting T Cell Turnover To Reduce HIV-1 Reservoirs.

Trends Immunol 2020 Jun 12;41(6):466-480. Epub 2020 May 12.

Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2020.04.003DOI Listing
June 2020

Association between statin use, atherosclerosis, and mortality in HIV-infected adults.

PLoS One 2020 30;15(4):e0232636. Epub 2020 Apr 30.

Division of Cardiology, San Francisco General Hospital, Department of Medicine, University of California, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232636PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192415PMC
July 2020

The immune response fails to control HIV early in initial virus spread.

J Clin Invest 2020 Jun;130(6):2803-2805

Department of Medicine, UCSF, San Francisco, California, USA.

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http://dx.doi.org/10.1172/JCI136886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259984PMC
June 2020

Editorial: HIV and Cancer Immunotherapy: Similar Challenges and Converging Approaches.

Front Immunol 2020 31;11:519. Epub 2020 Mar 31.

Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.

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http://dx.doi.org/10.3389/fimmu.2020.00519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138010PMC
March 2020

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.

Cell Host Microbe 2020 04;27(4):519-530

Department of Medicine, University of California, San Francisco, CA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2020.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219958PMC
April 2020

Why and where an HIV cure is needed and how it might be achieved.

Nature 2019 12 18;576(7787):397-405. Epub 2019 Dec 18.

Department of Medicine, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41586-019-1841-8DOI Listing
December 2019

Statistical analysis of single-copy assays when some observations are zero.

J Virus Erad 2019 Sep 18;5(3):167-173. Epub 2019 Sep 18.

The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.

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September 2019

Statistical analysis of single-copy assays when some observations are zero.

J Virus Erad 2019 Sep 18;5(3):167-173. Epub 2019 Sep 18.

The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.

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September 2019

Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform.

Cell 2019 10 24;179(4):880-894.e10. Epub 2019 Oct 24.

Gladstone Center for HIV Cure Research, Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA; Departments of Medicine and Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922308PMC
October 2019

How Unavoidable Are Analytical Treatment Interruptions in HIV Cure-Related Studies?

J Infect Dis 2019 07;220(220 Suppl 1):S24-S26

Department of Medicine, University of California-San Francisco.

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http://dx.doi.org/10.1093/infdis/jiz222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636248PMC
July 2019

Risk to Nonparticipants in HIV Remission Studies With Treatment Interruption: A Symposium.

J Infect Dis 2019 07;220(220 Suppl 1):S1-S4

Department of Medicine, University of California, San Francisco.

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http://dx.doi.org/10.1093/infdis/jiz173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603969PMC
July 2019

Unusual Cysteine Content in V1 Region of gp120 From an Elite Suppressor That Produces Broadly Neutralizing Antibodies.

Front Immunol 2019 15;10:1021. Epub 2019 May 15.

Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530427PMC
May 2019

Carnitine Is Associated With Atherosclerotic Risk and Myocardial Infarction in HIV -Infected Adults.

J Am Heart Assoc 2019 05;8(9):e011037

3 Division of Cardiology Department of Medicine San Francisco General Hospital University of California, San Francisco San Francisco CA.

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http://dx.doi.org/10.1161/JAHA.118.011037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512101PMC
May 2019

HIV "cure": A shot in the arm?

EBioMedicine 2019 04 11;42:3-5. Epub 2019 Apr 11.

Global Health Discovery & Translational Sciences, The Bill & Melinda Gates Foundation, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491910PMC
April 2019

Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency.

PLoS Pathog 2019 01 15;15(1):e1007498. Epub 2019 Jan 15.

Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1007498
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http://dx.doi.org/10.1371/journal.ppat.1007498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333332PMC
January 2019

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.

PLoS Pathog 2018 11 15;14(11):e1007357. Epub 2018 Nov 15.

San Francisco Veterans Affairs (VA) Medical Center and University of California, San Francisco (UCSF), San Francisco, CA, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237391PMC
November 2018

HIV control: Is getting there the same as staying there?

PLoS Pathog 2018 11 1;14(11):e1007222. Epub 2018 Nov 1.

Department of Medicine, University of California, San Francisco, California, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1007222
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http://dx.doi.org/10.1371/journal.ppat.1007222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211749PMC
November 2018

Stimulant Use and Viral Suppression in the Era of Universal Antiretroviral Therapy.

J Acquir Immune Defic Syndr 2019 01;80(1):89-93

Department of Medicine, University of California, San Francisco School of Medicine, San Francisco, CA.

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http://Insights.ovid.com/crossref?an=00126334-201901010-0001
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http://dx.doi.org/10.1097/QAI.0000000000001867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289664PMC
January 2019

Unique Circulating MicroRNA Profiles in HIV Infection.

J Acquir Immune Defic Syndr 2018 12;79(5):644-650

Division of Cardiology and the Center of Excellence in Vascular Research, San Francisco General Hospital, University of California, San Francisco, CA.

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http://Insights.ovid.com/crossref?an=00126334-900000000-9657
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http://dx.doi.org/10.1097/QAI.0000000000001851DOI Listing
December 2018

Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial.

Clin Pharmacol Ther 2019 03 9;105(3):692-702. Epub 2018 Oct 9.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1002/cpt.1220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379104PMC
March 2019

Maximising the global health impact of future HIV cure-related interventions through advance planning.

J Virus Erad 2018 Jul 1;4(3):182-185. Epub 2018 Jul 1.

Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038126PMC
July 2018

Ethical issues in HIV remission trials.

Curr Opin HIV AIDS 2018 09;13(5):422-427

Department of Medicine, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1097/COH.0000000000000489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112842PMC
September 2018

Differential Expression of CD8 T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection.

J Immunol 2018 03 19;200(5):1876-1888. Epub 2018 Jan 19.

Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, CA 95616;

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http://dx.doi.org/10.4049/jimmunol.1701532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821568PMC
March 2018

The end of HIV: Still a very long way to go, but progress continues.

PLoS Med 2017 Nov 30;14(11):e1002466. Epub 2017 Nov 30.

Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1371/journal.pmed.1002466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708775PMC
November 2017

Detection of HIV-1-specific gastrointestinal tissue resident CD8 T-cells in chronic infection.

Mucosal Immunol 2018 05 15;11(3):909-920. Epub 2017 Nov 15.

Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California, USA.

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http://www.nature.com/doifinder/10.1038/mi.2017.96
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http://dx.doi.org/10.1038/mi.2017.96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953759PMC
May 2018

Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers.

Retrovirology 2017 Aug 22;14(1):41. Epub 2017 Aug 22.

Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1186/s12977-017-0365-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568399PMC
August 2017

Association of HIV-1 Gag-Specific IgG Antibodies With Natural Control of HIV-1 Infection in Individuals Not Carrying HLA-B*57: 01 Is Only Observed in Viremic Controllers.

J Acquir Immune Defic Syndr 2017 11;76(3):e90-e92

*School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia †Division of Clinical Epidemiology, University of California, San Francisco, CA ‡School of Medicine, University of California, San Francisco, CA §Stem Cell Unit, Institute of Respiratory Health, Perth, Western Australia, Australia ‖Department of Microbiology and Infectious Diseases, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Western Australia, Australia ¶School of Biomedical Sciences, Curtin University, Perth, Western Australia, Australia #Medical School, University of Western Australia, Perth, Western Australia, Australia **Department of Clinical Immunology, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1097/QAI.0000000000001477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634911PMC
November 2017

Measuring the Size of the Latent Human Immunodeficiency Virus Reservoir: The Present and Future of Evaluating Eradication Strategies.

J Infect Dis 2017 03;215(suppl_3):S134-S141

Blood Systems Research Institute and Department of Laboratory Medicine, University of California, San Francisco.

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http://dx.doi.org/10.1093/infdis/jiw648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410981PMC
March 2017

Signature of the Sleeper Cell: A Biomarker of HIV Latency Revealed.

Trends Immunol 2017 07 13;38(7):457-458. Epub 2017 May 13.

Positive Health Program, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.it.2017.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091624PMC
July 2017

SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.

Cell Host Microbe 2017 May;21(5):569-579.e6

Gladstone Institute for Virology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490666PMC
May 2017