Steven G Clarke

Steven G Clarke

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Steven G Clarke

Publications by authors named "Steven G Clarke"

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The l-isoaspartate modification within protein fragments in the aging lens can promote protein aggregation.

J Biol Chem 2019 Aug 25;294(32):12203-12219. Epub 2019 Jun 25.

Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095

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http://dx.doi.org/10.1074/jbc.RA119.009052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690693PMC
August 2019

Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.

Nat Commun 2019 Jul 26;10(1):3357. Epub 2019 Jul 26.

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, 90095-1569, USA.

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http://dx.doi.org/10.1038/s41467-019-11183-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659688PMC
July 2019

PRMT7 as a unique member of the protein arginine methyltransferase family: A review.

Arch Biochem Biophys 2019 Apr 22;665:36-45. Epub 2019 Feb 22.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA, 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2019.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461449PMC
April 2019

Oxidative Modifications in Tissue Pathology and Autoimmune Disease.

Antioxid Redox Signal 2018 11 11;29(14):1415-1431. Epub 2017 Dec 11.

1 Section of Rheumatology, Yale University School of Medicine , New Haven, Connecticut.

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http://dx.doi.org/10.1089/ars.2017.7382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166690PMC
November 2018

The ribosome: A hot spot for the identification of new types of protein methyltransferases.

Authors:
Steven G Clarke

J Biol Chem 2018 07 9;293(27):10438-10446. Epub 2018 May 9.

From the Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, California 90095

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http://dx.doi.org/10.1074/jbc.AW118.003235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036201PMC
July 2018

APP/Aβ structural diversity and Alzheimer's disease pathogenesis.

Neurochem Int 2017 Nov 12;110:1-13. Epub 2017 Aug 12.

Laboratory of Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA.

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http://dx.doi.org/10.1016/j.neuint.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688956PMC
November 2017

Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases.

Proc Natl Acad Sci U S A 2017 09 5;114(38):10101-10106. Epub 2017 Sep 5.

Department of Chemistry and Biochemistry, The Molecular Biology Institute, University of California, Los Angeles, CA 90095

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http://dx.doi.org/10.1073/pnas.1706978114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617285PMC
September 2017

Caenorhabditis elegans PRMT-7 and PRMT-9 Are Evolutionarily Conserved Protein Arginine Methyltransferases with Distinct Substrate Specificities.

Biochemistry 2017 05 9;56(20):2612-2626. Epub 2017 May 9.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles , 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States.

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http://pubs.acs.org/doi/10.1021/acs.biochem.7b00283
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http://dx.doi.org/10.1021/acs.biochem.7b00283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503151PMC
May 2017

The Major Protein Arginine Methyltransferase in Functions as an Enzyme-Prozyme Complex.

J Biol Chem 2017 02 20;292(6):2089-2100. Epub 2016 Dec 20.

From the Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, and Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14214,

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http://dx.doi.org/10.1074/jbc.M116.757112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313084PMC
February 2017

Determining the Mitochondrial Methyl Proteome in Saccharomyces cerevisiae using Heavy Methyl SILAC.

J Proteome Res 2016 12 18;15(12):4436-4451. Epub 2016 Oct 18.

Department of Chemistry and Biochemistry and the Molecular Biology Institute and ‡Department of Biological Chemistry and the David Geffen School of Medicine, UCLA , Los Angeles, California 90095, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148652PMC
December 2016

Deuteration protects asparagine residues against racemization.

Amino Acids 2016 09 12;48(9):2189-96. Epub 2016 May 12.

Retrotope, Inc., Los Altos Hills, CA, 94022, USA.

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http://dx.doi.org/10.1007/s00726-016-2250-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990494PMC
September 2016

Racemized and Isomerized Proteins in Aging Rat Teeth and Eye Lens.

Rejuvenation Res 2016 Aug 26;19(4):309-17. Epub 2016 Feb 26.

1 Department of Chemistry and Biochemistry, The Molecular Biology Institute, University of California , Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1089/rej.2015.1778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971426PMC
August 2016

Protein Arginine Methyltransferase Product Specificity Is Mediated by Distinct Active-site Architectures.

J Biol Chem 2016 08 7;291(35):18299-308. Epub 2016 Jul 7.

From the Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, California 90095 and

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http://dx.doi.org/10.1074/jbc.M116.740399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000077PMC
August 2016

Methylation of yeast ribosomal protein Rpl3 promotes translational elongation fidelity.

RNA 2016 Apr 29;22(4):489-98. Epub 2016 Jan 29.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1261/rna.054569.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793205PMC
April 2016

Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme.

Sci Rep 2016 Apr 7;6:24239. Epub 2016 Apr 7.

Department of Chemistry and Biochemistry UCLA-DOE Institute Molecular Biology Institute, University of California, Los Angeles, USA.

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http://www.nature.com/articles/srep24239
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http://dx.doi.org/10.1038/srep24239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823748PMC
April 2016

A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase.

Proc Natl Acad Sci U S A 2016 Feb 8;113(8):2068-73. Epub 2016 Feb 8.

Laboratory of Cell Biology, The Rockefeller University, New York, NY 10065; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065; Laboratory of Lymphocyte Biology, The Rockefeller University, New York, NY 10065

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http://dx.doi.org/10.1073/pnas.1525783113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776506PMC
February 2016

10 Genetic approaches to understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins.

Enzymes 2006 4;24:273-301. Epub 2007 Jun 4.

Division of Cardiology Department of Internal Medicine, University of California, Los Angeles 405 Hilgard Avenue Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/S1874-6047(06)80012-0DOI Listing
January 2016

16 Inhibition of mammalian protein methyltransferases by 5'-methylthioadenosine (MTA): A mechanism of action of dietary same?

Authors:
Steven G Clarke

Enzymes 2006 4;24:467-93. Epub 2007 Jun 4.

Department of Chemistry and Biochemistry and the Molecular Biology Institute University of California, Los Angeles 405 Hilgard Avenue Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/S1874-6047(06)80018-1DOI Listing
January 2016

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

Cell Metab 2015 Sep 16;22(3):508-15. Epub 2015 Jul 16.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663076PMC
September 2015

Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.

J Biol Chem 2015 Jul 15;290(27):16723-43. Epub 2015 May 15.

From the Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los, Angeles, California 90095 and

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http://dx.doi.org/10.1074/jbc.M115.659433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505422PMC
July 2015

The invertebrate Caenorhabditis elegans biosynthesizes ascorbate.

Arch Biochem Biophys 2015 Mar 7;569:32-44. Epub 2015 Feb 7.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2015.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357563PMC
March 2015

PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145.

Nat Commun 2015 Mar 4;6:6428. Epub 2015 Mar 4.

Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas 78957, USA.

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http://dx.doi.org/10.1038/ncomms7428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351962PMC
March 2015

A new type of protein lysine methyltransferase trimethylates Lys-79 of elongation factor 1A.

Biochem Biophys Res Commun 2014 Dec 15;455(3-4):382-9. Epub 2014 Nov 15.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263273PMC
December 2014

Substrate specificity of human protein arginine methyltransferase 7 (PRMT7): the importance of acidic residues in the double E loop.

J Biol Chem 2014 Nov 7;289(47):32604-16. Epub 2014 Oct 7.

From the Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, California 90095-1569

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http://dx.doi.org/10.1074/jbc.M114.609271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239614PMC
November 2014

Translational roles of elongation factor 2 protein lysine methylation.

J Biol Chem 2014 Oct 17;289(44):30511-24. Epub 2014 Sep 17.

From the Department of Chemistry and Biochemistry and the Molecular Biology Institute and

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http://dx.doi.org/10.1074/jbc.M114.605527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215232PMC
October 2014

Histidine methylation of yeast ribosomal protein Rpl3p is required for proper 60S subunit assembly.

Mol Cell Biol 2014 Aug 27;34(15):2903-16. Epub 2014 May 27.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, California, USA

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http://dx.doi.org/10.1128/MCB.01634-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135575PMC
August 2014

Non-repair pathways for minimizing protein isoaspartyl damage in the yeast Saccharomyces cerevisiae.

J Biol Chem 2014 Jun 24;289(24):16936-53. Epub 2014 Apr 24.

From the Department of Chemistry and Biochemistry and the Molecular Biology Institute and

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http://dx.doi.org/10.1074/jbc.M114.564385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059137PMC
June 2014

A novel small molecule methyltransferase is important for virulence in Candida albicans.

ACS Chem Biol 2013 Dec 16;8(12):2785-93. Epub 2013 Oct 16.

Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto , 160 College St., Toronto, M5S 3E1, Canada.

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http://dx.doi.org/10.1021/cb400607hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928151PMC
December 2013

Thermal-stable proteins of fruit of long-living Sacred Lotus Gaertn var. China Antique.

Trop Plant Biol 2013 Sep;6(2-3)

Department of Chemistry and Biochemistry University of California, Los Angeles 402 Boyer Hall, Hilgard Avenue Los Angeles, CA 90095-1569, USA.

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http://dx.doi.org/10.1007/s12042-013-9124-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869599PMC
September 2013

Protein methylation at the surface and buried deep: thinking outside the histone box.

Authors:
Steven G Clarke

Trends Biochem Sci 2013 May 13;38(5):243-52. Epub 2013 Mar 13.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09680004130002
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http://dx.doi.org/10.1016/j.tibs.2013.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634909PMC
May 2013

A novel automethylation reaction in the Aspergillus nidulans LaeA protein generates S-methylmethionine.

J Biol Chem 2013 May 26;288(20):14032-45. Epub 2013 Mar 26.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.465765
Publisher Site
http://dx.doi.org/10.1074/jbc.M113.465765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656261PMC
May 2013

Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice.

PLoS One 2012 5;7(10):e46719. Epub 2012 Oct 5.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046719PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465263PMC
April 2013

Lupus autoimmunity altered by cellular methylation metabolism.

Autoimmunity 2013 Feb 1;46(1):21-31. Epub 2012 Nov 1.

Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8031, USA.

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http://dx.doi.org/10.3109/08916934.2012.732133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543504PMC
February 2013

Integrated proteomic analysis of major isoaspartyl-containing proteins in the urine of wild type and protein L-isoaspartate O-methyltransferase-deficient mice.

Anal Chem 2013 Feb 6;85(4):2423-30. Epub 2013 Feb 6.

Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/ac303428hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599293PMC
February 2013

Caenorhabditis elegans battling starvation stress: low levels of ethanol prolong lifespan in L1 larvae.

PLoS One 2012 18;7(1):e29984. Epub 2012 Jan 18.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029984PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261173PMC
July 2012

Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation.

Biochemistry 2012 Jun 15;51(25):5091-104. Epub 2012 Jun 15.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1021/bi300186gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383884PMC
June 2012

Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming ω-NG-monomethylated arginine residues.

J Biol Chem 2012 Mar 12;287(11):7859-70. Epub 2012 Jan 12.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, California 90095-1569, USA.

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http://dx.doi.org/10.1074/jbc.M111.336271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318701PMC
March 2012

The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans.

PLoS One 2011 13;6(6):e20850. Epub 2011 Jun 13.

Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020850PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113807PMC
October 2011

A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.

J Biol Chem 2011 Jun 20;286(24):21511-23. Epub 2011 Apr 20.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1074/jbc.M111.238774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122210PMC
June 2011

The ribosomal l1 protuberance in yeast is methylated on a lysine residue catalyzed by a seven-beta-strand methyltransferase.

J Biol Chem 2011 May 1;286(21):18405-13. Epub 2011 Apr 1.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, California 90095-1569, USA.

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http://dx.doi.org/10.1074/jbc.M110.200410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099657PMC
May 2011

Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.

J Biol Chem 2011 Apr 1;286(14):12234-44. Epub 2011 Feb 1.

Department of Molecular Carcinogenesis at The Virginia Harris Cockrell Cancer Research Center, University of Texas M. D. Anderson Cancer Center Science Park, Smithville, Texas 78957, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.202416
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http://dx.doi.org/10.1074/jbc.M110.202416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069427PMC
April 2011

Uncovering the human methyltransferasome.

Mol Cell Proteomics 2011 Jan 7;10(1):M110.000976. Epub 2010 Oct 7.

Department of Chemistry and Biochemistry and Molecular Biology Institute, UCLA, Los Angeles, California 90095-1570, USA.

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http://www.mcponline.org/lookup/doi/10.1074/mcp.M110.000976
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http://dx.doi.org/10.1074/mcp.M110.000976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013446PMC
January 2011

A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase.

J Biol Chem 2010 Nov 23;285(48):37598-606. Epub 2010 Sep 23.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095-1569, USA.

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http://dx.doi.org/10.1074/jbc.M110.170787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988365PMC
November 2010

Yeast, plants, worms, and flies use a methyltransferase to metabolize age-damaged (R,S)-AdoMet, but what do mammals do?

Rejuvenation Res 2010 Apr-Jun;13(2-3):362-4

Department of Chemistry and Biochemistry , Molecular Biology Institute, University of California , Los Angeles, Los Angeles, California 90095-1569, USA.

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http://dx.doi.org/10.1089/rej.2009.0956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946053PMC
August 2010

Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae.

Arch Biochem Biophys 2010 Aug 26;500(2):137-43. Epub 2010 May 26.

Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, CA 90095-1569, USA.

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http://dx.doi.org/10.1016/j.abb.2010.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904425PMC
August 2010

Homocysteine methyltransferases Mht1 and Sam4 prevent the accumulation of age-damaged (R,S)-AdoMet in the yeast Saccharomyces cerevisiae.

J Biol Chem 2010 Jul 26;285(27):20526-31. Epub 2010 Apr 26.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, CA 90095-1569, USA.

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http://dx.doi.org/10.1074/jbc.M110.113076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898356PMC
July 2010

TbPRMT6 is a type I protein arginine methyltransferase that contributes to cytokinesis in Trypanosoma brucei.

Eukaryot Cell 2010 Jun 23;9(6):866-77. Epub 2010 Apr 23.

Department of Microbiology & Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA.

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http://dx.doi.org/10.1128/EC.00018-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901642PMC
June 2010

Identification of protein N-terminal methyltransferases in yeast and humans.

Biochemistry 2010 Jun;49(25):5225-35

Department of Chemistry and Biochemistry and Molecular Biology Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, USA.

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http://www.biochemistry.ucla.edu/biochem/Faculty/SClarke/pdf
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http://pubs.acs.org/doi/abs/10.1021/bi100428x
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http://dx.doi.org/10.1021/bi100428xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890028PMC
June 2010

Approaches to measuring the activities of protein arginine N-methyltransferases.

Anal Biochem 2010 Feb 15;397(1):1-11. Epub 2009 Sep 15.

The Division of Biomolecular and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z3.

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http://dx.doi.org/10.1016/j.ab.2009.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808438PMC
February 2010

Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae.

Biochem Biophys Res Commun 2010 Jan 24;391(4):1658-62. Epub 2009 Dec 24.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, 607 Charles E Young Drive East, Los Angeles, CA 90095-1569, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.12.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813213PMC
January 2010

Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans.

Mech Ageing Dev 2009 Oct 12;130(10):670-80. Epub 2009 Aug 12.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.mad.2009.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757507PMC
October 2009

Multiple Motif Scanning to identify methyltransferases from the yeast proteome.

Mol Cell Proteomics 2009 Jul 7;8(7):1516-26. Epub 2009 Apr 7.

Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1074/mcp.M900025-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709183PMC
July 2009

A type III protein arginine methyltransferase from the protozoan parasite Trypanosoma brucei.

J Biol Chem 2009 Apr 2;284(17):11590-600. Epub 2009 Mar 2.

Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14124, USA.

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http://www.biochemistry.ucla.edu/biochem/Faculty/SClarke/pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M807279200
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670164PMC
April 2009

Protein arginine methylation in mammals: who, what, and why.

Mol Cell 2009 Jan;33(1):1-13

The University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, P.O. Box 389, Smithville, TX 78957, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372459PMC
January 2009

Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab.

J Biol Chem 2008 Dec 28;283(51):35561-8. Epub 2008 Oct 28.

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, USA.

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December 2008

The protein L-isoaspartyl-O-methyltransferase functions in the Caenorhabditis elegans stress response.

Mech Ageing Dev 2008 Dec 14;129(12):752-8. Epub 2008 Oct 14.

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.mad.2008.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605584PMC
December 2008

L-Ascorbate biosynthesis in higher plants: the role of VTC2.

Trends Plant Sci 2008 Nov 27;13(11):567-73. Epub 2008 Sep 27.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.tplants.2008.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583178PMC
November 2008

Hsl7 is a substrate-specific type II protein arginine methyltransferase in yeast.

Biochem Biophys Res Commun 2008 Aug 2;372(4):811-5. Epub 2008 Jun 2.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, 607 Charles E. Young Drive East, Los Angeles, CA 90095-1569, USA.

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http://dx.doi.org/10.1016/j.bbrc.2008.05.121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2505109PMC
August 2008

A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction.

J Biol Chem 2008 Jul 7;283(27):18483-92. Epub 2008 May 7.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441562PMC
July 2008

Chemo-enzymatic detection of protein isoaspartate using protein isoaspartate methyltransferase and hydrazine trapping.

Anal Chem 2008 May 18;80(10):3882-9. Epub 2008 Apr 18.

Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.

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May 2008

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Authors:
Daniel J Klionsky Hagai Abeliovich Patrizia Agostinis Devendra K Agrawal Gjumrakch Aliev David S Askew Misuzu Baba Eric H Baehrecke Ben A Bahr Andrea Ballabio Bruce A Bamber Diane C Bassham Ettore Bergamini Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Dale E Bredesen Jeffrey L Brodsky John H Brumell Ulf T Brunk Wilfried Bursch Nadine Camougrand Eduardo Cebollero Francesco Cecconi Yingyu Chen Lih-Shen Chin Augustine Choi Charleen T Chu Jongkyeong Chung Peter G H Clarke Robert S B Clark Steven G Clarke Corinne Clavé John L Cleveland Patrice Codogno María I Colombo Ana Coto-Montes James M Cregg Ana Maria Cuervo Jayanta Debnath Francesca Demarchi Patrick B Dennis Phillip A Dennis Vojo Deretic Rodney J Devenish Federica Di Sano J Fred Dice Marian Difiglia Savithramma Dinesh-Kumar Clark W Distelhorst Mojgan Djavaheri-Mergny Frank C Dorsey Wulf Dröge Michel Dron William A Dunn Michael Duszenko N Tony Eissa Zvulun Elazar Audrey Esclatine Eeva-Liisa Eskelinen László Fésüs Kim D Finley José M Fuentes Juan Fueyo Kozo Fujisaki Brigitte Galliot Fen-Biao Gao David A Gewirtz Spencer B Gibson Antje Gohla Alfred L Goldberg Ramon Gonzalez Cristina González-Estévez Sharon Gorski Roberta A Gottlieb Dieter Häussinger You-Wen He Kim Heidenreich Joseph A Hill Maria Høyer-Hansen Xun Hu Wei-Pang Huang Akiko Iwasaki Marja Jäättelä William T Jackson Xuejun Jiang Shengkan Jin Terje Johansen Jae U Jung Motoni Kadowaki Chanhee Kang Ameeta Kelekar David H Kessel Jan A K W Kiel Hong Pyo Kim Adi Kimchi Timothy J Kinsella Kirill Kiselyov Katsuhiko Kitamoto Erwin Knecht Masaaki Komatsu Eiki Kominami Seiji Kondo Attila L Kovács Guido Kroemer Chia-Yi Kuan Rakesh Kumar Mondira Kundu Jacques Landry Marianne Laporte Weidong Le Huan-Yao Lei Michael J Lenardo Beth Levine Andrew Lieberman Kah-Leong Lim Fu-Cheng Lin Willisa Liou Leroy F Liu Gabriel Lopez-Berestein Carlos López-Otín Bo Lu Kay F Macleod Walter Malorni Wim Martinet Ken Matsuoka Josef Mautner Alfred J Meijer Alicia Meléndez Paul Michels Giovanni Miotto Wilhelm P Mistiaen Noboru Mizushima Baharia Mograbi Iryna Monastyrska Michael N Moore Paula I Moreira Yuji Moriyasu Tomasz Motyl Christian Münz Leon O Murphy Naweed I Naqvi Thomas P Neufeld Ichizo Nishino Ralph A Nixon Takeshi Noda Bernd Nürnberg Michinaga Ogawa Nancy L Oleinick Laura J Olsen Bulent Ozpolat Shoshana Paglin Glen E Palmer Issidora Papassideri Miles Parkes David H Perlmutter George Perry Mauro Piacentini Ronit Pinkas-Kramarski Mark Prescott Tassula Proikas-Cezanne Nina Raben Abdelhaq Rami Fulvio Reggiori Bärbel Rohrer David C Rubinsztein Kevin M Ryan Junichi Sadoshima Hiroshi Sakagami Yasuyoshi Sakai Marco Sandri Chihiro Sasakawa Miklós Sass Claudio Schneider Per O Seglen Oleksandr Seleverstov Jeffrey Settleman John J Shacka Irving M Shapiro Andrei Sibirny Elaine C M Silva-Zacarin Hans-Uwe Simon Cristiano Simone Anne Simonsen Mark A Smith Katharina Spanel-Borowski Vickram Srinivas Meredith Steeves Harald Stenmark Per E Stromhaug Carlos S Subauste Seiichiro Sugimoto David Sulzer Toshihiko Suzuki Michele S Swanson Ira Tabas Fumihiko Takeshita Nicholas J Talbot Zsolt Tallóczy Keiji Tanaka Kozo Tanaka Isei Tanida Graham S Taylor J Paul Taylor Alexei Terman Gianluca Tettamanti Craig B Thompson Michael Thumm Aviva M Tolkovsky Sharon A Tooze Ray Truant Lesya V Tumanovska Yasuo Uchiyama Takashi Ueno Néstor L Uzcátegui Ida van der Klei Eva C Vaquero Tibor Vellai Michael W Vogel Hong-Gang Wang Paul Webster John W Wiley Zhijun Xi Gutian Xiao Joachim Yahalom Jin-Ming Yang George Yap Xiao-Ming Yin Tamotsu Yoshimori Li Yu Zhenyu Yue Michisuke Yuzaki Olga Zabirnyk Xiaoxiang Zheng Xiongwei Zhu Russell L Deter

Autophagy 2008 Feb 21;4(2):151-75. Epub 2007 Nov 21.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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February 2008

Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.

J Biol Chem 2007 Dec 9;282(50):36444-53. Epub 2007 Oct 9.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, California 90095-1569, USA.

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December 2007

S-adenosylmethionine-dependent protein methylation in mammalian cytosol via tyrphostin modification by catechol-O-methyltransferase.

J Biol Chem 2007 Oct 27;282(42):31094-102. Epub 2007 Aug 27.

Department of Chemistry, University of California, Los Angeles, California 90095, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M705456200
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October 2007

Autophagy and insulin/TOR signaling in Caenorhabditis elegans pcm-1 protein repair mutants.

Autophagy 2007 Jul-Aug;3(4):357-9. Epub 2007 Jul 15.

Department of Chemistry and Biochemistry, Molecular Biology Institute, University of California, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.4161/auto.4143DOI Listing
August 2007

Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants.

J Biol Chem 2007 Jun 26;282(26):18879-85. Epub 2007 Apr 26.

Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556065PMC
June 2007

The L-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy.

Dev Biol 2007 Mar 21;303(2):493-500. Epub 2006 Nov 21.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California-Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868680PMC
March 2007

Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae.

J Biol Chem 2007 Mar 30;282(12):8604-12. Epub 2007 Jan 30.

Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, California 90095-1569, USA.

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March 2007

Arabidopsis Protein Repair L-Isoaspartyl Methyltransferases: Predominant Activities at Lethal Temperatures.

Physiol Plant 2006 Dec;128(4):581-592

Department of Chemistry and Biochemistry and the Molecular Biology Institute, Paul D. Boyer Hall, University of California, Los Angeles, California 90095-1569.

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http://dx.doi.org/10.1111/j.1399-3054.2006.00772.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980331PMC
December 2006

Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice.

J Comp Neurol 2005 Dec;493(4):524-37

Department of Neurobiology, University of California, Los Angeles, Los Angeles, California 90095, USA.

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December 2005

A second protein L-isoaspartyl methyltransferase gene in Arabidopsis produces two transcripts whose products are sequestered in the nucleus.

Plant Physiol 2004 Sep 3;136(1):2652-64. Epub 2004 Sep 3.

Department of Horticulture, University of Kentucky Agriculture Experiment Station, S129, Agriculture Science Center North, University of Kentucky, 800 Rose Street, Lexington, KY 40546-0312, USA.

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http://dx.doi.org/10.1104/pp.104.046094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC523330PMC
September 2004

Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity.

J Mol Biol 2003 Mar;326(5):1559-75

Howard Hughes Medical Institute and UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, 201 Boyer Hall, Box 951570, Los Angeles, CA 90095-1570, USA.

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March 2003