Steven D Leach

Steven D Leach

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Steven D Leach

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Zebrafish model of -initiated pancreatic cancer.

Anim Cells Syst (Seoul) 2018 8;22(6):353-359. Epub 2018 Oct 8.

Department of Molecular and Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

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http://dx.doi.org/10.1080/19768354.2018.1530301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282427PMC
October 2018

Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas.

Sci Rep 2017 12 13;7(1):17539. Epub 2017 Dec 13.

Department of Surgery, University of Pittsburgh Medical Center, One Children's Drive, 4401 Penn Avenue, Rangos Research Center, Pittsburgh, PA, 15244, USA.

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http://dx.doi.org/10.1038/s41598-017-17884-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727523PMC
December 2017

New insights in the development of pancreatic cancer.

Curr Opin Gastroenterol 2016 Sep;32(5):394-400

aDavid M. Rubenstein Center for Pancreatic Cancer Research bGastroenterology and Nutrition Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1097/MOG.0000000000000295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028298PMC
September 2016

p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia.

Cancer Res 2016 06 31;76(11):3351-63. Epub 2016 Mar 31.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. The McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891257PMC
June 2016

A pancreatic exocrine-like cell regulatory circuit operating in the upper stomach of the sea urchin Strongylocentrotus purpuratus larva.

BMC Evol Biol 2016 05 26;16(1):117. Epub 2016 May 26.

Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Napoli, 80121, Italy.

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http://dx.doi.org/10.1186/s12862-016-0686-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880809PMC
May 2016

Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions.

Gastroenterology 2016 Apr 8;150(4):918-30.e13. Epub 2015 Dec 8.

Nashville VA Medical Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Section of Surgical Sciences and the Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.11.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808451PMC
April 2016

Ablation of Dicer leads to widespread perturbation of signaling pathways.

Biochem Biophys Res Commun 2015 Jul 30;463(3):389-94. Epub 2015 May 30.

Institute of Bioinformatics, International Technology Park, Bangalore 560066, India; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.05.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696065PMC
July 2015

Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish.

Dev Dyn 2015 Jun 22;244(6):724-35. Epub 2015 May 22.

The McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/dvdy.24271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838417PMC
June 2015

p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas.

Dev Biol 2015 Mar 16;399(1):41-53. Epub 2014 Dec 16.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2014.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868343PMC
March 2015

Interleukin interrupted: a new strategy for the treatment of pancreatic cancer.

Authors:
Steven D Leach

J Exp Med 2015 Mar;212(3):284

Memorial Sloan Kettering Cancer Center

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http://dx.doi.org/10.1084/jem.2123insight1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354364PMC
March 2015

Aldh1-expressing endocrine progenitor cells regulate secondary islet formation in larval zebrafish pancreas.

PLoS One 2013 17;8(9):e74350. Epub 2013 Sep 17.

Department of Surgery and the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074350PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798260PMC
February 2015

The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer.

Zebrafish 2014 Dec;11(6):551-9

1 Department of Surgery, Johns Hopkins University , Baltimore, Maryland.

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http://dx.doi.org/10.1089/zeb.2014.1024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248247PMC
December 2014

Annotation of the zebrafish genome through an integrated transcriptomic and proteomic analysis.

Mol Cell Proteomics 2014 Nov 24;13(11):3184-98. Epub 2014 Jul 24.

From the *Institute of Bioinformatics, International Technology Park, Bangalore 560 066, India; ¶McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205; **Departments of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

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http://dx.doi.org/10.1074/mcp.M114.038299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223501PMC
November 2014

Targeting IL-17 for pancreatic cancer prevention.

Oncotarget 2014 Oct;5(20):9530-1

The David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259416PMC
http://dx.doi.org/10.18632/oncotarget.2618DOI Listing
October 2014

TAILOR: transgene activation and inactivation using lox and rox in zebrafish.

PLoS One 2013 31;8(12):e85218. Epub 2013 Dec 31.

Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085218PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877360PMC
September 2014

Regulation of PPAR-alpha pathway by Dicer revealed through proteomic analysis.

J Proteomics 2014 Aug 24;108:306-15. Epub 2014 Apr 24.

Institute of Bioinformatics, International Technology Park, Bangalore 560066, India; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.04.027DOI Listing
August 2014

A draft map of the human proteome.

Nature 2014 May;509(7502):575-81

1] McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [3] Institute of Bioinformatics, International Tech Park, Bangalore 560066, India [4] Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130, USA [5] The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [6] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA [7] Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130, USA.

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http://dx.doi.org/10.1038/nature13302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403737PMC
May 2014

A red-shifted fluorescent substrate for aldehyde dehydrogenase.

Nat Commun 2014 Apr 23;5:3662. Epub 2014 Apr 23.

1] Russel H. Morgan Department of Radiology and Radiological Science, Baltimore, Maryland 21287, USA [2] Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1038/ncomms4662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063304PMC
April 2014

DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer.

Gastroenterology 2014 Jan 2;146(1):245-56. Epub 2013 Oct 2.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; The McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085130141
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http://dx.doi.org/10.1053/j.gastro.2013.09.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910427PMC
January 2014

Sphere-forming assays for assessment of benign and malignant pancreatic stem cells.

Methods Mol Biol 2013 ;980:281-90

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/978-1-62703-287-2_15DOI Listing
July 2013

Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation.

Cell Rep 2013 Jul 11;4(2):287-301. Epub 2013 Jul 11.

Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740126PMC
July 2013

Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells.

Hepatology 2013 Jun;57(6):2458-68

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://doi.wiley.com/10.1002/hep.26237
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http://dx.doi.org/10.1002/hep.26237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633649PMC
June 2013

Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia.

Cancer Cell 2012 Dec;22(6):701-3

Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526877PMC
December 2012

Exocrine ontogenies: on the development of pancreatic acinar, ductal and centroacinar cells.

Semin Cell Dev Biol 2012 Aug 26;23(6):711-9. Epub 2012 Jun 26.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, United States.

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http://dx.doi.org/10.1016/j.semcdb.2012.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470423PMC
August 2012

Cyclic caged morpholinos: conformationally gated probes of embryonic gene function.

Angew Chem Int Ed Engl 2012 Jul 11;51(28):6908-11. Epub 2012 Jun 11.

Department of Chemical and Systems Biology, Stanford University School of Medicine, CA 94305, USA.

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http://dx.doi.org/10.1002/anie.201201690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434341PMC
July 2012

Regulation of lipid metabolism by Dicer revealed through SILAC mice.

J Proteome Res 2012 Apr 28;11(4):2193-205. Epub 2012 Feb 28.

McKusick-Nathans Institute of Genetic Medicine, Department of Biological Chemistry, Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.

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http://dx.doi.org/10.1021/pr2009884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612551PMC
April 2012

Screening pancreatic oncogenes in zebrafish using the Gal4/UAS system.

Methods Cell Biol 2011 ;105:367-81

Department of Surgery and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/B978-0-12-381320-6.00015-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910423PMC
January 2012

EMT and dissemination precede pancreatic tumor formation.

Cell 2012 Jan;148(1-2):349-61

Gastroenterology Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.cell.2011.11.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266542PMC
January 2012

p53: Guardian of pancreatic epithelial identity.

Cell Cycle 2011 Jun 1;10(11):1717. Epub 2011 Jun 1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233485PMC
http://dx.doi.org/10.4161/cc.10.11.15686DOI Listing
June 2011

Zebrafish models for cancer.

Annu Rev Pathol 2011 ;6:71-93

Department of Surgery, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1146/annurev-pathol-011110-130330DOI Listing
April 2011

The role of PET scanning in pancreatic cancer.

Adv Surg 2010 ;44:313-25

Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Hospital, 733 North Broadway, Baltimore, MD 21205, USA.

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October 2010

Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas.

Proc Natl Acad Sci U S A 2010 Jan 15;107(1):75-80. Epub 2009 Dec 15.

Department of Surgery and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.0912589107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806716PMC
January 2010

Pisces and cancer: the stars align.

Authors:
Steven D Leach

Zebrafish 2009 Dec;6(4):317

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http://dx.doi.org/10.1089/zeb.2009.9988DOI Listing
December 2009

Pancreatic ductal morphogenesis and the Pdx1 homeodomain transcription factor.

Mol Biol Cell 2009 Nov 30;20(22):4838-44. Epub 2009 Sep 30.

Division of Gastroenterology, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e09-03-0203
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http://dx.doi.org/10.1091/mbc.e09-03-0203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777112PMC
November 2009

Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas.

Mech Dev 2009 Oct 10;126(10):898-912. Epub 2009 Jul 10.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.mod.2009.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640481PMC
October 2009

In vivo imaging of zebrafish digestive organ function using multiple quenched fluorescent reporters.

Am J Physiol Gastrointest Liver Physiol 2009 Feb 4;296(2):G445-53. Epub 2008 Dec 4.

Department of Embriology, Carnegie Institution, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1152/ajpgi.90513.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643917PMC
February 2009

Hedgehog signaling is required for effective regeneration of exocrine pancreas.

Gastroenterology 2008 Aug 16;135(2):621-31. Epub 2008 Apr 16.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666349PMC
August 2008

Characterization of Kras-mediated pancreatic tumorigenesis in zebrafish.

Methods Enzymol 2008 ;438:391-417

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)38027-0DOI Listing
June 2008

Truncal sarcomas and abdominal desmoids.

Surg Clin North Am 2008 Jun;88(3):571-82, vi-vii

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.suc.2008.04.001DOI Listing
June 2008

Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas.

Genes Dev 2008 Jun;22(11):1445-50

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1101/gad.1663208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418581PMC
June 2008

Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas.

Gastroenterology 2008 Jun 5;134(7):2080-90. Epub 2008 Mar 5.

Department of Surgery, The Sol Goldman Center for Pancreatic Cancer Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.02.084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654247PMC
June 2008

Nonapical symmetric divisions underlie horizontal cell layer formation in the developing retina in vivo.

Neuron 2007 Nov;56(4):597-603

Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089662730700811
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http://dx.doi.org/10.1016/j.neuron.2007.09.036DOI Listing
November 2007

Viral 2A peptides allow expression of multiple proteins from a single ORF in transgenic zebrafish embryos.

Genesis 2007 Oct;45(10):625-9

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://doi.wiley.com/10.1002/dvg.20338
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http://dx.doi.org/10.1002/dvg.20338DOI Listing
October 2007

Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas.

Dev Biol 2007 Apr 25;304(2):786-99. Epub 2007 Jan 25.

Laboratory of Molecular Organogenesis, Institut de Recherches Cliniques de Montréal, 110 Pine Avenue West, Montreal, QC, Canada H2W 1R7.

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http://dx.doi.org/10.1016/j.ydbio.2007.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868342PMC
April 2007

Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration.

J Clin Invest 2007 Apr;117(4):971-7

Division of Endocrinology, Diabetes, and Metabolism and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI29988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838936PMC
April 2007

A histological survey of green fluorescent protein expression in 'green' mice: implications for stem cell research.

Pathology 2007 Apr;39(2):247-51

Epithelial Stem Cell Working Group, Department of Surgery, Sidney Kimmel Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, USA.

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http://dx.doi.org/10.1080/00313020701230807DOI Listing
April 2007

Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase.

Mech Dev 2007 Mar 8;124(3):218-29. Epub 2006 Dec 8.

Department of Comparative Medicine, Johns Hopkins School of Medicine, 720 Rutland Avenue, Ross 771, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.mod.2006.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583263PMC
March 2007

A case of mistaken identity? Nonductal origins of pancreatic "ductal" cancers.

Cancer Cell 2007 Mar;11(3):211-3

Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.02.020DOI Listing
March 2007

Wnt/beta-catenin signaling is required for development of the exocrine pancreas.

BMC Dev Biol 2007 Jan 12;7. Epub 2007 Jan 12.

Department of Developmental Biology, Cincinnati Children's Hospital Research 45267, Cincinnati, OH 45267, USA.

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http://dx.doi.org/10.1186/1471-213X-7-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783845PMC
January 2007

Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex.

Biochem J 2006 Feb;393(Pt 3):679-85

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1042/BJ20051063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360720PMC
February 2006

Targeting of amacrine cell neurites to appropriate synaptic laminae in the developing zebrafish retina.

Development 2005 Nov;132(22):5069-79

Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8108, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/dev.02075DOI Listing
November 2005

Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates.

Development 2005 Aug 14;132(16):3767-76. Epub 2005 Jul 14.

Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1242/dev.01925DOI Listing
August 2005

Primary explant cultures of adult and embryonic pancreas.

Methods Mol Med 2005 ;103:259-71

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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July 2005

Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma.

Mod Pathol 2005 Jun;18(6):779-87

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205-2196, USA.

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http://dx.doi.org/10.1038/modpathol.3800337DOI Listing
June 2005

Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression.

Gastroenterology 2005 May;128(5):1292-305

Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2733, USA.

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http://dx.doi.org/10.1053/j.gastro.2005.03.019DOI Listing
May 2005

Epithelial differentiation in pancreatic development and neoplasia: new niches for nestin and Notch.

Authors:
Steven D Leach

J Clin Gastroenterol 2005 Apr;39(4 Suppl 2):S78-82

Department of Surgery and Oncology, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1097/01.mcg.0000155547.83901.a3DOI Listing
April 2005

Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater.

J Clin Oncol 2005 Mar;23(9):1811-8

MBBS, Department of Surgery, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 771, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1200/JCO.2005.03.068DOI Listing
March 2005

Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays.

Oncogene 2004 Dec;23(56):9042-51

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1038/sj.onc.1208117DOI Listing
December 2004

Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas.

Dev Biol 2004 Oct;274(2):491-503

Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.ydbio.2004.07.001DOI Listing
October 2004

Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas.

Development 2004 Sep 27;131(17):4213-24. Epub 2004 Jul 27.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1242/dev.01280DOI Listing
September 2004

Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas.

Dev Biol 2004 Jun;270(2):474-86

Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.ydbio.2004.02.023DOI Listing
June 2004

Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas.

Mech Dev 2004 Jan;121(1):15-25

Department of Surgery, Johns Hopkins University School of Medicine, 600 N Wolfe St/Osler 603, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.mod.2003.08.010DOI Listing
January 2004

Mouse models of pancreatic cancer: the fur is finally flying!

Authors:
Steven D Leach

Cancer Cell 2004 Jan;5(1):7-11

The Sidney Kimmel Cancer Center at Johns Hopkins, 600 North Wolfe Street/Osler 603, Baltimore, MD 21287, USA.

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January 2004

Current treatment of gastric cancer: is adjuvant therapy of benefit?

Adv Surg 2003 ;37:95-121

Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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October 2003

Notch in malignancy.

Cancer Treat Res 2003 ;115:95-121

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http://dx.doi.org/10.1007/0-306-48158-8_4DOI Listing
July 2003

Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis.

Cancer Cell 2003 Jun;3(6):565-76

Departments of Surgery, Oncology, and Pathology, The Sidney Kimmel Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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June 2003

Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia.

Gastroenterology 2003 Apr;124(4):1020-36

Department of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1053/gast.2003.50150DOI Listing
April 2003

Pancreatic cancer.

Curr Probl Cancer 2002 Jul-Aug;26(4):176-275

Departments of Surgery, Oncology, Pathology and Medicine Johns Hopkins Medical Institutions Baltimore, Maryland, USA.

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February 2003

Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas.

J Clin Invest 2002 Jun;109(11):1437-44

Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1172/JCI15051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150998PMC
June 2002