Steven D Crowley

Steven D Crowley

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Steven D Crowley

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Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis.

Am J Physiol Renal Physiol 2019 Aug 29;317(2):F221-F228. Epub 2019 May 29.

Division of Nephrology, Department of Medicine, Duke University School of Medicine , Durham, North Carolina.

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http://dx.doi.org/10.1152/ajprenal.00104.2019DOI Listing
August 2019

Role of T-cell activation in salt-sensitive hypertension.

Am J Physiol Heart Circ Physiol 2019 Jun 22;316(6):H1345-H1353. Epub 2019 Mar 22.

Division of Nephrology, Department of Medicine, Durham Veterans Affairs and Duke University Medical Centers , Durham, North Carolina.

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https://www.physiology.org/doi/10.1152/ajpheart.00096.2019
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http://dx.doi.org/10.1152/ajpheart.00096.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620682PMC
June 2019

Stimulating Type 1 Angiotensin Receptors on T Lymphocytes Attenuates Renal Fibrosis.

Am J Pathol 2019 May 15;189(5):981-988. Epub 2019 Apr 15.

Division of Nephrology, Department of Medicine, Duke University, Durham, North Carolina; Department of Medicine, Durham Veterans Affairs Medical Centers, Durham, North Carolina. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183107
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http://dx.doi.org/10.1016/j.ajpath.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521889PMC
May 2019

Dynamic contrast-enhanced MRI promotes early detection of toxin-induced acute kidney injury.

Am J Physiol Renal Physiol 2019 Feb 5;316(2):F351-F359. Epub 2018 Dec 5.

Department of Medicine, Duke University Medical Center , Durham, North Carolina.

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https://www.physiology.org/doi/10.1152/ajprenal.00416.2018
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http://dx.doi.org/10.1152/ajprenal.00416.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397378PMC
February 2019

HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation.

Kidney Int 2019 02 11;95(2):388-404. Epub 2018 Dec 11.

Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.09.013DOI Listing
February 2019

No energy wasted in the fight against vascular inflammation.

Authors:
Steven D Crowley

Cardiovasc Res 2018 Dec;114(14):1822-1824

Division of Nephrology, Department of Medicine at Duke University and Durham VA Medical Centers, DUMC Durham, NC, USA.

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http://dx.doi.org/10.1093/cvr/cvy232DOI Listing
December 2018

Urinary Exosomes and Exosomal CCL2 mRNA as Biomarkers of Active Histologic Injury in IgA Nephropathy.

Am J Pathol 2018 Nov 22;188(11):2542-2552. Epub 2018 Aug 22.

Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183037
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http://dx.doi.org/10.1016/j.ajpath.2018.07.017DOI Listing
November 2018

ATAC-ing the mechanisms of renin regulation.

Authors:
Steven D Crowley

J Clin Invest 2018 Nov 2;128(11):4748-4750. Epub 2018 Oct 2.

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http://dx.doi.org/10.1172/JCI124177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205367PMC
November 2018

Inflammation in Salt-Sensitive Hypertension and Renal Damage.

Curr Hypertens Rep 2018 10 30;20(12):103. Epub 2018 Oct 30.

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC, 27710, USA.

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http://link.springer.com/10.1007/s11906-018-0903-x
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http://dx.doi.org/10.1007/s11906-018-0903-xDOI Listing
October 2018

Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury.

Am J Physiol Renal Physiol 2018 09 23;315(3):F682-F691. Epub 2018 May 23.

Department of Medicine, Duke University Medical Center , Durham, North Carolina.

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https://www.physiology.org/doi/10.1152/ajprenal.00104.2018
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http://dx.doi.org/10.1152/ajprenal.00104.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172579PMC
September 2018

Renal effects of cytokines in hypertension.

Curr Opin Nephrol Hypertens 2018 03;27(2):70-76

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA.

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http://dx.doi.org/10.1097/MNH.0000000000000385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792304PMC
March 2018

Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation.

J Am Soc Nephrol 2018 Mar 2;29(3):919-935. Epub 2018 Jan 2.

Institute of Nephrology, Zhongda Hospitial, Southeast University School of Medicine, Nanjing, China; and

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http://dx.doi.org/10.1681/ASN.2017050523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827595PMC
March 2018

Intersection of salt- and immune-mediated mechanisms of hypertension in the gut microbiome.

Kidney Int 2018 03;93(3):532-534

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360934PMC
March 2018

Salt, Hypertension, and Immunity.

Annu Rev Physiol 2018 02 16;80:283-307. Epub 2017 Nov 16.

Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA; email:

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http://dx.doi.org/10.1146/annurev-physiol-021317-121134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811318PMC
February 2018

Characterization and Functional Phenotyping of Renal Immune Cells via Flow Cytometry.

Methods Mol Biol 2017 ;1614:87-98

Division of Nephrology, Department of Medicine, Durham VA and Duke University Medical Centers, MSRB2 Rm 2018, Box 103015, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1007/978-1-4939-7030-8_8DOI Listing
January 2018

A novel role for renal epithelial cells and the medullary sodium gradient in the local immune response.

Kidney Int 2017 12;92(6):1308-1311

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.10.005DOI Listing
December 2017

Immunologic Effects of the Renin-Angiotensin System.

J Am Soc Nephrol 2017 May 1;28(5):1350-1361. Epub 2017 Feb 1.

Division of Nephrology, Department of Medicine, Durham Veterans Affairs and Duke University Medical Centers, Durham, North Carolina.

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http://dx.doi.org/10.1681/ASN.2016101066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407736PMC
May 2017

The role of chemokines in hypertension and consequent target organ damage.

Pharmacol Res 2017 05 6;119:404-411. Epub 2017 Mar 6.

Division of Nephrology Department of Medicine, Durham VA and Duke University Medical Centers, DUMC Box 103015, Durham, 27710, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2017.02.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424532PMC
May 2017

The role of macrophages in hypertension and its complications.

Pflugers Arch 2017 04 1;469(3-4):419-430. Epub 2017 Mar 1.

Division of Nephrology, Department of Medicine, Durham, VA, USA.

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http://dx.doi.org/10.1007/s00424-017-1950-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773253PMC
April 2017

Elevated PTH induces endothelial-to-chondrogenic transition in aortic endothelial cells.

Am J Physiol Renal Physiol 2017 03 31;312(3):F436-F444. Epub 2016 Aug 31.

Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, China; and

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http://dx.doi.org/10.1152/ajprenal.00210.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374307PMC
March 2017

Erratum to: Characterization and Functional Phenotyping of Renal Immune Cells via Flow Cytometry.

Methods Mol Biol 2017 ;1614:E1

Division of Nephrology, Department of Medicine, Durham VA and Duke University Medical Centers, MSRB2 Rm 2018, Box 103015, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1007/978-1-4939-7030-8_16DOI Listing
January 2017

Targeting cytokine signaling in salt-sensitive hypertension.

Am J Physiol Renal Physiol 2016 12 24;311(6):F1153-F1158. Epub 2016 Aug 24.

Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina.

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http://dx.doi.org/10.1152/ajprenal.00273.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210191PMC
December 2016

C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration.

Am J Pathol 2016 11 15;186(11):2846-2856. Epub 2016 Sep 15.

Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; Durham VA Medical Center, Durham, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222967PMC
November 2016

Interactions Between the Immune and the Renin-Angiotensin Systems in Hypertension.

Hypertension 2016 08 27;68(2):289-96. Epub 2016 Jun 27.

From the Division of Nephrology, Department of Medicine, Durham VA and Duke University Medical Centers, Durham, NC.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.06591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945449PMC
August 2016

Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis.

Kidney Int 2016 May 25;89(5):1062-1074. Epub 2016 Mar 25.

Department of Medicine, Division of Nephrology, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834146PMC
May 2016

Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron.

Cell Metab 2016 Feb 17;23(2):360-8. Epub 2015 Dec 17.

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749461PMC
February 2016

Role of T lymphocytes in hypertension.

Curr Opin Pharmacol 2015 Apr 15;21:14-9. Epub 2014 Dec 15.

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714892140017
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http://dx.doi.org/10.1016/j.coph.2014.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380788PMC
April 2015

Tumor necrosis factor-α produced in the kidney contributes to angiotensin II-dependent hypertension.

Hypertension 2014 Dec 2;64(6):1275-81. Epub 2014 Sep 2.

From the Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (J.Z., M.B.P., R.G., A.M., Y.-s.S., N.S.K., M.S., H.J., S.D.C.); Department of Biology, University of Virginia, Charlottesville (E.E.L.); and Department of Medicine, Southeast University, Nanjing, China (M.W.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339088PMC
December 2014

Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: a novel mechanism of albumin-induced tubulointerstitial inflammation.

Int J Biochem Cell Biol 2014 Dec 2;57:7-19. Epub 2014 Oct 2.

Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414121PMC
December 2014

Linking angiotensin II to nuclear factor-κ light chain enhancer of activated B cells-induced cardiovascular damage: bad CARMAs.

Authors:
Steven D Crowley

Hypertension 2014 Nov 2;64(5):933-4. Epub 2014 Sep 2.

From the Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192119PMC
November 2014

Classical Renin-Angiotensin system in kidney physiology.

Compr Physiol 2014 Jul;4(3):1201-28

Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1002/cphy.c130040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137912PMC
July 2014

Cinacalcet ameliorates cardiac fibrosis in uremic hearts through suppression of endothelial-to-mesenchymal transition.

Int J Cardiol 2014 Feb 7;171(3):e65-9. Epub 2013 Dec 7.

Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing City, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2013.11.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887190PMC
February 2014

The cooperative roles of inflammation and oxidative stress in the pathogenesis of hypertension.

Authors:
Steven D Crowley

Antioxid Redox Signal 2014 Jan 19;20(1):102-20. Epub 2013 Apr 19.

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers , Durham, North Carolina.

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http://dx.doi.org/10.1089/ars.2013.5258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880899PMC
January 2014

The role of type 1 angiotensin receptors on T lymphocytes in cardiovascular and renal diseases.

Curr Hypertens Rep 2013 Feb;15(1):39-46

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, DUMC, Durham, NC 27710, USA.

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http://link.springer.com/10.1007/s11906-012-0318-z
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http://dx.doi.org/10.1007/s11906-012-0318-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545101PMC
February 2013

Taking a sound approach to acute kidney injury.

Authors:
Steven D Crowley

Am J Physiol Renal Physiol 2012 Dec 19;303(11):F1505-6. Epub 2012 Sep 19.

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http://dx.doi.org/10.1152/ajprenal.00519.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532488PMC
December 2012

Recent advances involving the renin-angiotensin system.

Exp Cell Res 2012 May 3;318(9):1049-56. Epub 2012 Mar 3.

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27705, USA.

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http://dx.doi.org/10.1016/j.yexcr.2012.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625040PMC
May 2012

Prehypertension and chronic kidney disease: the ox or the plow?

Kidney Int 2012 Feb;81(3):229-32

Division of Nephrology, Duke University, Durham, North Carolina 27705, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S008525381555299
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http://dx.doi.org/10.1038/ki.2011.393DOI Listing
February 2012

Role of AT₁ receptor-mediated salt retention in angiotensin II-dependent hypertension.

Am J Physiol Renal Physiol 2011 Nov 17;301(5):F1124-30. Epub 2011 Aug 17.

Division of Nephrology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.1152/ajprenal.00305.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213900PMC
November 2011

Gene expression profiles linked to AT1 angiotensin receptors in the kidney.

Physiol Genomics 2010 Nov 31;42A(3):211-8. Epub 2010 Aug 31.

Department of Medicine, Division of Nephrology, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00063.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008363PMC
November 2010

Lymphocyte responses exacerbate angiotensin II-dependent hypertension.

Am J Physiol Regul Integr Comp Physiol 2010 Apr 10;298(4):R1089-97. Epub 2010 Feb 10.

Department of Medicine, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1152/ajpregu.00373.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422347PMC
April 2010

In hypertension, the kidney breaks your heart.

Curr Cardiol Rep 2008 Nov;10(6):470-6

MSRB II, Room 2018, Duke University Medical Center, 106 Research Drive, Durham, NC 27710, USA.

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November 2008

Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension.

Am J Physiol Renal Physiol 2008 Aug 21;295(2):F515-24. Epub 2008 May 21.

Division of Nephrology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1152/ajprenal.00527.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519187PMC
August 2008

Kidney in hypertension: guyton redux.

Hypertension 2008 Apr 10;51(4):811-6. Epub 2008 Mar 10.

Division of Nephrology, Department of Medicine, Duke University and Durham Veterans'Affairs Medical Centers, Durham, NC, USA.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.105.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.105.063636DOI Listing
April 2008

In hypertension, the kidney rules.

Curr Hypertens Rep 2007 Apr;9(2):148-53

Nephrology, VA Medical Center, Durham, NC 27705, USA.

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April 2007

AT(1) receptors and control of blood pressure: the kidney and more...

Trends Cardiovasc Med 2007 Jan;17(1):30-4

Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.tcm.2006.11.002DOI Listing
January 2007

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.

Proc Natl Acad Sci U S A 2006 Nov 7;103(47):17985-90. Epub 2006 Nov 7.

Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0605545103
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http://dx.doi.org/10.1073/pnas.0605545103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693859PMC
November 2006

Effector mechanisms in transplant rejection.

Immunol Rev 2003 Dec;196:51-64

Duke University and Durham VA Medical Centers, Durham, NC 27705, USA.

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December 2003

A Web-based compendium of clinical questions and medical evidence to educate internal medicine residents.

Acad Med 2003 Mar;78(3):270-4

Division of Nephrology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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March 2003

Coronary steal from a left internal mammary artery coronary bypass graft by a left upper extremity arteriovenous hemodialysis fistula.

Am J Kidney Dis 2002 Oct;40(4):852-5

Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1053/ajkd.2002.35701DOI Listing
October 2002