Publications by authors named "Steven C Clifford"

81Publications

Medulloblastoma.

Nat Rev Dis Primers 2019 02 14;5(1):11. Epub 2019 Feb 14.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41572-019-0063-6DOI Listing
February 2019

TAp73 is a marker of glutamine addiction in medulloblastoma.

Genes Dev 2017 09 26;31(17):1738-1753. Epub 2017 Sep 26.

Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, United Kingdom.

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http://dx.doi.org/10.1101/gad.302349.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666673PMC
September 2017

Divergent clonal selection dominates medulloblastoma at recurrence.

Authors:
A Sorana Morrissy Livia Garzia David J H Shih Scott Zuyderduyn Xi Huang Patryk Skowron Marc Remke Florence M G Cavalli Vijay Ramaswamy Patricia E Lindsay Salomeh Jelveh Laura K Donovan Xin Wang Betty Luu Kory Zayne Yisu Li Chelsea Mayoh Nina Thiessen Eloi Mercier Karen L Mungall Yusanne Ma Kane Tse Thomas Zeng Karey Shumansky Andrew J L Roth Sohrab Shah Hamza Farooq Noriyuki Kijima Borja L Holgado John J Y Lee Stuart Matan-Lithwick Jessica Liu Stephen C Mack Alex Manno K A Michealraj Carolina Nor John Peacock Lei Qin Juri Reimand Adi Rolider Yuan Y Thompson Xiaochong Wu Trevor Pugh Adrian Ally Mikhail Bilenky Yaron S N Butterfield Rebecca Carlsen Young Cheng Eric Chuah Richard D Corbett Noreen Dhalla An He Darlene Lee Haiyan I Li William Long Michael Mayo Patrick Plettner Jenny Q Qian Jacqueline E Schein Angela Tam Tina Wong Inanc Birol Yongjun Zhao Claudia C Faria José Pimentel Sofia Nunes Tarek Shalaby Michael Grotzer Ian F Pollack Ronald L Hamilton Xiao-Nan Li Anne E Bendel Daniel W Fults Andrew W Walter Toshihiro Kumabe Teiji Tominaga V Peter Collins Yoon-Jae Cho Caitlin Hoffman David Lyden Jeffrey H Wisoff James H Garvin Duncan S Stearns Luca Massimi Ulrich Schüller Jaroslav Sterba Karel Zitterbart Stephanie Puget Olivier Ayrault Sandra E Dunn Daniela P C Tirapelli Carlos G Carlotti Helen Wheeler Andrew R Hallahan Wendy Ingram Tobey J MacDonald Jeffrey J Olson Erwin G Van Meir Ji-Yeoun Lee Kyu-Chang Wang Seung-Ki Kim Byung-Kyu Cho Torsten Pietsch Gudrun Fleischhack Stephan Tippelt Young Shin Ra Simon Bailey Janet C Lindsey Steven C Clifford Charles G Eberhart Michael K Cooper Roger J Packer Maura Massimino Maria Luisa Garre Ute Bartels Uri Tabori Cynthia E Hawkins Peter Dirks Eric Bouffet James T Rutka Robert J Wechsler-Reya William A Weiss Lara S Collier Adam J Dupuy Andrey Korshunov David T W Jones Marcel Kool Paul A Northcott Stefan M Pfister David A Largaespada Andrew J Mungall Richard A Moore Nada Jabado Gary D Bader Steven J M Jones David Malkin Marco A Marra Michael D Taylor

Nature 2016 Jan 13;529(7586):351-7. Epub 2016 Jan 13.

Developmental &Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

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http://dx.doi.org/10.1038/nature16478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936195PMC
January 2016

Improved health-related quality of life outcomes associated with SHH subgroup medulloblastoma in SIOP-UKCCSG PNET3 trial survivors.

Acta Neuropathol 2014 Jul 31;128(1):151-3. Epub 2014 May 31.

Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.

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http://dx.doi.org/10.1007/s00401-014-1300-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313076PMC
July 2014

Cytogenetic prognostication within medulloblastoma subgroups.

J Clin Oncol 2014 Mar 3;32(9):886-96. Epub 2014 Feb 3.

David J.H. Shih, Marc Remke, Vijay Ramaswamy, Betty Luu, Yuan Yao, Xin Wang, Adrian M. Dubuc, Livia Garzia, John Peacock, Stephen C. Mack, Xiaochong Wu, Adi Rolider, A. Sorana Morrissy, Florence M.G. Cavalli, Claudia C. Faria, Stephen W. Scherer, Uri Tabori, Cynthia E. Hawkins, David Malkin, Eric Bouffet, James T. Rutka, and Michael D. Taylor, Hospital for Sick Children; David J.H. Shih, Marc Remke, Vijay Ramaswamy, Yuan Yao, Xin Wang, Adrian M. Dubuc, John Peacock, Stephen C. Mack, and Michael D. Taylor, University of Toronto, Toronto; Boleslaw Lach, McMaster University, Hamilton, Ontario; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Steffen Albrecht, Adam Fontebasso, and Nada Jabado, McGill University, Montreal, Quebec, Canada; Paul A. Northcott, Andrey Korshunov, Marcel Kool, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Ulrich Schüller, Ludwig-Maximilians-University, Munich; Stefan Rutkowski, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Karel Zitterbart, Masaryk University School of Medicine; Karel Zitterbart and Leos Kren, University Hospital Brno, Brno, Czech Republic; Toshihiro Kumabe and Teiji Tominaga, Tohoku University Graduate School of Medicine, Sendai, Japan; Young Shin Ra, University of Ulsan, Asan Medical Center; Ji-Yeoun Lee, Byung-Kyu Cho, Seung-Ki Kim, and Kyu-Chang Wang, Seoul National University Children's Hospital, Seoul; Shin Jung, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Chonnam, South Korea; Peter Hauser and Miklós Garami, Semmelweis University, Budapest; László Bognár and Almos Klekner, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary; Shenandoah Robinson, Boston Children's Hospital; Scott L. Pomeroy, Harvard Medical School, Boston, MA; Ali G. Saad, University of Arkansas for Medical Sciences, Little

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http://dx.doi.org/10.1200/JCO.2013.50.9539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948094PMC
March 2014

TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours.

Acta Neuropathol 2014 Feb 12;127(2):307-9. Epub 2013 Dec 12.

Northern Institute for Cancer Research, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1007/s00401-013-1225-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313075PMC
February 2014

Dissecting the genomic complexity underlying medulloblastoma.

Nature 2012 Aug;488(7409):100-5

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1038/nature11284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662966PMC
August 2012

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Authors:
Paul A Northcott David J H Shih John Peacock Livia Garzia A Sorana Morrissy Thomas Zichner Adrian M Stütz Andrey Korshunov Jüri Reimand Steven E Schumacher Rameen Beroukhim David W Ellison Christian R Marshall Anath C Lionel Stephen Mack Adrian Dubuc Yuan Yao Vijay Ramaswamy Betty Luu Adi Rolider Florence M G Cavalli Xin Wang Marc Remke Xiaochong Wu Readman Y B Chiu Andy Chu Eric Chuah Richard D Corbett Gemma R Hoad Shaun D Jackman Yisu Li Allan Lo Karen L Mungall Ka Ming Nip Jenny Q Qian Anthony G J Raymond Nina T Thiessen Richard J Varhol Inanc Birol Richard A Moore Andrew J Mungall Robert Holt Daisuke Kawauchi Martine F Roussel Marcel Kool David T W Jones Hendrick Witt Africa Fernandez-L Anna M Kenney Robert J Wechsler-Reya Peter Dirks Tzvi Aviv Wieslawa A Grajkowska Marta Perek-Polnik Christine C Haberler Olivier Delattre Stéphanie S Reynaud François F Doz Sarah S Pernet-Fattet Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Wolfram Scheurlen Charles G Eberhart Michelle Fèvre-Montange Anne Jouvet Ian F Pollack Xing Fan Karin M Muraszko G Yancey Gillespie Concezio Di Rocco Luca Massimi Erna M C Michiels Nanne K Kloosterhof Pim J French Johan M Kros James M Olson Richard G Ellenbogen Karel Zitterbart Leos Kren Reid C Thompson Michael K Cooper Boleslaw Lach Roger E McLendon Darell D Bigner Adam Fontebasso Steffen Albrecht Nada Jabado Janet C Lindsey Simon Bailey Nalin Gupta William A Weiss László Bognár Almos Klekner Timothy E Van Meter Toshihiro Kumabe Teiji Tominaga Samer K Elbabaa Jeffrey R Leonard Joshua B Rubin Linda M Liau Erwin G Van Meir Maryam Fouladi Hideo Nakamura Giuseppe Cinalli Miklós Garami Peter Hauser Ali G Saad Achille Iolascon Shin Jung Carlos G Carlotti Rajeev Vibhakar Young Shin Ra Shenandoah Robinson Massimo Zollo Claudia C Faria Jennifer A Chan Michael L Levy Poul H B Sorensen Matthew Meyerson Scott L Pomeroy Yoon-Jae Cho Gary D Bader Uri Tabori Cynthia E Hawkins Eric Bouffet Stephen W Scherer James T Rutka David Malkin Steven C Clifford Steven J M Jones Jan O Korbel Stefan M Pfister Marco A Marra Michael D Taylor

Nature 2012 Aug;488(7409):49-56

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://is.muni.cz/repo/990835/nature11327.pdf
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http://www.nature.com/doifinder/10.1038/nature11327
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http://dx.doi.org/10.1038/nature11327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683624PMC
August 2012

Cancer genetics: Evolution after tumour spread.

Nature 2012 Feb 15;482(7386):481-2. Epub 2012 Feb 15.

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http://dx.doi.org/10.1038/nature10949DOI Listing
February 2012

The importance of biopsy following radiological diagnosis of relapsed medulloblastoma.

Br J Neurosurg 2012 Aug 15;26(4):542-4. Epub 2011 Dec 15.

Paediatric Oncology Department, Great North Children's Hospital, Queen Victoria Road, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.3109/02688697.2011.638997DOI Listing
August 2012

RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines.

Neuro Oncol 2011 Dec 31;13(12):1265-76. Epub 2011 Aug 31.

Children's Brain Tumour Research Centre, Queen's Medical Centre, Medical School, Nottingham University, Nottingham NG7 2UH, UK.

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https://academic.oup.com/neuro-oncology/article-lookup/doi/1
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http://dx.doi.org/10.1093/neuonc/nor129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223089PMC
December 2011

Genome-wide analysis of alternative splicing in medulloblastoma identifies splicing patterns characteristic of normal cerebellar development.

Cancer Res 2011 Mar 19;71(6):2045-55. Epub 2011 Jan 19.

Molecular Haematology and Cancer Biology Unit and Neural Development Unit, UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060131PMC
March 2011

The potential impact of tumour biology on improved clinical practice for medulloblastoma: progress towards biologically driven clinical trials.

Br J Neurosurg 2009 Aug;23(4):364-75

Department of Paediatric Oncology, Alder Hey Children's Hospital, Liverpool, UK.

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http://dx.doi.org/10.1080/02688690903121807DOI Listing
August 2009

Novel mechanisms of gene disruption at the medulloblastoma isodicentric 17p11 breakpoint.

Genes Chromosomes Cancer 2009 Feb;48(2):121-31

Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1002/gcc.20625DOI Listing
February 2009

Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2.

Neuro Oncol 2008 Dec 29;10(6):981-94. Epub 2008 Jul 29.

Northern Institute for Cancer Research, The Medical School, Framlington Place, University of Newcastle, Newcastle-upon-Tyne, UK.

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http://academic.oup.com/neuro-oncology/article/10/6/981/1054
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http://dx.doi.org/10.1215/15228517-2008-048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719012PMC
December 2008

Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behavior.

Brain Pathol 2007 Apr;17(2):151-64

Northern Institute for Cancer Research, University of Newcastle, and Department of Neuropathology, Newcastle-upon-Tyne Hospitals Trust, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1111/j.1750-3639.2007.00058.xDOI Listing
April 2007

Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.

Cell Cycle 2006 Nov 15;5(22):2666-70. Epub 2006 Nov 15.

Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.4161/cc.5.22.3446DOI Listing
November 2006

Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma.

Cell Cycle 2006 Oct 16;5(20):2381-9. Epub 2006 Oct 16.

Northern Institute for Cancer Research, The Medical School, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.4161/cc.5.20.3360DOI Listing
October 2006

APC and CTNNB1 mutations are rare in sporadic ependymomas.

Cancer Genet Cytogenet 2006 Jul;168(2):158-61

Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S016546080600148
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http://dx.doi.org/10.1016/j.cancergencyto.2006.02.019DOI Listing
July 2006

Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma.

Eur J Cancer 2006 Mar 24;42(5):646-9. Epub 2006 Jan 24.

Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK, and Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.ejca.2005.11.023DOI Listing
March 2006

Epigenetic events in medulloblastoma development.

Neurosurg Focus 2005 Nov 15;19(5):E10. Epub 2005 Nov 15.

Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.3171/foc.2005.19.5.11DOI Listing
November 2005

Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma.

Cancer Lett 2005 Sep 25;227(1):75-81. Epub 2004 Dec 25.

Northern Institute for Cancer Research, Paul O'Gorman Building, The Medical School, University of Newcastle, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.canlet.2004.11.044DOI Listing
September 2005

Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours.

Int J Cancer 2006 Jan;118(2):346-52

Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/ijc.21353DOI Listing
January 2006

Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients.

Clin Cancer Res 2004 Aug;10(16):5482-93

Northern Institute for Cancer Research, University of Newcastle, Newcastle-upon-Tyne, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-03-0721DOI Listing
August 2004

The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma.

Brain Res Mol Brain Res 2004 Feb;121(1-2):137-40

Northern Institute for Cancer Research, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.molbrainres.2003.11.016DOI Listing
February 2004

PDGFRB is overexpressed in metastatic medulloblastoma.

Nat Genet 2003 Nov;35(3):197-8

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http://dx.doi.org/10.1038/ng1103-197DOI Listing
November 2003

Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas.

J Neuropathol Exp Neurol 2003 Jun;62(6):627-32

Northern Institute for Cancer Research, University of Newcastle, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1093/jnen/62.6.627DOI Listing
June 2003

What's new in neuro-oncology? Recent advances in medulloblastoma.

Eur J Paediatr Neurol 2003 ;7(2):53-66

The Northern Institute for Cancer Research, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/s1090-3798(03)00014-xDOI Listing
July 2003

Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development.

Cancer Res 2002 Oct;62(20):5906-11

Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle-upon-Tyne, NE2 4HH, United Kingdom.

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October 2002