Steven Ballet

Steven Ballet

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Steven Ballet

Steven Ballet

Publications by authors named "Steven Ballet"

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Corrigendum to "Chemical space screening around Phe in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings" [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320-2323].

Bioorg Med Chem Lett 2018 Nov 5;28(20):3418. Epub 2018 Sep 5.

Research Group of Organic Chemistry, Departments of Bioengineering Sciences and Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address:

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November 2018

The Neurokinins: Peptidomimetic Ligand Design and Therapeutic Applications.

Curr Med Chem 2018 Sep 12. Epub 2018 Sep 12.

Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussels, Pleinlaan 2, B-1050 Brussels. Belgium.

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September 2018

Efficient One-Pot Access to Trisubstituted 2-Benzazepin-3-ones as Constrained Pseudopeptide Analogues and Privileged Scaffolds.

Med Chem 2018 ;14(4):400-408

Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050, Brussels, Belgium.

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August 2018

Bromotryptophans and their incorporation in cyclic and bicyclic privileged peptides.

Biopolymers 2018 Aug 12;109(10):e23112. Epub 2018 Mar 12.

Institute for Research in Biomedicine (IRB Barcelona), Chemistry and Molecular Pharmacology Program, Barcelona Institute of Science and Technology (BIST), Barcelona, 08028, Spain.

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August 2018

Chemical space screening around Phe in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings.

Bioorg Med Chem Lett 2018 Jul 12;28(13):2320-2323. Epub 2018 May 12.

Research Group of Organic Chemistry, Departments of Bioengineering Sciences and Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address:

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July 2018

Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors.

Angew Chem Int Ed Engl 2018 May 30;57(19):5292-5295. Epub 2018 Mar 30.

VIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, 1050, Brussels, Belgium.

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May 2018

Synthesis and Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists.

ACS Med Chem Lett 2018 May 23;9(5):496-501. Epub 2018 Apr 23.

Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.

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May 2018

Indoloazepinone-Constrained Oligomers as Cell-Penetrating and Blood-Brain-Barrier-Permeating Compounds.

Chembiochem 2018 Apr 28;19(7):696-705. Epub 2018 Feb 28.

Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium.

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April 2018

Binding-Site Compatible Fragment Growing Applied to the Design of β-Adrenergic Receptor Ligands.

J Med Chem 2018 Feb 24;61(3):1118-1129. Epub 2018 Jan 24.

Department of Pharmaceutical Chemistry, Philipps-University Marburg , Marbacher Weg 6, 35032 Marburg, Germany.

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February 2018

Development of potent and proteolytically stable human neuromedin U receptor agonists.

Eur J Med Chem 2018 Jan 14;144:887-897. Epub 2017 Dec 14.

Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium. Electronic address:

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January 2018

Site-Specific Radioactive Labeling of Nanobodies.

Methods Mol Biol 2018 ;1827:505-540

Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussel, Belgium.

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January 2018

Antimicrobial peptides in frog poisons constitute a molecular toxin delivery system against predators.

Nat Commun 2017 11 14;8(1):1495. Epub 2017 Nov 14.

Amphibian Evolution Lab, Biology Department, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Elsene, Belgium.

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November 2017

χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.

ACS Med Chem Lett 2017 Nov 4;8(11):1177-1182. Epub 2017 Oct 4.

Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.

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November 2017

Bifunctional opioid/nociceptin hybrid KGNOP1 effectively attenuates pain-related behaviour in a rat model of neuropathy.

Eur J Pharm Sci 2017 Jun 24;104:221-229. Epub 2017 Mar 24.

Institute of Pharmacology, Department of Pain Pharmacology, Krakow, Poland. Electronic address:

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June 2017

Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain.

Pain 2017 03;158(3):505-515

aInserm, UMR-S 1144, Paris, France bParis-Descartes University, UMR-S 1144, Paris, France cParis-Diderot University, UMR-S 1144, Paris, France dResearch Group of Organic Chemistry, Departments of Chemistry and Bio-engineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium eAssistance Publique-Hôpitaux de Paris, Lariboisière Hospital, Laboratory of Biochemistry and Molecular Biology, Paris, France fDepartment of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria gAssistance Publique-Hôpitaux de Paris, Lariboisière Hospital, Department of Medical and Toxicological Critical Care, Paris, France.

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March 2017

In Vivo Imaging of the Stability and Sustained Cargo Release of an Injectable Amphipathic Peptide-Based Hydrogel.

Biomacromolecules 2017 03 20;18(3):994-1001. Epub 2017 Feb 20.

Research Group of Organic Chemistry, Vrije Universiteit Brussel , Pleinlaan 2, 1050 Brussels, Belgium.

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March 2017

Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds.

ACS Med Chem Lett 2017 Jan 1;8(1):73-77. Epub 2016 Nov 1.

Department of Neuropeptides, Mossakowski Medical Research Centre Polish Academy of Sciences , 5 Pawińskiego Str., 02-106 Warsaw, Poland.

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January 2017

Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design.

J Med Chem 2016 12 12;59(24):10865-10890. Epub 2016 Oct 12.

Research Group of Organic Chemistry, Departments of Chemistry and Bio-Engineering Sciences, Vrije Universiteit Brussel , Pleinlaan 2, 1050 Brussels, Belgium.

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December 2016

Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases.

Chemistry 2016 Sep 12;22(39):14022-14028. Epub 2016 Aug 12.

Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.

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September 2016

Synthesis and binding characteristics of [(3)H]neuromedin N, a NTS2 receptor ligand.

Neuropeptides 2016 Jun 8;57:15-20. Epub 2015 Dec 8.

Department of Neuropeptides, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, 02106 Warsaw, Poland; Department of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, 1B Banacha Str., 02-106 Warsaw, Poland. Electronic address:

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June 2016

Mixed α/β-Peptides as a Class of Short Amphipathic Peptide Hydrogelators with Enhanced Proteolytic Stability.

Biomacromolecules 2016 Feb 25;17(2):437-45. Epub 2016 Jan 25.

Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel , Laarbeeklaan 103, B-1090 Brussels, Belgium.

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February 2016

T3P-Promoted, Mild, One-Pot Syntheses of Constrained Polycyclic Lactam Dipeptide Analogues via Stereoselective Pictet-Spengler and Meyers Lactamization Reactions.

Org Lett 2015 Sep 31;17(18):4482-5. Epub 2015 Aug 31.

Research Group of Organic Chemistry, Departments of Chemistry and Bio-Engineering Sciences, Vrije Universiteit Brussel , Pleinlaan 2, B-1050 Brussels, Belgium.

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September 2015

Draft genome sequence analysis of a Pseudomonas putida W15Oct28 strain with antagonistic activity to Gram-positive and Pseudomonas sp. pathogens.

PLoS One 2014 4;9(11):e110038. Epub 2014 Nov 4.

Department of Bioengineering Sciences, Research group Microbiology, Vrije Universiteit Brussel and VIB Structural Biology Brussels, Brussels, Belgium.

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July 2015

Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist.

ACS Med Chem Lett 2015 Feb 3;6(2):192-7. Epub 2014 Dec 3.

Research Group of Organic Chemistry, Vrije Universiteit Brussel , Pleinlaan 2, B-1050 Brussels, Belgium.

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February 2015

Hybrid opioid/non-opioid ligands in pain research.

Curr Pharm Des 2013 ;19(42):7435-50

Department of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.

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September 2014

One-pot isomerization-cross metathesis-reduction (ICMR) synthesis of lipophilic tetrapeptides.

ACS Comb Sci 2014 Jul 18;16(7):342-51. Epub 2014 Jun 18.

Department of Organic Chemistry, Vrije Universiteit Brussel , Pleinlaan 2, B-1050 Brussels, Belgium.

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July 2014

Synthesis of fused 3-aminoazepinones via trapping of a new class of cyclic seven-membered allenamides with furan.

Org Lett 2014 Jul 9;16(14):3712-5. Epub 2014 Jul 9.

Research Group of Organic Chemistry, Department of Chemistry and Department of Bio-engineering Sciences, Faculty of Science and Bio-engineering Sciences and ‡Department of General Chemistry, Vrije Universiteit Brussel , Pleinlaan 2, B-1050 Brussels, Belgium.

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July 2014

The first one-pot synthesis of L-7-iodotryptophan from 7-iodoindole and serine, and an improved synthesis of other L-7-halotryptophans.

Org Lett 2014 May 7;16(10):2622-5. Epub 2014 May 7.

School of Chemistry and BSRC, University of St. Andrews , St. Andrews, KY16 9ST, U.K.

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May 2014

Regulatory mechanisms after short- and long-term perturbed lysine biosynthesis in the aspartate pathway: the need for isogenes in Arabidopsis thaliana.

Physiol Plant 2013 Dec 15;149(4):449-60. Epub 2013 Apr 15.

Laboratory of Plant Genetics, Institute for Molecular Biology and Biotechnology, Vrije Universiteit Brussel (VUB), Pleinlaan 2, B-1050, Brussels, Belgium.

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December 2013

Highly diastereoselective synthesis of 1-carbamoyl-4-aminoindoloazepinone derivatives via the Ugi reaction.

Org Lett 2013 Nov 25;15(22):5866-9. Epub 2013 Oct 25.

Department of Organic Chemistry, Vrije Universiteit Brussel , Pleinlaan 2, B-1050 Brussels, Belgium , and Institute of Organic Chemistry , Polish Academy of Sciences, Kasprzaka Str. 44/52, 01-224 Warsaw, Poland.

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November 2013

A combinatorial approach to the structure elucidation of a pyoverdine siderophore produced by a Pseudomonas putida isolate and the use of pyoverdine as a taxonomic marker for typing P. putida subspecies.

Biometals 2013 Aug 23;26(4):561-75. Epub 2013 Jul 23.

Research Group Microbiology, Department of Bioengineering Sciences, VIB Department of Structural Biology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.

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August 2013

Stabilisation of a short α-helical VIP fragment by side chain to side chain cyclisation: a comparison of common cyclisation motifs by circular dichroism.

J Pept Sci 2013 Jul 27;19(7):423-32. Epub 2013 May 27.

Department of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, B-1050, Brussels, Belgium.

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July 2013

Amino triazolo diazepines (Ata) as constrained histidine mimics.

Org Lett 2011 Dec 16;13(24):6468-71. Epub 2011 Nov 16.

Laboratory of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.

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December 2011

PK20, a new opioid-neurotensin hybrid peptide that exhibits central and peripheral antinociceptive effects.

Mol Pain 2010 Dec 6;6:86. Epub 2010 Dec 6.

Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego Street 5, 02106 Warsaw, Poland.

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December 2010

Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.

Bioorg Med Chem Lett 2010 Mar 20;20(5):1610-3. Epub 2010 Jan 20.

Department of Organic Chemistry, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.

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March 2010

Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold.

Bioorg Med Chem Lett 2009 Jan 19;19(2):433-7. Epub 2008 Nov 19.

Department of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.

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January 2009

Multiple ligands in opioid research.

Protein Pept Lett 2008 ;15(7):668-82

School of Chemistry and Physics, University of Adelaide, North Terrace, Adelaide SA 5005, Australia.

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November 2008

Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.

J Med Chem 2008 Apr 28;51(8):2571-4. Epub 2008 Mar 28.

Organic Chemistry Department, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.

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April 2008

Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties.

J Med Chem 2008 Jan 7;51(1):173-7. Epub 2007 Dec 7.

Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Temesvári krt. 62., H-6726 Szeged, Hungary.

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January 2008

High-performance liquid chromatographic separation of stereoisomers of N-phthaloyl-protected amino acids and dipeptidomimetics.

J Sep Sci 2007 Aug;30(12):1881-7

Department of Inorganic and Analytical Chemistry, University of Szeged, H-6720 Szeged, Dóm tér 7, Hungary.

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August 2007

Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists.

J Med Chem 2007 Jan;50(2):328-33

Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, Post Office Box 521, H-6701 Szeged, Hungary.

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January 2007