Steven A Carr

Steven A Carr

UNVERIFIED PROFILE

Are you Steven A Carr?   Register this Author

Register author
Steven A Carr

Steven A Carr

Publications by authors named "Steven A Carr"

Are you Steven A Carr?   Register this Author

100Publications

4489Reads

48Profile Views

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells.

Proc Natl Acad Sci U S A 2019 Sep 4;116(39):19609-19618. Epub 2019 Sep 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1908626116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765243PMC
September 2019

SMAC mimetics promote NIK-dependent inhibition of CD4 T17 cell differentiation.

Sci Signal 2019 Aug 27;12(596). Epub 2019 Aug 27.

Department of Health Technology, Technical University of Denmark, Kemitorvet, Building 202, 2800 Kgs Lyngby, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.aaw3469DOI Listing
August 2019

In Situ Peroxidase Labeling and Mass Spectrometry of Alpha-Synuclein in Rat Cortical Neurons.

Methods Mol Biol 2019 ;1948:235-246

Ann Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-4939-9124-2_18
Publisher Site
http://dx.doi.org/10.1007/978-1-4939-9124-2_18DOI Listing
July 2019

TMT Labeling for the Masses: A Robust and Cost-efficient, In-solution Labeling Approach.

Mol Cell Proteomics 2019 07 9;18(7):1468-1478. Epub 2019 Apr 9.

From the ‡Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany;

View Article

Download full-text PDF

Source
http://www.mcponline.org/lookup/doi/10.1074/mcp.TIR119.00138
Publisher Site
http://dx.doi.org/10.1074/mcp.TIR119.001385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601210PMC
July 2019

Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits.

Cell Rep 2019 Mar;26(10):2805-2817.e9

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510, USA; Department of Neuroscience, Yale University, New Haven, CT 06510, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247193019
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2019.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436967PMC
March 2019

Evaluation of Advanced Precursor Determination for Tandem Mass Tag (TMT)-Based Quantitative Proteomics across Instrument Platforms.

J Proteome Res 2019 01 31;18(1):542-547. Epub 2018 Oct 31.

The Broad Institute of MIT and Harvard , Cambridge , Massachusetts , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.8b00611DOI Listing
January 2019

Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures.

Cell Chem Biol 2018 12 11;25(12):1506-1518.e13. Epub 2018 Oct 11.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24519456183033
Publisher Site
http://dx.doi.org/10.1016/j.chembiol.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309532PMC
December 2018

Efficient proximity labeling in living cells and organisms with TurboID.

Nat Biotechnol 2018 10 20;36(9):880-887. Epub 2018 Aug 20.

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1038/nbt.4201
Publisher Site
http://dx.doi.org/10.1038/nbt.4201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126969PMC
October 2018

Homo-PROTACs for the Chemical Knockdown of Cereblon.

ACS Chem Biol 2018 09 5;13(9):2771-2782. Epub 2018 Sep 5.

Department of Internal Medicine III , University Hospital Ulm , Albert-Einstein-Allee 23 , 89081 Ulm , Germany.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acschembio.8b00693
Publisher Site
http://dx.doi.org/10.1021/acschembio.8b00693DOI Listing
September 2018

Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast.

PLoS Biol 2018 09 12;16(9):e2005903. Epub 2018 Sep 12.

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pbio.2005903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135351PMC
September 2018

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.

Cell Rep 2018 07;24(4):838-850

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.06.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156773PMC
July 2018

Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4 T Cells.

Immunity 2018 06 22;48(6):1183-1194.e5. Epub 2018 May 22.

Infectious Disease Division, Brigham and Women's Hospital, Boston, MA 02115, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013384PMC
June 2018

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

Cell 2018 03 15;173(1):90-103.e19. Epub 2018 Mar 15.

Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2018.02.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866246PMC
March 2018

Antibodies to biotin enable large-scale detection of biotinylation sites on proteins.

Nat Methods 2017 Dec 16;14(12):1167-1170. Epub 2017 Oct 16.

Proteomics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.4465DOI Listing
December 2017

Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1.

J Cell Biol 2017 12 7;216(12):4255-4270. Epub 2017 Nov 7.

Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201703105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716279PMC
December 2017

Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress.

J Biol Chem 2017 11 14;292(46):18878-18885. Epub 2017 Sep 14.

From the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M117.797084
Publisher Site
http://dx.doi.org/10.1074/jbc.M117.797084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704472PMC
November 2017

Proximity Biotinylation as a Method for Mapping Proteins Associated with mtDNA in Living Cells.

Cell Chem Biol 2017 Mar 23;24(3):404-414. Epub 2017 Feb 23.

Departments of Genetics, Biology, and Chemistry, Stanford University, Stanford, CA 94305, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2017.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886301PMC
March 2017

In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons.

Cell Syst 2017 02 25;4(2):242-250.e4. Epub 2017 Jan 25.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cels.2017.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578869PMC
February 2017

Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction.

Immunity 2017 02;46(2):315-326

Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2017.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405381PMC
February 2017

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

Sci Rep 2017 01 10;7:40495. Epub 2017 Jan 10.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, U.S.A.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep40495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223159PMC
January 2017

Multiplexed Immunoaffinity Enrichment of Peptides with Anti-peptide Antibodies and Quantification by Stable Isotope Dilution Multiple Reaction Monitoring Mass Spectrometry.

Methods Mol Biol 2016 ;1410:135-67

Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-3524-6_9DOI Listing
December 2016

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.

Cell Rep 2016 12;17(11):2955-2965

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.11.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661940PMC
December 2016

Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation.

Sci Rep 2016 10 31;6:36298. Epub 2016 Oct 31.

The Ragon Institute of Massachusetts General Hospital, The Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, MA 02139, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep36298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087089PMC
October 2016

Automated Microchromatography Enables Multiplexing of Immunoaffinity Enrichment of Peptides to Greater than 150 for Targeted MS-Based Assays.

Anal Chem 2016 08 12;88(15):7548-55. Epub 2016 Jul 12.

Broad Institute of MIT and Harvard , Cambridge, Massachusetts 02142, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.6b00946DOI Listing
August 2016

Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.

Cell 2016 Aug;166(5):1295-1307.e21

Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2016.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167540PMC
August 2016

Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease.

Circulation 2016 Jul;134(4):270-85

From Division of Pulmonary and Critical Care Medicine, Department of Medicine (D.N.) and the Cardiovascular Research Center (D.N., S.S., D.S., M.J.K., X.S., M.D.B., J.F.O., L.A.F., R.E.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Broad Institute of MIT and Harvard, Cambridge, MA (E.W.K., H.K., S.A.C., R.E.G.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (M.D.B., M.S.S.); Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston (M.A.F., M.S.S., R.E.G.); Preventive Medicine Section, Department of Medicine, Boston University School of Medicine, MA (R.S.V.); Department of Biostatistics, Boston University School of Public Health, MA (M.G.L.); The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (M.G.L.); Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN (T.J.W.); and Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (R.E.G.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.116.021803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963294PMC
July 2016

Targeted MS Assay Predicting Tamoxifen Resistance in Estrogen-Receptor-Positive Breast Cancer Tissues and Sera.

J Proteome Res 2016 Apr 18;15(4):1230-42. Epub 2016 Mar 18.

Erasmus University Medical Center Rotterdam , Erasmus MC Cancer Institute, Department of Medical Oncology, 3015 CN Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.5b01119DOI Listing
April 2016

Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2.

Nat Protoc 2016 Mar 11;11(3):456-75. Epub 2016 Feb 11.

Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2016.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863649PMC
March 2016

Antibody-based capture of target peptides in multiple reaction monitoring experiments.

Methods Mol Biol 2015 ;1293:123-35

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-2519-3_7DOI Listing
February 2016

H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs.

Cell Rep 2016 Feb 21;14(5):1142-1155. Epub 2016 Jan 21.

Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2015.12.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764991PMC
February 2016

The extracellular matrix: Tools and insights for the "omics" era.

Matrix Biol 2016 Jan 8;49:10-24. Epub 2015 Jul 8.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0945053X150012
Publisher Site
http://dx.doi.org/10.1016/j.matbio.2015.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013529PMC
January 2016

A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation.

Mol Cell 2015 Dec;60(5):816-827

Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco and California Institute for Quantitative Biomedical Research, San Francisco, CA 94158, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10972765150090
Publisher Site
http://dx.doi.org/10.1016/j.molcel.2015.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720255PMC
December 2015

Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase.

Proc Natl Acad Sci U S A 2015 Sep 11;112(39):12093-8. Epub 2015 Sep 11.

Department of Genetics, Harvard Medical School, Boston, MA 02115; Howard Hughes Medical Institute, Boston, MA 02115

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1515623112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593093PMC
September 2015

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.

Cell Rep 2015 Jun 18;11(12):1905-18. Epub 2015 Jun 18.

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2015.05.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507440PMC
June 2015