Publications by authors named "Steven A Belinsky"

100Publications

Smoke Chemistry, In vitro Cytotoxicity, and Genotoxicity Demonstrates Enhanced Toxicity of Cigarillos Compared to Cigarettes.

Toxicol Sci 2020 Oct 6. Epub 2020 Oct 6.

Center for Tobacco Products, Office of Science, U.S. Food and Drug Administration, Silver Spring, MD.

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http://dx.doi.org/10.1093/toxsci/kfaa155DOI Listing
October 2020

Voltage and e-liquid composition affect nicotine deposition within the oral cavity and carbonyl formation.

Tob Control 2020 Jun 25. Epub 2020 Jun 25.

Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA

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http://dx.doi.org/10.1136/tobaccocontrol-2020-055619DOI Listing
June 2020

Identification of novel epigenetic abnormalities as sputum biomarkers for lung cancer risk among smokers and COPD patients.

Lung Cancer 2020 Aug 25;146:189-196. Epub 2020 May 25.

COPD Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA; Currently, Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2020.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384485PMC
August 2020

Carbon content in airway macrophages and genomic instability in Chinese carbon black packers.

Arch Toxicol 2020 03 19;94(3):761-771. Epub 2020 Feb 19.

School of Public Health, Qingdao University, Qingdao, 266021, Shandong, China.

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http://dx.doi.org/10.1007/s00204-020-02678-6DOI Listing
March 2020

Epigenetic Regulation of RIP3 Suppresses Necroptosis and Increases Resistance to Chemotherapy in NonSmall Cell Lung Cancer.

Transl Oncol 2020 Feb 27;13(2):372-382. Epub 2019 Dec 27.

Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2019.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938879PMC
February 2020

Vasorin/ATIA Promotes Cigarette Smoke-Induced Transformation of Human Bronchial Epithelial Cells by Suppressing Autophagy-Mediated Apoptosis.

Transl Oncol 2020 Jan 21;13(1):32-41. Epub 2019 Nov 21.

Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM, 87108, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2019.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883318PMC
January 2020

Inhibition of the hexosamine biosynthesis pathway potentiates cisplatin cytotoxicity by decreasing BiP expression in non-small-cell lung cancer cells.

Mol Carcinog 2019 06 6;58(6):1046-1055. Epub 2019 Mar 6.

Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico.

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http://dx.doi.org/10.1002/mc.22992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525013PMC
June 2019

Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop.

Carcinogenesis 2017 06;38(6):604-614

Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest DR. SE, Albuquerque, NM 87108, USA and.

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http://dx.doi.org/10.1093/carcin/bgx039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862300PMC
June 2017

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Nat Genet 2017 Mar 6;49(3):426-432. Epub 2017 Feb 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381275PMC
March 2017

TSC2 Deficiency Unmasks a Novel Necrosis Pathway That Is Suppressed by the RIP1/RIP3/MLKL Signaling Cascade.

Cancer Res 2016 12 18;76(24):7130-7139. Epub 2016 Oct 18.

Lovelace Respiratory Research Institute, Albuquerque, New Mexico.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1052DOI Listing
December 2016

miR-196b Is Epigenetically Silenced during the Premalignant Stage of Lung Carcinogenesis.

Cancer Res 2016 08 14;76(16):4741-51. Epub 2016 Jun 14.

Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987256PMC
August 2016

Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer.

J Thorac Oncol 2015 Aug;10(8):1181-8

*Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico; †Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania; ‡Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota; and §COPD Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico.

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http://dx.doi.org/10.1097/JTO.0000000000000592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511946PMC
August 2015

Low plasma CC16 levels in smokers are associated with a higher risk for chronic bronchitis.

Eur Respir J 2015 Nov 9;46(5):1501-3. Epub 2015 Jul 9.

Lovelace Respiratory Research Institute, Albuquerque, NM, USA

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http://dx.doi.org/10.1183/13993003.00682-2015DOI Listing
November 2015

15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers.

J Natl Cancer Inst 2015 Feb 23;107(5). Epub 2015 Feb 23.

: Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM (SL, YL, CLT, MAP, RPW, KCD, XZ, EAB, YT, SAB); Department of Epidemiology, Graduate School of Public Health (JLW) and Department of Medicine (TN, MR), University of Pittsburgh, Pittsburgh, PA; Center for Genomic Medicine, Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH (YH, CIA); Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA (CKE, DVDB, WJG, FDG); Department of Pharmacology & Chemical Biology, Hillman Cancer Center of the University of Pittsburgh Medical Center, Pittsburgh, PA (ALGD, JMS); Department of Internal Medicine, University of New Mexico, Albuquerque, NM (REC, CAS); Department of Pharmacology, University of Minnesota, Minneapolis, MN (JMS).

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http://jnci.oxfordjournals.org/content/107/5/djv035.full.pdf
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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/djv035
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http://dx.doi.org/10.1093/jnci/djv035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555640PMC
February 2015

Unmasking the lung cancer epigenome.

Annu Rev Physiol 2015 ;77:453-74

Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108; email:

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http://dx.doi.org/10.1146/annurev-physiol-021014-072018DOI Listing
November 2015

Epigenetic change (GATA-4 gene methylation) is associated with health status in chronic obstructive pulmonary disease.

Biol Res Nurs 2015 Mar 27;17(2):191-8. Epub 2014 Jun 27.

Lovelace Respiratory Research Institute, Albuquerque, NM, USA.

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http://journals.sagepub.com/doi/ 10.1177/1099800414538113
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http://dx.doi.org/10.1177/1099800414538113DOI Listing
March 2015

SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome.

Int J Cancer 2014 Nov 5;135(9):2223-31. Epub 2014 Apr 5.

Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM.

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http://dx.doi.org/10.1002/ijc.28865DOI Listing
November 2014

Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer.

Clin Cancer Res 2014 Apr 31;20(7):1856-64. Epub 2014 Jan 31.

Authors' Affiliations: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland; Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium; MDxHealth Inc, Irvine, California; Shinshu University School of Medicine, Asahi, Matsumoto, Nagano, Japan; and Lovelace Respiratory Research Institute, Albuquerque, New Mexico.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019442PMC
April 2014

Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers.

Carcinogenesis 2014 Jun 7;35(6):1248-57. Epub 2014 Jan 7.

Department of Lung Cancer, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA, MDxHealth Inc., Irvine, CA 92618, USA, Department of Pathology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD, Maastricht, The Netherlands and Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgt494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110480PMC
June 2014

MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer.

Cancer Res 2014 Jan 26;74(2):460-70. Epub 2013 Nov 26.

Authors' Affiliations: Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico; and Department of Physiology & Lung Center, Temple University School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947020PMC
January 2014

Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice.

Dose Response 2012 Dec 22;10(4):516-26. Epub 2012 Nov 22.

University of New Mexico, Biomedical Sciences Graduate Program, Health Sciences Center, and Lovelace Respiratory Research Institute, Respiratory Immunology Program, Albuquerque, NM.

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http://dx.doi.org/10.2203/dose-response.12-040.BruceDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526325PMC
December 2012

Softwares and methods for estimating genetic ancestry in human populations.

Hum Genomics 2013 Jan 5;7. Epub 2013 Jan 5.

Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.

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http://dx.doi.org/10.1186/1479-7364-7-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542037PMC
January 2013

Defining a gene promoter methylation signature in sputum for lung cancer risk assessment.

Clin Cancer Res 2012 Jun 17;18(12):3387-95. Epub 2012 Apr 17.

Lung Cancer Program, Lovelace Respiratory Research Institute, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87108, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483793PMC
June 2012

HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer.

Carcinogenesis 2012 Jun 31;33(6):1187-92. Epub 2012 Mar 31.

Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.

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http://dx.doi.org/10.1093/carcin/bgs142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388491PMC
June 2012

MUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activation.

PLoS One 2012 22;7(3):e33846. Epub 2012 Mar 22.

Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033846PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310874PMC
August 2012

Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis.

Mol Pharmacol 2010 Mar 23;77(3):416-23. Epub 2009 Nov 23.

Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr., SE, Albuquerque, NM 87108, USA.

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http://dx.doi.org/10.1124/mol.109.061226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835422PMC
March 2010

MS-qFRET: a quantum dot-based method for analysis of DNA methylation.

Genome Res 2009 Aug 14;19(8):1455-61. Epub 2009 May 14.

Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1101/gr.088831.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720185PMC
August 2009

Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers.

Carcinogenesis 2009 Jul 12;30(7):1132-8. Epub 2009 May 12.

Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive Southeast, Albuquerque, NM 87108, USA.

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http://dx.doi.org/10.1093/carcin/bgp114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704285PMC
July 2009

Mining the epigenome for methylated genes in lung cancer.

Proc Am Thorac Soc 2008 Dec;5(8):806-10

Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA.

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http://dx.doi.org/10.1513/pats.200805-045THDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645235PMC
December 2008

DNA methylation biomarkers to assess therapy and chemoprevention for non-small cell lung cancer.

Nutr Rev 2008 Aug;66 Suppl 1:S24-6

The Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA.

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http://dx.doi.org/10.1111/j.1753-4887.2008.00061.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683838PMC
August 2008

Association between common genetic variation in Cockayne syndrome A and B genes and nucleotide excision repair capacity among smokers.

Cancer Epidemiol Biomarkers Prev 2008 Aug;17(8):2062-9

Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive South East, Albuquerque, NM 87108, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-08-0308DOI Listing
August 2008

Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells.

Mol Cancer Ther 2008 May;7(5):1156-63

Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive Southeast, Albuquerque, NM 87108, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-07
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http://dx.doi.org/10.1158/1535-7163.MCT-07-2183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715176PMC
May 2008

Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.

Cancer Res 2008 Feb;68(4):1037-45

Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-07-5782DOI Listing
February 2008

Genotypes in matrix metalloproteinase 9 are a risk factor for COPD.

Int J Chron Obstruct Pulmon Dis 2006 ;1(3):267-78

Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive, SE, Albuquerque, NM 87108, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707156PMC
http://dx.doi.org/10.2147/copd.2006.1.3.267DOI Listing
January 2008

Towards Clinical Application of Methylated DNA Sequences as Cancer Biomarkers: A Joint NCI's EDRN and NIST Workshop on Standards, Methods, Assays, Reagents and Tools.

Cancer Res 2007 May;67(10):4545-9

Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2888DOI Listing
May 2007

A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells.

Mol Pharmacol 2007 May 12;71(5):1381-8. Epub 2007 Feb 12.

Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.106.03
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http://dx.doi.org/10.1124/mol.106.032185DOI Listing
May 2007

Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer.

Cancer Res 2006 Jun;66(12):6210-8

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4447DOI Listing
June 2006

Gene promoter hypermethylation in mouse lung tumors.

Mol Cancer Res 2006 Apr;4(4):267-73

Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive Southeast, Albuquerque, NM 87108, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-05-0218DOI Listing
April 2006

Nested multigene MSP/DHPLC method for analyzing promoter hypermethylation status in clinical samples.

Biotechniques 2006 Jan;40(1):40, 42, 44 passim

Lovelace Respiratory Research Institute, Albuquerque, NM 87108-5127, USA.

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http://dx.doi.org/10.2144/000112095DOI Listing
January 2006

17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway.

Cancer Res 2006 Jan;66(2):1089-95

Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2698DOI Listing
January 2006

Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer.

Carcinogenesis 2005 Sep 20;26(9):1481-7. Epub 2005 Jan 20.

Lung Cancer Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA.

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http://academic.oup.com/carcin/article/26/9/1481/2390921/Sil
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http://dx.doi.org/10.1093/carcin/bgi020DOI Listing
September 2005