Steve Sideris

Steve Sideris

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Steve Sideris

Steve Sideris

Publications by authors named "Steve Sideris"

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Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.

J Med Chem 2014 Dec 20;57(23):10176-91. Epub 2014 Nov 20.

Departments of †Discovery Chemistry, ‡Structural Biology, §Drug Metabolism and Pharmacokinetics, ∥Biochemical and Cellular Pharmacology, ⊥Molecular Oncology, and #Protein Expression, Genentech Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

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http://pubs.acs.org/doi/10.1021/jm501578n
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http://dx.doi.org/10.1021/jm501578nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266342PMC
December 2014

Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1.

Bioorg Med Chem Lett 2014 Dec 27;24(24):5704-5709. Epub 2014 Oct 27.

Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States.

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http://dx.doi.org/10.1016/j.bmcl.2014.10.063DOI Listing
December 2014

Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.

Cancer Cell 2014 Sep 21;26(3):402-413. Epub 2014 Aug 21.

Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.07.007DOI Listing
September 2014

A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors.

Bioorg Med Chem Lett 2013 Sep 23;23(18):5097-104. Epub 2013 Jul 23.

Department of Discovery Chemistry, Genentech, Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.bmcl.2013.07.027DOI Listing
September 2013

A plate-based assay to measure cellular ERK substrate phosphorylation: utility for drug discovery of the MAPK-signaling cascade.

Assay Drug Dev Technol 2010 Aug;8(4):497-503

Department of Biochemical Pharmacology, Genentech, Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1089/adt.2009.0259DOI Listing
August 2010

Establishment of intein-mediated protein ligation under denaturing conditions: C-terminal labeling of a single-chain antibody for biochip screening.

Bioconjug Chem 2002 Jul-Aug;13(4):707-12

Zyomyx, Inc., 26101 Research Road, Hayward, California 94545, USA.

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http://dx.doi.org/10.1021/bc025534zDOI Listing
August 2003