Steve P Watson

Steve P Watson

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Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice.

Haematologica 2019 Aug 7;104(8):1648-1660. Epub 2019 Feb 7.

Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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http://dx.doi.org/10.3324/haematol.2018.208363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669159PMC
August 2019

Adenosine and Forskolin Inhibit Platelet Aggregation by Collagen but not the Proximal Signalling Events.

Thromb Haemost 2019 Jul 26;119(7):1124-1137. Epub 2019 May 26.

Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1055/s-0039-1688788DOI Listing
July 2019

Mucor circinelloides induces platelet aggregation through integrin αIIbβ3 and FcγRIIA.

Platelets 2019 3;30(2):256-263. Epub 2018 Jan 3.

a School of Biosciences and Institute of Microbiology and Infection, College of Life and Environmental Sciences , University of Birmingham , Birmingham UK.

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https://www.tandfonline.com/doi/full/10.1080/09537104.2017.1
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http://dx.doi.org/10.1080/09537104.2017.1420152DOI Listing
April 2019

Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?

Platelets 2019 15;30(3):281-289. Epub 2018 Aug 15.

a Institute of Cardiovascular Sciences, College of Medical and Dental Sciences , University of Birmingham , Birmingham , UK.

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http://dx.doi.org/10.1080/09537104.2018.1508649DOI Listing
April 2019

LAIR-1 Limits Neutrophilic Airway Inflammation.

Front Immunol 2019 26;10:842. Epub 2019 Apr 26.

Laboratory for Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2019.00842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497752PMC
April 2019

Anagrelide is an anti-megakaryocytic and not an anti-platelet agent.

Platelets 2019 7;30(1):136-137. Epub 2018 Nov 7.

a IBR: Level 1, Institute of Cardiovascular Sciences, College of Medical and Dental Sciences , University of Birmingham , Birmingham , United Kingdom.

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http://dx.doi.org/10.1080/09537104.2018.1542124DOI Listing
March 2019

Comparison of the GPVI inhibitors losartan and honokiol.

Platelets 2019 Mar 8:1-11. Epub 2019 Mar 8.

a Institute of Cardiovascular Sciences, IBR Building , College of Medical and Dental Sciences, University of Birmingham , Birmingham , UK.

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http://dx.doi.org/10.1080/09537104.2019.1585526DOI Listing
March 2019

Functional significance of the platelet immune receptors GPVI and CLEC-2.

J Clin Invest 2019 Jan 2;129(1):12-23. Epub 2019 Jan 2.

Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany.

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https://www.jci.org/articles/view/122955
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http://dx.doi.org/10.1172/JCI122955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307936PMC
January 2019

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis.

Platelets 2018 Nov 1;29(7):716-722. Epub 2017 Nov 1.

a Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham , Edgbaston , Birmingham , UK.

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http://dx.doi.org/10.1080/09537104.2017.1356919DOI Listing
November 2018

Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry.

Platelets 2018 Nov 1;29(7):686-689. Epub 2018 May 1.

a The Blizard Institute, Barts & The London School of Medicine and Dentistry , Queen Mary University of London , London , UK.

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http://dx.doi.org/10.1080/09537104.2018.1466388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178086PMC
November 2018

Platelet aggregation induced by polystyrene and platinum nanoparticles is dependent on surface area.

RSC Adv 2018 Nov;8(66):37789-37794

School of Chemical Engineering, College of Engineering and Physical Sciences, University of Birmingham B15 2TT, UK. Email:

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http://dx.doi.org/10.1039/c8ra07315eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333253PMC
November 2018

Mutation in is associated with severe congenital thrombocytopenia.

Blood 2018 10 25;132(17):1855-1858. Epub 2018 Jun 25.

Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1182/blood-2018-04-847798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238157PMC
October 2018

Signalling through Src family kinase isoforms is not redundant in models of thrombo-inflammatory vascular disease.

J Cell Mol Med 2018 09 4;22(9):4317-4327. Epub 2018 Jul 4.

Institute of Cardiovascular Sciences, College of Medical and Dental Science, The Medical School, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1111/jcmm.13721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111872PMC
September 2018

Modulation of VEGF-induced migration and network formation by lymphatic endothelial cells: Roles of platelets and podoplanin.

Platelets 2018 Jul 20;29(5):486-495. Epub 2017 Jul 20.

a Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham , Birmingham , UK.

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http://dx.doi.org/10.1080/09537104.2017.1336210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589745PMC
July 2018

The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent.

Haematologica 2018 06 1;103(6):e256-e258. Epub 2018 Feb 1.

Institut National de la Santé et de la Recherche Médicale, UMR_S1148, Université Paris Diderot, Sorbonne Paris Cité, Hôpital Bichat, France

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http://dx.doi.org/10.3324/haematol.2017.182162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058802PMC
June 2018

P2X1 Receptors Amplify FcγRIIa-Induced Ca2+ Increases and Functional Responses in Human Platelets.

Thromb Haemost 2018 02 29;118(2):369-380. Epub 2018 Jan 29.

Department of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1160/TH17-07-0530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260114PMC
February 2018

Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse.

Am J Physiol Lung Cell Mol Physiol 2017 Dec 24;313(6):L1016-L1029. Epub 2017 Aug 24.

Institute of Cardiovascular Science, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1152/ajplung.00023.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814702PMC
December 2017

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis.

Nat Commun 2017 12 21;8(1):2239. Epub 2017 Dec 21.

Institute of Cardiovascular Science, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, B15 2TT, UK.

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http://dx.doi.org/10.1038/s41467-017-02402-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740111PMC
December 2017

CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice.

Blood 2017 11 23;130(20):2224-2228. Epub 2017 Aug 23.

Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1182/blood-2017-03-771907DOI Listing
November 2017

Effect of anti-podoplanin antibody administration during lipopolysaccharide-induced lung injury in mice.

BMJ Open Respir Res 2017 8;4(1):e000257. Epub 2017 Nov 8.

Institute of Cardiovascular Science, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1136/bmjresp-2017-000257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687585PMC
November 2017

Whole exome sequencing identifies a mutation in thrombomodulin as the genetic cause of a suspected platelet disorder in a family with normal platelet function.

Platelets 2017 Sep 7;28(6):611-613. Epub 2017 Mar 7.

a Institute of Cardiovascular Sciences, College of Medical and Dental Sciences , University of Birmingham , Birmingham , UK.

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http://dx.doi.org/10.1080/09537104.2017.1283011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646180PMC
September 2017

Fibrin and D-dimer bind to monomeric GPVI.

Blood Adv 2017 Aug 15;1(19):1495-1504. Epub 2017 Aug 15.

Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1182/bloodadvances.2017007732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728468PMC
August 2017

Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets.

Arterioscler Thromb Vasc Biol 2017 05 23;37(5):823-835. Epub 2017 Mar 23.

From the Institute of Cardiovascular Sciences, College of Medical and Dental Sciences (C.W.S., S.G.T., Z.R., P.P., M.B., M.L., Y.A.S., S.P.W., A.M.), and Institute of Applied Health Research, College of Medical and Dental Sciences (D.B.), University of Birmingham, United Kingdom; and Laboratory of Translational Immunology, Department of Immunology, University Medical Center Utrecht, the Netherlands (L.M.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309253DOI Listing
May 2017

Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis.

Blood 2017 04 19;129(14):2013-2020. Epub 2017 Jan 19.

Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1182/blood-2016-09-742999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408561PMC
April 2017

Inherited platelet disorders: Insight from platelet genomics using next-generation sequencing.

Platelets 2017 Jan 27;28(1):14-19. Epub 2016 Jun 27.

a Institute of Cardiovascular Sciences, College of Medical and Dental Sciences , University of Birmingham , Birmingham , B15 2TT , UK.

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http://dx.doi.org/10.1080/09537104.2016.1195492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359778PMC
January 2017

Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes.

Arterioscler Thromb Vasc Biol 2017 01 3;37(1):108-117. Epub 2016 Nov 3.

From the Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zurich, Switzerland (R.B., E.R., S.B.B., S.T.P., M.S., N.S., C.H., M.D.); Centre for Cardiovascular Sciences, College of Medical and Dental Sciences (S.P.W.) and Rheumatology Research Group, Institute for Biomedical Research, College of Medical and Dental Sciences (C.D.B.), University of Birmingham, United Kingdom.

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http://dx.doi.org/10.1161/ATVBAHA.116.308020DOI Listing
January 2017

ISTH Advanced Training Course on platelet bleeding disorders: How should they be investigated?.

Platelets 2016 12 14;27(8):719-721. Epub 2016 Nov 14.

a Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham , Birmingham , UK.

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http://dx.doi.org/10.1080/09537104.2016.1256726DOI Listing
December 2016

Platelets: No longer bystanders in liver disease.

Hepatology 2016 11 7;64(5):1774-1784. Epub 2016 Apr 7.

Centre for Liver Research, and NIHR Birmingham Liver Biomedical Research Unit, Institute of Biomedical Research, Birmingham, UK.

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http://dx.doi.org/10.1002/hep.28526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082495PMC
November 2016

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3.

Platelets 2016 Sep 30;27(6):535-40. Epub 2016 Mar 30.

a Institute of Cardiovascular Sciences , College of Medical and Dental Sciences, University of Birmingham , Birmingham , UK.

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http://dx.doi.org/10.3109/09537104.2016.1148129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000871PMC
September 2016

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.

Blood 2016 09 27;128(9):1282-9. Epub 2016 May 27.

Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, Instituto Murciano de Investigaciones Biomédicas-Arrixaca, Murcia, Spain;

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http://dx.doi.org/10.1182/blood-2015-11-683102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009515PMC
September 2016

Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures.

J Immunol 2016 09 29;197(5):1957-67. Epub 2016 Jul 29.

Rheumatology Research Group, Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham B15 2WD, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1500686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991245PMC
September 2016

Fibrin activates GPVI in human and mouse platelets.

Blood 2015 Sep 17;126(13):1601-8. Epub 2015 Aug 17.

Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; and.

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http://dx.doi.org/10.1182/blood-2015-04-641654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582337PMC
September 2015

Platelet GPVI repairs its own damage.

Blood 2015 Aug;126(8):933-4

UNIVERSITY OF BIRMINGHAM.

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http://dx.doi.org/10.1182/blood-2015-06-650838DOI Listing
August 2015

Phosphatidylinositol-3,4,5-trisphosphate stimulates Ca(2+) elevation and Akt phosphorylation to constitute a major mechanism of thromboxane A2 formation in human platelets.

Cell Signal 2015 Jul 19;27(7):1488-98. Epub 2015 Mar 19.

Cardiovascular Division, BHF Centre for Research Excellence, King's College London, Franklin Wilkins Building, Stamford Street, London SE1 9NH, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2015.03.008DOI Listing
July 2015

VPS33B regulates protein sorting into and maturation of α-granule progenitor organelles in mouse megakaryocytes.

Blood 2015 Jul 6;126(2):133-43. Epub 2015 May 6.

Medical Research Council, Laboratory for Molecular Cell Biology, University College London, London, United Kingdom; Inherited Metabolic Diseases, Great Ormond Street Hospital, London, United Kingdom.

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http://dx.doi.org/10.1182/blood-2014-12-614677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497959PMC
July 2015

In vivo evidence for platelet-induced physiological angiogenesis by a COX driven mechanism.

PLoS One 2014 19;9(9):e107503. Epub 2014 Sep 19.

Centre for Cardiovascular Sciences, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107503PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169573PMC
June 2015

Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization.

Blood 2015 Jun 20;125(26):4069-77. Epub 2015 Mar 20.

Department of Experimental Biomedicine, University Hospital of Würzburg and Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany;

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http://www.bloodjournal.org/content/125/26/4069.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-11-61
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http://dx.doi.org/10.1182/blood-2014-11-611905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598192PMC
June 2015

Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development.

Blood 2015 Jun 23;125(24):3769-77. Epub 2015 Apr 23.

Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;

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http://dx.doi.org/10.1182/blood-2014-09-603803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463737PMC
June 2015

Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling.

Thromb Haemost 2015 May 19;113(5):1109-20. Epub 2015 Feb 19.

Steve P. Watson, Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, United Kingdom, Tel.: +44 1214158678; Fax: +44 1214158817, E-mail:

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http://dx.doi.org/10.1160/TH14-09-0762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990172PMC
May 2015

Diversity and impact of rare variants in genes encoding the platelet G protein-coupled receptors.

Thromb Haemost 2015 Apr 8;113(4):826-37. Epub 2015 Jan 8.

Dr. A. D. Mumford, University of Bristol, Level 7 Bristol Royal Infirmary, Bristol, BS2 8HW, United Kingdom, Tel.: +44 117 3423152, Fax: +44 117 3424036, E-mail

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http://dx.doi.org/10.1160/TH14-08-0679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510585PMC
April 2015

Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: haemostasis, platelet activation and antithrombotic therapy.

Biochem Pharmacol 2015 Apr 16;94(3):186-94. Epub 2015 Feb 16.

Centre for Cardiovascular Sciences, Institute for Biomedical Research, The College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.1016/j.bcp.2015.02.004DOI Listing
April 2015

The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.

Blood 2015 Jan 28;125(1):144-54. Epub 2014 Oct 28.

Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom; and.

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http://www.bloodjournal.org/content/early/2014/10/28/blood-2
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http://www.bloodjournal.org/content/125/1/144.full.pdf
Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-05-57
Publisher Site
http://dx.doi.org/10.1182/blood-2014-05-579375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281823PMC
January 2015

Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.

J Biol Chem 2014 Dec 3;289(52):35695-710. Epub 2014 Nov 3.

From the University of Birmingham, Centre for Cardiovascular Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, Edgbaston, Birmingham B15 2TT, United Kingdom,

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http://dx.doi.org/10.1074/jbc.M114.584284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276840PMC
December 2014

CLEC-2 expression is maintained on activated platelets and on platelet microparticles.

Blood 2014 Oct 22;124(14):2262-70. Epub 2014 Aug 22.

Centre for Cardiovascular Sciences, College of Medical and Dental Sciences, National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, and.

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http://dx.doi.org/10.1182/blood-2014-05-572818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183985PMC
October 2014

A novel thromboxane A2 receptor N42S variant results in reduced surface expression and platelet dysfunction.

Thromb Haemost 2014 May 23;111(5):923-32. Epub 2014 Jan 23.

S. J. Mundell, School of Physiology and Pharmacology, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, UK, Tel: +44 (0) 117 3311440, E-mail:

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http://dx.doi.org/10.1160/TH13-08-0672DOI Listing
May 2014

Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4.

Blood 2014 May 18;123(20):3166-74. Epub 2014 Mar 18.

Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;

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http://dx.doi.org/10.1182/blood-2013-11-540526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023422PMC
May 2014

Platelets in lymph vessel development and integrity.

Adv Anat Embryol Cell Biol 2014 ;214:93-105

Centre for Cardiovascular Sciences, The College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK,

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http://dx.doi.org/10.1007/978-3-7091-1646-3_8DOI Listing
April 2014

What is the role of genetic testing in the investigation of patients with suspected platelet function disorders?

Br J Haematol 2014 Apr 30;165(2):193-203. Epub 2014 Jan 30.

Department of Cardiovascular Science, University of Sheffield Medical School, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1111/bjh.12751DOI Listing
April 2014

Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets.

Circ Res 2014 Mar;114(7):1185-203

From the Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom (V.B.O'D.); Department of Pharmacology, University of Colorado at Denver, Aurora (R.C.M.); and Birmingham Platelet Group, Centre for Cardiovascular Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, Birmingham, United Kingdom (S.P.W.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.301597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021279PMC
March 2014

Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets.

Circ Res 2014 Jan 21;114(3):444-453. Epub 2013 Nov 21.

Department of Experimental Biomedicine, University Hospital Würzburg (S.D., T.V., M.M., S.S., B.N.) and Rudolf Virchow Center for Experimental Biomedicine (S.D., T.V., C.M.S., H.M.H., B.N.), University of Würzburg, Würzburg, Germany; Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom (S.K.W., C.E.H., S.P.W.); and Department of Biology, Division of Genetics, University of Erlangen, Erlangen, Germany (J.A.A., D.R., L.N.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.302670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405766PMC
January 2014

Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P).

Blood 2013 Aug 17;122(5):791-802. Epub 2013 Jun 17.

Medizinische Klinik und Poliklinik I, Klinikum der Universität, Ludwig-Maximilians-Universität, Marchioninistrasse 15, Munich, Germany.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-12-47
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http://dx.doi.org/10.1182/blood-2012-12-473884DOI Listing
August 2013

The physiological and pathophysiological roles of platelet CLEC-2.

Thromb Haemost 2013 Jun 28;109(6):991-8. Epub 2013 Mar 28.

Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1160/TH13-01-0060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693086PMC
June 2013

Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice.

Arterioscler Thromb Vasc Biol 2013 May 28;33(5):926-34. Epub 2013 Feb 28.

University Hospital Würzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1161/ATVBAHA.112.300672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485540PMC
May 2013

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.

Blood 2013 May 18;121(20):4205-20. Epub 2013 Mar 18.

Centre for Cardiovascular Sciences, School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, United Kingdom.

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http://dx.doi.org/10.1182/blood-2012-08-449272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656453PMC
May 2013

Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo.

Eur J Cell Biol 2012 Nov-Dec;91(11-12):923-929. Epub 2012 May 31.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD.

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http://dx.doi.org/10.1016/j.ejcb.2012.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930012PMC
March 2013

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane.

Blood 2013 Mar 10;121(13):2542-52. Epub 2013 Jan 10.

University of Glasgow College of Medical, Veterinary and Life Sciences and Beatson Institute for Cancer Research, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1182/blood-2012-07-443457DOI Listing
March 2013

Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2).

J Biol Chem 2013 Mar 22;288(11):7717-26. Epub 2013 Jan 22.

Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1074/jbc.M112.424473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597812PMC
March 2013

Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).

J Biol Chem 2013 Feb 21;288(7):5127-35. Epub 2012 Dec 21.

Centre for Cardiovascular Sciences, Institute for Biomedical Research, The College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.411462
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576117PMC
http://dx.doi.org/10.1074/jbc.M112.411462DOI Listing
February 2013

50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams.

Platelets 2012 18;23(6):415-22. Epub 2011 Nov 18.

Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham , Edgbaston, Birmingham B15 2TT , United Kingdom.

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http://dx.doi.org/10.3109/09537104.2011.632032DOI Listing
December 2012

Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B.

Arterioscler Thromb Vasc Biol 2012 Dec 11;32(12):2956-65. Epub 2012 Oct 11.

Centre for Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1161/ATVBAHA.112.300447DOI Listing
December 2012

In vivo activity of an azole series of CCR2 antagonists.

Bioorg Med Chem Lett 2012 Dec 23;22(23):7252-5. Epub 2012 Sep 23.

GlaxoSmithKline Research and Development, Medicines Research Centre, Stevenage, UK.

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http://dx.doi.org/10.1016/j.bmcl.2012.09.020DOI Listing
December 2012

Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.

Sci Signal 2012 Oct 30;5(248):ra78. Epub 2012 Oct 30.

Centre of Cardiovascular Sciences, Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1126/scisignal.2002936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973664PMC
October 2012