Steve H Thorne

Steve H Thorne

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Steve H Thorne

Steve H Thorne

Publications by authors named "Steve H Thorne"

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Oncolytic Virotherapy and the Tumor Microenvironment.

Adv Exp Med Biol 2017 ;1036:157-172

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/978-3-319-67577-0_11DOI Listing
June 2018

Noninvasive Imaging of Fluorescent Reporters in Small Rodent Models Using Fluorescence Molecular Tomography.

Methods Mol Biol 2016 ;1444:67-72

Department of Radiology, Hillman Cancer Center, University of Pittsburgh, Suite 1.46e, 5117 Centre Avenue, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1007/978-1-4939-3721-9_7DOI Listing
January 2018

Arming viruses in multi-mechanistic oncolytic viral therapy: current research and future developments, with emphasis on poxviruses.

Oncolytic Virother 2014 5;3:1-9. Epub 2013 Dec 5.

Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.2147/OV.S36703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918358PMC
August 2016

Novel therapeutic strategies in human malignancy: combining immunotherapy and oncolytic virotherapy.

Oncolytic Virother 2015 18;4:75-82. Epub 2015 Jun 18.

Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.2147/OV.S54738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918382PMC
August 2016

Oncolytic Virus-Mediated Targeting of PGE2 in the Tumor Alters the Immune Status and Sensitizes Established and Resistant Tumors to Immunotherapy.

Cancer Cell 2016 07 30;30(1):108-119. Epub 2016 Jun 30.

Department of Cell Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Immunology, G17a, Hillman Cancer Center, University of Pittsburgh, 5117 Center Avenue, Pittsburgh, PA 15213, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962335PMC
July 2016

Virus fuels NK cell killing of leukemia.

Authors:
Steve H Thorne

Blood 2016 05;127(21):2509

UNIVERSITY OF PITTSBURGH.

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http://dx.doi.org/10.1182/blood-2016-03-704247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882801PMC
May 2016

Manipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies.

Cell Rep 2016 Apr 31;15(2):264-73. Epub 2016 Mar 31.

Department of Cell Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830920PMC
April 2016

Adding STING to the Tale of Oncolytic Virotherapy.

Authors:
Steve H Thorne

Trends Cancer 2016 Feb;2(2):67-68

University of Pittsburgh, Departments of Cell Biology and Immunology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.trecan.2016.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797336PMC
February 2016

Defining Effective Combinations of Immune Checkpoint Blockade and Oncolytic Virotherapy.

Clin Cancer Res 2015 Dec 17;21(24):5543-51. Epub 2015 Jul 17.

Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania. Department of Immunology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681662PMC
December 2015

In vivo inflammation imaging using a CB2R-targeted near infrared fluorescent probe.

Am J Nucl Med Mol Imaging 2015 15;5(3):246-58. Epub 2015 Feb 15.

Molecular Imaging Laboratory, Department of Radiology, University of Pittsburgh Pittsburgh, PA 15219, USA ; Department of Bioengineering, University of Pittsburgh Pittsburgh, PA 15261, USA ; University of Pittsburgh Cancer Institute Pittsburgh, PA 15232, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446393PMC
June 2015

Immunotherapeutic potential of oncolytic vaccinia virus.

Authors:
Steve H Thorne

Front Oncol 2014 17;4:155. Epub 2014 Jun 17.

Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh , Pittsburgh, PA , USA ; Department of Immunology, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh , Pittsburgh, PA , USA.

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http://journal.frontiersin.org/article/10.3389/fonc.2014.001
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http://dx.doi.org/10.3389/fonc.2014.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060052PMC
July 2014

Giving oncolytic vaccinia virus more BiTE.

Mol Ther 2014 Jan;22(1):6-8

University of Pittsburgh Cancer Institute and Departments of Surgery and Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1038/mt.2013.271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978795PMC
January 2014

The role of GM-CSF in enhancing immunotherapy of cancer.

Authors:
Steve H Thorne

Immunotherapy 2013 Aug;5(8):817-9

University of Pittsburgh Cancer Institute, University of Pittsburgh, 1.46e HCC, 5117 Center Avenue, Pittsburgh, PA 15238, USA.

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https://www.futuremedicine.com/doi/10.2217/imt.13.65
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http://dx.doi.org/10.2217/imt.13.65DOI Listing
August 2013

Expression of CCL19 from oncolytic vaccinia enhances immunotherapeutic potential while maintaining oncolytic activity.

Neoplasia 2012 Dec;14(12):1115-21

Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540938PMC
http://dx.doi.org/10.1593/neo.121272DOI Listing
December 2012

Theranostic potential of oncolytic vaccinia virus.

Theranostics 2012 5;2(4):363-73. Epub 2012 Apr 5.

Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.7150/thno.3724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326721PMC
October 2012

Next-generation oncolytic vaccinia vectors.

Authors:
Steve H Thorne

Methods Mol Biol 2012 ;797:205-15

Department of Surgery and Immunology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/978-1-61779-340-0_14DOI Listing
January 2012

Differential biodistribution of oncolytic poxvirus administered systemically in an autochthonous model of hepatocellular carcinoma.

J Gene Med 2011 Dec;13(12):692-701

INSERM U948, Nantes, France; Centre de Biophysique Moléculaire, CNRS, UPR4301, Univerity of Orléans, France.

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http://dx.doi.org/10.1002/jgm.1624DOI Listing
December 2011

Immunotherapeutic potential of oncolytic vaccinia virus.

Authors:
Steve H Thorne

Immunol Res 2011 Aug;50(2-3):286-93

Department of Surgery and Department of Immunology, University of Pittsburgh Cancer Institute, University of Pittsburgh, 1.46e, Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1007/s12026-011-8211-4DOI Listing
August 2011

Chemokine expression from oncolytic vaccinia virus enhances vaccine therapies of cancer.

Mol Ther 2011 Apr 25;19(4):650-7. Epub 2011 Jan 25.

Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1038/mt.2010.312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070102PMC
April 2011

Variola and monkeypox viruses utilize conserved mechanisms of virion motility and release that depend on abl and SRC family tyrosine kinases.

J Virol 2011 Jan 20;85(1):21-31. Epub 2010 Oct 20.

Microbiology and Molecular Genetics Graduate Program, Emory University School of Medicine, 615 Michael Street, Whitehead Research Building 155, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1128/JVI.01814-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014172PMC
January 2011

Role of nitric oxide in Salmonella typhimurium-mediated cancer cell killing.

BMC Cancer 2010 Apr 17;10:146. Epub 2010 Apr 17.

Department of Microbiology and Immunology, Sherman Fairchild Science Building, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA.

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http://web.stanford.edu/~amatin/MatinLabHomePage/PDF/Nitric%
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http://www.biomedcentral.com/1471-2407/10/146
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http://dx.doi.org/10.1186/1471-2407-10-146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868810PMC
April 2010

Enhancing biological therapy through conditional regulation of protein stability.

Authors:
Steve H Thorne

Expert Rev Mol Med 2010 Jan 12;12:e2. Epub 2010 Jan 12.

Departments of Surgery and Immunology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1017/S1462399409001331DOI Listing
January 2010

The initial phase of an immune response functions to activate regulatory T cells.

J Immunol 2009 Jul;183(1):332-9

Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA.

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http://dx.doi.org/10.4049/jimmunol.0900691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753472PMC
July 2009

Design and testing of novel oncolytic vaccinia strains.

Authors:
Steve H Thorne

Methods Mol Biol 2009 ;542:635-47

Division of Surgical Oncology, University of Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/978-1-59745-561-9_32DOI Listing
July 2009

A general method for conditional regulation of protein stability in living animals.

Cold Spring Harb Protoc 2009 Mar;2009(3):pdb.prot5173

Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1101/pdb.prot5173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215584PMC
March 2009

CNOB/ChrR6, a new prodrug enzyme cancer chemotherapy.

Mol Cancer Ther 2009 Feb 3;8(2):333-41. Epub 2009 Feb 3.

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670992PMC
February 2009

Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer.

Nat Rev Cancer 2009 Jan;9(1):64-71

Jennerex Biotherapeutics Inc., San Francisco, California 94105, USA .

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http://www.nature.com/articles/nrc2545
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http://dx.doi.org/10.1038/nrc2545DOI Listing
January 2009

Chemical control of protein stability and function in living mice.

Nat Med 2008 Oct 28;14(10):1123-7. Epub 2008 Sep 28.

Department of Chemistry, Radiology and Microbiology & Immunology, Stanford University, 318 Campus Drive, Stanford, California 94305, USA.

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http://www.nature.com/articles/nm.1754
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http://dx.doi.org/10.1038/nm.1754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605277PMC
October 2008

Oncolytic vaccinia virus: from bedside to benchtop and back.

Authors:
Steve H Thorne

Curr Opin Mol Ther 2008 Aug;10(4):387-92

University of Pittsburgh Cancer Institute and Division of Surgical Oncology, Hillman Cancer Center, 5150 Centre Avenue, University of Pittsburgh, Pittsburgh, PA 15232, USA.

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August 2008

Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters.

Proc Natl Acad Sci U S A 2008 Aug 19;105(34):12128-33. Epub 2008 Aug 19.

Department of Chemistry and Chemical and Systems Biology, Stanford University, Stanford, CA 94305-5080, USA.

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http://dx.doi.org/10.1073/pnas.0805374105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527877PMC
August 2008

Targeting of interferon-beta to produce a specific, multi-mechanistic oncolytic vaccinia virus.

PLoS Med 2007 Dec;4(12):e353

Jennerex Biotherapeutics, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.0040353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222946PMC
December 2007

Strategies to achieve systemic delivery of therapeutic cells and microbes to tumors.

Authors:
Steve H Thorne

Expert Opin Biol Ther 2007 Jan;7(1):41-51

Stanford University, Bio-X Programme and Department of Pediatrics, Clark Center, California 94305, USA.

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http://dx.doi.org/10.1517/14712598.7.1.41DOI Listing
January 2007

Enhanced killing of primary ovarian cancer by retargeting autologous cytokine-induced killer cells with bispecific antibodies: a preclinical study.

Clin Cancer Res 2006 Mar;12(6):1859-67

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford Cancer Center, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-2019DOI Listing
March 2006

Synergistic antitumor effects of immune cell-viral biotherapy.

Science 2006 Mar;311(5768):1780-4

Departments of Pediatrics, Radiology, Microbiology, and Immunology Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/science.1121411DOI Listing
March 2006

Future directions for the field of oncolytic virotherapy: a perspective on the use of vaccinia virus.

Expert Opin Biol Ther 2004 Aug;4(8):1307-21

Bio-X Program, Dept of Pediatrics, School of Medicine, Stanford University, CA, USA.

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http://dx.doi.org/10.1517/14712598.4.8.1307DOI Listing
August 2004