Publications by authors named "Steve Goldstein"

62Publications

TOK channels use the two gates in classical K channels to achieve outward rectification.

FASEB J 2020 Jul 10;34(7):8902-8919. Epub 2020 Jun 10.

Departments of Physiology & Biophysics and Pediatrics, School of Medicine, Samueli College of Health Sciences, University of California, Irvine, Irvine, CA, USA.

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July 2020

Fibroblast Growth Factor Receptors as Targets for Radiosensitization in Head and Neck Squamous Cell Carcinomas.

Int J Radiat Oncol Biol Phys 2020 Jul 13;107(4):793-803. Epub 2020 Apr 13.

Department of Human Oncology, University of Wisconsin Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin. Electronic address:

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July 2020

Tethered peptide neurotoxins display two blocking mechanisms in the K channel pore as do their untethered analogs.

Sci Adv 2020 03 4;6(10):eaaz3439. Epub 2020 Mar 4.

Departments of Pediatrics and Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA.

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March 2020

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of Na1.5 Channels.

Cell Rep 2020 02;30(7):2225-2236.e4

Departments of Pediatrics and Physiology & Biophysics, University of California, Irvine, 1001 Health Sciences Road, Irvine Hall, Irvine, CA 92697, USA. Electronic address:

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February 2020

Archaeological assessment reveals Earth's early transformation through land use.

Authors:
Lucas Stephens Dorian Fuller Nicole Boivin Torben Rick Nicolas Gauthier Andrea Kay Ben Marwick Chelsey Geralda Armstrong C Michael Barton Tim Denham Kristina Douglass Jonathan Driver Lisa Janz Patrick Roberts J Daniel Rogers Heather Thakar Mark Altaweel Amber L Johnson Maria Marta Sampietro Vattuone Mark Aldenderfer Sonia Archila Gilberto Artioli Martin T Bale Timothy Beach Ferran Borrell Todd Braje Philip I Buckland Nayeli Guadalupe Jiménez Cano José M Capriles Agustín Diez Castillo Çiler Çilingiroğlu Michelle Negus Cleary James Conolly Peter R Coutros R Alan Covey Mauro Cremaschi Alison Crowther Lindsay Der Savino di Lernia John F Doershuk William E Doolittle Kevin J Edwards Jon M Erlandson Damian Evans Andrew Fairbairn Patrick Faulkner Gary Feinman Ricardo Fernandes Scott M Fitzpatrick Ralph Fyfe Elena Garcea Steve Goldstein Reed Charles Goodman Jade Dalpoim Guedes Jason Herrmann Peter Hiscock Peter Hommel K Ann Horsburgh Carrie Hritz John W Ives Aripekka Junno Jennifer G Kahn Brett Kaufman Catherine Kearns Tristram R Kidder François Lanoë Dan Lawrence Gyoung-Ah Lee Maureece J Levin Henrik B Lindskoug José Antonio López-Sáez Scott Macrae Rob Marchant John M Marston Sarah McClure Mark D McCoy Alicia Ventresca Miller Michael Morrison Giedre Motuzaite Matuzeviciute Johannes Müller Ayushi Nayak Sofwan Noerwidi Tanya M Peres Christian E Peterson Lucas Proctor Asa R Randall Steve Renette Gwen Robbins Schug Krysta Ryzewski Rakesh Saini Vivian Scheinsohn Peter Schmidt Pauline Sebillaud Oula Seitsonen Ian A Simpson Arkadiusz Sołtysiak Robert J Speakman Robert N Spengler Martina L Steffen Michael J Storozum Keir M Strickland Jessica Thompson T L Thurston Sean Ulm M Cemre Ustunkaya Martin H Welker Catherine West Patrick Ryan Williams David K Wright Nathan Wright Muhammad Zahir Andrea Zerboni Ella Beaudoin Santiago Munevar Garcia Jeremy Powell Alexa Thornton Jed O Kaplan Marie-José Gaillard Kees Klein Goldewijk Erle Ellis

Science 2019 08;365(6456):897-902

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August 2019

Bunyavirus requirement for endosomal K+ reveals new roles of cellular ion channels during infection.

PLoS Pathog 2018 01 19;14(1):e1006845. Epub 2018 Jan 19.

School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom.

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January 2018

SUMOylation determines the voltage required to activate cardiac channels.

Proc Natl Acad Sci U S A 2017 08 25;114(32):E6686-E6694. Epub 2017 Jul 25.

Department of Biochemistry, Brandeis University, Waltham, MA 02453;

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August 2017

Hox11 Function Is Required for Region-Specific Fracture Repair.

J Bone Miner Res 2017 Aug 28;32(8):1750-1760. Epub 2017 Jun 28.

Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.

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August 2017

Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme.

EMBO Mol Med 2017 04;9(4):399-402

Department of Biochemistry, Brandeis University, Waltham, MA, USA.

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April 2017

SUMOylation of Na1.2 channels mediates the early response to acute hypoxia in central neurons.

Elife 2016 12 28;5. Epub 2016 Dec 28.

Department of Biochemistry, Brandeis University, Waltham, United States.

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December 2016

Regionally Restricted Hox Function in Adult Bone Marrow Multipotent Mesenchymal Stem/Stromal Cells.

Dev Cell 2016 12 8;39(6):653-666. Epub 2016 Dec 8.

Department of Cell and Developmental Biology, University of Michigan Medical Center, University of Michigan, 109 Zina Pitcher, 2053 BSRB, Ann Arbor, MI 48109-2200, USA; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109-2200, USA; Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-2200, USA. Electronic address:

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December 2016

Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display.

Proc Natl Acad Sci U S A 2015 Dec 1;112(50):E7013-21. Epub 2015 Dec 1.

Department of Biochemistry, Brandeis University, Waltham, MA 02453;

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December 2015

Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice.

FASEB J 2016 Jan 23;30(1):360-9. Epub 2015 Sep 23.

*Bioelectricity Laboratory, Department of Pharmacology and Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, California, USA; Department of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China; Section of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois, USA; and Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA

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January 2016

A clone-free, single molecule map of the domestic cow (Bos taurus) genome.

BMC Genomics 2015 Aug 28;16:644. Epub 2015 Aug 28.

Laboratory for Molecular and Computational Genomics, Department of Chemistry, Laboratory of Genetics, and the UW Biotechnology Center, University of Wisconsin-Madison, 425 Henry Mall, Madison, WI, 53706, USA.

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August 2015

Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits.

Proc Natl Acad Sci U S A 2014 Apr 3;111(14):E1438-46. Epub 2014 Mar 3.

Department of Biochemistry, Brandeis University, Waltham, MA, 02453.

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April 2014

Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species.

Gigascience 2013 Jul 22;2(1):10. Epub 2013 Jul 22.

Genome Center, UC, Davis, CA 95616, USA.

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July 2013

Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: a periodic paralysis mutation in Na(V)1.4 (L689I).

J Gen Physiol 2013 Mar 11;141(3):323-34. Epub 2013 Feb 11.

Department of Biochemistry, Brandeis University, Waltham, MA 02453, USA.

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March 2013

Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: wild-type skeletal muscle Na(V)1.4.

J Gen Physiol 2013 Mar 11;141(3):309-21. Epub 2013 Feb 11.

Department of Biochemistry, Brandeis University, Waltham, MA 02453, USA.

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March 2013

SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.

Sci Signal 2012 Nov 20;5(251):ra84. Epub 2012 Nov 20.

Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.

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November 2012

Recombination modulates how selection affects linked sites in Drosophila.

PLoS Biol 2012 13;10(11):e1001422. Epub 2012 Nov 13.

Biology Department, Duke University, Durham, North Carolina, United States of America.

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April 2013

AGORA: Assembly Guided by Optical Restriction Alignment.

BMC Bioinformatics 2012 Aug 2;13:189. Epub 2012 Aug 2.

Center for Bioinformatics and Computational Biology, University of Maryland-College Park, College Park, MD, USA.

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August 2012

Statistical significance of optical map alignments.

J Comput Biol 2012 May 16;19(5):478-92. Epub 2012 Apr 16.

Theoretical Statistics and Mathematics Unit, Indian Statistical Institute, New Delhi, India.

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May 2012

K2P potassium channels, mysterious and paradoxically exciting.

Sci Signal 2011 Jul 26;4(184):pe35. Epub 2011 Jul 26.

Department of Pediatrics and Institute for Molecular Pediatric Sciences, University of Chicago, Chicago, IL 60615, USA.

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July 2011

SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons.

J Gen Physiol 2011 May;137(5):441-54

Department of Pediatrics and Institute for Molecular Pediatric Sciences, Biological Sciences Division, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.

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May 2011

The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.

J Physiol 2010 Jul 24;588(Pt 14):2657-68. Epub 2010 May 24.

Department of Medicine, Biological Sciences Division, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.

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July 2010

One SUMO is sufficient to silence the dimeric potassium channel K2P1.

Proc Natl Acad Sci U S A 2010 Jun 24;107(23):10743-8. Epub 2010 May 24.

Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA.

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June 2010

A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.

Proc Natl Acad Sci U S A 2009 Dec 10;106(52):22211-6. Epub 2009 Dec 10.

Department of Pediatrics and Institute of Molecular Pediatric Sciences, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.

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December 2009

A single molecule scaffold for the maize genome.

PLoS Genet 2009 Nov 20;5(11):e1000711. Epub 2009 Nov 20.

Laboratory for Molecular and Computational Genomics, Department of Chemistry, Laboratory of Genetics, UW Biotechnology Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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November 2009

A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics.

J Gen Physiol 2009 Jul;134(1):53-68

Institute for Molecular Pediatric Sciences, Department of Pediatrics, The University of Chicago, Pritzker School of Medicine, Chicago, IL 60637, USA.

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July 2009

Pentameric assembly of potassium channel tetramerization domain-containing protein 5.

J Mol Biol 2009 Mar 23;387(1):175-91. Epub 2009 Jan 23.

Department of Pediatrics and Institute of Molecular Pediatric Sciences, University of Chicago, Chicago, IL 60637, USA.

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March 2009

Optical mapping discerns genome wide DNA methylation profiles.

BMC Mol Biol 2008 Jul 30;9:68. Epub 2008 Jul 30.

Department of Chemistry, Laboratory for Molecular and Computational Genomics, University of Wisconsin Biotechnology Center, University of Wisconsin-Madison, Madison, WI 53706, USA.

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July 2008

Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium.

Neuron 2008 Jun;58(6):859-70

Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, University of Chicago, 5721 South Maryland Avenue, Chicago, IL 60637, USA.

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June 2008

MiRP3 acts as an accessory subunit with the BK potassium channel.

Am J Physiol Renal Physiol 2008 Aug 7;295(2):F380-7. Epub 2008 May 7.

Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, Illinois, USA.

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August 2008

I SA channel complexes include four subunits each of DPP6 and Kv4.2.

J Biol Chem 2008 May 25;283(22):15072-7. Epub 2008 Mar 25.

Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL 60637, USA.

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May 2008

Forward Transport of K2p3.1: mediation by 14-3-3 and COPI, modulation by p11.

Traffic 2008 Jan 24;9(1):72-8. Epub 2007 Oct 24.

The Faculty of Life Sciences, The University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.

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January 2008

Validation of rice genome sequence by optical mapping.

BMC Genomics 2007 Aug 15;8:278. Epub 2007 Aug 15.

Laboratory for Molecular and Computational Genomics, University of Wisconsin-Madison, UW Biotechnology Centre, 425 Henry Mall, Madison, Wisconsin 53706, USA.

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August 2007

Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus.

Biophys J 2007 Oct 1;93(7):2332-40. Epub 2007 Jun 1.

The Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA.

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October 2007

A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y.

J Clin Invest 2006 Feb;116(2):430-5

Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, Biological Sciences Division, University of Chicago, Chicago, Illinois 60637, USA.

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February 2006

Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis.

FASEB J 2006 Feb;20(2):293-301

Greenberg Division of Cardiology, Department of Medicine and Department of Pharmacology, Cornell University, Weill Medical College, New York, New York, USA.

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February 2006

International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.

Pharmacol Rev 2005 Dec;57(4):527-40

Department of Pediatrics and Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA.

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December 2005

Whole-genome shotgun optical mapping of Rhodospirillum rubrum.

Appl Environ Microbiol 2005 Sep;71(9):5511-22

Laboratory for Molecular and Computational Genomics, University of Wisconsin-Madison, UW-Biotechnology Center, 425 Henry Mall, Madison, WI 53706, USA.

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September 2005

K2P channels and their protein partners.

Curr Opin Neurobiol 2005 Jun;15(3):326-33

Department of Pediatrics and Institute for Molecular Pediatric Sciences, University of Chicago, Pritzker School of Medicine, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.

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June 2005

Sumoylation silences the plasma membrane leak K+ channel K2P1.

Cell 2005 Apr;121(1):37-47

Department of Pediatrics, Institute for Molecular Pediatric Sciences, Pritzker School of Medicine, University of Chicago, 5721 South Maryland Avenue, Chicago, Illinois 60637, USA.

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April 2005

A microfluidic system for large DNA molecule arrays.

Anal Chem 2004 Sep;76(18):5293-301

Laboratory for Molecular and Computational Genomics, Department of Chemistry, and Laboratory of Genetics, University of Wisconsin-Madison, 425 Henry Mall, Madison, Wisconsin 53706, USA.

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September 2004

Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution.

Neuron 2004 Feb;41(4):513-9

Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06535, USA.

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February 2004

Segment-specific expression of 2P domain potassium channel genes in human nephron.

Kidney Int 2004 Mar;65(3):918-26

Department of Pediatrics, Yale University, School of Medicine, New Haven, Connecticut, USA.

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March 2004

Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2.

J Biol Chem 2004 Feb 17;279(7):5549-54. Epub 2003 Nov 17.

Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.

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February 2004

Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex.

Neuron 2003 Sep;40(1):15-23

Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.

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September 2003

Pore- and state-dependent cadmium block of I(Ks) channels formed with MinK-55C and wild-type KCNQ1 subunits.

Biophys J 2003 Jun;84(6):3679-89

Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

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June 2003

Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel.

Nat Neurosci 2003 Apr;6(4):353-61

Department of Pediatrics, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06536, USA.

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April 2003

Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals.

Cell 2002 Nov;111(4):577-88

Yale University School of Medicine, Department of Pediatrics, Department of Cellular and Molecular Physiology, Boyer Center for Molecular Medicine, New Haven, CT 06536, USA.

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November 2002

Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism.

FASEB J 2002 Mar;16(3):390-400

Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 USA.

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March 2002