Steve Franks

Steve Franks

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Steve Franks

Steve Franks

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Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

Authors:
Praveen Surendran Fotios Drenos Robin Young Helen Warren James P Cook Alisa K Manning Niels Grarup Xueling Sim Daniel R Barnes Kate Witkowska James R Staley Vinicius Tragante Taru Tukiainen Hanieh Yaghootkar Nicholas Masca Daniel F Freitag Teresa Ferreira Olga Giannakopoulou Andrew Tinker Magdalena Harakalova Evelin Mihailov Chunyu Liu Aldi T Kraja Sune Fallgaard Nielsen Asif Rasheed Maria Samuel Wei Zhao Lori L Bonnycastle Anne U Jackson Narisu Narisu Amy J Swift Lorraine Southam Jonathan Marten Jeroen R Huyghe Alena Stančáková Cristiano Fava Therese Ohlsson Angela Matchan Kathleen E Stirrups Jette Bork-Jensen Anette P Gjesing Jukka Kontto Markus Perola Susan Shaw-Hawkins Aki S Havulinna He Zhang Louise A Donnelly Christopher J Groves N William Rayner Matt J Neville Neil R Robertson Andrianos M Yiorkas Karl-Heinz Herzig Eero Kajantie Weihua Zhang Sara M Willems Lars Lannfelt Giovanni Malerba Nicole Soranzo Elisabetta Trabetti Niek Verweij Evangelos Evangelou Alireza Moayyeri Anne-Claire Vergnaud Christopher P Nelson Alaitz Poveda Tibor V Varga Muriel Caslake Anton Jm de Craen Stella Trompet Jian'an Luan Robert A Scott Sarah E Harris David Cm Liewald Riccardo Marioni Cristina Menni Aliki-Eleni Farmaki Göran Hallmans Frida Renström Jennifer E Huffman Maija Hassinen Stephen Burgess Ramachandran S Vasan Janine F Felix Maria Uria-Nickelsen Anders Malarstig Dermot F Reily Maarten Hoek Thomas Vogt Honghuang Lin Wolfgang Lieb Matthew Traylor Hugh F Markus Heather M Highland Anne E Justice Eirini Marouli Jaana Lindström Matti Uusitupa Pirjo Komulainen Timo A Lakka Rainer Rauramaa Ozren Polasek Igor Rudan Olov Rolandsson Paul W Franks George Dedoussis Timothy D Spector Pekka Jousilahti Satu Männistö Ian J Deary John M Starr Claudia Langenberg Nick J Wareham Morris J Brown Anna F Dominiczak John M Connell J Wouter Jukema Naveed Sattar Ian Ford Chris J Packard Tõnu Esko Reedik Mägi Andres Metspalu Rudolf A de Boer Peter van der Meer Pim van der Harst Giovanni Gambaro Erik Ingelsson Lars Lind Paul Iw de Bakker Mattijs E Numans Ivan Brandslund Cramer Christensen Eva Rb Petersen Eeva Korpi-Hyövälti Heikki Oksa John C Chambers Jaspal S Kooner Alexandra If Blakemore Steve Franks Marjo-Riitta Jarvelin Lise L Husemoen Allan Linneberg Tea Skaaby Betina Thuesen Fredrik Karpe Jaakko Tuomilehto Alex Sf Doney Andrew D Morris Colin Na Palmer Oddgeir Lingaas Holmen Kristian Hveem Cristen J Willer Tiinamaija Tuomi Leif Groop AnneMari Käräjämäki Aarno Palotie Samuli Ripatti Veikko Salomaa Dewan S Alam Abdulla Al Shafi Majumder Emanuele Di Angelantonio Rajiv Chowdhury Mark I McCarthy Neil Poulter Alice V Stanton Peter Sever Philippe Amouyel Dominique Arveiler Stefan Blankenberg Jean Ferrières Frank Kee Kari Kuulasmaa Martina Müller-Nurasyid Giovanni Veronesi Jarmo Virtamo Panos Deloukas Paul Elliott Eleftheria Zeggini Sekar Kathiresan Olle Melander Johanna Kuusisto Markku Laakso Sandosh Padmanabhan David Porteous Caroline Hayward Generation Scotland Francis S Collins Karen L Mohlke Torben Hansen Oluf Pedersen Michael Boehnke Heather M Stringham Philippe Frossard Christopher Newton-Cheh Martin D Tobin Børge Grønne Nordestgaard Mark J Caulfield Anubha Mahajan Andrew P Morris Maciej Tomaszewski Nilesh J Samani Danish Saleheen Folkert W Asselbergs Cecilia M Lindgren John Danesh Louise V Wain Adam S Butterworth Joanna Mm Howson Patricia B Munroe

Nat Genet 2016 10 12;48(10):1151-1161. Epub 2016 Sep 12.

Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056636PMC
http://dx.doi.org/10.1038/ng.3654DOI Listing
October 2016

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

Authors:
Janine F Felix Jonathan P Bradfield Claire Monnereau Ralf J P van der Valk Evie Stergiakouli Alessandra Chesi Romy Gaillard Bjarke Feenstra Elisabeth Thiering Eskil Kreiner-Møller Anubha Mahajan Niina Pitkänen Raimo Joro Alana Cavadino Ville Huikari Steve Franks Maria M Groen-Blokhuis Diana L Cousminer Julie A Marsh Terho Lehtimäki John A Curtin Jesus Vioque Tarunveer S Ahluwalia Ronny Myhre Thomas S Price Natalia Vilor-Tejedor Loïc Yengo Niels Grarup Ioanna Ntalla Wei Ang Mustafa Atalay Hans Bisgaard Alexandra I Blakemore Amelie Bonnefond Lisbeth Carstensen Johan Eriksson Claudia Flexeder Lude Franke Frank Geller Mandy Geserick Anna-Liisa Hartikainen Claire M A Haworth Joel N Hirschhorn Albert Hofman Jens-Christian Holm Momoko Horikoshi Jouke Jan Hottenga Jinyan Huang Haja N Kadarmideen Mika Kähönen Wieland Kiess Hanna-Maaria Lakka Timo A Lakka Alexandra M Lewin Liming Liang Leo-Pekka Lyytikäinen Baoshan Ma Per Magnus Shana E McCormack George McMahon Frank D Mentch Christel M Middeldorp Clare S Murray Katja Pahkala Tune H Pers Roland Pfäffle Dirkje S Postma Christine Power Angela Simpson Verena Sengpiel Carla M T Tiesler Maties Torrent André G Uitterlinden Joyce B van Meurs Rebecca Vinding Johannes Waage Jane Wardle Eleftheria Zeggini Babette S Zemel George V Dedoussis Oluf Pedersen Philippe Froguel Jordi Sunyer Robert Plomin Bo Jacobsson Torben Hansen Juan R Gonzalez Adnan Custovic Olli T Raitakari Craig E Pennell Elisabeth Widén Dorret I Boomsma Gerard H Koppelman Sylvain Sebert Marjo-Riitta Järvelin Elina Hyppönen Mark I McCarthy Virpi Lindi Niinikoski Harri Antje Körner Klaus Bønnelykke Joachim Heinrich Mads Melbye Fernando Rivadeneira Hakon Hakonarson Susan M Ring George Davey Smith Thorkild I A Sørensen Nicholas J Timpson Struan F A Grant Vincent W V Jaddoe

Hum Mol Genet 2016 Jan 24;25(2):389-403. Epub 2015 Nov 24.

The Generation R Study Group, Department of Pediatrics, Department of Epidemiology.

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http://hmg.oxfordjournals.org/content/early/2015/12/16/hmg.d
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http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
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http://dx.doi.org/10.1093/hmg/ddv472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854022PMC
January 2016

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

Authors:
Norihiro Kato Marie Loh Fumihiko Takeuchi Niek Verweij Xu Wang Weihua Zhang Tanika N Kelly Danish Saleheen Benjamin Lehne Irene Mateo Leach Alexander W Drong James Abbott Simone Wahl Sian-Tsung Tan William R Scott Gianluca Campanella Marc Chadeau-Hyam Uzma Afzal Tarunveer S Ahluwalia Marc Jan Bonder Peng Chen Abbas Dehghan Todd L Edwards Tõnu Esko Min Jin Go Sarah E Harris Jaana Hartiala Silva Kasela Anuradhani Kasturiratne Chiea-Chuen Khor Marcus E Kleber Huaixing Li Zuan Yu Mok Masahiro Nakatochi Nur Sabrina Sapari Richa Saxena Alexandre F R Stewart Lisette Stolk Yasuharu Tabara Ai Ling Teh Ying Wu Jer-Yuarn Wu Yi Zhang Imke Aits Alexessander Da Silva Couto Alves Shikta Das Rajkumar Dorajoo Jemma C Hopewell Yun Kyoung Kim Robert W Koivula Jian'an Luan Leo-Pekka Lyytikäinen Quang N Nguyen Mark A Pereira Iris Postmus Olli T Raitakari Molly Scannell Bryan Robert A Scott Rossella Sorice Vinicius Tragante Michela Traglia Jon White Ken Yamamoto Yonghong Zhang Linda S Adair Alauddin Ahmed Koichi Akiyama Rasheed Asif Tin Aung Inês Barroso Andrew Bjonnes Timothy R Braun Hui Cai Li-Ching Chang Chien-Hsiun Chen Ching-Yu Cheng Yap-Seng Chong Rory Collins Regina Courtney Gail Davies Graciela Delgado Loi D Do Pieter A Doevendans Ron T Gansevoort Yu-Tang Gao Tanja B Grammer Niels Grarup Jagvir Grewal Dongfeng Gu Gurpreet S Wander Anna-Liisa Hartikainen Stanley L Hazen Jing He Chew-Kiat Heng James E Hixson Albert Hofman Chris Hsu Wei Huang Lise L N Husemoen Joo-Yeon Hwang Sahoko Ichihara Michiya Igase Masato Isono Johanne M Justesen Tomohiro Katsuya Muhammad G Kibriya Young Jin Kim Miyako Kishimoto Woon-Puay Koh Katsuhiko Kohara Meena Kumari Kenneth Kwek Nanette R Lee Jeannette Lee Jiemin Liao Wolfgang Lieb David C M Liewald Tatsuaki Matsubara Yumi Matsushita Thomas Meitinger Evelin Mihailov Lili Milani Rebecca Mills Nina Mononen Martina Müller-Nurasyid Toru Nabika Eitaro Nakashima Hong Kiat Ng Kjell Nikus Teresa Nutile Takayoshi Ohkubo Keizo Ohnaka Sarah Parish Lavinia Paternoster Hao Peng Annette Peters Son T Pham Mohitha J Pinidiyapathirage Mahfuzar Rahman Hiromi Rakugi Olov Rolandsson Michelle Ann Rozario Daniela Ruggiero Cinzia F Sala Ralhan Sarju Kazuro Shimokawa Harold Snieder Thomas Sparsø Wilko Spiering John M Starr David J Stott Daniel O Stram Takao Sugiyama Silke Szymczak W H Wilson Tang Lin Tong Stella Trompet Väinö Turjanmaa Hirotsugu Ueshima André G Uitterlinden Satoshi Umemura Marja Vaarasmaki Rob M van Dam Wiek H van Gilst Dirk J van Veldhuisen Jorma S Viikari Melanie Waldenberger Yiqin Wang Aili Wang Rory Wilson Tien-Yin Wong Yong-Bing Xiang Shuhei Yamaguchi Xingwang Ye Robin D Young Terri L Young Jian-Min Yuan Xueya Zhou Folkert W Asselbergs Marina Ciullo Robert Clarke Panos Deloukas Andre Franke Paul W Franks Steve Franks Yechiel Friedlander Myron D Gross Zhirong Guo Torben Hansen Marjo-Riitta Jarvelin Torben Jørgensen J Wouter Jukema Mika Kähönen Hiroshi Kajio Mika Kivimaki Jong-Young Lee Terho Lehtimäki Allan Linneberg Tetsuro Miki Oluf Pedersen Nilesh J Samani Thorkild I A Sørensen Ryoichi Takayanagi Daniela Toniolo Habibul Ahsan Hooman Allayee Yuan-Tsong Chen John Danesh Ian J Deary Oscar H Franco Lude Franke Bastiaan T Heijman Joanna D Holbrook Aaron Isaacs Bong-Jo Kim Xu Lin Jianjun Liu Winfried März Andres Metspalu Karen L Mohlke Dharambir K Sanghera Xiao-Ou Shu Joyce B J van Meurs Eranga Vithana Ananda R Wickremasinghe Cisca Wijmenga Bruce H W Wolffenbuttel Mitsuhiro Yokota Wei Zheng Dingliang Zhu Paolo Vineis Soterios A Kyrtopoulos Jos C S Kleinjans Mark I McCarthy Richie Soong Christian Gieger James Scott Yik-Ying Teo Jiang He Paul Elliott E Shyong Tai Pim van der Harst Jaspal S Kooner John C Chambers

Nat Genet 2015 11 21;47(11):1282-1293. Epub 2015 Sep 21.

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/ng.3405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719169PMC
November 2015

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.

Authors:
Andrea D Coviello Robin Haring Melissa Wellons Dhananjay Vaidya Terho Lehtimäki Sarah Keildson Kathryn L Lunetta Chunyan He Myriam Fornage Vasiliki Lagou Massimo Mangino N Charlotte Onland-Moret Brian Chen Joel Eriksson Melissa Garcia Yong Mei Liu Annemarie Koster Kurt Lohman Leo-Pekka Lyytikäinen Ann-Kristin Petersen Jennifer Prescott Lisette Stolk Liesbeth Vandenput Andrew R Wood Wei Vivian Zhuang Aimo Ruokonen Anna-Liisa Hartikainen Anneli Pouta Stefania Bandinelli Reiner Biffar Georg Brabant David G Cox Yuhui Chen Steven Cummings Luigi Ferrucci Marc J Gunter Susan E Hankinson Hannu Martikainen Albert Hofman Georg Homuth Thomas Illig John-Olov Jansson Andrew D Johnson David Karasik Magnus Karlsson Johannes Kettunen Douglas P Kiel Peter Kraft Jingmin Liu Östen Ljunggren Mattias Lorentzon Marcello Maggio Marcello R P Markus Dan Mellström Iva Miljkovic Daniel Mirel Sarah Nelson Laure Morin Papunen Petra H M Peeters Inga Prokopenko Leslie Raffel Martin Reincke Alex P Reiner Kathryn Rexrode Fernando Rivadeneira Stephen M Schwartz David Siscovick Nicole Soranzo Doris Stöckl Shelley Tworoger André G Uitterlinden Carla H van Gils Ramachandran S Vasan H-Erich Wichmann Guangju Zhai Shalender Bhasin Martin Bidlingmaier Stephen J Chanock Immaculata De Vivo Tamara B Harris David J Hunter Mika Kähönen Simin Liu Pamela Ouyang Tim D Spector Yvonne T van der Schouw Jorma Viikari Henri Wallaschofski Mark I McCarthy Timothy M Frayling Anna Murray Steve Franks Marjo-Riitta Järvelin Frank H de Jong Olli Raitakari Alexander Teumer Claes Ohlsson Joanne M Murabito John R B Perry

PLoS Genet 2012 19;8(7):e1002805. Epub 2012 Jul 19.

Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400553PMC
January 2013

Variants implicated in cortisone reductase deficiency do not contribute to susceptibility to common forms of polycystic ovary syndrome.

Clin Endocrinol (Oxf) 2006 Jul;65(1):64-70

Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, UK.

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http://doi.wiley.com/10.1111/j.1365-2265.2006.02547.x
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http://dx.doi.org/10.1111/j.1365-2265.2006.02547.xDOI Listing
July 2006

A steroid cell tumor outside the ovary is a rare cause of virilization.

Fertil Steril 2006 Jan;85(1):227

Department of Investigative Endocrinology, St Vincent's University Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.fertnstert.2005.06.055DOI Listing
January 2006

Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome.

J Clin Endocrinol Metab 2002 Jun;87(6):2606-10

Complex Traits Analysis Group, Department of Medicine, Imperial College Genetics and Genomics Research Institute, Imperial College School of Medicine, London W12 0NN, UK.

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http://dx.doi.org/10.1210/jcem.87.6.8608DOI Listing
June 2002