Publications by authors named "Steve Eyre"

49Publications

Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31.

BMC Biol 2020 05 4;18(1):47. Epub 2020 May 4.

Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s12915-020-00779-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199343PMC
May 2020

Genetic susceptibility to rheumatoid arthritis and its implications for novel drug discovery.

Expert Opin Drug Discov 2016 Aug 7;11(8):805-13. Epub 2016 Jun 7.

a Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre , The University of Manchester , Manchester , UK.

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http://dx.doi.org/10.1080/17460441.2016.1195366DOI Listing
August 2016

Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci.

Nat Commun 2015 Nov 30;6:10069. Epub 2015 Nov 30.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1038/ncomms10069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674669PMC
November 2015

Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: a Mendelian randomisation study.

Ann Rheum Dis 2016 Jan 17;75(1):317-20. Epub 2015 Sep 17.

Faculty of Medical and Human Sciences, Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2014-207210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717396PMC
January 2016

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls.

Nat Genet 2015 Jul 8;47(7):839-46. Epub 2015 Jun 8.

1] JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. [2] Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754941PMC
July 2015

TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

PLoS One 2015 7;10(4):e0122271. Epub 2015 Apr 7.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122271PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388675PMC
March 2016

Rare variants and autoimmune disease.

Brief Funct Genomics 2014 Sep 9;13(5):392-7. Epub 2014 May 9.

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http://dx.doi.org/10.1093/bfgp/elu011DOI Listing
September 2014

Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.

Am J Hum Genet 2014 Apr 20;94(4):522-32. Epub 2014 Mar 20.

Division of Genetics, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Partners HealthCare Center for Personalized Genetic Medicine, Boston, MA 02115, USA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA; Arthritis Research UK Epidemiology Unit, Musculoskeletal Research Group, University of Manchester, Manchester Academic Health Sciences Centre, Manchester M13 9PT, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297140007
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http://dx.doi.org/10.1016/j.ajhg.2014.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980428PMC
April 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Nature 2014 Feb 25;506(7488):376-81. Epub 2013 Dec 25.

1] Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature12873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098PMC
February 2014

Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach.

Ann Rheum Dis 2014 May 9;73(5):938-40. Epub 2013 Dec 9.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, , Manchester, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2013-20444
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http://dx.doi.org/10.1136/annrheumdis-2013-204443DOI Listing
May 2014

A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk.

Ann Rheum Dis 2015 Jan 3;74(1):170-6. Epub 2013 Oct 3.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2013-20413
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http://dx.doi.org/10.1136/annrheumdis-2013-204133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283663PMC
January 2015

Genetic analysis of the Trichuris muris-induced model of colitis reveals QTL overlap and a novel gene cluster for establishing colonic inflammation.

BMC Genomics 2013 Feb 26;14:127. Epub 2013 Feb 26.

Gastrointestinal Sciences, Institute of Inflammation and Repair, Faculty of Medicine and Human Sciences, University of Manchester, 4.004 AV Hill Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1186/1471-2164-14-127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621453PMC
February 2013

Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis.

Arthritis Res Ther 2011 Jan 31;13(1):R12. Epub 2011 Jan 31.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, The University of Manchester, Manchester M139PT, UK.

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http://arthritis-research.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/ar3235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241356PMC
January 2011

Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus.

Ann Rheum Dis 2011 Mar 10;70(3):463-8. Epub 2010 Nov 10.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1136/ard.2010.137174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033530PMC
March 2011

Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients.

Ann Rheum Dis 2011 Jan 30;70(1):98-103. Epub 2010 Aug 30.

NIHR-Leeds Musculoskeletal Biomedical Research Unit (NIHR-LMBRU), University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1136/ard.2010.133249DOI Listing
January 2011

Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.

Ann Rheum Dis 2010 Dec 20;69(12):2169-72. Epub 2010 Jul 20.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, The University of Manchester, Manchester, UK.

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http://ard.bmj.com/cgi/doi/10.1136/ard.2009.126938
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http://dx.doi.org/10.1136/ard.2009.126938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002762PMC
December 2010

Meta-analysis and imputation refines the association of 15q25 with smoking quantity.

Authors:
Jason Z Liu Federica Tozzi Dawn M Waterworth Sreekumar G Pillai Pierandrea Muglia Lefkos Middleton Wade Berrettini Christopher W Knouff Xin Yuan Gérard Waeber Peter Vollenweider Martin Preisig Nicholas J Wareham Jing Hua Zhao Ruth J F Loos Inês Barroso Kay-Tee Khaw Scott Grundy Philip Barter Robert Mahley Antero Kesaniemi Ruth McPherson John B Vincent John Strauss James L Kennedy Anne Farmer Peter McGuffin Richard Day Keith Matthews Per Bakke Amund Gulsvik Susanne Lucae Marcus Ising Tanja Brueckl Sonja Horstmann H-Erich Wichmann Rajesh Rawal Norbert Dahmen Claudia Lamina Ozren Polasek Lina Zgaga Jennifer Huffman Susan Campbell Jaspal Kooner John C Chambers Mary Susan Burnett Joseph M Devaney Augusto D Pichard Kenneth M Kent Lowell Satler Joseph M Lindsay Ron Waksman Stephen Epstein James F Wilson Sarah H Wild Harry Campbell Veronique Vitart Muredach P Reilly Mingyao Li Liming Qu Robert Wilensky William Matthai Hakon H Hakonarson Daniel J Rader Andre Franke Michael Wittig Arne Schäfer Manuela Uda Antonio Terracciano Xiangjun Xiao Fabio Busonero Paul Scheet David Schlessinger David St Clair Dan Rujescu Gonçalo R Abecasis Hans Jörgen Grabe Alexander Teumer Henry Völzke Astrid Petersmann Ulrich John Igor Rudan Caroline Hayward Alan F Wright Ivana Kolcic Benjamin J Wright John R Thompson Anthony J Balmforth Alistair S Hall Nilesh J Samani Carl A Anderson Tariq Ahmad Christopher G Mathew Miles Parkes Jack Satsangi Mark Caulfield Patricia B Munroe Martin Farrall Anna Dominiczak Jane Worthington Wendy Thomson Steve Eyre Anne Barton Vincent Mooser Clyde Francks Jonathan Marchini

Nat Genet 2010 May 25;42(5):436-40. Epub 2010 Apr 25.

Department of Statistics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612983PMC
May 2010

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

Authors:
Nick Craddock Matthew E Hurles Niall Cardin Richard D Pearson Vincent Plagnol Samuel Robson Damjan Vukcevic Chris Barnes Donald F Conrad Eleni Giannoulatou Chris Holmes Jonathan L Marchini Kathy Stirrups Martin D Tobin Louise V Wain Chris Yau Jan Aerts Tariq Ahmad T Daniel Andrews Hazel Arbury Anthony Attwood Adam Auton Stephen G Ball Anthony J Balmforth Jeffrey C Barrett Inês Barroso Anne Barton Amanda J Bennett Sanjeev Bhaskar Katarzyna Blaszczyk John Bowes Oliver J Brand Peter S Braund Francesca Bredin Gerome Breen Morris J Brown Ian N Bruce Jaswinder Bull Oliver S Burren John Burton Jake Byrnes Sian Caesar Chris M Clee Alison J Coffey John M C Connell Jason D Cooper Anna F Dominiczak Kate Downes Hazel E Drummond Darshna Dudakia Andrew Dunham Bernadette Ebbs Diana Eccles Sarah Edkins Cathryn Edwards Anna Elliot Paul Emery David M Evans Gareth Evans Steve Eyre Anne Farmer I Nicol Ferrier Lars Feuk Tomas Fitzgerald Edward Flynn Alistair Forbes Liz Forty Jayne A Franklyn Rachel M Freathy Polly Gibbs Paul Gilbert Omer Gokumen Katherine Gordon-Smith Emma Gray Elaine Green Chris J Groves Detelina Grozeva Rhian Gwilliam Anita Hall Naomi Hammond Matt Hardy Pile Harrison Neelam Hassanali Husam Hebaishi Sarah Hines Anne Hinks Graham A Hitman Lynne Hocking Eleanor Howard Philip Howard Joanna M M Howson Debbie Hughes Sarah Hunt John D Isaacs Mahim Jain Derek P Jewell Toby Johnson Jennifer D Jolley Ian R Jones Lisa A Jones George Kirov Cordelia F Langford Hana Lango-Allen G Mark Lathrop James Lee Kate L Lee Charlie Lees Kevin Lewis Cecilia M Lindgren Meeta Maisuria-Armer Julian Maller John Mansfield Paul Martin Dunecan C O Massey Wendy L McArdle Peter McGuffin Kirsten E McLay Alex Mentzer Michael L Mimmack Ann E Morgan Andrew P Morris Craig Mowat Simon Myers William Newman Elaine R Nimmo Michael C O'Donovan Abiodun Onipinla Ifejinelo Onyiah Nigel R Ovington Michael J Owen Kimmo Palin Kirstie Parnell David Pernet John R B Perry Anne Phillips Dalila Pinto Natalie J Prescott Inga Prokopenko Michael A Quail Suzanne Rafelt Nigel W Rayner Richard Redon David M Reid Renwick Susan M Ring Neil Robertson Ellie Russell David St Clair Jennifer G Sambrook Jeremy D Sanderson Helen Schuilenburg Carol E Scott Richard Scott Sheila Seal Sue Shaw-Hawkins Beverley M Shields Matthew J Simmonds Debbie J Smyth Elilan Somaskantharajah Katarina Spanova Sophia Steer Jonathan Stephens Helen E Stevens Millicent A Stone Zhan Su Deborah P M Symmons John R Thompson Wendy Thomson Mary E Travers Clare Turnbull Armand Valsesia Mark Walker Neil M Walker Chris Wallace Margaret Warren-Perry Nicholas A Watkins John Webster Michael N Weedon Anthony G Wilson Matthew Woodburn B Paul Wordsworth Allan H Young Eleftheria Zeggini Nigel P Carter Timothy M Frayling Charles Lee Gil McVean Patricia B Munroe Aarno Palotie Stephen J Sawcer Stephen W Scherer David P Strachan Chris Tyler-Smith Matthew A Brown Paul R Burton Mark J Caulfield Alastair Compston Martin Farrall Stephen C L Gough Alistair S Hall Andrew T Hattersley Adrian V S Hill Christopher G Mathew Marcus Pembrey Jack Satsangi Michael R Stratton Jane Worthington Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem Ouwehand Miles Parkes Nazneen Rahman John A Todd Nilesh J Samani Peter Donnelly

Nature 2010 Apr;464(7289):713-20

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http://dx.doi.org/10.1038/nature08979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892339PMC
April 2010

Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.

Ann Rheum Dis 2010 Jun 11;69(6):1049-53. Epub 2009 Aug 11.

Stopford Building, Oxford Road, The University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1136/ard.2009.110650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935325PMC
June 2010

Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study.

Ann Rheum Dis 2010 May 11;69(5):813-6. Epub 2009 May 11.

Epidemiology Unit, Faculty of Medical and Human Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1136/ard.2009.109579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009392PMC
May 2010

Genetic variation in efflux transporters influences outcome to methotrexate therapy in patients with psoriasis.

J Invest Dermatol 2008 Aug 7;128(8):1925-9. Epub 2008 Feb 7.

Dermatological Sciences, The University of Manchester, Salford Royal Hospital, Manchester, UK.

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http://dx.doi.org/10.1038/jid.2008.16DOI Listing
August 2008

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

Authors:
Paul R Burton David G Clayton Lon R Cardon Nick Craddock Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem H Ouwehand Nilesh J Samani John A Todd Peter Donnelly Jeffrey C Barrett Dan Davison Doug Easton David M Evans Hin-Tak Leung Jonathan L Marchini Andrew P Morris Chris C A Spencer Martin D Tobin Antony P Attwood James P Boorman Barbara Cant Ursula Everson Judith M Hussey Jennifer D Jolley Alexandra S Knight Kerstin Koch Elizabeth Meech Sarah Nutland Christopher V Prowse Helen E Stevens Niall C Taylor Graham R Walters Neil M Walker Nicholas A Watkins Thilo Winzer Richard W Jones Wendy L McArdle Susan M Ring David P Strachan Marcus Pembrey Gerome Breen David St Clair Sian Caesar Katharine Gordon-Smith Lisa Jones Christine Fraser Elaine K Green Detelina Grozeva Marian L Hamshere Peter A Holmans Ian R Jones George Kirov Valentina Moskivina Ivan Nikolov Michael C O'Donovan Michael J Owen David A Collier Amanda Elkin Anne Farmer Richard Williamson Peter McGuffin Allan H Young I Nicol Ferrier Stephen G Ball Anthony J Balmforth Jennifer H Barrett Timothy D Bishop Mark M Iles Azhar Maqbool Nadira Yuldasheva Alistair S Hall Peter S Braund Richard J Dixon Massimo Mangino Suzanne Stevens John R Thompson Francesca Bredin Mark Tremelling Miles Parkes Hazel Drummond Charles W Lees Elaine R Nimmo Jack Satsangi Sheila A Fisher Alastair Forbes Cathryn M Lewis Clive M Onnie Natalie J Prescott Jeremy Sanderson Christopher G Matthew Jamie Barbour M Khalid Mohiuddin Catherine E Todhunter John C Mansfield Tariq Ahmad Fraser R Cummings Derek P Jewell John Webster Morris J Brown Mark G Lathrop John Connell Anna Dominiczak Carolina A Braga Marcano Beverley Burke Richard Dobson Johannie Gungadoo Kate L Lee Patricia B Munroe Stephen J Newhouse Abiodun Onipinla Chris Wallace Mingzhan Xue Mark Caulfield Martin Farrall Anne Barton Ian N Bruce Hannah Donovan Steve Eyre Paul D Gilbert Samantha L Hilder Anne M Hinks Sally L John Catherine Potter Alan J Silman Deborah P M Symmons Wendy Thomson Jane Worthington David B Dunger Barry Widmer Timothy M Frayling Rachel M Freathy Hana Lango John R B Perry Beverley M Shields Michael N Weedon Andrew T Hattersley Graham A Hitman Mark Walker Kate S Elliott Christopher J Groves Cecilia M Lindgren Nigel W Rayner Nicolas J Timpson Eleftheria Zeggini Melanie Newport Giorgio Sirugo Emily Lyons Fredrik Vannberg Adrian V S Hill Linda A Bradbury Claire Farrar Jennifer J Pointon Paul Wordsworth Matthew A Brown Jayne A Franklyn Joanne M Heward Matthew J Simmonds Stephen C L Gough Sheila Seal Michael R Stratton Nazneen Rahman Maria Ban An Goris Stephen J Sawcer Alastair Compston David Conway Muminatou Jallow Melanie Newport Giorgio Sirugo Kirk A Rockett Suzannah J Bumpstead Amy Chaney Kate Downes Mohammed J R Ghori Rhian Gwilliam Sarah E Hunt Michael Inouye Andrew Keniry Emma King Ralph McGinnis Simon Potter Rathi Ravindrarajah Pamela Whittaker Claire Widden David Withers Niall J Cardin Dan Davison Teresa Ferreira Joanne Pereira-Gale Ingeleif B Hallgrimsdo'ttir Bryan N Howie Zhan Su Yik Ying Teo Damjan Vukcevic David Bentley Matthew A Brown Alastair Compston Martin Farrall Alistair S Hall Andrew T Hattersley Adrian V S Hill Miles Parkes Marcus Pembrey Michael R Stratton Sarah L Mitchell Paul R Newby Oliver J Brand Jackie Carr-Smith Simon H S Pearce R McGinnis A Keniry P Deloukas John D Reveille Xiaodong Zhou Anne-Marie Sims Alison Dowling Jacqueline Taylor Tracy Doan John C Davis Laurie Savage Michael M Ward Thomas L Learch Michael H Weisman Mathew Brown

Nat Genet 2007 Nov 21;39(11):1329-37. Epub 2007 Oct 21.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1038/ng.2007.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680141PMC
November 2007

Investigation of genetic variation across the protein tyrosine phosphatase gene in patients with rheumatoid arthritis in the UK.

Ann Rheum Dis 2007 May 14;66(5):683-6. Epub 2006 Dec 14.

Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, UK.

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http://ard.bmj.com/cgi/doi/10.1136/ard.2006.060459
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http://dx.doi.org/10.1136/ard.2006.060459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1954621PMC
May 2007