Steve D Brown

Steve D Brown

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Precision and Functional Genomics.

Mamm Genome 2020 Feb;31(1-2)

Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME, USA.

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http://dx.doi.org/10.1007/s00335-020-09828-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087741PMC
February 2020

Mutation in Leads to Altered Immune Cell Content in Mouse Model of Otitis Media.

Front Genet 2020 11;11:50. Epub 2020 Feb 11.

Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, United Kingdom.

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http://dx.doi.org/10.3389/fgene.2020.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026503PMC
February 2020

Cellular Immune Response against Nontypeable Infecting the Preinflamed Middle Ear of the Mouse.

Infect Immun 2019 12 18;87(12). Epub 2019 Nov 18.

Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, United Kingdom.

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http://dx.doi.org/10.1128/IAI.00689-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867859PMC
December 2019

The dark genome and pleiotropy: challenges for precision medicine.

Mamm Genome 2019 08;30(7-8):212-216

MRC Harwell Institute, Harwell, OX11 0RD, UK.

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http://dx.doi.org/10.1007/s00335-019-09813-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759675PMC
August 2019

Precision medicine and Mammalian Genome.

Mamm Genome 2019 06;30(5-6):89

Pacific Northwest Research Institute, Seattle, WA, USA.

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http://link.springer.com/10.1007/s00335-019-09801-8
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http://dx.doi.org/10.1007/s00335-019-09801-8DOI Listing
June 2019

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Commun Biol 2019 7;2:97. Epub 2019 Mar 7.

Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, Sacramento, CA, 95817, USA.

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http://dx.doi.org/10.1038/s42003-019-0349-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405960PMC
March 2019

Cellular content plays a crucial role in Non-typeable Haemophilus influenzae infection of preinflamed Junbo mouse middle ear.

Cell Microbiol 2019 01 15;21(1):e12960. Epub 2018 Oct 15.

Mammalian Genetics Unit, MRC Harwell Institute, Harwell Campus, Oxfordshire, OX11 0RD, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.12960
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http://dx.doi.org/10.1111/cmi.12960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491974PMC
January 2019

Genetic landscape of auditory dysfunction.

Hum Mol Genet 2018 08;27(R2):R130-R135

Mammalian Genetics Unit, MRC Harwell Institute, Harwell Campus, Oxfordshire, UK.

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http://dx.doi.org/10.1093/hmg/ddy158DOI Listing
August 2018

Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".

Nat Methods 2018 04 30;15(4):235-236. Epub 2018 Mar 30.

IMPC Cas9 Working Group and the IMPC Steering Committee and executive director of the IMPC (www.mousephenotype.org).

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http://dx.doi.org/10.1038/nmeth.4559DOI Listing
April 2018

Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model.

Sci Rep 2018 02 15;8(1):3128. Epub 2018 Feb 15.

Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1038/s41598-018-21166-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814562PMC
February 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Nat Commun 2018 01 18;9(1):288. Epub 2018 Jan 18.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41467-017-01995-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773596PMC
January 2018

Corrigendum: High-throughput discovery of novel developmental phenotypes.

Nature 2017 11 8;551(7680):398. Epub 2017 Nov 8.

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http://dx.doi.org/10.1038/nature24643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849394PMC
November 2017

An in vitro model of murine middle ear epithelium.

Dis Model Mech 2016 11 22;9(11):1405-1417. Epub 2016 Sep 22.

Academic Unit of Respiratory Medicine, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2JF, UK

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http://dx.doi.org/10.1242/dmm.026658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117233PMC
November 2016

High-throughput discovery of novel developmental phenotypes.

Nature 2016 09 14;537(7621):508-514. Epub 2016 Sep 14.

The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/nature19356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295821PMC
September 2016

Mouse Models of NMNAT1-Leber Congenital Amaurosis (LCA9) Recapitulate Key Features of the Human Disease.

Am J Pathol 2016 07 18;186(7):1925-1938. Epub 2016 May 18.

Ocular Genomics Institute, Department of Ophthalmology, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929402PMC
July 2016

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models.

PLoS One 2015 10;10(4):e0122650. Epub 2015 Apr 10.

Academic Endocrine Unit, Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122650PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393098PMC
March 2016

A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse.

Dis Model Mech 2016 Jan 26;9(1):69-79. Epub 2015 Nov 26.

MRC Mammalian Genetics Unit, MRC Harwell, Didcot, Oxford, OX11 0RD, UK Developmental Biology Division, The Roslin Institute and Royal (Dick) School of Veterinary Studies, Easter Bush Campus, University of Edinburgh, EH25 9RG, UK Mary Lyon Centre, MRC Harwell, Harwell, Didcot, Oxford, OX11 0RD, UK

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http://dmm.biologists.org/content/dmm/early/2015/11/19/dmm.0
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http://dmm.biologists.org/cgi/doi/10.1242/dmm.021659
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http://dx.doi.org/10.1242/dmm.021659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728332PMC
January 2016

Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung.

Dis Model Mech 2015 Dec 15;8(12):1531-42. Epub 2015 Oct 15.

Medical Research Council, Mammalian Genetics Unit, Harwell OX11 0RD, UK

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http://dx.doi.org/10.1242/dmm.022426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728322PMC
December 2015

Myringotomy in the Junbo mouse model of chronic otitis media alleviates inflammation and cellular hypoxia.

Laryngoscope 2014 Sep 30;124(9):E377-83. Epub 2014 May 30.

UCL Ear Institute, London, United Kingdom; MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom; Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; Department of Otolaryngology, Barts Health NHS Trust, London, United Kingdom.

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http://dx.doi.org/10.1002/lary.24698DOI Listing
September 2014

Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition.

Nat Commun 2013 ;4:2816

1] Institute of Cellular Medicine, The Medical School, Newcastle University, 4th Floor William Leech Building, Framlington Place, Newcastle Upon Tyne NE2 4HH, UK [2] Mammalian Genetics Unit, MRC Harwell, Oxford OX11 0RD, UK [3] Department of Gastroenterology and Hepatology, Imperial College, St Mary's Hospital Campus, Praed Street, London W2 1NY, UK [4].

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http://dx.doi.org/10.1038/ncomms3816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843143PMC
July 2014

An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess.

Endocrinology 2014 Mar 3;155(3):908-22. Epub 2013 Dec 3.

Mammalian Genetics Unit (L.B., C.T.E., R.A.H., S.D.M.B., R.D.C.) and Mary Lyon Centre (C.L.S., T.A.H.), Medical Research Council Harwell, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, United Kingdom; Academic Endocrine Unit (C.T.E., M.A.N., R.A.H., F.M.H., R.V.T.), Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford OX3 7LE, United Kingdom; The Mellanby Centre for Bone Research (H.E., D.L.), Department of Human Metabolism, University of Sheffield, Sheffield S10 2RX, United Kingdom; Wellcome Trust Sanger Institute (C.P.), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom; Norwich Medical School (W.D.F.), University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom; Garvan Institute of Medical Research (P.I.C.), Musculoskeletal Medicine Division, University of New South Wales, Sydney 2010, Australia; and University of Queensland Diamantina Institute (M.A.B.), Princess Alexandra Hospital, University of Queensland, Brisbane 4102, Australia.

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http://dx.doi.org/10.1210/en.2013-1247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192286PMC
March 2014

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.

Nucleic Acids Res 2014 Jan 4;42(Database issue):D802-9. Epub 2013 Nov 4.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK and Mouse Informatics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1093/nar/gkt977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964955PMC
January 2014

Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media.

Mamm Genome 2013 Dec 26;24(11-12):439-45. Epub 2013 Sep 26.

Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Room 6607 Level 6, Headley Way, Oxford, OX3 9DU, UK,

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http://dx.doi.org/10.1007/s00335-013-9475-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843744PMC
December 2013

IGF-1 receptor antagonism inhibits autophagy.

Hum Mol Genet 2013 Nov 25;22(22):4528-44. Epub 2013 Jun 25.

Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

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http://hmg.oxfordjournals.org/content/22/22/4528.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddt300
Publisher Site
http://dx.doi.org/10.1093/hmg/ddt300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889807PMC
November 2013

Panel 4: Recent advances in otitis media in molecular biology, biochemistry, genetics, and animal models.

Otolaryngol Head Neck Surg 2013 Apr;148(4 Suppl):E52-63

Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1177/0194599813479772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006668PMC
April 2013

A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation.

PLoS One 2012 14;7(9):e45217. Epub 2012 Sep 14.

Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045217PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443222PMC
February 2013

The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping.

Mamm Genome 2012 Oct 1;23(9-10):632-40. Epub 2012 Sep 1.

MRC Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1007/s00335-012-9427-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774932PMC
October 2012

The mammalian gene function resource: the International Knockout Mouse Consortium.

Mamm Genome 2012 Oct 12;23(9-10):580-6. Epub 2012 Sep 12.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1007/s00335-012-9422-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463800PMC
October 2012

Accessing data from the International Mouse Phenotyping Consortium: state of the art and future plans.

Mamm Genome 2012 Oct 19;23(9-10):641-52. Epub 2012 Sep 19.

Mammalian Genetics Unit, Medical Research Council Harwell, Harwell, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1007/s00335-012-9428-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106044PMC
October 2012

A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation.

J Bone Miner Res 2012 Feb;27(2):413-28

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/jbmr.547DOI Listing
February 2012

Disease model discovery and translation. Introduction.

Authors:
Steve D M Brown

Mamm Genome 2011 Aug;22(7-8):361

Medical Research Council, Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire, UK.

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http://link.springer.com/10.1007/s00335-011-9352-4
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http://dx.doi.org/10.1007/s00335-011-9352-4DOI Listing
August 2011

High-throughput mouse phenotyping.

Methods 2011 Apr 23;53(4):394-404. Epub 2010 Dec 23.

MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Harwell OX11 0RD, UK.

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http://dx.doi.org/10.1016/j.ymeth.2010.12.017DOI Listing
April 2011

Unraveling the genetics of otitis media: from mouse to human and back again.

Mamm Genome 2011 Feb 25;22(1-2):66-82. Epub 2010 Nov 25.

Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Subiaco, WA 6008, Australia.

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http://dx.doi.org/10.1007/s00335-010-9295-1DOI Listing
February 2011

The Opdc missense mutation of Pax2 has a milder than loss-of-function phenotype.

Hum Mol Genet 2011 Jan 13;20(2):223-34. Epub 2010 Oct 13.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, UK.

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http://dx.doi.org/10.1093/hmg/ddq457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005898PMC
January 2011

Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity.

J Biol Chem 2011 Jan 3;286(1):192-8. Epub 2010 Nov 3.

Section of Human Physiology, University of Perugia School of Medicine, Perugia 06100, Italy.

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http://dx.doi.org/10.1074/jbc.M110.189290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012974PMC
January 2011

Melody, an ENU mutation in Caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice.

Mamm Genome 2010 Dec 30;21(11-12):565-76. Epub 2010 Nov 30.

MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK.

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http://dx.doi.org/10.1007/s00335-010-9306-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002157PMC
December 2010

Establishing normal plasma and 24-hour urinary biochemistry ranges in C3H, BALB/c and C57BL/6J mice following acclimatization in metabolic cages.

Lab Anim 2010 Jul 10;44(3):218-25. Epub 2010 May 10.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Oxford, UK.

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http://dx.doi.org/10.1258/la.2010.009128DOI Listing
July 2010

Gelsolin plays a role in the actin polymerization complex of hair cell stereocilia.

PLoS One 2010 Jul 16;5(7):e11627. Epub 2010 Jul 16.

Medical Research Council Mammalian Genetics Unit, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011627PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905391PMC
July 2010

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease.

Hum Mol Genet 2010 Jun 27;19(11):2144-53. Epub 2010 Feb 27.

Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1093/hmg/ddq093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865373PMC
June 2010

Protein 4.1 expression in the developing hair cells of the mouse inner ear.

Brain Res 2010 Jan 22;1307:53-62. Epub 2009 Oct 22.

Department of Bioproduction, Tokyo University of Agriculture, 196, Yasaka, Abashiri, Hokkaido 099-2493, Japan.

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http://dx.doi.org/10.1016/j.brainres.2009.10.039DOI Listing
January 2010

MouseBook: an integrated portal of mouse resources.

Nucleic Acids Res 2010 Jan 23;38(Database issue):D593-9. Epub 2009 Oct 23.

MRC Harwell, Mammalian Genetics Unit and the Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1093/nar/gkp867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808969PMC
January 2010

EuroPhenome: a repository for high-throughput mouse phenotyping data.

Nucleic Acids Res 2010 Jan 23;38(Database issue):D577-85. Epub 2009 Nov 23.

MRC Harwell, Mammalian Genetics Unit, MRC Harwell, Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK.

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http://dx.doi.org/10.1093/nar/gkp1007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808931PMC
January 2010

A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.

Nat Protoc 2010 Jan 7;5(1):177-90. Epub 2010 Jan 7.

MRC Harwell, Mammalian Genetics Unit, Harwell Science and Innovation Campus, Harwell, UK.

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http://dx.doi.org/10.1038/nprot.2009.204DOI Listing
January 2010

The functional annotation of mammalian genomes: the challenge of phenotyping.

Annu Rev Genet 2009 ;43:305-33

MRC Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, United Kingdom.

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http://dx.doi.org/10.1146/annurev-genet-102108-134143DOI Listing
December 2009

ENU mutagenesis, a way forward to understand gene function.

Annu Rev Genomics Hum Genet 2008 ;9:49-69

MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom.

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http://dx.doi.org/10.1146/annurev.genom.9.081307.164224DOI Listing
December 2008

Quiet as a mouse: dissecting the molecular and genetic basis of hearing.

Nat Rev Genet 2008 Apr 19;9(4):277-90. Epub 2008 Feb 19.

MRC Mammalian Genetics Unit, Harwell, OX11 ORD, UK.

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http://dx.doi.org/10.1038/nrg2309DOI Listing
April 2008