Stevan R Hubbard

Stevan R Hubbard

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Stevan R Hubbard

Publications by authors named "Stevan R Hubbard"

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Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations.

J Allergy Clin Immunol 2019 Apr 6;143(4):1549-1559.e6. Epub 2018 Aug 6.

Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Fimlab Laboratories, Tampere, Finland; Institute of Biotechnology, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363912PMC
April 2019

Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1.

PLoS One 2018 28;13(6):e0199942. Epub 2018 Jun 28.

Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199942PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023178PMC
December 2018

Mechanistic Insights into Regulation of JAK2 Tyrosine Kinase.

Authors:
Stevan R Hubbard

Front Endocrinol (Lausanne) 2017 5;8:361. Epub 2018 Jan 5.

Department of Biochemistry and Molecular Pharmacology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, United States.

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http://dx.doi.org/10.3389/fendo.2017.00361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770812PMC
January 2018

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1.

Elife 2016 08 19;5. Epub 2016 Aug 19.

Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States.

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http://dx.doi.org/10.7554/eLife.16093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005030PMC
August 2016

Targeting the Inactive Conformation of JAK2 in Hematological Malignancies.

Cancer Cell 2015 Jul;28(1):1-2

Kimmel Center for Biology and Medicine at the Skirball Institute and Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.ccell.2015.06.010DOI Listing
July 2015

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms.

Blood 2015 May 30;125(22):3388-92. Epub 2015 Mar 30.

Kimmel Center for Biology and Medicine at the Skirball Institute and Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY.

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http://dx.doi.org/10.1182/blood-2015-01-621110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447858PMC
May 2015

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.

Proc Natl Acad Sci U S A 2015 Apr 30;112(15):4642-7. Epub 2015 Mar 30.

School of Medicine, University of Tampere, FI-33014 Tampere, Finland; Clinical Hematology, Department of Internal Medicine, Tampere University Hospital, FI-33520 Tampere, Finland

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http://dx.doi.org/10.1073/pnas.1423201112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403165PMC
April 2015

Proteasomal control of cytokinin synthesis protects Mycobacterium tuberculosis against nitric oxide.

Mol Cell 2015 Mar 26;57(6):984-994. Epub 2015 Feb 26.

Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369403PMC
March 2015

The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.

Nat Commun 2015 Mar 11;6:6406. Epub 2015 Mar 11.

Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York 11794, USA.

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http://www.nature.com/articles/ncomms7406
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http://dx.doi.org/10.1038/ncomms7406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758444PMC
March 2015

Closing in on a mechanism for activation.

Elife 2014 Oct 28;3. Epub 2014 Oct 28.

W Todd Miller is in the Department of Physiology and Biophysics, Stony Brook University, Stony Brook, United States

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http://dx.doi.org/10.7554/eLife.04909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210822PMC
October 2014

IRAK4 activation: a cautious embrace.

Authors:
Stevan R Hubbard

Mol Cell 2014 Sep;55(6):805-806

Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.09.003DOI Listing
September 2014

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.

Nat Struct Mol Biol 2014 Jul 11;21(7):579-84. Epub 2014 Jun 11.

Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.2849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508010PMC
July 2014

Structural basis for the interaction of the adaptor protein grb14 with activated ras.

PLoS One 2013 13;8(8):e72473. Epub 2013 Aug 13.

Kimmel Center for Biology and Medicine of the Skirball Institute and Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072473PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742580PMC
May 2014

Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation.

Biochim Biophys Acta 2013 Oct 5;1834(10):2166-9. Epub 2013 Mar 5.

Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2013.02.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923368PMC
October 2013

New insights into the structure and function of the pseudokinase domain in JAK2.

Biochem Soc Trans 2013 Aug;41(4):1002-7

School of Medicine and Institute of Biomedical Technology, University of Tampere, 33014 Tampere, Finland.

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http://dx.doi.org/10.1042/BST20130005DOI Listing
August 2013

The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.

Authors:
Stevan R Hubbard

Cold Spring Harb Perspect Biol 2013 Mar 1;5(3):a008946. Epub 2013 Mar 1.

Kimmel Center for Biology and Medicine of the Skirball Institute and Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1101/cshperspect.a008946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578362PMC
March 2013

Structural biology: Insulin meets its receptor.

Authors:
Stevan R Hubbard

Nature 2013 Jan;493(7431):171-2

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http://dx.doi.org/10.1038/493171aDOI Listing
January 2013

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.

Nat Struct Mol Biol 2012 Aug 22;19(8):754-9. Epub 2012 Jul 22.

Structural Biology Program, Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.2348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414675PMC
August 2012

Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK).

J Biol Chem 2011 Nov 3;286(47):40624-30. Epub 2011 Oct 3.

Molecular Neurobiology Program, Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, New York 10016, USA.

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http://dx.doi.org/10.1074/jbc.M111.279307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220470PMC
November 2011

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling.

Nat Struct Mol Biol 2011 Aug 14;18(9):971-6. Epub 2011 Aug 14.

Institute of Biomedical Technology, University of Tampere, and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1038/nsmb.2099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504201PMC
August 2011

Structure-guided identification of a laminin binding site on the laminin receptor precursor.

J Mol Biol 2011 Jan 30;405(1):24-32. Epub 2010 Oct 30.

Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.jmb.2010.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008175PMC
January 2011

Cytokine signaling exposed.

Authors:
Stevan R Hubbard

Structure 2011 Jan;19(1):1-2

Structural Biology Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.str.2010.12.010DOI Listing
January 2011

Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis.

Mol Microbiol 2010 Sep;77(5):1123-35

New York University School of Medicine, Department of Microbiology, 550 First Avenue, New York, NY 10016, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2010.07276.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975802PMC
September 2010

The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.

Mol Cell 2010 Jul;39(1):100-9

Structural Biology Program, Kimmel Center for Biology and Medicine of the Skirball Institute and Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109727651000448
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http://dx.doi.org/10.1016/j.molcel.2010.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917201PMC
July 2010

Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK.

J Mol Biol 2009 Oct 4;393(1):1-9. Epub 2009 Aug 4.

Structural Biology Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.07.091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754272PMC
October 2009

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.

Nat Struct Mol Biol 2009 Aug 2;16(8):833-9. Epub 2009 Aug 2.

Structural Biology Program, Kimmel Center for Biology and Medicine of the Skirball Institute, and Department of Pharmacology, New York University School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.1642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748937PMC
August 2009

The juxtamembrane region of EGFR takes center stage.

Authors:
Stevan R Hubbard

Cell 2009 Jun;137(7):1181-3

Structural Biology Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.cell.2009.06.008DOI Listing
June 2009

Lrp4 is a receptor for Agrin and forms a complex with MuSK.

Cell 2008 Oct 9;135(2):334-42. Epub 2008 Oct 9.

Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Helen and Martin Kimmel Center for Biology and Medicine, NYU Medical School, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.cell.2008.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933840PMC
October 2008

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor.

EMBO J 2008 Jul 19;27(14):1985-94. Epub 2008 Jun 19.

Structural Biology Program, Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1038/emboj.2008.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486273PMC
July 2008

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.

Nat Struct Mol Biol 2008 Mar 17;15(3):251-8. Epub 2008 Feb 17.

Structural Biology Program, Kimmel Center for Biology and Medicine of the Skirball Institute, and Department of Pharmacology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA.

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http://dx.doi.org/10.1038/nsmb.1388DOI Listing
March 2008

Crystal structure of the human laminin receptor precursor.

J Biol Chem 2008 Feb 6;283(6):3002-5. Epub 2007 Dec 6.

Gene Therapy Center, Cancer Institute and Department of Pathology, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1074/jbc.C700206200DOI Listing
February 2008

How IRE1 reacts to ER stress.

Cell 2008 Jan;132(1):24-6

Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.cell.2007.12.017DOI Listing
January 2008

Receptor tyrosine kinases: mechanisms of activation and signaling.

Curr Opin Cell Biol 2007 Apr 16;19(2):117-23. Epub 2007 Feb 16.

Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09550674070002
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http://dx.doi.org/10.1016/j.ceb.2007.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536775PMC
April 2007

Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK.

J Mol Biol 2006 Dec 12;364(3):424-33. Epub 2006 Sep 12.

Structural Biology Program, Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1752213PMC
December 2006

Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS.

J Mol Biol 2006 Aug 16;361(1):69-79. Epub 2006 Jun 16.

Structural Biology Program, Skirball Institute of Biomolecular Medicine, and Department of Pharmacology, New York University School of Medicine, NY 10016, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.05.070DOI Listing
August 2006

Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3.

Structure 2006 Aug;14(8):1285-92

Structural Biology Program, Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1016/j.str.2006.06.011DOI Listing
August 2006

EGF receptor activation: push comes to shove.

Authors:
Stevan R Hubbard

Cell 2006 Jun;125(6):1029-31

Structural Biology Program, Skirball Institute of Biomolecular Medicine, and Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.cell.2006.05.028DOI Listing
June 2006

Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase.

Structure 2005 Nov;13(11):1643-51

Structural Biology Program, Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1016/j.str.2005.07.019DOI Listing
November 2005

Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.

Mol Cell 2005 Oct;20(2):325-33

Structural Biology Program, Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526137PMC
October 2005

Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: molecular yardsticks for analyzing catalytic mechanism and inhibitor design.

Bioorg Chem 2005 Aug 19;33(4):285-97. Epub 2005 Apr 19.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.bioorg.2005.02.002DOI Listing
August 2005

Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins.

J Biol Chem 2005 May 28;280(19):18943-9. Epub 2005 Feb 28.

Structural Biology Program, Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1074/jbc.M414157200DOI Listing
May 2005

EGF receptor inhibition: attacks on multiple fronts.

Authors:
Stevan R Hubbard

Cancer Cell 2005 Apr;7(4):287-8

Structural Biology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.04.004DOI Listing
April 2005

Juxtamembrane autoinhibition in receptor tyrosine kinases.

Authors:
Stevan R Hubbard

Nat Rev Mol Cell Biol 2004 Jun;5(6):464-71

Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York 10016, USA.

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http://dx.doi.org/10.1038/nrm1399DOI Listing
June 2004

Oncogenic mutations in B-Raf: some losses yield gains.

Authors:
Stevan R Hubbard

Cell 2004 Mar;116(6):764-6

Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/s0092-8674(04)00256-9DOI Listing
March 2004

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.

Mol Cell 2003 Dec;12(6):1379-89

Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/s1097-2765(03)00487-8DOI Listing
December 2003

Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor.

J Biol Chem 2003 Jul 21;278(28):26007-14. Epub 2003 Apr 21.

Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1074/jbc.M302425200DOI Listing
July 2003

Agrin/MuSK signaling: willing and Abl.

Nat Neurosci 2003 Jul;6(7):653-4

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http://dx.doi.org/10.1038/nn0703-653DOI Listing
July 2003

Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity.

J Biol Chem 2003 Apr 27;278(15):13257-64. Epub 2003 Jan 27.

Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1074/jbc.M212026200DOI Listing
April 2003

Protein tyrosine kinases: autoregulation and small-molecule inhibition.

Authors:
Stevan R Hubbard

Curr Opin Struct Biol 2002 Dec;12(6):735-41

Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York 10016, USA.

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http://dx.doi.org/10.1016/s0959-440x(02)00383-4DOI Listing
December 2002

Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.

Structure 2002 Sep;10(9):1187-96

Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York university School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/s0969-2126(02)00814-6DOI Listing
September 2002

Autoinhibitory mechanisms in receptor tyrosine kinases.

Authors:
Stevan R Hubbard

Front Biosci 2002 Feb 1;7:d330-40. Epub 2002 Feb 1.

Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.

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February 2002

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.

Nature 2002 Jan;415(6867):92-6

Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1038/415092aDOI Listing
January 2002